Bifidobacterium mechanisms of immune modulation and tolerance

References

• Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, van Sinderen D. Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol Rev. 2007;71(3):495–23. doi:10.1128/MMBR.00005-07.
   PubMed Web of Science ®Google Scholar
• Lugli GA, Milani C, Duranti S, Alessandri G, Turroni F, Mancabelli L, Tatoni D, Ossiprandi MC, van Sinderen D, Ventura M, et al. Isolation of novel gut bifidobacteria using a combination of metagenomic and cultivation approaches. Genome Biol. 2019;20(1):96. doi:10.1186/s13059-019-1711-6.
   PubMedGoogle Scholar
• Roy D. Media for the isolation and enumeration of bifidobacteria in dairy products. Int J Food Microbiol. 2001;69(3):167–182. doi:10.1016/S0168-1605(01)00496-2.
   PubMed Web of Science ®Google Scholar
• Sghir A, Chow JM, Mackie RI. Continuous culture selection of bifidobacteria and lactobacilli from human faecal samples using fructooligosaccharide as selective substrate. J Appl Microbiol. 1998;85(4):769–777. doi:10.1111/j.1365-2672.1998.00590.x.
   PubMed Web of Science ®Google Scholar
• Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019;16(10):605–616. doi:10.1038/s41575-019-0173-3.
   PubMed Web of Science ®Google Scholar
• Verma R, Lee C, Jeun EJ, Yi J, Kim KS, Ghosh A, Byun S, Lee, CG, Kang, HJ, Kim, GC et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+regulatory T cells. Sci Immunol. 2018;3(28):3. doi:10.1126/sciimmunol.aat6975.
   Web of Science ®Google Scholar
• Guo S, Gillingham T, Guo Y, Meng D, Zhu W, Walker WA, Ganguli K. Secretions of Bifidobacterium infantis and Lactobacillus acidophilus protect intestinal epithelial barrier function. J Pediatr Gastroenterol Nutr. 2017;64(3):404–12. doi:10.1097/MPG.0000000000001310.
   PubMed Web of Science ®Google Scholar
• Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, Olin A, Wang J, Mikes J, Tan Z, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021;184(15):3884–98 e11. doi:10.1016/j.cell.2021.05.030.
   PubMed Web of Science ®Google Scholar
• Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song S, Yassour M, et al. The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host & Microbe. 2014;15(3):382–392. doi:10.1016/j.chom.2014.02.005.
   PubMed Web of Science ®Google Scholar
• Shi P, Qu H, Nian D, Chen Y, Liu X, Li Q, Li Q, Wang C, Ye M, Ma B, et al. Treatment of guillain-barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290–6. doi:10.1016/j.intimp.2018.06.015.
   PubMed Web of Science ®Google Scholar
• Bromberg JS, Hittle LE, Xiong Y, Saxena V, Smyth EM, Li L, Zhang T, Wagner C, Fricke WF, Simon T, et al. Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. JCI Insight. 2018;3(19):3. doi:10.1172/jci.insight.121045.
   Web of Science ®Google Scholar
• Romano S, Savva GM, Bedarf JR, Charles IG, Hildebrand F, Narbad A. Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation. NPJ Parkinsons Dis. 2021;7(1):27. doi:10.1038/s41531-021-00156-z.
   PubMed Web of Science ®Google Scholar
• Forbes JD, Chen CY, Knox NC, Marrie RA, El-Gabalawy H, de Kievit T, Alfa M, Bernstein CN, Van Domselaar G. A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist? Microbiome. 2018;6(1):221. doi:10.1186/s40168-018-0603-4.
   PubMed Web of Science ®Google Scholar
• Fan L, Qi Y, Qu S, Chen X, Li A, Hendi M, Xu C, Wang L, Hou T, Si J, et al. B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling. Gut Microbes. 2021;13(1):1–17. doi:10.1080/19490976.2020.1826746.
   PubMed Web of Science ®Google Scholar
• Nicola S, Amoruso A, Deidda F, Pane M, Allesina S, Mogna L, Del Piano M, Mogna G. Searching for the perfect homeostasis: five strains of Bifidobacterium longum from centenarians have a similar Behavior in the production of cytokines. J Clin Gastroenterol. 2016;50(Suppl 2):S126–S30. Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015. doi:10.1097/MCG.0000000000000678.
   PubMedGoogle Scholar
• Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, et al. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell. 2017;168(5):928–943.e11. doi:10.1016/j.cell.2017.01.022.
