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Statistics in Biopharmaceutical Research Volume 15, 2023 - Issue 2
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Special Section: Estimands, Design and Analysis of Clinical Trials with Time-to-Event Outcomes

Comment on “Robust Design and Analysis of Clinical Trials With Nonproportional Hazards: A Straw Man Guidance From a Cross-Pharma Working Group”: The Test Statistic Should Estimate Some Reasonable Measure of Treatment Benefit

Steven Snapinna Seattle-Quilcene Biostatistics LLC, Seattle, WACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2961-8774
ORCID Icon,
Qi Jiangb Seagen Inc., Bothell, WA
&
Chunlei Kec Apellis Pharmaceuticals, Waltham, MA
Pages 297-299 | Received 19 Apr 2021, Accepted 22 Apr 2021, Published online: 06 Jul 2021

References

  • Efron, B. (1967), “The Two Sample Problem with Censored Data,” Berkeley Symposium on Mathematical Statistics and Probability, 5, 831–853.
  • Roychoudhery, S., Anderson, K. M., Jiabu, Y., and Mukhopadhyay, P. (2021), “Robust Design and Analysis of Clinical Trials with Non-Proportional Hazards: A Straw Man Guidance from a Cross-Pharma Working Group,” Statistics in Biopharmaceutical Research, 1–37, DOI: 10.1080/19466315.2021.1874507.

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