3,209
Views
5
CrossRef citations to date
0
Altmetric
Research Paper

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

, ORCID Icon, &
Article: 2018898 | Received 04 May 2021, Accepted 24 Nov 2021, Published online: 11 Jan 2022

References

  • Dekaney CM, Gulati AS, Garrison AP, Helmrath MA, Henning SJ. Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice. Am J Physiol - Gastrointest Liver Physiol. 2009;297:G461–19.
  • Barker N, van Es JH, Kuipers J, Kujala P, van Den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003–1007. doi:10.1038/nature06196.
  • Barker N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol. 2013;15:19–33. doi:10.1038/nrm3721.
  • Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM. Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes. 2016;7:414–23.
  • Carr JS, King S, Dekaney CM, Singh SR. Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLOS ONE. 2017;12:e0173429. doi:10.1371/journal.pone.0173429.
  • Sheahan BJ, Freeman AN, Keeley TM, Samuelson LC, Roper J, Hasapis S, Lee C-L, Dekaney CM. Epithelial regeneration after doxorubicin arises primarily from early progeny of active intestinal stem Cells. Cell Mol Gastroenterol Hepatol. Epub ahead of print February 8, 2021;12:119–140. doi:10.1016/j.jcmgh.2021.01.015.
  • Lee Y-S, Kim T-Y, Kim Y, Lee S-H, Kim S, Kang SW, Yang J-Y, Baek I-J, Sung YH, Park -Y-Y, et al. Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development. Cell Host Microbe. 2018;24:833–846.e6. doi:10.1016/j.chom.2018.11.002.
  • Nigro G, Sansonetti PJ. Microbiota and gut stem cells cross-talks: a new view of epithelial homeostasis. Curr Stem Cell Rep. 2015;1:48–52. doi:10.1007/s40778-014-0005-x.
  • Levy A, Stedman A, Deutsch E, Donnadieu F, Virgin HW, Sansonetti PJ, Nigro G. Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation. Proc Natl Acad Sci. 2020;117:1994–2003. doi:10.1073/pnas.1902788117.
  • Nigro G, Rossi R, Commere P-H, Jay P, Sansonetti PJ. The cytosolic bacterial peptidoglycan sensor NOD2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe. 2014;15:792–798. doi:10.1016/j.chom.2014.05.003.
  • Naito T, Mulet C, De Castro C, Molinaro A, Saffarian A, Nigro G, Bérard M, Clerc M, Pedersen AB, Sansonetti PJ, et al. Lipopolysaccharide from crypt-specific core microbiota modulates the colonic epithelial proliferation-to-differentiation balance. mBio. Epub ahead of print October 17, 2017;8. 10.1128/mBio.01680-17.
  • Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012;287:37296–37308. doi:10.1074/jbc.M112.375881.
  • Reikvam DH, Erofeev A, Sandvik A, Grcic V, Jahnsen FL, Gaustad P, McCoy KD, Macpherson AJ, Meza-Zepeda LA, Johansen F-E. Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression. PLoS ONE. Epub ahead of print March 21, 2011;6:e17996. doi:10.1371/journal.pone.0017996.
  • Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018;9:2872. doi:10.1038/s41467-018-05336-9.
  • Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, et al. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019 Feb;20(2):183–194. doi:10.1038/s41590-018-0297-6.
  • Schuijers J, van der Flier LG, van Es J, Clevers H. Robust cre-mediated recombination in small intestinal stem cells utilizing the Olfm4 locus. Stem Cell Rep. 2014;3:234–241. doi:10.1016/j.stemcr.2014.05.018.
  • Matthews JD, Weight CM, Parkos CA. Leukocyte-epithelial interactions and mucosal homeostasis. Toxicol Pathol. 2014 Jan;42(1):91–98. doi:10.1177/0192623313511336.
  • Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong S-J, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53–58. doi:10.1038/nature17173.
  • Aidy SE, Merrifield CA, Derrien M, van BP, Hooiveld G, Levenez F, Doré J, Dekker J, Holmes E, Claus SP, et al. The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation. Gut. 2013;62:1306–1314. doi:10.1136/gutjnl-2011-301955.
  • Zoetendal EG, Raes J, van Den Bogert B, Arumugam M, Booijink CC, Troost FJ, Bork P, Wels M, de Vos WM, Kleerebezem M. The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates. ISME J. 2012;6:1415–1426. doi:10.1038/ismej.2011.212.
  • Rhodes KA, Schweizer HP. Antibiotic resistance in Burkholderia species. Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother. 2016;28:82–90.
  • Beeton ML, Spiller OB. Antibiotic resistance among Ureaplasma spp. isolates: cause for concern? J Antimicrob Chemother. 2017;72:330–337. doi:10.1093/jac/dkw425.
  • Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N, Raffatellu M. Lipopolysaccharides from different burkholderia species with different lipid a structures induce toll-like receptor 4 activation and react with melioidosis patient sera. Infect Immun. Epub ahead of print December 1, 2019;87. 10.1128/IAI.00692-19.
  • Glaser K, Silwedel C, Fehrholz M, Waaga-Gasser AM, Henrich B, Claus H, Speer CP. Ureaplasma species differentially modulate pro- and anti-inflammatory cytokine responses in newborn and adult human monocytes pushing the state toward pro-inflammation. Front Cell Infect Microbiol. Epub ahead of print November 28, 2017;7. 10.3389/fcimb.2017.00484.
  • Silwedel C, Haarmann A, Fehrholz M, Claus H, Speer CP, Glaser K. More than just inflammation: ureaplasma species induce apoptosis in human brain microvascular endothelial cells. J Neuroinflammation. 2019;16:38. doi:10.1186/s12974-019-1413-8.
  • Westman EL, Canova MJ, Radhi IJ, Koteva K, Kireeva I, Waglechner N, Wright GD. Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012;19:1255–1264. doi:10.1016/j.chembiol.2012.08.011.
  • Yan A, Culp E, Perry J, Lau JT, MacNeil LT, Surette MG, Wright GD. Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018;4:68–76. doi:10.1021/acsinfecdis.7b00166.
  • Kennedy EA, King KY, Baldridge MT. Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria. Front Physiol. Epub ahead of print October 31, 2018;9. 10.3389/fphys.2018.01534.
  • Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ,O. Single Lgr5 stem cells build crypt villus structures in vitro without a mesenchymal niche. Nature. 2009;459:262–265. doi:10.1038/nature07935.
  • Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676–682. doi:10.1038/nmeth.2019.
  • Besson D, Pavageau A-H, Valo I, Bourreau A, Bélanger A, Eymerit-Morin C, Moulière A, Chassevent A, Boisdron-Celle M, Morel A, et al. A quantitative proteomic approach of the different stages of colorectal cancer establishes OLFM4 as a new nonmetastatic tumor marker. Mol Cell Proteomics MCP. 2011;10:M111.009712. doi:10.1074/mcp.M111.009712.
  • Am S, Cm T, Ct M, Kl W, Il B, Vb Y. Fecal microbiota transplantation eliminates clostridium difficile in a murine model of relapsing disease. Infect Immun. Epub ahead of print October 2015;83. 10.1128/IAI.00459-15.
  • Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the miseq illumina sequencing platform. Appl Environ Microbiol. 2013;79:5112–5120. doi:10.1128/AEM.01043-13.
  • Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: high resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13:581–583. doi:10.1038/nmeth.3869.
  • McMurdie PJ, Holmes S, Watson M. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLOS ONE. 2013;8:e61217. doi:10.1371/journal.pone.0061217.
  • Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. doi:10.1186/s13059-014-0550-8.
  • Wickham H. ggplot2: elegant graphics for data analysis. New York: Springer-Verlag . Epub ahead of print 2009. 10.1007/978-0-387-98141-3.
  • McLaren, Michael R.Silva SSU taxonomic training data formatted for DADA2 (Silva version 138). Zenodo. Epub ahead of print March 27, 2020. 10.5281/zenodo.3731176.
  • Parks DH, Chuvochina M, Chaumeil P-A, Rinke C, Mussig AJ, Hugenholtz P. A complete domain-to-species taxonomy for bacteria and archaea. Nat Biotechnol . 2020;9(38):1–8.
  • McMurdie PJ, Holmes S, McHardy AC. Waste not, want not: why rarefying microbiome data is inadmissible. PLOS Comput Biol. 2014;10:e1003531. doi:10.1371/journal.pcbi.1003531.