Axin1‘s mystique in manipulating microbiome amidst colitis

References

• Li Vivian SW, Ng Ser S, Boersema Paul J, Low Teck Y, Karthaus Wouter R, Gerlach Jan P, Mohammed S, Heck AR, Maurice M, Mahmoudi T, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell. 2012;149:1245–1773. doi:10.1016/j.cell.2012.05.002.
   PubMed Web of Science ®Google Scholar
• Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, et al. Axis inhibition protein 1 (Axin1) deletion–induced hepatocarcinogenesis requires intact β‐catenin but not notch cascade in mice. Hepatology. 2019;70(6):2003–2017. doi:10.1002/hep.30556.
   PubMed Web of Science ®Google Scholar
• Garrett S, Zhang Y, Xia Y, Sun J. Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiota. Engineering. 2023. doi:10.1016/j.eng.2023.06.007.
   Google Scholar
• Sanson R, Lazzara SL, Cune D, Pitasi CL, Trentesaux C, Fraudeau M, Letourneur F, Saintpierre B, Le Gall M, Bossard P, et al. Axin1 protects colon carcinogenesis by an immune-mediated effect. Cell Mol Gastroenterol Hepatol. 2023;15:689–715. doi:10.1016/j.jcmgh.2022.10.017.
   PubMed Web of Science ®Google Scholar
• Thorvaldsen TE, Pedersen NM, Wenzel EM, Stenmark H, Katoh M. Differential roles of AXIN1 and AXIN2 in tankyrase inhibitor-induced formation of degradasomes and β-catenin degradation. PLoS One. 2017;12(1):e0170508. doi:10.1371/journal.pone.0170508.
   PubMed Web of Science ®Google Scholar
• JJDd R, Chhatta A, Garcia-Perez L, Naber BAE, Vloemans SA, Salvatori DCF, Pike-Overzet K, Mikkers H, Staal FJT. Axin2/Conductin is required for normal haematopoiesis and T Lymphopoiesis. Cells. 2022;11:2679. doi:10.3390/cells11172679.
   PubMed Web of Science ®Google Scholar
• Moshkovsky AR, Kirschner MW. The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway. Proc Natl Acad Sci. 2022;119:e2108408119. doi:10.1073/pnas.2108408119.
   PubMed Web of Science ®Google Scholar
• Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, van de Geer WS, van de Werken HJG, Peppelenbosch MP, Smits R, et al. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Sci Rep. 2021;11(1):7470. doi:10.1038/s41598-021-87091-4.
   PubMed Web of Science ®Google Scholar
• Chia IV, Costantini F. Mouse axin and Axin2/Conductin proteins are functionally equivalent in vivo. Mol Cell Biol. 2005;25:4371–4376. doi:10.1128/MCB.25.11.4371-4376.2005.
   PubMed Web of Science ®Google Scholar
• Zhang Y-G, Wu S, Xia Y, Chen D, Petrof EO, Claud EC, Hsu W, Sun J. Axin1 Prevents Salmonella Invasiveness and Inflammatory Response in Intestinal Epithelial Cells. PLoS One. 2012;7:e34942. doi:10.1371/journal.pone.0034942.
   PubMed Web of Science ®Google Scholar
• Mazzoni SM, Fearon ER. AXIN1 and AXIN2 variants in gastrointestinal cancers. Cancer Lett. 2014;355(1):1–8. doi:10.1016/j.canlet.2014.09.018.
   PubMed Web of Science ®Google Scholar
• Guo Y, Bamunuarachchi G, Vaddadi K, Zhu Z, Gandikota C, Ahmed K, Pushparaj S, More S, Xiao X, Yang X, et al. Axin1: a novel scaffold protein joins the antiviral network of interferon. Mol Microbiol. 2022;118(6):731–743. doi:10.1111/mmi.14995.
   PubMed Web of Science ®Google Scholar
• Zhang YG, Wu S, Xia Y, Chen D, Petrof EO, Claud EC, Hsu W, Sun J. Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells. PLoS One. 2012;7:e34942. doi:10.1371/journal.pone.0034942.
   PubMed Web of Science ®Google Scholar
• Moraes L, Magnusson MK, Mavroudis G, Polster A, Jonefjäll B, Törnblom H, Sundin J, Simrén M, Strid H, Öhman L, et al. Systemic inflammatory protein profiles distinguish irritable bowel syndrome (IBS) and ulcerative colitis, irrespective of inflammation or IBS-Like symptoms. Inflamm Bowel Dis. 2020;26(6):874–884. doi:10.1093/ibd/izz322.
   PubMed Web of Science ®Google Scholar
• Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, et al. Paneth cell defects induce microbiota dysbiosis in mice and promote visceral hypersensitivity. Gastroenterology. 2017;153(6):1594–606.e2. doi:10.1053/j.gastro.2017.08.044.
   PubMed Web of Science ®Google Scholar
• Salzman NH. Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces. Gut Microbes. 2010;1(6):401–406. doi:10.4161/gmic.1.6.14076.
   PubMed Web of Science ®Google Scholar
• Beisner J, Teltschik Z, Ostaff MJ, Tiemessen MM, Staal FJT, Wang G, Gersemann, M, Perminow, G, Vatn, MH, Schwab, M, et al. TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn’s disease. Ame J Physiol-Gastrointest and Liver Physiol. 2014;307(5):G487–G498. doi:10.1152/ajpgi.00347.2013.
   PubMed Web of Science ®Google Scholar
• Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, Singh R, Liu Y, Macazana C, et al. Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine. Immunity. 2020;53(2):398–416.e8. doi:10.1016/j.immuni.2020.07.010.
   PubMed Web of Science ®Google Scholar
• Meyer K, Gellhorn A, Prudden JF, Lehman WL, Steinberg A. Lysozyme in chronic ulcerative colitis. Proceedings of the Society for Experimental Biology and Medicine. 1947;65(2):221–222.
   Google Scholar
• Di Ruscio M, Vernia F, Ciccone A, Frieri G, Latella G. Surrogate fecal biomarkers in inflammatory bowel disease: rivals or complementary tools of fecal calprotectin? Inflamm Bowel Dis. 2018;24(1):78–92. doi:10.1093/ibd/izx011.
   Web of Science ®Google Scholar
• Swafford D, Shanmugam A, Ranganathan P, Hussein MS, Koni PA, Prasad PD, Thangaraju M, Manicassamy S. Canonical Wnt signaling in CD11c+ APCs regulates microbiota-induced inflammation and immune cell homeostasis in the colon. J Immunol. 2018;200:3259–3268. doi:10.4049/jimmunol.1701086.
   PubMed Web of Science ®Google Scholar
• Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Y-C W, Pulendran B. Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Sci. 2010;329:849–853. doi:10.1126/science.1188510.
   PubMed Web of Science ®Google Scholar
• Crovesy L, Masterson D, Rosado EL. Profile of the gut microbiota of adults with obesity: a systematic review. Eur J Clin Nutr. 2020;74(9):1251–1262. doi:10.1038/s41430-020-0607-6.
   PubMed Web of Science ®Google Scholar
• Zhang X, Shen D, Fang Z, Jie Z, Qiu X, Zhang C, Chen Y, Ji L. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One. 2013;8:e71108. doi:10.1371/journal.pone.0071108.
   PubMed Web of Science ®Google Scholar
• Chang C-S, Liao Y-C, Huang C-T, Lin C-M, Cheung CHY, Ruan J-W, Yu W-H, Tsai Y-T, Lin I-J, Huang C-H, et al. Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice. Cell Rep. 2021;37(8):110016. doi:10.1016/j.celrep.2021.110016.
   PubMed Web of Science ®Google Scholar
• Imhann F, Vich Vila A, Bonder MJ, Fu J, Gevers D, Visschedijk MC, Spekhorst LM, Alberts R, Franke L, van Dullemen HM, et al. Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut. 2018;67(1):108–119. doi:10.1136/gutjnl-2016-312135.
   PubMed Web of Science ®Google Scholar
• Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL, et al. The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/β-catenin signaling. Cancer Res. 2020;80:3519–3529. doi:10.1158/0008-5472.CAN-20-0216.
   PubMed Web of Science ®Google Scholar
• Alula KM, Delgado-Deida Y, Jackson DN, Venuprasad K, Theiss AL. Nuclear partitioning of prohibitin 1 inhibits Wnt/beta-catenin-dependent intestinal tumorigenesis. Oncogene. 2021;40:369–383. doi:10.1038/s41388-020-01538-y.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Cai J, Hou W, Xu K, Wu X, Song Y, Bai C, Mo Y-Y, Zhang Z. Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice. Gut Microbes. 2023;15:2166700. doi:10.1080/19490976.2023.2166700.
   PubMed Web of Science ®Google Scholar