   PubMed Web of Science ®Google Scholar
• Hrdy J, Alard J, Couturier-Maillard A, Boulard O, Boutillier D, Delacre M, Lapadatescu C, Cesaro A, Blanc P, Pot B, et al. Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses. Sci Rep. 2020;10(1):5345. doi:10.1038/s41598-020-62161-1.
   PubMed Web of Science ®Google Scholar
• Hickey A, Stamou P, Udayan S, Ramon-Vazquez A, Esteban-Torres M, Bottacini F, Woznicki JA, Hughes O, Melgar S, Ventura M, et al. Bifidobacterium breve exopolysaccharide blocks dendritic cell maturation and activation of CD4+ T cells. Front Microbiol. 2021;12:653587. doi:10.3389/fmicb.2021.653587.
   PubMed Web of Science ®Google Scholar
• Riviere A, Gagnon M, Weckx S, Roy D, De Vuyst L, Schloss PD. Mutual cross-feeding interactions between Bifidobacterium longum subsp. longum NCC2705 and Eubacterium rectale ATCC 33656 explain the Bifidogenic and butyrogenic effects of Arabinoxylan oligosaccharides. Appl Environ Microbiol. 2015;81(22):7767–7781. doi:10.1128/AEM.02089-15.
   PubMed Web of Science ®Google Scholar
• Chia LW, Mank M, Blijenberg B, Bongers RS, van Limpt K, Wopereis H, Tims S, Stahl B, Belzer C, Knol J, et al. Cross-feeding between Bifidobacterium infantis and Anaerostipes caccae on lactose and human milk oligosaccharides. Benef Microbes. 2021;12(1):69–83. doi:10.3920/BM2020.0005.
   PubMed Web of Science ®Google Scholar
• Rios-Covian D, Gueimonde M, Duncan SH, Flint HJ, de Los Reyes-Gavilan CG, Cox M. Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis. FEMS Microbiol Lett. 2015;362(21):fnv176. doi:10.1093/femsle/fnv176.
   PubMed Web of Science ®Google Scholar
• Kim H, Jeong Y, Kang S, You HJ, Ji GE. Co-Culture with Bifidobacterium catenulatum Improves the Growth, Gut Colonization and Butyrate Production. Of Faecalibacterium Prausnitzii: In Vitro And In Vivo Studies. Microorganisms. 2020;8(5):8. doi:10.3390/microorganisms8050788.
   Web of Science ®Google Scholar
• Egan M, Motherway MO, Kilcoyne M, Kane M, Joshi L, Ventura M, van Sinderen D. Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium. BMC Microbiol. 2014;14(1):282. doi:10.1186/s12866-014-0282-7.
   PubMedGoogle Scholar
• Lawson MAE, O’Neill IJ, Kujawska M, Gowrinadh Javvadi S, Wijeyesekera A, Flegg Z, Chalklen L, Hall LJ. Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem. ISME J. 2020;14(2):635–48. doi:10.1038/s41396-019-0553-2.
   PubMed Web of Science ®Google Scholar
• Turroni F, Ozcan E, Milani C, Mancabelli L, Viappiani A, van Sinderen D, Sela DA, Ventura M. Glycan cross-feeding activities between bifidobacteria under in vitro conditions. Front Microbiol. 2015;6:1030. doi:10.3389/fmicb.2015.01030.
   PubMed Web of Science ®Google Scholar
• Milani C, Lugli GA, Duranti S, Turroni F, Mancabelli L, Ferrario C, Mangifesta M, Hevia A, Viappiani A, Scholz M, et al. Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut. Sci Rep. 2015;5(1):15782. doi:10.1038/srep15782.
   PubMedGoogle Scholar
• Riviere A, Selak M, Geirnaert A, Van den Abbeele P, De Vuyst L, Björkroth J. Complementary mechanisms for degradation of inulin-type fructans and arabinoxylan oligosaccharides among Bifidobacterial strains suggest bacterial cooperation. Appl Environ Microbiol. 2018;84(9):84. doi:10.1128/AEM.02893-17.
   Web of Science ®Google Scholar
• Falony G, Vlachou A, Verbrugghe K, De Vuyst L. Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol. 2006;72(12):7835–7841. doi:10.1128/AEM.01296-06.
