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Addendum

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

ORCID Icon, ORCID Icon & ORCID Icon
Pages 581-586 | Received 14 May 2019, Accepted 22 May 2019, Published online: 14 Jun 2019

References

  • Abreu MT. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol. 2010;10:131–144. doi:10.1038/nri2707.
  • Loddo I, Romano C. Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Front Immunol. 2015;6:551. doi:10.3389/fimmu.2015.00551.
  • Kiesler P, Fuss IJ, Strober W. Experimental models of inflammatory bowel diseases. Cell Mol Gastroenterol Hepatol. 2015;1:154–170. doi:10.1016/j.jcmgh.2015.01.006.
  • Park G-S, Park MH, Shin W, Zhao C, Sheikh S, Oh SJ, Kim HJ. Emulating host-microbiome ecosystem of human gastrointestinal tract in vitro. Stem Cell Rev Rep. 2017;13:321–334. doi:10.1007/s12015-017-9739-z.
  • Nguyen TLA, Vieira-Silva S, Liston A, Raes J. How informative is the mouse for human gut microbiota research? Dis Models Mech. 2015;8:1–16. doi:10.1242/dmm.017400.
  • Bein A, Shin W, Jalili-Firoozinezhad S, Park MH, Sontheimer-Phelps A, Tovaglieri A, Chalkiadaki A, Kim HJ, Ingber DE. Microfluidic Organ-on-a-Chip Models of Human Intestine. Cell Mol Gastroenterol Hepatol. 2018;5:659–668. doi:10.1016/j.jcmgh.2017.12.010.
  • Shin W, Kim HJ. Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip. Proc Natl Acad Sci U S A. 2018;115:E10539–E47. doi:10.1073/pnas.1810819115.
  • Perše M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. Biomed Res Int. 2012;2012:718617, 13 p. doi:10.1155/2012/718617.
  • Chassaing B, Aitken JD, Malleshappa M, Vijay‐Kumar M. Dextran sulfate sodium (DSS)‐induced colitis in mice. Curr Protoc Immunol. 2014;104:15–25. doi:10.1002/0471142735.im1525s104.
  • Kim HJ, Huh D, Hamilton G, Ingber DE. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip. 2012;12:2165–2174. doi:10.1039/c2lc40074j.
  • Kim HJ, Li H, Collins JJ, Ingber DE. Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip. Proc Natl Acad Sci U S A. 2016;113:E7–15. doi:10.1073/pnas.1522193112.
  • Kim HJ, Ingber DE. Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol. 2013;5:1130–1140. doi:10.1039/c3ib40126j.
  • Shin W, Hinojosa CD, Ingber DE, Kim HJ. Human intestinal morphogenesis controlled by transepithelial morphogen gradient and flow-dependent physical cues in a microengineered gut-on-a-chip. iScience. 2019;15:391–406. doi:10.1016/j.isci.2019.04.037.
  • Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL. A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium. Biomaterials. 2017;128:44–55. doi:10.1016/j.biomaterials.2017.03.005.
  • Sung JH, Yu J, Luo D, Shuler ML, March JC. Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model. Lab Chip. 2011;11:389–392. doi:10.1039/c0lc00273a.
  • Biswas SK. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxid Med Cell Longev. 2016;2016:1–9. doi:10.1155/2016/5698931.
  • Hatton GB, Yadav V, Basit AW, Merchant HA. Animal farm: considerations in animal gastrointestinal physiology and relevance to drug delivery in humans. J Pharm Sci. 2015;104:2747–2776. doi:10.1002/jps.24365.
  • Boyapati R, Satsangi J, Ho G-T. Pathogenesis of Crohn’s disease. F1000Prime Rep. 2015;7:44. doi:10.12703/P7-44.
  • Torres J, Mehandru S, Colombel J-F, Peyrin-Biroulet L. Crohn’s disease. Lancet. 2017;389:1741–1755. doi:10.1016/S0140-6736(16)31711-1.
  • McGuckin MA, Eri R, Simms LA, Florin TH, Radford-Smith G. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis. 2008;15:100–113. doi:10.1002/ibd.20539.
  • Rigottier-Gois L. Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis. ISME J. 2013;7:1256–1261. doi:10.1038/ismej.2013.80.
  • Zheng L, Kelly CJ, Colgan SP. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia. Am J Physiol Cell Physiol. 2015;309:C350–C60. doi:10.1152/ajpcell.00191.2015.
  • de la Cuesta-Zuluaga J, Mueller N, Álvarez-Quintero R, Velásquez-Mejía E, Sierra J, Corrales-Agudelo V, Carmona JA, Abad JM, Escobar JS. Higher Fecal short-chain fatty acid levels are associated with cut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors. Nutrients. 2019;11:51. doi:10.3390/nu11010051.
  • Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks?–. Am J Clin Nutr. 2006;83:1256–1264. doi:10.1093/ajcn/83.6.1256.
  • Claes IJ, De Keersmaecker SC, Vanderleyden J, Lebeer S. Lessons from probiotic–host interaction studies in murine models of experimental colitis. Mol Nutr Food Res. 2011;55:1441–1453. doi:10.1002/mnfr.201100139.
  • Herias M, Koninkx J, Vos J, Van Dijk J. Probiotic effects of Lactobacillus casei on DSS-induced ulcerative colitis in mice. Int J Food Microbiol. 2005;103:143–155. doi:10.1016/j.ijfoodmicro.2004.11.032.
  • Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr. 2004;38:457–458.
  • Ingber DE. Reverse engineering human pathophysiology with organs-on-chips. Cell. 2016;164:1105–1109. doi:10.1016/j.cell.2016.02.049.
  • Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14:667–685. doi:10.1038/nri3738.
  • Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–795. doi:10.1056/NEJMp1500523.
  • Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA, Kelly C, Khoruts A, Louie T, Martinelli LP, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol. 2011;9:1044–1049. doi:10.1016/j.cgh.2011.08.014.
  • Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis. 2014;8:1569–1581. doi:10.1016/j.crohns.2014.08.006.
  • Shin W, Wu A, Massidda MW, Foster C, Thomas N, Lee D-W, Koh H, Ju Y, Kim J, Kim HJ. A Robust Longitudinal Co-culture of Obligate Anaerobic Gut Microbiome With Human Intestinal Epithelium in an Anoxic-Oxic Interface-on-a-Chip. Front Bioeng Biotechnol. 2019;7:13.

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