Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function

References

• Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI. Gut microbiota and immune System interactions. Microorganisms. 2020;8:12. doi:10.3390/microorganisms8101587. PMID: 33076307.
   Web of Science ®Google Scholar
• Sandoval DA, Seeley RJ. The microbes made me eat it. Sci. 2010;328:179–20. doi:10.1126/science.1188876. PMID: 20378804.
   PubMed Web of Science ®Google Scholar
• Tang C, Ding R, Sun J, Liu J, Kan J, Jin C. The impacts of natural polysaccharides on intestinal microbiota and immune responses - a review. Food Funct. 2019;10:2290–2312. doi:10.1039/c8fo01946k. PMID: 31032827.
   PubMed Web of Science ®Google Scholar
• Tang M, Cheng L, Liu Y, Wu Z, Zhang X, Luo S. Plant polysaccharides modulate immune function via the gut microbiome and May have potential in COVID-19 therapy. Molecules. 2022;27:27. doi:10.3390/molecules27092773. PMID: 35566123.
   Web of Science ®Google Scholar
• Wang G, Huang S, Wang YM, Cai S, Yu HT, Liu HB, Zeng X, Zhang G, Qiao S. Bridging intestinal immunity and gut microbiota by metabolites. Cell Mol Life Sci. 2019;76:3917–3937. doi:10.1007/s00018-019-03190-6. PMID: 31250035.
   PubMed Web of Science ®Google Scholar
• Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, et al. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. Elife. 2019;8. doi:10.7554/eLife.47117. PMID: 31309928.
   Web of Science ®Google Scholar
• Sun Y, Zhang ZP, Cheng L, Zhang X, Liu YN, Zhang RL, Weng PF, Wu ZF. Polysaccharides confer benefits in immune regulation and multiple sclerosis by interacting with gut microbiota. Food Res Int. 2021;149:110675. doi:10.1016/j.foodres.2021.110675. PMID: 34600677.
   PubMed Web of Science ®Google Scholar
• Grao-Cruces E, Lopez-Enriquez S, Martin ME, Paz M. High-density lipoproteins and immune response: A review. Int J Biol Macromol. 2022;195:117–123. doi:10.1016/j.ijbiomac.2021.12.009. PMID: 34896462.
   PubMed Web of Science ®Google Scholar
• Liu ZQ, Hu YY, Tao XY, Li JJ, Guo XM, Liu G, Song S, Zhu BW. Metabolites of sea cucumber sulfated polysaccharides fermented by parabacteroides distasonis and their effects on cross-feeding. Food Res Int. 2023;167. doi:10.1016/j.foodres.2023.112633. PMID: 37087229.
   Web of Science ®Google Scholar
• Zhang J, Zhu S, Ma N, Johnston LJ, Wu C, Ma X. Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: a therapeutic target to control intestinal inflammation. Med Res Rev. 2020;41:1061–1088. doi:10.1002/med.21752. PMID: 33174230.
   PubMed Web of Science ®Google Scholar
• Liu JP, Wang J, Zhou SX, Huang DC, Qi GH, Chen GT. Ginger polysaccharides enhance intestinal immunity by modulating gut microbiota in cyclophosphamide-induced immunosuppressed mice. Int J Biol Macromol. 2022;223:1308–1319. doi:10.1016/j.ijbiomac.2022.11.104. PMID: 36395935.
   PubMed Web of Science ®Google Scholar
• Li C, Duan S, Li Y, Pan X, Han L. Polysaccharides in natural products that repair the damage to intestinal mucosa caused by cyclophosphamide and their mechanisms: a review. Carbohyd Polym. 2021;261:117876. doi:10.1016/j.carbpol.2021.117876. PMID: 33766363.
   PubMed Web of Science ®Google Scholar
• Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al. The intestinal microbiota modulates the anticancer immune Effects of cyclophosphamide. Sci. 2013;342:971–976. doi:10.1126/science.1240537. PMID: 24264990.