   PubMed Web of Science ®Google Scholar
• Moens F, Weckx S, De Vuyst L. Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii. Int J Food Microbiol. 2016;231:76–85. doi:10.1016/j.ijfoodmicro.2016.05.015.
   PubMed Web of Science ®Google Scholar
• Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480):451–5. doi:10.1038/nature12726.
   PubMed Web of Science ®Google Scholar
• Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, Glickman JN, Garrett WS. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Sci. 2013;341(6145):569–73. doi:10.1126/science.1241165.
   PubMed Web of Science ®Google Scholar
• Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad P, Manicassamy S, Munn D, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 2014;40(1):128–139. doi:10.1016/j.immuni.2013.12.007.
   PubMed Web of Science ®Google Scholar
• Kitada Y, Muramatsu K, Toju H, Kibe R, Benno Y, Kurihara S, Matsumoto M. Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies. Sci Adv. 2018;4(6):eaat0062. doi:10.1126/sciadv.aat0062.
   PubMed Web of Science ®Google Scholar
• Chung SW, Chan BT. Trimethylamine oxide, dimethylamine, trimethylamine and formaldehyde levels in main traded fish species in Hong Kong. Food Addit Contam Part B Surveill. 2009;2(1):44–51. doi:10.1080/02652030902858921.
   PubMed Web of Science ®Google Scholar
• Wang Q, Guo M, Liu Y, Xu M, Shi L, Li X, Zhao J, Zhang H, Wang G, Chen W, et al. Bifidobacterium breve and Bifidobacterium longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice. Nutrients. 2022;14(6):14. doi:10.3390/nu14061222.
   Web of Science ®Google Scholar
• Bromberg JS, Hittle L, Xiong Y, Saxena V, Smyth EM, Li L, Zhang T, Wagner C, Fricke WF, Simon T, et al. Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. JCI Insight. 2018;3(19):3. doi:10.1172/jci.insight.121045.
   Web of Science ®Google Scholar
• Li L, Shirkey MW, Zhang T, Piao W, Li X, Zhao J, Mei Z, Guo Y, Saxena V, Kensiski A, et al. Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4. J Clin Invest. 2022;132(13):132. doi:10.1172/JCI156994.
   Web of Science ®Google Scholar
• Ren Z-G, Liu H, Jiang J-W, Jiang L, Chen H, Xie H-Y, Zhou, L., Zheng, S-S. Protective effect of probiotics on intestinal barrier function in malnourished rats after liver transplantation. Hepatobiliary & Pancreatic Diseases International. 2011;10(5):489–496. doi:10.1016/S1499-3872(11)60083-0.
   PubMed Web of Science ®Google Scholar
• Xing HC, Li LJ, Xu KJ, Shen T, Chen YB, Sheng JF, Chen Y, Fu S-Z, Chen C-L, Wang J-G, et al. Protective role of supplement with foreign Bifidobacterium and Lactobacillus in experimental hepatic ischemia-reperfusion injury. J Gastroenterol Hepatol. 2006;21(4):647–56. doi:10.1111/j.1440-1746.2006.04306.x.
   PubMed Web of Science ®Google Scholar
• Xie Y, Chen H, Zhu B, Qin N, Chen Y, Li Z, Deng M, Jiang H, Xu X, Yang J, et al. Effect of intestinal microbiota alteration on hepatic damage in rats with acute rejection after liver transplantation. Microb Ecol. 2014;68(4):871–880. doi:10.1007/s00248-014-0452-z.
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Fagan A, Sikaroodi M, White MB, Sterling RK, Gilles H, Heuman D, Stravitz RT, Matherly SC, Siddiqui MS, et al. Liver transplant modulates gut microbial dysbiosis and cognitive function in cirrhosis. Liver Transpl. 2017;23(7):907–914. doi:10.1002/lt.24754.
   PubMed Web of Science ®Google Scholar
• Wu Z-W, Ling Z-X, Lu H-F, Zuo J, Sheng J-F, Zheng S-S, Li L-J. Changes of gut bacteria and immune parameters in liver transplant recipients. Hepatob Pancreat Dis. 2012;11(1):40–50. doi:10.1016/S1499-3872(11)60124-0.
   PubMed Web of Science ®Google Scholar
• Swarte JC, Douwes RM, Hu S, Vich Vila A, Eisenga MF, van Londen M, Gomes-Neto AW, Weersma RK, Harmsen HJM, Bakker SJL, et al. Characteristics and dysbiosis of the gut microbiome in renal transplant recipients. J Clin Med. 2020;9(2):386. doi:10.3390/jcm9020386.
   PubMed Web of Science ®Google Scholar
• Kato K, Nagao M, Miyamoto K, Oka K, Takahashi M, Yamamoto M, Matsumura Y, Kaido T, Uemoto S, Ichiyama S, et al. Longitudinal analysis of the intestinal microbiota in liver transplantation. Transplant Direct. 2017;3(4):e144. doi:10.1097/TXD.0000000000000661.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yang B, Stanton C, Ross RP, Zhao J, Zhang H, Chen W. Bifidobacterium pseudocatenulatum Ameliorates DSS-Induced Colitis by Maintaining Intestinal Mechanical Barrier, Blocking Proinflammatory Cytokines, Inhibiting TLR4/NF-κB Signaling, and Altering Gut Microbiota. J Agric Food Chem. 2021;69(5):1496–512. doi:10.1021/acs.jafc.0c06329.
   PubMed Web of Science ®Google Scholar
• Han T, Hu X, Li K, Zhang D, Zhang Y, Li J. Bifidobacterium infantis maintains genome stability in ulcerative colitis via regulating anaphase-promoting complex subunit 7. Front Microbiol. 2021;12:761113. doi:10.3389/fmicb.2021.761113.
   PubMed Web of Science ®Google Scholar
• Wang N, Wang S, Xu B, Liu F, Huo G, Li B. Alleviation effects of Bifidobacterium animalis subsp. lactis XLTG11 on Dextran Sulfate sodium-induced colitis in mice. Microorganisms. 2021;9(10):2093. doi:10.3390/microorganisms9102093.
   PubMed Web of Science ®Google Scholar
• Chen Y, Jin Y, Stanton C, Paul Ross R, Zhao J, Zhang H, Yang B, Chen W. Alleviation effects of Bifidobacterium breve on DSS-induced colitis depends on intestinal tract barrier maintenance and gut microbiota modulation. Eur J Nutr. 2021;60(1):369–87. doi:10.1007/s00394-020-02252-x.
   PubMed Web of Science ®Google Scholar
• Sun S, Luo L, Liang W, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach, MA, Sonnenburg, JL et al. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020; 117:27509–15.
   PubMed Web of Science ®Google Scholar
• Laparra JM, Olivares M, Gallina O, Sanz Y, Leulier F. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS ONE. 2012;7(2):e30744. doi:10.1371/journal.pone.0030744.
   PubMed Web of Science ®Google Scholar
• Olivares M, Laparra M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model. J Proteomics. 2012;77:310–320. doi:10.1016/j.jprot.2012.09.005.
   PubMed Web of Science ®Google Scholar
• McCarville JL, Dong J, Caminero A, Bermudez-Brito M, Jury J, Murray JA, Duboux S, Steinmann M, Delley M, Tangyu M, et al. A commensal Bifidobacterium longum strain prevents gluten-related immunopathology in mice through expression of a serine protease inhibitor. Appl Environ Microbiol. 2017;83(19). doi:10.1128/AEM.01323-17.
   PubMed Web of Science ®Google Scholar
• Medina M, De Palma G, Ribes-Koninckx C, Calabuig M, Sanz Y. Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. J Inflamm (Lond). 2008;5(1):19. doi:10.1186/1476-9255-5-19.
   PubMedGoogle Scholar
• Lindfors K, Blomqvist T, Juuti-Uusitalo K, Stenman S, Venalainen J, Maki M, Kaukinen K. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008;152(3):552–558. doi:10.1111/j.1365-2249.2008.03635.x.
   PubMed Web of Science ®Google Scholar
• Consonni A, Cordiglieri C, Rinaldi E, Marolda R, Ravanelli I, Guidesi E, Elli M, Mantegazza R, Baggi F. Administration of bifidobacterium and lactobacillus strains modulates experimental myasthenia gravis and experimental encephalomyelitis in Lewis rats. Oncotarget. 2018;9(32):22269–87. doi:10.18632/oncotarget.25170.
   PubMedGoogle Scholar
• Chae CS, Kwon HK, Hwang JS, Kim JE, Im SH, Platten M. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS ONE. 2012;7(12):e52119. doi:10.1371/journal.pone.0052119.
   PubMed Web of Science ®Google Scholar
• Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, Soltan Dallal MM, Tabasi N, Khazaee M, Nasiraii LR, Mahmoudi M, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535–1548. doi:10.1016/j.biopha.2017.08.117.
   PubMed Web of Science ®Google Scholar
• Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A, Kim J-E, Nam JH, Im S-H. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 2013;146(3):217–27. doi:10.1016/j.clim.2013.01.001.
   PubMed Web of Science ®Google Scholar
• Tremlett H, Fadrosh DW, Faruqi AA, Zhu F, Hart J, Roalstad S, Graves J, Lynch S, Waubant E. Gut microbiota in early pediatric multiple sclerosis: a case−control study. Eur J Neurol. 2016;23(8):1308–21. doi:10.1111/ene.13026.
   PubMed Web of Science ®Google Scholar
• Baum K, Rejmus R, Dorffel Y. Commensal gut flora in MS: Spatial organization and composition. Mult Scler. 2015;21:458–459.
   Web of Science ®Google Scholar
• Liu Q, Jing W, Wang W. Bifidobacterium lactis ameliorates the risk of food allergy in Chinese children by affecting relative percentage of Treg and Th17 cells. Can J Infect Dis Med Microbiol. 2018;2018:1–12. doi:10.1155/2018/4561038.
   Web of Science ®Google Scholar
• Fu L, Song J, Wang C, Fu S, Wang Y. Bifidobacterium infantis potentially alleviates Shrimp tropomyosin-induced allergy by tolerogenic dendritic cell-dependent induction of regulatory T cells and alterations in gut microbiota. Front Immunol. 2017;8:1536. doi:10.3389/fimmu.2017.01536.
   PubMed Web of Science ®Google Scholar
• Li N, Yu Y, Chen X, Gao S, Zhang Q, Xu C. Bifidobacterium breve M-16V alters the gut microbiota to alleviate OVA-induced food allergy through IL-33/ST2 signal pathway. J Cell Physiol. 2020;235(12):9464–9473. doi:10.1002/jcp.29751.
   PubMed Web of Science ®Google Scholar
• An SB, Yang BG, Jang G, Kim DY, Kim J, Oh SM, Oh N, Lee S, Moon J-Y, Kim J-A, et al. Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy. Nat Commun. 2022;13(1):5669. doi:10.1038/s41467-022-33176-1.
   PubMed Web of Science ®Google Scholar
• Ren J, Zhao Y, Huang S, Lv D, Yang F, Lou L, Zheng Y, Zhang J, Liu S, Zhang N, et al. Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice. Exp Ther Med. 2018;16:3996–4004. doi:10.3892/etm.2018.6704.
   PubMed Web of Science ®Google Scholar
• Rinaldi E, Consonni A, Cordiglieri C, Sacco G, Crasa C, Fontana A, Morelli L, Elli M, Mantegazza R, Baggi F, et al. Therapeutic Effect of Bifidobacterium Administration on Experimental Autoimmune Myasthenia Gravis in Lewis Rats. Front Immunol. 2019;10:2949. doi:10.3389/fimmu.2019.02949.
   PubMed Web of Science ®Google Scholar
• Castro-Bravo N, Wells JM, Margolles A, Ruas-Madiedo P. Interactions of surface Exopolysaccharides from Bifidobacterium and Lactobacillus within the intestinal environment. Front Microbiol. 2018;9:2426. doi:10.3389/fmicb.2018.02426.
   PubMed Web of Science ®Google Scholar
• Costa OYA, Raaijmakers JM, Kuramae EE. Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation. Front Microbiol. 2018;9:1636. doi:10.3389/fmicb.2018.01636.
   PubMed Web of Science ®Google Scholar
• Alessandri G, Ossiprandi MC, MacSharry J, van Sinderen D, Ventura M. Bifidobacterial dialogue with its human host and consequent modulation of the immune system. Front Immunol. 2019;10:2348. doi:10.3389/fimmu.2019.02348.
   PubMed Web of Science ®Google Scholar
• López P, Monteserín DC, Gueimonde M, de Los Reyes-Gavilán CG, Margolles A, Suárez A, Ruas-Madiedo P. Exopolysaccharide-producing Bifidobacterium strains elicit different in vitro responses upon interaction with human cells. Food Res Int. 2012;46(1):99–107. doi:10.1016/j.foodres.2011.11.020.
   Web of Science ®Google Scholar
• Fanning S, Hall LJ, Cronin M, Zomer A, MacSharry J, Goulding D, O’Connell Motherway M, Shanahan F, Nally K, Dougan G, et al. Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection. Proc Natl Acad Sci U S A. 2012;109(6):2108–2113. doi:10.1073/pnas.1115621109.
   PubMed Web of Science ®Google Scholar
• Hidalgo-Cantabrana C, Lopez P, Gueimonde M, de Los Reyes-Gavilan CG, Suarez A, Margolles A, Ruas-Madiedo P. Immune modulation capability of Exopolysaccharides synthesised by lactic acid bacteria and Bifidobacteria. Probiotics Antimicrob Proteins. 2012;4(4):227–37. doi:10.1007/s12602-012-9110-2.
   PubMed Web of Science ®Google Scholar
• Ma B, Gavzy SJ, Saxena V, Song Y, Piao W, Lwin HW, Lakhan R, Iyyathurai J, Li L, France M, et al. Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum. Sci Rep. 2023;13(1):1023. doi:10.1038/s41598-023-27706-0.
   PubMed Web of Science ®Google Scholar
• Medina M, Izquierdo E, Ennahar S, Sanz Y. Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. 2007;150(3):531–538. doi:10.1111/j.1365-2249.2007.03522.x.
   PubMed Web of Science ®Google Scholar
• Turroni F, Serafini F, Foroni E, Duranti S, O’Connell Motherway M, Taverniti V, Mangifesta M, Milani C, Viappiani A, Roversi T, et al. Role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium–host interactions. Proc Natl Acad Sci U S A. 2013;110(27):11151–6. doi:10.1073/pnas.1303897110.
   PubMed Web of Science ®Google Scholar
• O’Connell Motherway M, Zomer A, Leahy SC, Reunanen J, Bottacini F, Claesson MJ, O’Brien F, Flynn K, Casey PG, Moreno Munoz JA, et al. Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor. Proc Natl Acad Sci USA. 2011;108(27):11217–22. doi:10.1073/pnas.1105380108.
   PubMed Web of Science ®Google Scholar
• Milani C, Mangifesta M, Mancabelli L, Lugli GA, Mancino W, Viappiani A, Faccini A, van Sinderen D, Ventura M, Turroni F, et al. The sortase-dependent fimbriome of the genus Bifidobacterium: extracellular structures with potential to modulate Microbe-host dialogue. Appl Environ Microbiol. 2017;83(19). doi:10.1128/AEM.01295-17.
   Web of Science ®Google Scholar
• Call EK, Klaenhammer TR. Relevance and application of sortase and sortase-dependent proteins in lactic acid bacteria. Front Microbiol. 2013;4:73. doi:10.3389/fmicb.2013.00073.
   PubMed Web of Science ®Google Scholar
• Vieira AT, Rocha VM, Tavares L, Garcia CC, Teixeira MM, Oliveira SC, Cassali GD, Gamba C, Martins FS, Nicoli JR. Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 51A. Microbes Infect. 2016;18(3):180–9. doi:10.1016/j.micinf.2015.10.008.
   PubMed Web of Science ®Google Scholar
• Devika NT, Raman K. Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models. Sci Rep. 2019;9(1):18222. doi:10.1038/s41598-019-54696-9.
   PubMedGoogle Scholar
• Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature. 2011;469(7331):543–547. doi:10.1038/nature09646.
   PubMed Web of Science ®Google Scholar
• Fukuda S, Toh H, Taylor TD, Ohno H, Hattori M. Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters. Gut Microbes. 2012;3(5):449–454. doi:10.4161/gmic.21214.
   PubMed Web of Science ®Google Scholar
• Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ. Lactate reduces liver and pancreatic injury in Toll-like receptor– and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology. 2014;146(7):1763–74. doi:10.1053/j.gastro.2014.03.014.
   PubMed Web of Science ®Google Scholar
• Li H, Xie J, Guo X, Yang G, Cai B, Liu J, Yue M, Tang Y, Wang G, Chen S, et al. Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses. Gut Microbes. 2022;14(1):2127456. doi:10.1080/19490976.2022.2127456.
   PubMed Web of Science ®Google Scholar
• Mei Y, Chen H, Yang B, Zhao J, Zhang H, Chen W. Computational analysis and Heterologous expression of BBI-like proteins from food-grade Bifidobacterium species reveal possibly a key factor in conjugated linoleic acid bioconversion. J Agric Food Chem. 2023;71(21):8093–103. doi:10.1021/acs.jafc.3c00857.
   PubMed Web of Science ®Google Scholar
• Senizza A, