Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis

References

• Ndip RN, MacKay WG, Farthing MJG, Weaver LT. Culturing Helicobacter pylori from clinical specimens: review of microbiologic methods. J Pediatr Gastroenterol Nutr 2003; 36:616-22; PMID:12717085; http://dx.doi.org/10.1097/00005176-200305000-00005
   PubMed Web of Science ®Google Scholar
• McNulty SL, Mole BM, Dailidiene D, Segal I, Ally R, Mistry R, Secka O, Adegbola RA, Thomas JE, Lenarcic EM, et al. Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori. J Clin Microbiol 2004; 42:5658-63; PMID:15583296; http://dx.doi.org/10.1128/JCM.42.12.5658-5663.2004
   PubMed Web of Science ®Google Scholar
• Mane SP, Dominguez-Bello MG, Blaser MJ, Sobral BW, Hontecillas R, Skoneczka J, Mohapatra SK, Crasta OR, Evans C, Modise T, et al. Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses. J Bacteriol 2010; 192:3078-92; PMID:20400544; http://dx.doi.org/10.1128/JB.00063-10
   PubMed Web of Science ®Google Scholar
• Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1:1311-5; PMID:6145023; http://dx.doi.org/10.1016/S0140-6736(84)91816-6
   PubMed Web of Science ®Google Scholar
• Danesh J. Helicobacter pylori infection and gastric cancer: systematic review of the epidemiological studies. Aliment Pharmacol Ther 1999; 13:851-6; PMID:10383517; http://dx.doi.org/10.1046/j.1365-2036.1999.00546.x
   PubMed Web of Science ®Google Scholar
• Permin H, Andersen LP. Inflammation, immunity, and vaccines for Helicobacter infection. Helicobacter 2005; 10 Suppl 1:21-5; PMID:16178967; http://dx.doi.org/10.1111/j.1523-5378.2005.00337.x
   PubMed Web of Science ®Google Scholar
• Blaser MJ. Disappearing microbiota: Helicobacter pylori protection against esophageal adenocarcinoma. Cancer Prev Res (Phila) 2008; 1:308-11; PMID:19138974; http://dx.doi.org/10.1158/1940-6207.CAPR-08-0170
   PubMed Web of Science ®Google Scholar
• Vieth M, Masoud B, Meining A, Stolte M. Helicobacter pylori infection: protection against Barrett's mucosa and neoplasia? Digestion 2000; 62:225-31; PMID:11070405; http://dx.doi.org/10.1159/000007820
   PubMed Web of Science ®Google Scholar
• Vaezi MF, Falk GW, Peek RM, Vicari JJ, Goldblum JR, Perez-Perez GI, Rice TW, Blaser MJ, Richter JE. CagA-positive strains of Helicobacter pylori may protect against Barrett's esophagus. Am J Gastroenterol 2000; 95:2206-11; PMID:11007219; http://dx.doi.org/10.1111/j.1572-0241.2000.02305.x
   PubMed Web of Science ®Google Scholar
• Chow WH, Blaser MJ, Blot WJ, Gammon MD, Vaughan TL, Risch HA, Perez-Perez GI, Schoenberg JB, Stanford JL, Rotterdam H, et al. An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res 1998; 58:588-90; PMID:9485003
   PubMed Web of Science ®Google Scholar
• Lang L. Childhood acquisition of Helicobacter pylori linked to reduced asthma and allergy risk. Gastroenterology 2007; 133:6; PMID:17631119; http://dx.doi.org/10.1053/j.gastro.2007.05.011
   PubMed Web of Science ®Google Scholar
• Chen Y, Blaser MJ. Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 2007; 167:821-7; PMID:17452546; http://dx.doi.org/10.1001/archinte.167.8.821
   PubMed Web of Science ®Google Scholar
• Blaser MJ, Chen Y, Reibman J. Does Helicobacter pylori protect against asthma and allergy? Gut 2008; 57:561-7; PMID:18194986; http://dx.doi.org/10.1136/gut.2007.133462
   PubMed Web of Science ®Google Scholar
• McCune A, Lane A, Murray L, Harvey I, Nair P, Donovan J, Harvey R. Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2003; 15:637-40; PMID:12840675; http://dx.doi.org/10.1097/00042737-200306000-00010
   PubMed Web of Science ®Google Scholar
• Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology 2009; 136:1863-73; PMID:19457415; http://dx.doi.org/10.1053/j.gastro.2009.01.073
   PubMed Web of Science ®Google Scholar
• Kuipers EJ, Israel DA, Kusters JG, Gerrits MM, Weel J, van Der Ende A, van Der Hulst RW, Wirth HP, Höök-Nikanne J, Thompson SA, et al. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host. J Infect Dis 2000; 181:273-82; PMID:10608776; http://dx.doi.org/10.1086/315173
   PubMed Web of Science ®Google Scholar
• Hazell SL, Lee A, Brady L, Hennessy W. Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis 1986; 153:658-63; PMID:3950447; http://dx.doi.org/10.1093/infdis/153.4.658
   PubMed Web of Science ®Google Scholar
• Zanotti G, Cendron L. Structural and functional aspects of the Helicobacter pylori secretome. World J Gastroenterol 2014; 20:1402-23; PMID:24587618; http://dx.doi.org/10.3748/wjg.v20.i6.1402
   PubMed Web of Science ®Google Scholar
• Sgouras DN, Trang TTH, Yamaoka Y. Pathogenesis of Helicobacter pylori Infection. Helicobacter 2015; 20 Suppl 1:8-16; PMID:26372819; http://dx.doi.org/10.1111/hel.12251
   PubMed Web of Science ®Google Scholar
• Roesler BM, Rabelo-Gonçalves EMA, Zeitune JMR. Virulence Factors of Helicobacter pylori: A Review. Clin Med Insights Gastroenterol 2014; 7:9-17; PMID:24833944; http://dx.doi.org/10.4137/CGast.S13760
   PubMedGoogle Scholar
• Petersson C, Forsberg M, Aspholm M, Olfat FO, Forslund T, Borén T, Magnusson KE. Helicobacter pylori SabA adhesin evokes a strong inflammatory response in human neutrophils which is down-regulated by the neutrophil-activating protein. Med Microbiol Immunol 2006; 195:195-206; PMID:16758245; http://dx.doi.org/10.1007/s00430-006-0018-x
   PubMed Web of Science ®Google Scholar
• Guruge JL, Falk PG, Lorenz RG, Dans M, Wirth HP, Blaser MJ, Berg DE, Gordon JI. Epithelial attachment alters the outcome of Helicobacter pylori infection. Proc Natl Acad Sci U S A 1998; 95:3925-30; PMID:9520469; http://dx.doi.org/10.1073/pnas.95.7.3925
   PubMed Web of Science ®Google Scholar
• Tan S, Tompkins LS, Amieva MR. Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche. PLoS Pathog 2009; 5:e1000407; PMID:19412339; http://dx.doi.org/10.1371/journal.ppat.1000407
   PubMed Web of Science ®Google Scholar
• Howitt MR, Lee JY, Lertsethtakarn P, Vogelmann R, Joubert L-M, Ottemann KM, Amieva MR. ChePep controls Helicobacter pylori Infection of the gastric glands and chemotaxis in the Epsilonproteobacteria. MBio 2011; 2:e00098-11; PMID:21791582; http://dx.doi.org/10.1128/mBio.00098-11
   PubMed Web of Science ®Google Scholar
• Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E. Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology 2007; 132:1009-23; PMID:17383424; http://dx.doi.org/10.1053/j.gastro.2007.01.049
   PubMed Web of Science ®Google Scholar
• Chu YT, Wang YH, Wu JJ, Lei HY. Invasion and multiplication of Helicobacter pylori in gastric epithelial cells: implications for antibiotic resistance. Infect Immun 2010; 78:4157-65; PMID:20696835; http://dx.doi.org/10.1128/IAI.00524-10
   PubMed Web of Science ®Google Scholar
• Oh JD, Karam SM, Gordon JI. Intracellular Helicobacter pylori in gastric epithelial progenitors. Proc Natl Acad Sci U S A 2005; 102:5186-91; PMID:15795379; http://dx.doi.org/10.1073/pnas.0407657102
   PubMed Web of Science ®Google Scholar
• Liu H, Semino-Mora C, Dubois A. Mechanism of H. pylori intracellular entry: an in vitro study. Front Cell Infect Microbiol 2012; 2:13; PMID:22919605
   PubMed Web of Science ®Google Scholar
• Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, et al. Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. J Biol Chem 2006; 281:34888-96; PMID:16990273; http://dx.doi.org/10.1074/jbc.M607067200
   PubMed Web of Science ®Google Scholar
• Nilsson C, Sillén A, Eriksson L, Strand M-L, Enroth H, Normark S, Falk P, Engstrand L. Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect Immun 2003; 71:6573-81; PMID:14573679; http://dx.doi.org/10.1128/IAI.71.11.6573-6581.2003
   PubMed Web of Science ®Google Scholar
• Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995; 270:17771-7; PMID:7629077; http://dx.doi.org/10.1074/jbc.270.30.17771
   PubMed Web of Science ®Google Scholar
• Basak C, Pathak SK, Bhattacharyya A, Mandal D, Pathak S, Kundu M. NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem 2005; 280:4279-88; PMID:15561713; http://dx.doi.org/10.1074/jbc.M412820200
   PubMed Web of Science ®Google Scholar
• Castaño-Rodríguez N, Kaakoush NO, Mitchell HM. Pattern-recognition receptors and gastric cancer. Front Immunol 2014; 5:336
   PubMed Web of Science ®Google Scholar
• Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, Michalak P, Kang L, Girardin SE, Hontecillas R. Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection. PLoS One 2015; 10:e0137839; PMID:26367386; http://dx.doi.org/10.1371/journal.pone.0137839
   PubMedGoogle Scholar
• Lee JM, Kim SS, Cho Y-S. The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis. PPAR Res 2012; 2012:687570; PMID:22936949; http://dx.doi.org/10.1155/2012/687570
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140:805-20; PMID:20303872; http://dx.doi.org/10.1016/j.cell.2010.01.022
   PubMed Web of Science ®Google Scholar
• Rohde M, Püls J, Buhrdorf R, Fischer W, Haas R. A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol Microbiol 2003; 49:219-34; PMID:12823823; http://dx.doi.org/10.1046/j.1365-2958.2003.03549.x
   PubMed Web of Science ®Google Scholar
• Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, König W, et al. Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 2007; 449:862-6; PMID:17943123; http://dx.doi.org/10.1038/nature06187
   PubMed Web of Science ®Google Scholar
• Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Mémet S, Huerre MR, Coyle AJ, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5:1166-74; PMID:15489856; http://dx.doi.org/10.1038/ni1131
   PubMed Web of Science ®Google Scholar
• Allison CC, Kufer TA, Kremmer E, Kaparakis M, Ferrero RL. Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol 2009; 183:8099-109; PMID:20007577; http://dx.doi.org/10.4049/jimmunol.0900664
   PubMed Web of Science ®Google Scholar
• Hutton ML, Kaparakis-Liaskos M, Turner L, Cardona A, Kwok T, Ferrero RL. Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells. Infect Immun 2010; 78:4523-31; PMID:20713621; http://dx.doi.org/10.1128/IAI.00439-10
   PubMed Web of Science ®Google Scholar
• Lu DY, Chen HC, Yang MS, Hsu YM, Lin HJ, Tang CH, Lee CH, Lai CK, Lin CJ, Shyu WC, et al. Ceramide and Toll-like receptor 4 are mobilized into membrane rafts in response to Helicobacter pylori infection in gastric epithelial cells. Infect Immun 2012; 80:1823-33; PMID:22354030; http://dx.doi.org/10.1128/IAI.05856-11
   PubMed Web of Science ®Google Scholar
• Triantafilou M, Gamper FGJ, Lepper PM, Mouratis MA, Schumann C, Harokopakis E, Schifferle RE, Hajishengallis G, Triantafilou K. Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell Microbiol 2007; 9:2030-9; PMID:17419716; http://dx.doi.org/10.1111/j.1462-5822.2007.00935.x
   PubMed Web of Science ®Google Scholar
• Smith MF, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 2003; 278:32552-60; PMID:12807870; http://dx.doi.org/10.1074/jbc.M305536200
   PubMed Web of Science ®Google Scholar
• Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun 2004; 72:6446-54; PMID:15501775; http://dx.doi.org/10.1128/IAI.72.11.6446-6454.2004
   PubMed Web of Science ®Google Scholar
• Yokota S, Ohnishi T, Muroi M, Tanamoto K, Fujii N, Amano K. Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex. FEMS Immunol Med Microbiol 2007; 51:140-8; PMID:17645528; http://dx.doi.org/10.1111/j.1574-695X.2007.00288.x
   PubMed Web of Science ®Google Scholar
• Smith SM, Moran AP, Duggan SP, Ahmed SE, Mohamed AS, Windle HJ, O'Neill LA, Kelleher DP. Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide. J Immunol 2011; 186:2462-71; PMID:21220698; http://dx.doi.org/10.4049/jimmunol.1000864
   PubMed Web of Science ®Google Scholar
• Cullen TW, Giles DK, Wolf LN, Ecobichon C, Boneca IG, Trent MS. Helicobacter pylori vs. the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa. PLoS Pathog 2011; 7:e1002454; PMID:22216004; http://dx.doi.org/10.1371/journal.ppat.1002454
   PubMedGoogle Scholar
• Yokota SI, Okabayashi T, Rehli M, Fujii N, Amano KI. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun 2010; 78:468-76; PMID:19858308; http://dx.doi.org/10.1128/IAI.00903-09
   PubMed Web of Science ®Google Scholar
• Backert S, Naumann M. What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol 2010; 18:479-86; PMID:20863705; http://dx.doi.org/10.1016/j.tim.2010.08.003
   PubMed Web of Science ®Google Scholar
• Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am J Pathol 2011; 178:1448-52; PMID:21406172
   PubMed Web of Science ®Google Scholar
• Eck M, Schmausser B, Scheller K, Toksoy A, Kraus M, Menzel T, Müller-Hermelink HK, Gillitzer R. CXC chemokines Gro(α)/IL-8 and IP-10/MIG in Helicobacter pylori gastritis. Clin Exp Immunol 2000; 122:192-9; PMID:11091274; http://dx.doi.org/10.1046/j.1365-2249.2000.01374.x
   PubMed Web of Science ®Google Scholar
• Nishi T, Okazaki K, Kawasaki K, Fukui T, Tamaki H, Matsuura M, Asada M, Watanabe T, Uchida K, Watanabe N, et al. Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid follicles in Helicobacter pylori-infected neonatally thymectomized BALB/c mice. Infect Immun 2003; 71:2153-62; PMID:12654837; http://dx.doi.org/10.1128/IAI.71.4.2153-2162.2003
   PubMed Web of Science ®Google Scholar
• Alvarez-Arellano L, Camorlinga-Ponce M, Maldonado-Bernal C, Torres J. Activation of human neutrophils with Helicobacter pylori and the role of Toll-like receptors 2 and 4 in the response. FEMS Immunol Med Microbiol 2007; 51:473-9; PMID:17892476; http://dx.doi.org/10.1111/j.1574-695X.2007.00327.x
   PubMedGoogle Scholar
• Amedei A, Cappon A, Codolo G, Cabrelle A, Polenghi A, Benagiano M, Tasca E, Azzurri A, D'Elios MM, Del Prete G, et al. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest 2006; 116:1092-101; PMID:16543949; http://dx.doi.org/10.1172/JCI27177
   PubMed Web of Science ®Google Scholar
• Uno K, Kato K, Shimosegawa T. Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy. World J Gastroenterol 2014; 20:5244-51; PMID:24833854; http://dx.doi.org/10.3748/wjg.v20.i18.5244
   PubMed Web of Science ®Google Scholar
• Rad R, Ballhorn W, Voland P, Eisenächer K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, et al. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 2009; 136:2247-57; PMID:19272387; http://dx.doi.org/10.1053/j.gastro.2009.02.066
   PubMed Web of Science ®Google Scholar
• Sun X, Zhang M, El-Zataari M, Owyang SY, Eaton KA, Liu M, Chang YM, Zou W, Kao JY. TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice. PLoS One 2013; 8:e74595; PMID:24058595; http://dx.doi.org/10.1371/journal.pone.0074595
   PubMedGoogle Scholar
• Käbisch R, Mejías-Luque R, Gerhard M, Prinz C. Involvement of Toll-Like Receptors on Helicobacter pylori-Induced Immunity. PLoS One 2014; 9:e104804; http://dx.doi.org/10.1371/journal.pone.0104804
   Google Scholar
• Otani K, Tanigawa T, Watanabe T, Nadatani Y, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, et al. Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun 2012; 426:342-9; PMID:22940550; http://dx.doi.org/10.1016/j.bbrc.2012.08.080
   PubMed Web of Science ®Google Scholar
• Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10:241-7; PMID:19221555; http://dx.doi.org/10.1038/ni.1703
   PubMed Web of Science ®Google Scholar
• Kim DJ, Park JH, Franchi L, Backert S, Núñez G. The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Eur J Immunol 2013; 43:2650-8; PMID:23818043; http://dx.doi.org/10.1002/eji.201243281
   PubMed Web of Science ®Google Scholar
• Semper RP, Mejías-Luque R, Groß C, Anderl F, Müller A, Vieth M, Busch DH, Prazeres da Costa C, Ruland J, Groß O, et al. Helicobacter pylori-Induced IL-1β Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island. J Immunol 2014; 193:3566-76; PMID:25172489; http://dx.doi.org/10.4049/jimmunol.1400362
   PubMed Web of Science ®Google Scholar
• Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Fukuda M, et al. Role of ASC in the mouse model of Helicobacter pylori infection. J Histochem Cytochem 2009; 57:327-38; PMID:19064716; http://dx.doi.org/10.1369/jhc.2008.952366
   PubMed Web of Science ®Google Scholar
• Castaño-Rodríguez N, Kaakoush NO, Goh K-L, Fock KM, Mitchell HM. The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses. PLoS One 2014; 9:e98899; http://dx.doi.org/10.1371/journal.pone.0098899
   PubMed Web of Science ®Google Scholar
• Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity 2011; 34:854-65; PMID:21703540; http://dx.doi.org/10.1016/j.immuni.2011.03.026
   PubMed Web of Science ®Google Scholar
• Xia X, Cui J, Wang HY, Zhu L, Matsueda S, Wang Q, Yang X, Hong J, Songyang Z, Chen ZJ, et al. NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity 2011; 34:843-53; PMID:21703539; http://dx.doi.org/10.1016/j.immuni.2011.02.022
   PubMed Web of Science ®Google Scholar
• Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, et al. Suppression of NLRX1 in chronic obstructive pulmonary disease. J Clin Invest 2015; 125:2458-62; PMID:25938787; http://dx.doi.org/10.1172/JCI71747
   PubMed Web of Science ®Google Scholar
• Lord CA, Savitsky D, Sitcheran R, Calame K, Wright JR, Ting JPY, Williams KL. Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol 2009; 182:2948-58; PMID:19234190; http://dx.doi.org/10.4049/jimmunol.0801692
   PubMed Web of Science ®Google Scholar
• Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson K V, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, et al. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol 2012; 13:823-31; PMID:22863753; http://dx.doi.org/10.1038/ni.2378
   PubMed Web of Science ®Google Scholar
• Shi Y, Liu XF, Zhuang Y, Zhang JY, Liu T, Yin Z, Wu C, Mao XH, Jia KR, Wang FJ, et al. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol 2010; 184:5121-9; PMID:20351183; http://dx.doi.org/10.4049/jimmunol.0901115
   PubMed Web of Science ®Google Scholar
• Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G. Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun 2010; 78:845-53; PMID:19917709; http://dx.doi.org/10.1128/IAI.00524-09
   PubMed Web of Science ®Google Scholar
• Al-Sammak F, Kalinski T, Weinert S, Link A, Wex T, Malfertheiner P. Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in human: is it head or tail of the coin? PLoS One 2013; 8:e75192; PMID:24069393; http://dx.doi.org/10.1371/journal.pone.0075192
   PubMed Web of Science ®Google Scholar
• Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201:233-40; PMID:15657292; http://dx.doi.org/10.1084/jem.20041257
   PubMed Web of Science ®Google Scholar
• Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M, Andrei F, Fantini MC, et al. IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur J Immunol 2008; 38:470-8; PMID:18200634; http://dx.doi.org/10.1002/eji.200737635
   PubMed Web of Science ®Google Scholar
• Munari F, Fassan M, Capitani N, Codolo G, Vila-Caballer M, Pizzi M, Rugge M, Della Bella C, Troilo A, D'Elios S, et al. Cytokine BAFF released by Helicobacter pylori-infected macrophages triggers the Th17 response in human chronic gastritis. J Immunol 2014; 193:5584-94; PMID:25339679; http://dx.doi.org/10.4049/jimmunol.1302865
   PubMed Web of Science ®Google Scholar
• Kao JY, Rathinavelu S, Eaton K a, Bai L, Zavros Y, Takami M, Pierzchala A, Merchant JL. Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. Am J Physiol Gastrointest Liver Physiol 2006; 291:G73-81; PMID:16469828; http://dx.doi.org/10.1152/ajpgi.00139.2005
   PubMed Web of Science ®Google Scholar
• Weiss G, Forster S, Irving A, Tate M, Ferrero RL, Hertzog P, Frøkiær H, Kaparakis-Liaskos M. Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon β signaling in macrophages via alterations in the endocytic pathway. MBio 2013; 4:e00609-12; PMID:23760466; http://dx.doi.org/10.1128/mBio.00609-12
   PubMed Web of Science ®Google Scholar
• Bimczok D, Grams JM, Stahl RD, Waites KB, Smythies LE, Smith PD. Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori. Gastroenterology 2011; 141:929-38; PMID:21699795; http://dx.doi.org/10.1053/j.gastro.2011.06.006
   PubMed Web of Science ®Google Scholar
• Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, Hansson M, Taube C, Quiding-Järbrink M, et al. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 2012; 122:1082-96; PMID:22307326; http://dx.doi.org/10.1172/JCI61029
   PubMed Web of Science ®Google Scholar
• Mitchell P, Germain C, Fiori PL, Khamri W, Foster GR, Ghosh S, Lechler RI, Bamford KB, Lombardi G. Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development. Infect Immun 2007; 75:810-9; PMID:17101659; http://dx.doi.org/10.1128/IAI.00228-06
   PubMed Web of Science ®Google Scholar
• Wang YH, Gorvel JP, Chu YT, Wu JJ, Lei HY. Helicobacter pylori lmpairs murine dendritic cell responses to infection. PLoS One 2010; 5:e10844; PMID:20523725; http://dx.doi.org/10.1371/journal.pone.0010844
   PubMed Web of Science ®Google Scholar
• Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes 2010; 1:325-9; PMID:21327041; http://dx.doi.org/10.4161/gmic.1.5.13052
   PubMedGoogle Scholar
• Kaebisch R, Mejías-Luque R, Prinz C, Gerhard M. Helicobacter pylori cytotoxin-associated gene A impairs human dendritic cell maturation and function through IL-10-mediated activation of STAT3. J Immunol 2014; 192:316-23; PMID:24293633; http://dx.doi.org/10.4049/jimmunol.1302476
   PubMed Web of Science ®Google Scholar
• Lundgren A, Trollmo C, Edebo A, Svennerholm AM, Lundin BS. Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa. Infect Immun 2005; 73:5612-9; PMID:16113278; http://dx.doi.org/10.1128/IAI.73.9.5612-5619.2005
   PubMed Web of Science ®Google Scholar
• Serrano C, Diaz MI, Valdivia A, Godoy A, Peña A, Rollan A, Kirberg A, Hebel E, Fierro J, Klapp G, et al. Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome. Microbes Infect 2007; 9:428-34; PMID:17336120; http://dx.doi.org/10.1016/j.micinf.2006.12.012
   PubMed Web of Science ®Google Scholar
• Harris PR, Wright SW, Serrano C, Riera F, Duarte I, Torres J, Peña A, Rollán A, Viviani P, Guiraldes E, et al. Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 2008; 134:491-9; PMID:18242215; http://dx.doi.org/10.1053/j.gastro.2007.11.006
   PubMed Web of Science ®Google Scholar
• Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest 2009; 119:2475-87; PMID:19729845; http://dx.doi.org/10.1172/JCI38605
   PubMed Web of Science ®Google Scholar
• Müller A, Oertli M, Arnold IC. H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Commun Signal 2011; 9:25; PMID:22044597; http://dx.doi.org/10.1186/1478-811X-9-25
   PubMed Web of Science ®Google Scholar
• Gray BM, Fontaine C A, Poe S A, Eaton K A. Complex T cell interactions contribute to Helicobacter pylori gastritis in mice. Infect Immun 2013; 81:740-52; PMID:23264048; http://dx.doi.org/10.1128/IAI.01269-12
   PubMed Web of Science ®Google Scholar
• Luther J, Dave M, Higgins PDR, Kao JY. Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature. Inflamm Bowel Dis 2010; 16:1077-84; PMID:19760778; http://dx.doi.org/10.1002/ibd.21116
   PubMed Web of Science ®Google Scholar
• Hitzler I, Sayi A, Kohler E, Engler DB, Koch KN, Hardt W-D, Müller A. Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. J Immunol 2012; 188:3594-602; PMID:22403439; http://dx.doi.org/10.4049/jimmunol.1103212
   PubMed Web of Science ®Google Scholar
• Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 2001; 19:423-74; PMID:11244043; http://dx.doi.org/10.1146/annurev.immunol.19.1.423
   PubMed Web of Science ®Google Scholar
• Yun CH, Lundgren A, Azem J, Sjöling A, Holmgren J, Svennerholm AM, Lundin BS. Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production. Infect Immun 2005; 73:1482-90; PMID:15731046; http://dx.doi.org/10.1128/IAI.73.3.1482-1490.2005
   PubMed Web of Science ®Google Scholar
• Lindgren A, Pavlovic V, Flach CF, Sjöling A, Lundin S. Interferon-gamma secretion is induced in IL-12 stimulated human NK cells by recognition of Helicobacter pylori or TLR2 ligands. Innate Immun 2011; 17:191-203; PMID:20130107; http://dx.doi.org/10.1177/1753425909357970
   PubMed Web of Science ®Google Scholar
• Quiding-Järbrink M, Lundin BS, Lönroth H, Svennerholm AM. CD4+ and CD8+ T cell responses in Helicobacter pylori-infected individuals. Clin Exp Immunol 2001; 123:81-7; http://dx.doi.org/10.1046/j.1365-2249.2001.01427.x
   PubMed Web of Science ®Google Scholar
• Krauss-Etschmann S, Gruber R, Plikat K, Antoni I, Demmelmair H, Reinhardt D, Koletzko S. Increase of antigen-presenting cells in the gastric mucosa of Helicobacter pylori-infected children. Helicobacter 2005; 10:214-22; PMID:15904479; http://dx.doi.org/10.1111/j.1523-5378.2005.00313.x
   PubMed Web of Science ®Google Scholar
• Lopes AI, Victorino RMM, Palha AM, Ruivo J, Fernandes A. Mucosal lymphocyte subsets and HLA-DR antigen expression in paediatric Helicobacter pylori-associated gastritis. Clin Exp Immunol 2006; 145:13-20; PMID:16792668; http://dx.doi.org/10.1111/j.1365-2249.2006.03100.x
   PubMed Web of Science ®Google Scholar
• Figueiredo Soares T, Aguiar Rocha G, Camargos Rocha AM, Corrêa-Oliveira R, Martins-Filho OA, Teles Carvalho AS, Souto Bittencourt PF, Afonso Oliveira C, Ferreira Nogueira AMM, Alvares Cabral MMD, et al. Differences in peripheral blood lymphocyte phenotypes between Helicobacter pylori-positive children and adults with duodenal ulcer. Clin Microbiol Infect 2007; 13:1083-8; PMID:17727687; http://dx.doi.org/10.1111/j.1469-0691.2007.01814.x
   PubMed Web of Science ®Google Scholar
• Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu M, Carbo A, Pedragosa M, Vento S, Hontecillas R. Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses. Infect Immun 2013; 81:3803-13; PMID:23897614; http://dx.doi.org/10.1128/IAI.00660-13
   PubMed Web of Science ®Google Scholar
• Stolfi C, Rizzo A, Franzè E, Rotondi A, Fantini MC, Sarra M, Caruso R, Monteleone I, Sileri P, Franceschilli L, et al. Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med 2011; 208:2279-90; PMID:21987656; http://dx.doi.org/10.1084/jem.20111106
   PubMed Web of Science ®Google Scholar
• Pallone F, Fina D, Caruso R, Monteleone G. Role of IL-21 in inflammatory bowel disease. Expert Rev Clin Immunol 2010; 6:537-41; PMID:20594126; http://dx.doi.org/10.1586/eci.10.44
   PubMed Web of Science ®Google Scholar
• Leber A, Abedi V, Hontecillas R, Viladomiu M, Hoops S, Ciupe S, Caughman J, Andrew T, Bassaganya-Riera J. Bistability analysis of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection. J Theor Biol; under review
   Google Scholar
• Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HMS. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio 2014; 5:e01243-14; PMID:25053783; http://dx.doi.org/10.1128/mBio.01243-14
   PubMed Web of Science ®Google Scholar
• Zhuang Y, Cheng P, Liu XF, Peng LS, Li BS, Wang TT, Chen N, Li WH, Shi Y, Chen W, et al. A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis. Gut 2015; 64:1368-78; PMID:25134787; http://dx.doi.org/10.1136/gutjnl-2014-307020
   PubMed Web of Science ®Google Scholar
• Muotiala A, Helander IM, Pyhälä L, Kosunen TU, Moran AP. Low biological activity of Helicobacter pylori lipopolysaccharide. Infect Immun 1992; 60:1714-6; PMID:1548097
   PubMed Web of Science ®Google Scholar
• Allen LAH, Beecher BR, Lynch JT, Rohner OV, Wittine LM. Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release. J Immunol 2005; 174:3658-67; PMID:15749904; http://dx.doi.org/10.4049/jimmunol.174.6.3658
   PubMed Web of Science ®Google Scholar
• Schmausser B, Josenhans C, Endrich S, Suerbaum S, Sitaru C, Andrulis M, Brändlein S, Rieckmann P, Müller-Hermelink HK, Eck M. Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection? Infect Immun 2004; 72:6773-9; PMID:15557597; http://dx.doi.org/10.1128/IAI.72.12.6773-6779.2004
   PubMed Web of Science ®Google Scholar
• Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KT. Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II. J Immunol 2011; 186:3632-41; PMID:21296975; http://dx.doi.org/10.4049/jimmunol.1003431
   PubMed Web of Science ®Google Scholar
• Jüttner S, Cramer T, Wessler S, Walduck A, Gao F, Schmitz F, Wunder C, Weber M, Fischer SM, Schmidt WE, et al. Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Cell Microbiol 2003; 5:821-34; PMID:14531897; http://dx.doi.org/10.1046/j.1462-5822.2003.00324.x
   PubMed Web of Science ®Google Scholar
• Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. J Immunol 2003; 171:3913-7; PMID:14530307; http://dx.doi.org/10.4049/jimmunol.171.8.3913
   PubMed Web of Science ®Google Scholar
• Ozbek A, Ozbek E, Dursun H, Kalkan Y, Demirci T. Can Helicobacter pylori invade human gastric mucosa?: an in vivo study using electron microscopy, immunohistochemical methods, and real-time polymerase chain reaction. J Clin Gastroenterol 2010; 44:416-22; PMID:19904218
   PubMed Web of Science ®Google Scholar
• Wang Y, Wu J, Lei H. When Helicobacter pylori invades and replicates in the cells. Autophagy 2009; 5:540-2; PMID:19270492; http://dx.doi.org/10.4161/auto.5.4.8167
   PubMed Web of Science ®Google Scholar
• Greenfield LK, Jones NL. Modulation of autophagy by Helicobacter pylori and its role in gastric carcinogenesis. Trends Microbiol 2013; 21:602-12; PMID:24156875; http://dx.doi.org/10.1016/j.tim.2013.09.004
   PubMed Web of Science ®Google Scholar
• Basu M, Czinn SJ, Blanchard TG. Absence of catalase reduces long-term survival of Helicobacter pylori in macrophage phagosomes. Helicobacter 2004; 9:211-6; PMID:15165256; http://dx.doi.org/10.1111/j.1083-4389.2004.00226.x
   PubMed Web of Science ®Google Scholar
• Gobert AP, McGee DJ, Akhtar M, Mendz GL, Newton JC, Cheng Y, Mobley HL, Wilson KT. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proc Natl Acad Sci U S A 2001; 98:13844-9; PMID:11717441; http://dx.doi.org/10.1073/pnas.241443798
   PubMed Web of Science ®Google Scholar
• Chaturvedi R, Asim M, Lewis ND, Algood HMS, Cover TL, Kim PY, Wilson KT. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect Immun 2007; 75:4305-15; PMID:17562760; http://dx.doi.org/10.1128/IAI.00578-07
   PubMed Web of Science ®Google Scholar
• Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA, Wilson KT. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Amino Acids 2014; 46:531-42; PMID:23820617; http://dx.doi.org/10.1007/s00726-013-1531-z
   PubMed Web of Science ®Google Scholar
• Rittig MG, Shaw B, Letley DP, Thomas RJ, Argent RH, Atherton JC. Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status. Cell Microbiol 2003; 5:887-99; PMID:14641174; http://dx.doi.org/10.1046/j.1462-5822.2003.00328.x
   PubMed Web of Science ®Google Scholar
• Ramarao N, Meyer TF. Helicobacter pylori resists phagocytosis by macrophages: quantitative assessment by confocal microscopy and fluorescence-activated cell sorting. Infect Immun 2001; 69:2604-11; PMID:11254625; http://dx.doi.org/10.1128/IAI.69.4.2604-2611.2001
   PubMed Web of Science ®Google Scholar
• Zheng PY, Jones NL. Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein. Cell Microbiol 2003; 5:25-40; PMID:12542468; http://dx.doi.org/10.1046/j.1462-5822.2003.00250.x
   PubMed Web of Science ®Google Scholar
• Du SY, Wang HJ, Cheng HH, Chen SD, Wang LHC, Wang WC. Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages. J Microbiol Immunol Infect 2014
   Google Scholar
• Borlace GN, Jones HF, Keep SJ, Butler RN, Brooks DA. Helicobacter pylori phagosome maturation in primary human macrophages. Gut Pathog 2011; 3:3; PMID:21426584; http://dx.doi.org/10.1186/1757-4749-3-3
   PubMed Web of Science ®Google Scholar
• Zabaleta J, McGee DJ, Zea AH, Hernández CP, Rodriguez PC, Sierra RA, Correa P, Ochoa AC. Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta). J Immunol 2004; 173:586-93; PMID:15210820; http://dx.doi.org/10.4049/jimmunol.173.1.586
   PubMed Web of Science ®Google Scholar
• Wüstner S, Mejías-Luque R, Koch MF, Rath E, Vieth M, Sieber SA, Haller D, Gerhard M. H. pylori γ-glutamyltranspeptidase impairs T-lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression. Cell Microbiol 2014; 17(1):51-61; PMID:23910799
   PubMed Web of Science ®Google Scholar
• Sewald X, Jiménez-Soto L, Haas R. PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. Cell Microbiol 2011; 13:482-96; PMID:21083636; http://dx.doi.org/10.1111/j.1462-5822.2010.01551.x
   PubMed Web of Science ®Google Scholar
• Sundrud MS, Torres VJ, Unutmaz D, Cover TL. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A 2004; 101:7727-32; PMID:15128946; http://dx.doi.org/10.1073/pnas.0401528101
   PubMed Web of Science ®Google Scholar
• Boncristiano M, Paccani SR, Barone S, Ulivieri C, Patrussi L, Ilver D, Amedei A, D'Elios MM, Telford JL, Baldari CT. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med 2003; 198:1887-97; PMID:14676300; http://dx.doi.org/10.1084/jem.20030621
   PubMed Web of Science ®Google Scholar
• Owyang SY, Luther J, Kao JY. Helicobacter pylori: beneficial for most? Expert Rev Gastroenterol Hepatol 2011; 5:649-51; PMID:22017690; http://dx.doi.org/10.1586/egh.11.69
   PubMed Web of Science ®Google Scholar
• Chen Y, Blaser MJ. Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 2008; 198:553-60; PMID:18598192; http://dx.doi.org/10.1086/590158
   PubMed Web of Science ®Google Scholar
• Herbarth O, Bauer M, Fritz GJ, Herbarth P, Rolle-Kampczyk U, Krumbiegel P, Richter M, Richter T. Helicobacter pylori colonisation and eczema. J Epidemiol Community Health 2007; 61:638-40; PMID:17568058; http://dx.doi.org/10.1136/jech.2006.046706
   PubMed Web of Science ®Google Scholar
• Raghunath A, Hungin APS, Wooff D, Childs S. Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. BMJ 2003; 326:737; PMID:12676842; http://dx.doi.org/10.1136/bmj.326.7392.737
   PubMed Web of Science ®Google Scholar
• Bassaganya-Riera J, Dominguez-Bello MG, Kronsteiner B, Carbo A, Lu P, Viladomiu M, Pedragosa M, Zhang X, Sobral BW, Mane SP, et al. Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism. PLoS One 2012; 7:e50069
   PubMedGoogle Scholar
• Codolo G, Mazzi P, Amedei A, Del Prete G, Berton G, D'Elios MM, de Bernard M. The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma. Cell Microbiol 2008; 10:2355-63; PMID:18671823; http://dx.doi.org/10.1111/j.1462-5822.2008.01217.x
   PubMed Web of Science ®Google Scholar
• Higgins PDR, Johnson LA, Luther J, Zhang M, Sauder KL, Blanco LP, Kao JY. Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine. Inflamm Bowel Dis 2011; 17:1398-408; PMID:21560200; http://dx.doi.org/10.1002/ibd.21489
   PubMed Web of Science ®Google Scholar
• Luther J, Owyang SY, Takeuchi T, Cole TS, Zhang M, Liu M, Erb-Downward J, Rubenstein JH, Chen CC, Pierzchala AV, et al. Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis. Gut 2011; 60:1479-86; PMID:21471567; http://dx.doi.org/10.1136/gut.2010.220087
   PubMed Web of Science ®Google Scholar
• Engler DB, Leonardi I, Hartung ML, Kyburz A, Spath S, Becher B, Rogler G, Müller A. Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3 inflammasome and IL-18. Inflamm Bowel Dis 2015; 21:854-61; PMID:25742401; http://dx.doi.org/10.1097/MIB.0000000000000318
   PubMed Web of Science ®Google Scholar
• Vo HD, Goli S, Gill R, Anderson V, Stefanov DG, Xu J, Kulsum-Mecci N, Schwarz SM, Rabinowitz SS. Inverse correlation between Helicobacter pylori colonization and obesity in a cohort of inner city children. Helicobacter 2015; 20:64-8; PMID:25308209; http://dx.doi.org/10.1111/hel.12154
   PubMed Web of Science ®Google Scholar
• Lender N, Talley NJ, Enck P, Haag S, Zipfel S, Morrison M, Holtmann GJ. Review article: Associations between Helicobacter pylori and obesity-an ecological study. Aliment Pharmacol Ther 2014; 40:24-31; PMID:24832176; http://dx.doi.org/10.1111/apt.12790
   PubMed Web of Science ®Google Scholar
• Cho I, Blaser MJ, François F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2005; 162:579-84; PMID:16093294; http://dx.doi.org/10.1093/aje/kwi237
   PubMed Web of Science ®Google Scholar
• Papamichael K, Konstantopoulos P, Mantzaris GJ. Helicobacter pylori infection and inflammatory bowel disease: is there a link? World J Gastroenterol 2014; 20:6374-85; PMID:24914359; http://dx.doi.org/10.3748/wjg.v20.i21.6374
   PubMed Web of Science ®Google Scholar
• Thia KT, Loftus EV, Sandborn WJ, Yang SK. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol 2008; 103:3167-82; PMID:19086963; http://dx.doi.org/10.1111/j.1572-0241.2008.02158.x
   PubMed Web of Science ®Google Scholar
• Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, Zaitoun AM, Atherton JC. Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut 2008; 57:1375-85; PMID:18467372; http://dx.doi.org/10.1136/gut.2007.137539
   PubMed Web of Science ®Google Scholar
• Wagtmans MJ, Witte AM, Taylor DR, Biemond I, Veenendaal RA, Verspaget HW, Lamers CB, van Hogezand RA. Low seroprevalence of Helicobacter pylori antibodies in historical sera of patients with Crohn's disease. Scand J Gastroenterol 1997; 32:712-8; PMID:9246713; http://dx.doi.org/10.3109/00365529708996523
   PubMed Web of Science ®Google Scholar
• Carbo A, Bassaganya-Riera J, Pedragosa M, Viladomiu M, Marathe M, Eubank S, Wendelsdorf K, Bisset K, Hoops S, Deng X, et al. Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection. PLoS One 2013; 8:e73365; PMID:24039925; http://dx.doi.org/10.1371/journal.pone.0073365
   PubMedGoogle Scholar
• Kronsteiner B, Bassaganya-Riera J, Philipson N, Hontecillas R. Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection. Gut Microbes 2014; 5:357-62; PMID:24755940; http://dx.doi.org/10.4161/gmic.28899
   PubMed Web of Science ®Google Scholar
• Lertsethtakarn P, Howitt MR, Castellon J, Amieva MR, Ottemann KM. Helicobacter pylori CheZHP and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor. Mol Microbiol 2015; 97:1063-78; PMID:26061894; http://dx.doi.org/10.1111/mmi.13086
   PubMed Web of Science ®Google Scholar
• Viladomiu M, Bassaganya-Riera J, Kronsteiner-Dobramysl B, Washington Philipson C, Michalak P, Eden K, Hontecillas R. Macrophages modulate bacterial persistence and gastric pathology during Helicobacter pylori infection (INC4P.346). J Immunol 2015; 194:125.25-125.25; PMID:25404365; http://dx.doi.org/10.4049/jimmunol.1401644
   PubMedGoogle Scholar
• Carbo A, Hontecillas R, Kronsteiner B, Viladomiu M, Pedragosa M, Lu P, Philipson CW, Hoops S, Marathe M, Eubank S, et al. Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity. PLoS Comput Biol 2013; 9:e1003027; PMID:23592971; http://dx.doi.org/10.1371/journal.pcbi.1003027
   PubMed Web of Science ®Google Scholar
• Carbo A, Hontecillas R, Andrew T, Eden K, Mei Y, Hoops S, Bassaganya-Riera J. Computational modeling of heterogeneity and function of CD4+ T cells. Front cell Dev Biol 2014; 2:31; PMID:25364738; http://dx.doi.org/10.3389/fcell.2014.00031
   PubMedGoogle Scholar
• Marwaha S, Schumacher MA, Zavros Y, Eghbalnia HR. Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model. PLoS One 2014; 9:e111338; PMID:25364910; http://dx.doi.org/10.1371/journal.pone.0111338
   PubMedGoogle Scholar
• Schumacher MA, Donnelly JM, Engevik AC, Xiao C, Yang L, Kenny S, Varro A, Hollande F, Samuelson LC, Zavros Y. Gastric sonic hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology 2012; 142:1150-9.e6; PMID:22285806; http://dx.doi.org/10.1053/j.gastro.2012.01.029
   PubMedGoogle Scholar