Gut microbiome diversity, variability, and latent community types compared with shifts in body weight during the freshman year of college in dormitory-housed adolescents

References

• Gropper SS, Simmons KP, Connell LJ, Ulrich PV. Changes in body weight, composition, and shape: a 4-year study of college students. Appl Physiol Nutr Metab. 2012;37(6):1118–26. doi:10.1139/h2012-139.
   PubMed Web of Science ®Google Scholar
• Racette SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH. Changes in weight and health behaviors from freshman through senior year of college. J Nutr Educ Behav. 2008;40(1):39–42. doi:10.1016/j.jneb.2007.01.001.
   PubMed Web of Science ®Google Scholar
• Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta‐analysis. Obes Rev. 2016;17(2):95–107. doi:10.1111/obr.12334.
   PubMed Web of Science ®Google Scholar
• Wei Y, Liang J, Su Y, Wang J, Amakye WK, Pan J, Chu X, Ma B, Song Y, Li Y, et al. The associations of the gut microbiome composition and short-chain fatty acid concentrations with body fat distribution in children. Clin Nutr. 2021;40(5):3379–3390. doi:10.1016/j.clnu.2020.11.014.
   PubMed Web of Science ®Google Scholar
• Ferrer M, Ruiz A, Lanza F, Haange S, Oberbach A, Till H, Bargiela R, Campoy C, Segura MT, Richter M, et al. Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure. Environ Microbiol. 2013;15(1):211–226. doi:10.1111/j.1462-2920.2012.02845.x.
   PubMed Web of Science ®Google Scholar
• Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, et al. A core gut microbiome in obese and lean twins. Nature. 2008;457(7228):480–484. doi:10.1038/nature07540.
   PubMed Web of Science ®Google Scholar
• David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2013;505(7484):559–563. doi:10.1038/nature12820.
   PubMed Web of Science ®Google Scholar
• Whisner CM, Maldonado J, Dente B, Krajmalnik-Brown R, Bruening M. Diet, physical activity and screen time but not body mass index are associated with the gut microbiome of a diverse cohort of college students living in university housing: a cross-sectional study. BMC Microbiol. 2018;18(1):210. doi:10.1186/s12866-018-1362-x.
   PubMedGoogle Scholar
• Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, Leeming E, Gibson R, Roy CL, Khatib HA, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27(2):321–332. doi:10.1038/s41591-020-01183-8.
   PubMed Web of Science ®Google Scholar
• Mohr AE, Jasbi P, Wyst KBV, Woerden I, van Shi X, Gu H, Whisner CM, Bruening M. Association of food insecurity on gut microbiome and metabolome profiles in a diverse college-based sample. Sci Rep-Uk. 2022;12(1):14358. doi:10.1038/s41598-022-18515-y.
   PubMed Web of Science ®Google Scholar
• Maruvada P, Leone V, Kaplan LM, Chang EB. The human microbiome and obesity: moving beyond associations. Cell Host & Microbe. 2017;22(5):589–599. doi:10.1016/j.chom.2017.10.005.
   PubMed Web of Science ®Google Scholar
• Flores GE, Caporaso JG, Henley JB, Rideout JR, Domogala D, Chase J, Leff JW, Vázquez-Baeza Y, Gonzalez A, Knight R, et al. Temporal variability is a personalized feature of the human microbiome. Genome Biol. 2014;15(12):531. doi:10.1186/s13059-014-0531-y.
   PubMed Web of Science ®Google Scholar
• Leong KSW, Jayasinghe TN, Wilson BC, Derraik JGB, Albert BB, Chiavaroli V, Svirskis DM, Beck KL, Conlon CA, Jiang Y, et al. Effects of fecal microbiome transfer in adolescents with obesity. JAMA Netw Open. 2020;3(12):e2030415. doi:10.1001/jamanetworkopen.2020.30415.
   PubMed Web of Science ®Google Scholar
• Fragiadakis GK, Wastyk HC, Robinson JL, Sonnenburg ED, Sonnenburg JL, Gardner CD. Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight. Am J Clin Nutrition. 2020;111(6):1127–1136. doi:10.1093/ajcn/nqaa046.
   PubMed Web of Science ®Google Scholar
• Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, et al. Integration of molecular profiles in a longitudinal wellness profiling cohort. Nat Commun. 2020;11(1):4487. doi:10.1038/s41467-020-18148-7.
   PubMed Web of Science ®Google Scholar
• Sowah SA, Milanese A, Schübel R, Wirbel J, Kartal E, Johnson TS, Hirche F, Grafetstätter M, Nonnenmacher T, Kirsten R, et al. Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial. Genome Med. 2022;14(1):30. doi:10.1186/s13073-022-01030-0.
   PubMed Web of Science ®Google Scholar
• Agans R, Rigsbee L, Kenche H, Michail S, Khamis HJ, Paliy O. Distal gut microbiota of adolescent children is different from that of adults. FEMS Microbiol Ecol. 2011;77(2):404–412. doi:10.1111/j.1574-6941.2011.01120.x.
   PubMed Web of Science ®Google Scholar
• Chierico FD, Abbatini F, Russo A, Quagliariello A, Reddel S, Capoccia D, Caccamo R, Corradini SG, Nobili V, Peppo FD, et al. Gut microbiota markers in obese adolescent and adult patients: age-dependent differential patterns. Front Microbiol. 2018;9:1210. doi:10.3389/fmicb.2018.01210.
   PubMed Web of Science ®Google Scholar
• Mika A, Treuren WV, González A, Herrera JJ, Knight R, Fleshner M, Cotter PD. Exercise is more effective at altering gut microbial composition and producing stable changes in lean mass in juvenile versus adult male F344 rats. PLoS One. 2015;10(5):e0125889. doi:10.1371/journal.pone.0125889.
   PubMed Web of Science ®Google Scholar
• Yee AL, Miller E, Dishaw LJ, Gordon JM, Ji M, Dutra S, Ho TTB, Gilbert JA, Groer M, Whiteson KL. Longitudinal microbiome composition and stability correlate with increased weight and length of very-low-birth-weight infants. mSystems. 2019;4(1):e00229–18. doi:10.1128/mSystems.00229-18.
   PubMed Web of Science ®Google Scholar
• Shen N, Caixàs A, Ahlers M, Patel K, Gao Z, Dutia R, Blaser MJ, Clemente JC, Laferrère B. Longitudinal changes of microbiome composition and microbial metabolomics after surgical weight loss in individuals with obesity. Surg Obes Relat Dis. 2019;15(8):1367–1373. doi:10.1016/j.soard.2019.05.038.
   PubMed Web of Science ®Google Scholar
• Monteleone AM, Troisi J, Fasano A, Grave RD, Marciello F, Serena G, Calugi S, Scala G, Corrivetti G, Cascino G, et al. Multi-omics data integration in anorexia nervosa patients before and after weight regain: a microbiome-metabolomics investigation. Clin Nutr. 2021;40(3):1137–1146. doi:10.1016/j.clnu.2020.07.021.
   PubMed Web of Science ®Google Scholar
• Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222–227. doi:10.1038/nature11053.
   PubMed Web of Science ®Google Scholar
• Bruening M, Ohri-Vachaspati P, Brewis A, Laska M, Todd M, Hruschka D, Schaefer DR, Whisner CM, Dunton G. Longitudinal social networks impacts on weight and weight-related behaviors assessed using mobile-based ecological momentary assessments: study protocols for the SPARC study. BMC Public Health. 2016;16(1):901. doi:10.1186/s12889-016-3536-5.
   PubMedGoogle Scholar
• Bruening M, van WI, Schaefer DR, Hruschka D, Brewis A, Whisner CM, Dunton GF, Todd M, Ohri-Vachaspati P, Laska MN, et al. Friendship as a social mechanism influencing body mass index (BMI) among emerging adults. PLoS One. 2018;13(12):e0208894. doi:10.1371/journal.pone.0208894.
   PubMed Web of Science ®Google Scholar
• van Woerden I, Hruschka D, Brewis A, Schaefer DR, Bruening M, Apolzan JW. First-year college students’ weight change is influenced by their randomly assigned roommates’ BMI. BMI PLoS One. 2020;15(11):e0242681. doi:10.1371/journal.pone.0242681.
   PubMed Web of Science ®Google Scholar
• Stevens J, Truesdale KP, McClain JE, Cai J. The definition of weight maintenance. Int J Obesity. 2006;30(3):391–399. doi:10.1038/sj.ijo.0803175.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th Edition. December 2020. Available at DietaryGuidelines.gov.
   Google Scholar
• Olsson LM, Boulund F, Nilsson S, Khan MT, Gummesson A, Fagerberg L, Engstrand L, Perkins R, Uhlén M, Bergström G, et al. Dynamics of the normal gut microbiota: a longitudinal one-year population study in Sweden. Cell Host & Microbe. 2022;30(5):726–739.e3. doi:10.1016/j.chom.2022.03.002.
   PubMed Web of Science ®Google Scholar
• Hjorth MF, Blædel T, Bendtsen LQ, Lorenzen JK, Holm JB, Kiilerich P, Roager HM, Kristiansen K, Larsen LH, Astrup A. Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. Int J Obesity. 2019;43(1):149–157. doi:10.1038/s41366-018-0093-2.
   Web of Science ®Google Scholar
• Wu GD, Chen J, Hoffmann C, Bittinger K, Chen Y-Y, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, et al. Linking long-term dietary patterns with gut microbial enterotypes. Sci. 2011;334(6052):105–108. doi:10.1126/science.1208344.
   PubMed Web of Science ®Google Scholar
• Lahti L, Salojärvi J, Salonen A, Scheffer M, de Vos WM. Tipping elements in the human intestinal ecosystem. Nat Commun. 2014;5(1):4344. doi:10.1038/ncomms5344.
   PubMedGoogle Scholar
• Levy R, Magis AT, Earls JC, Manor O, Wilmanski T, Lovejoy J, Gibbons SM, Omenn GS, Hood L, Price ND. Longitudinal analysis reveals transition barriers between dominant ecological states in the gut microbiome. Proc Natl Acad Sci USA. 2020;117(24):13839–13845. doi:10.1073/pnas.1922498117.
   PubMed Web of Science ®Google Scholar
• Sankaran K, Holmes SP. Latent variable modeling for the microbiome. Biostatistics. 2018;20(4):599–614. doi:10.1093/biostatistics/kxy018.
   Web of Science ®Google Scholar
• Flegal KM, Shepherd JA, Looker AC, Graubard BI, Borrud LG, Ogden CL, Harris TB, Everhart JE, Schenker N. Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutrit. 2008;89(2):500–508. doi:10.3945/ajcn.2008.26847.
   PubMed Web of Science ®Google Scholar
• Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K, Kurilshikov A, Bonder MJ, Valles-Colomer M, Vandeputte D, et al. Population-level analysis of gut microbiome variation. Science. 2016;352(6285):560–564. doi:10.1126/science.aad3503.
   PubMed Web of Science ®Google Scholar
• Hjorth MF, Christensen L, Larsen TM, Roager HM, Krych L, Kot W, Nielsen DS, Ritz C, Astrup A. Pretreatment Prevotella-to-bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss. Am J Clin Nutrition. 2020;111(5):1079–1086. doi:10.1093/ajcn/nqaa007.
   PubMed Web of Science ®Google Scholar
• Jie Z, Yu X, Liu Y, Sun L, Chen P, Ding Q, Gao Y, Zhang X, Yu M, Liu Y, et al. The baseline gut microbiota directs dieting-induced weight loss trajectories. Gastroenterol. 2021;160(6):2029–2042.e16. doi:10.1053/j.gastro.2021.01.029.
   PubMed Web of Science ®Google Scholar
• Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65(3):426. doi:10.1136/gutjnl-2014-308778.
   PubMed Web of Science ®Google Scholar
• Koutoukidis DA, Jebb SA, Zimmerman M, Otunla A, Henry JA, Ferrey A, Schofield E, Kinton J, Aveyard P, Marchesi JR. The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysis. Gut Microbes. 2022;14(1):2020068. doi:10.1080/19490976.2021.2020068.
   PubMed Web of Science ®Google Scholar
• Bervoets L, Hoorenbeeck KV, Kortleven I, Noten CV, Hens N, Vael C, Goossens H, Desager KN, Vankerckhoven V. Differences in gut microbiota composition between obese and lean children: a cross-sectional study. Gut Pathog. 2013;5(1):10. doi:10.1186/1757-4749-5-10.
   PubMedGoogle Scholar
• Mbakwa CA, Hermes GDA, Penders J, Savelkoul PHM, Thijs C, Dagnelie PC, Mommers M, Zoetendal EG, Smidt H, Arts ICW. Gut microbiota and body weight in school‐aged children: the KOALA birth cohort study. Obesity. 2018;26(11):1767–1776. doi:10.1002/oby.22320.
   PubMed Web of Science ®Google Scholar
• Arumugam M, Raes J, Pelletier E, Paslier DL, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto J-M, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. doi:10.1038/nature09944.
   PubMed Web of Science ®Google Scholar
• Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HMB, Coakley M, Lakshminarayanan B, O’Sullivan O, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488(7410):178–184. doi:10.1038/nature11319.
   PubMed Web of Science ®Google Scholar
• Christensen L, Roager HM, Astrup A, Hjorth MF. Microbial enterotypes in personalized nutrition and obesity management. Am J Clin Nutrition. 2018;108(4):645–651. doi:10.1093/ajcn/nqy175.
   PubMed Web of Science ®Google Scholar
• Roager HM, Licht TR, Poulsen SK, Larsen TM, Bahl MI. Microbial enterotypes, inferred by the prevotella-to-bacteroides ratio, remained stable during a 6-month randomized controlled diet intervention with the new Nordic diet. Appl Environ Microb. 2014;80(3):1142–1149. doi:10.1128/AEM.03549-13.
   PubMed Web of Science ®Google Scholar
• Costea PI, Hildebrand F, Arumugam M, Bäckhed F, Blaser MJ, Bushman FD, de Vos WM, Ehrlich SD, Fraser CM, Hattori M, et al. Enterotypes in the landscape of gut microbial community composition. Nature Microbiol. 2018;3(1):8–16. doi:10.1038/s41564-017-0072-8.
   PubMed Web of Science ®Google Scholar
• Knights D, Ward TL, McKinlay CE, Miller H, Gonzalez A, McDonald D, Knight R. Rethinking “enterotypes”. Cell Host & Microbe. 2014;16(4):433–437. doi:10.1016/j.chom.2014.09.013.
   PubMed Web of Science ®Google Scholar
• Wilson BC, Vatanen T, Jayasinghe TN, Leong KSW, Derraik JGB, Albert BB, Chiavaroli V, Svirskis DM, Beck KL, Conlon CA, et al. Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity. Microbiome. 2021;9(1):107. doi:10.1186/s40168-021-01060-7.
   PubMed Web of Science ®Google Scholar
• Diener C, Qin S, Zhou Y, Patwardhan S, Tang L, Lovejoy JC, Magis AT, Price ND, Hood L, Gibbons SM, et al. Baseline gut metagenomic functional gene signature associated with variable weight loss responses following a healthy lifestyle intervention in humans. mSystems. 2021;6(5):e00964–21. doi:10.1128/mSystems.00964-21.
   PubMed Web of Science ®Google Scholar
• Faust K, Sathirapongsasuti JF, Izard J, Segata N, Gevers D, Raes J, Huttenhower C, Ouzounis CA. Microbial co-occurrence relationships in the human microbiome. PLoS Comput Biol. 2012;8(7):e1002606. doi:10.1371/journal.pcbi.1002606.
   PubMed Web of Science ®Google Scholar
• Chen T, Long W, Zhang C, Liu S, Zhao L, Hamaker BR. Fiber-utilizing capacity varies in prevotella- versus bacteroides-dominated gut microbiota. Sci Rep-Uk. 2017;7(1):2594. doi:10.1038/s41598-017-02995-4.
   PubMedGoogle Scholar
• Hjorth MF, Roager HM, Larsen TM, Poulsen SK, Licht TR, Bahl MI, Zohar Y, Astrup A. Pre-treatment microbial prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. Int J Obesity. 2018;42(3):580–583. doi:10.1038/ijo.2017.220.
   Web of Science ®Google Scholar
• Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T, Hallen A, Martens E, Björck I, Bäckhed F. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 2015;22(6):971–982. doi:10.1016/j.cmet.2015.10.001.
   PubMed Web of Science ®Google Scholar
• Breuninger TA, Wawro N, Breuninger J, Reitmeier S, Clavel T, Six-Merker J, Pestoni G, Rohrmann S, Rathmann W, Peters A, et al. Associations between habitual diet, metabolic disease, and the gut microbiota using latent Dirichlet allocation. Microbiome. 2021;9(1):61. doi:10.1186/s40168-020-00969-9.
   PubMed Web of Science ®Google Scholar
• Hosoda S, Nishijima S, Fukunaga T, Hattori M, Hamada M. Revealing the microbial assemblage structure in the human gut microbiome using latent Dirichlet allocation. Microbiome. 2020;8(1):95. doi:10.1186/s40168-020-00864-3.
   PubMed Web of Science ®Google Scholar
• Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux J-J, Blugeon S, Bridonneau C, Furet J-P, Corthier G, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci. 2008;105(43):16731–16736. doi:10.1073/pnas.0804812105.
   PubMed Web of Science ®Google Scholar
• Rios-Covian D, Gueimonde M, Duncan SH, Flint HJ, de Los Reyes-Gavilan CG, Cox M. Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and bifidobacterium adolescentis. FEMS Microbiology Letters. 2015;362(21):fnv176. doi:10.1093/femsle/fnv176.
   PubMed Web of Science ®Google Scholar
• Haro C, Montes-Borrego M, Rangel-Zúñiga OA, Alcalá-Díaz JF, Gómez-Delgado F, Pérez-Martínez P, Delgado-Lista J, Quintana-Navarro GM, Tinahones FJ, Landa BB, et al. Two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population. J Clin Endocrinol Metabolism. 2016;101(1):233–242. doi:10.1210/jc.2015-3351.
   PubMed Web of Science ®Google Scholar
• Meslier V, Laiola M, Roager HM, Filippis FD, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, et al. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut. 2020;69(7):1258–1268. doi:10.1136/gutjnl-2019-320438.
   PubMed Web of Science ®Google Scholar
• Christensen L, Sørensen CV, Wøhlk FU, Kjølbæk L, Astrup A, Sanz Y, Hjorth MF, Benítez-Páez A. Microbial enterotypes beyond genus level: bacteroides species as a predictive biomarker for weight change upon controlled intervention with arabinoxylan oligosaccharides in overweight subjects. Gut Microbes. 2020;12(1):1–16. doi:10.1080/19490976.2020.1847627.
   Web of Science ®Google Scholar
• Lin H, An Y, Tang H, Wang Y. Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model. J Agr Food Chem. 2019;67(13):3624–3632. doi:10.1021/acs.jafc.9b00249.
   PubMed Web of Science ®Google Scholar
• Beaumont M, Goodrich JK, Jackson MA, Yet I, Davenport ER, Vieira-Silva S, Debelius J, Pallister T, Mangino M, Raes J, et al. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biol. 2016;17(1):189. doi:10.1186/s13059-016-1052-7.
   PubMed Web of Science ®Google Scholar
• Roy CIL, Beaumont M, Jackson MA, Steves CJ, Spector TD, Bell JT. Heritable components of the human fecal microbiome are associated with visceral fat. Gut Microbes. 2017;9(1):61–67. doi:10.1080/19490976.2017.1356556.
   PubMed Web of Science ®Google Scholar
• Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, Zhao J, Zhang H, Chen W. Blautia—a new functional genus with potential probiotic properties? Gut Microbes. 2021;13(1):1–21. doi:10.1080/19490976.2021.1875796.
   Web of Science ®Google Scholar
• Kim SG, Becattini S, Moody TU, Shliaha PV, Littmann ER, Seok R, Gjonbalaj M, Eaton V, Fontana E, Amoretti L, et al. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant enterococcus. Nature. 2019;572(7771):665–669. doi:10.1038/s41586-019-1501-z.
   PubMed Web of Science ®Google Scholar
• Caballero S, Kim S, Carter RA, Leiner IM, Sušac B, Miller L, Kim GJ, Ling L, Pamer EG. Cooperating commensals restore colonization resistance to vancomycin-resistant enterococcus faecium. Cell Host & Microbe. 2017;21(5):592–602.e4. doi:10.1016/j.chom.2017.04.002.
   PubMed Web of Science ®Google Scholar
• Eren AM, Sogin ML, Morrison HG, Vineis JH, Fisher JC, Newton RJ, McLellan SL. A single genus in the gut microbiome reflects host preference and specificity. ISME J. 2015;9(1):90–100. doi:10.1038/ismej.2014.97.
   PubMed Web of Science ®Google Scholar
• Litwinowicz K, Choroszy M, Waszczuk E. Changes in the composition of the human intestinal microbiome in alcohol use disorder: a systematic review. Am J Drug Alcohol Abus. 2019;46(1):4–12. doi:10.1080/00952990.2019.1669629.
   PubMed Web of Science ®Google Scholar
• Nosova T, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. Acetaldehyde production and metabolism by human indigenous and probiotic lactobacillus and bifidobacterium strains. Alcohol And Alcoholism. 2000;35(6):561–568. doi:10.1093/alcalc/35.6.561.
   PubMed Web of Science ®Google Scholar
• Lim T-J, Lim S, Yoon JH, Chung MJ. Effects of multi-species probiotic supplementation on alcohol metabolism in rats. J Microbiol. 2021;59(4):417–425. doi:10.1007/s12275-021-0573-2.
   PubMed Web of Science ®Google Scholar
• Jung S-J, Hwang J-H, Park E-O, Lee S-O, Chung Y-J, Chung M-J, Lim S, Lim T-J, Ha Y, Park B-H, et al. Regulation of alcohol and acetaldehyde metabolism by a mixture of lactobacillus and bifidobacterium species in human. Nutrients. 2021;13(6):1875. doi:10.3390/nu13061875.
   PubMed Web of Science ®Google Scholar
• Martino C, Zaramela LS, Gao B, Embree M, Tarasova J, Parker SJ, Wang Y, Chu H, Chen P, Lee K-C, et al. Acetate reprograms gut microbiota during alcohol consumption. Nat Commun. 2022;13(1):4630. doi:10.1038/s41467-022-31973-2.
   PubMed Web of Science ®Google Scholar
• Hashimoto Y, Hamaguchi M, Kaji A, Sakai R, Osaka T, Inoue R, Kashiwagi S, Mizushima K, Uchiyama K, Takagi T, et al. Intake of sucrose affects gut dysbiosis in patients with type 2 diabetes. J Diabetes Invest. 2020;11(6):1623–1634. doi:10.1111/jdi.13293.
   PubMed Web of Science ®Google Scholar
• de VW, Stouthamer AH. Fermentation of glucose, lactose, galactose, mannitol, and xylose by bifidobacteria. J Bacteriol. 1968;96(2):472–478. doi:10.1128/jb.96.2.472-478.1968.
   PubMed Web of Science ®Google Scholar
• Suzuki R, Katayama T, Kim B-J, Wakagi T, Shoun H, Ashida H, Yamamoto K, Fushinobu S. Crystal structures of phosphoketolase thiamine diphosphate-dependent dehydration mechanism*. J Biol Chem. 2010;285(44):34279–34287. doi:10.1074/jbc.M110.156281.
   PubMed Web of Science ®Google Scholar
• Chatelier EL, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto J-M, Kennedy S, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541–546. doi:10.1038/nature12506.
   PubMed Web of Science ®Google Scholar
• Hollister EB, Riehle K, Luna RA, Weidler EM, Rubio-Gonzales M, Mistretta T-A, Raza S, Doddapaneni HV, Metcalf GA, Muzny DM, et al. Structure and function of the healthy pre-adolescent pediatric gut microbiome. Microbiome. 2015;3(1):36. doi:10.1186/s40168-015-0101-x.
   PubMedGoogle Scholar
• Humphreys S. The unethical use of BMI in contemporary general practice. Br J Gen Pr. 2010;60(578):696–697. doi:10.3399/bjgp10X515548.
   PubMed Web of Science ®Google Scholar
• Berg S. AMA: Use of BMI alone is an imperfect clinical measure [Internet]. American Medical Association; 2023 [accessed 2023 Jun 20]. https://www.ama-assn.org/delivering-care/public-health/ama-use-bmi-alone-imperfect-clinical-measure.
   Google Scholar
• Sirard JR, Pate RR. Physical activity assessment in children and adolescents. Sports Med. 2001;31(6):439–454. doi:10.2165/00007256-200131060-00004.
   PubMed Web of Science ®Google Scholar
• Utter J, Neumark-Sztainer D, Jeffery R, Story M. Couch potatoes or French fries: are sedentary behaviors associated with body mass index, physical activity, and dietary behaviors among adolescents? J Am Diet Assoc. 2003;103(10):1298–1305. doi:10.1016/S0002-8223(03)01079-4.
   PubMed Web of Science ®Google Scholar
• National Cancer Institute. Dietary Screener Questionnaire in the NHANES 2009–10 [Internet]; 2009 [accessed 2022 Jun 15]. http://appliedresearch.cancer.gov/nhanes/dietscreen/dsq_english.pdf.
   Google Scholar
• Thompson LR, Sanders JG, McDonald D, Amir A, Ladau J, Locey KJ, Prill RJ, Tripathi A, Gibbons SM, Ackermann G, et al. A communal catalogue reveals earth’s multiscale microbial diversity. Nature. 2017;551(7681):457–463. doi:10.1038/nature24621.
   PubMed Web of Science ®Google Scholar
• Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019;37(8):852–857. doi:10.1038/s41587-019-0209-9.
   PubMed Web of Science ®Google Scholar
• Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, Peplies J, Glöckner FO. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2012;41(D1):D590–6. doi:10.1093/nar/gks1219.
   PubMed Web of Science ®Google Scholar
• Cao J, Xia T, Li J, Zhang Y, Tang S. A density-based method for adaptive LDA model selection. Neurocomputing. 2009;72(7–9):1775–1781. doi:10.1016/j.neucom.2008.06.011.
   Web of Science ®Google Scholar
• Arun R, Suresh V, Madhavan CEV, Murthy MNN. Advances in Knowledge Discovery and Data Mining, Part I, 14th Pacific-Asia Conference, PAKDD 2010, Hyderabat, India, June 21-24, 2010, Proceedings. In: Zaki MJ, Yu JX, Ravindran B, Pudi V, editors. Berlin Heidelberg: Springer; 2010. p. 391–402. doi:10.1007/978-3-642-13657-3.
   Google Scholar