   PubMed Web of Science ®Google Scholar
• Wu XC, Huang XJ, Ma WN, Li MZ, Wen JJ, Chen CH, Liu LD, Nie SP. Bioactive polysaccharides promote gut immunity via different ways. Food Funct. 2023;14:1387–1400. doi:10.1039/d2fo03181g. PMID: 36633119.
   PubMed Web of Science ®Google Scholar
• Eswar K, Mukherjee S, Ganesan PAR, Rengan AK. Immunomodulatory natural polysaccharides: an overview of the mechanisms involved. Eur Polym J. 2023;188:111935. doi:10.1016/j.eurpolymj.2023.111935.
   Web of Science ®Google Scholar
• Hu YY, He Y, Niu ZQ, Shen T, Zhang J, Wang XF, Hu WC, Cho JY. A review of the immunomodulatory activities of polysaccharides isolated from Panax species. J Ginseng Res. 2022;46:23–32. doi:10.1016/j.jgr.2021.06.003. PMID: 35058724.
   PubMed Web of Science ®Google Scholar
• Cao C, Gong GP, Huang WQ, Huang LJ, Song S, Zhu BW, Zhu B. Effects of Lycium barbarum polysaccharides on immunity and metabolic syndrome associated with the modulation of gut microbiota: a review. Foods. 2022;11:3177. doi:10.3390/foods11203177. PMID: 37430929.
   PubMed Web of Science ®Google Scholar
• Sun J, Chen H, Kan J, Gou Y, Jin C, Zhang X, Wu X, Tang S, Sun R, Qian C. Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice. Int J Biol Macromol. 2020;153:708–722. doi:10.1016/j.ijbiomac.2020.03.053. PMID: 32169445.
   PubMed Web of Science ®Google Scholar
• Yang Y, Ye HQ, Zhao CH, Ren L, Wang CN, Georgiev MI, Xiao JB, Zhang TH. Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota. Carbohyd Polym. 2021;262:117668. doi:10.1016/j.carbpol.2021.117668. PMID: 33838836.
   PubMed Web of Science ®Google Scholar
• Ying MX, Zheng B, Yu Q, Hou KY, Wang H, Zhao MM, Chen Y, Xie JH, Nie SP, Xie MY. Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice. Food Chem Toxicol. 2020;138:111244. doi:10.1016/j.fct.2020.111244. PMID: 32151603.
   PubMed Web of Science ®Google Scholar
• Zhao FQ, Ma TT, Zhang X, Zhao QC, Zhu KX, Cao J, Liu ZY, Shen XR, Li C. Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice. Mol Nutr Food Res. 2022;67:e2200317. doi:10.1002/mnfr.202200317. PMID: 36401832.
   Web of Science ®Google Scholar
• Shi HJ, Chang YG, Gao Y, Wang X, Chen X, Wang YM, Xue CH, Tang QJ. Dietary fucoidan of acaudina molpadioides alters gut microbiota and mitigates intestinal mucosal injury induced by cyclophosphamide. Food Funct. 2017;8(9):3383–3393. doi: 10.1039/c7fo00932a. PMID: 28861559.
   PubMed Web of Science ®Google Scholar
• Aipire A, Yuan PF, Aimaier A, Cai SS, Mahabati M, Lu J, Ying TL, Zhang BH, Li JY. Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis. Biomolecules. 2020;10:10. doi:10.3390/biom10010159. PMID: 31963790.
   Web of Science ®Google Scholar
• Simayi Z, Rozi P, Yang XJ, Ababaikeri G, Maimaitituoheti W, Bao XW, Ma SJ, Askar G, Yadikar N. Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: systematic review. Int J Biol Macromol. 2021;183:387–398. doi:10.1016/j.ijbiomac.2021.04.099. PMID: 33887291.
   PubMed Web of Science ®Google Scholar
• Xie H, Fang J, Farag MA, Li Z, Sun P, Shao P. Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice. Food Chem. 2022;13:100235. doi:10.1016/j.fochx.2022.100235. PMID: 35499019.
   Web of Science ®Google Scholar
• Zhou RR, He D, Xie J, Zhou QYJ, Zeng HL, Li HM, Huang LQ. The synergistic effects of polysaccharides and ginsenosides from American ginseng (Panax quinquefolius L.) ameliorating cyclophosphamide-induced intestinal immune disorders and gut barrier dysfunctions based on microbiome-metabolomics analysis. Front Immunol. 2021;12:665901. doi:10.3389/fimmu.2021.665901. PMID: 33968068.
   PubMed Web of Science ®Google Scholar
• Bilate AM, London M, Castro T, Mesin L, Mucida D, Kongthong S, Harnagel A, Victora GD, Mucida D. T cell receptor is required for differentiation, but not maintenance, of intestinal CD4+ intraepithelial lymphocytes. Immunity. 2020;53:1001–1014.e20. doi:10.1016/j.immuni.2020.09.003. PMID: 33022229.
   PubMed Web of Science ®Google Scholar
• Chen S, Wang J, Fang Q, Dong N, Nie S. Polysaccharide from natural Cordyceps sinensis ameliorated intestinal injury and enhanced antioxidant activity in immunosuppressed mice. Food Hydrocoll. 2019;89:661–667. doi:10.1016/j.foodhyd.2018.11.018.
   Web of Science ®Google Scholar
• Belghith M, Maghrebi O, Cherif A, Bahrini K, Saied Z, Belal S, Sassi SB, Barbouche MR, Kchaou M. Increased T-bet/GATA-3 and ROR-γt /Foxp3 Ratios in Cerebrospinal Fluid as Potential Criteria for Definite Neuro-Behçet’s Disease. J Clin Med. 2022;11:11. doi:10.3390/jcm11154415. PMID: 35956031.
   Web of Science ®Google Scholar
• Fan ST, Nie SP, Huang XJ, Wang SN, Hu JL, Xie JH, Nie QX, Xie MY. Protective properties of combined fungal polysaccharides from cordyceps sinensis and Ganoderma atrum on colon immune dysfunction. Int J Biol Macromol. 2018;114:1049–1055. doi:10.1016/j.ijbiomac.2018.04.004. PMID: 29626602.
   PubMed Web of Science ®Google Scholar
• Dong N, Li XR, Xue CY, Zhang L, Wang CS, Xu XY, Shan A. Astragalus polysaccharides alleviates LPS-induced inflammation via the NF-κB/MAPK signaling pathway. J Cell Physiol. 2020;235:5525–5540. doi:10.1002/jcp.29452. PMID: 32037545.
   PubMed Web of Science ®Google Scholar
• Xu H, Liu L, Ding M, Fan W, Song H, Hui S. Effect of Ganoderma applanatum polysaccharides on MAPK/ERK pathway affecting autophagy in breast cancer MCF-7 cells. Int J Biol Macromol. 2020;146:353–362. doi:10.1016/j.ijbiomac.2020.01.010. PMID: 31911173.
   PubMed Web of Science ®Google Scholar
• Tian BM, Liu RJ, Xu TR, Cai M, Mao RL, Huang LS, Yang K, Zeng XX, Sun PL. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric. 2023;103:3050–3064. doi:10.1002/jsfa.12404. PMID: 36546454.
   PubMed Web of Science ®Google Scholar
• Wang X, Qu YH, Wang Y, Wang X, Xu JL, Zhao HL, Zheng DL, Sun L, Tai GH, Zhou YF, et al. β-1,6-Glucan from Pleurotus eryngii Modulates the Immunity and Gut Microbiota. Front Immunol. 2022;13:859923. doi:10.3389/fimmu.2022.859923. PMID: 35585984.
   PubMed Web of Science ®Google Scholar
• Song QQ, Wang YK, Huang LX, Shen MY, Yu Y, Yu Q, Chen Y, Xie JH. Review of the relationships among polysaccharides, gut microbiota, and human health. Food Res Int. 2021;140:109858. doi:10.1016/j.foodres.2020.109858. PMID: 33648176.
   PubMed Web of Science ®Google Scholar
• Chen SP, Wang JQ, Fang QY, Dong N, Fang QY, Cui SW, Nie SP. A polysaccharide from natural Cordyceps sinensis regulates the intestinal immunity and gut microbiota in mice with cyclophosphamide-induced intestinal injury. Food Funct. 2021;12:6271–6282. doi:10.1039/d1fo00596k. PMID: 34105571.
   PubMedGoogle Scholar
• Guo CL, Guo DD, Fang L, Sang TT, Wu JJ, Guo CJ, Wang YJ, Wang Y, Chen CJ, Chen JJ, et al. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. Carbohydr Polym. 2021;267:118231. doi:10.1016/j.carbpol.2021.118231. PMID: 34119183.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yan Y, Zhou W, Chen D, Huang K, Yu S, Mi J, Lu L, Zeng X, Cao Y. Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice. J Funct Foods. 2020;72:104057. doi:10.1016/j.jff.2020.104057.
   Web of Science ®Google Scholar
• Liu H, Guo H, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Copper induces hepatic inflammatory responses by activation of MAPKs and NF-κB signalling pathways in the mouse. Ecotox Environ Safe. 2020;201:110806. doi:10.1016/j.ecoenv.2020.110806. PMID: 32512418.
   PubMed Web of Science ®Google Scholar
• Wang N, Ren D, Zhang L, Han N, Zhao Y, Yang X. Effects of sheep whey protein combined with fu brick tea polysaccharides and stachyose on immune function and intestinal metabolites of cyclophosphamide-treated mice. J Sci Food Agric. 2023;103:3402–3413. doi:10.1002/jsfa.12477. PMID: 36722467.
   PubMed Web of Science ®Google Scholar
• Zhao M, Shi W, Chen X, Liu Y, Yang Y, Kong X. Regulatory effects of Auricularia cornea var. Li. polysaccharides on immune system and gut microbiota in cyclophosphamide-induced mice. Front Microbiol. 2022;13:1056410. doi:10.3389/fmicb.2022.1056410. PMID: 36406390.
   PubMed Web of Science ®Google Scholar
• Sun WL, Hua S, Li XY, Shen L, Wu H, Ji HF. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nat Commun. 2023;14:1. doi:10.1038/s41467-023-36079-x. PMID: 36717576.
   PubMed Web of Science ®Google Scholar
• Wang L, Xian YF, Loo SKF, Ip SP, Yang W, Chan WY, Lin ZX, JCY W. Baicalin ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK/STAT pathway. Bioorg Chem. 2022;119:119. doi:10.1016/j.bioorg.2021.105538. PMID: 34929516.
   Web of Science ®Google Scholar
• Chen SY, Shen YC, Lin JA, Yen GC. Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota. Phytother Res. 2022;36:4631–4645. doi:10.1002/ptr.7582. PMID: 35918881.
   PubMed Web of Science ®Google Scholar
• Cai GF, Wu Y, Wusiman A, Gu PF, Mao NN, Xu SW, Zhu TY, Feng Z, Liu ZG, Wang DY. Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice. Food Funct. 2021;12:6863–6877. doi:10.1039/d1fo01008e. PMID: 34128029.
   PubMed Web of Science ®Google Scholar
• Li Y, Qin J, Cheng YH, Ai YQ, Han ZY, Li M, Qi YX, Zhao QC, Li ZB. Polysaccharide from Patinopecten yessoensis skirt boosts immune response via modulation of gut microbiota and short-chain fatty acids metabolism in mice. Foods. 2021;10:2478. doi:10.3390/foods10102478. PMID: 34681527.
   PubMed Web of Science ®Google Scholar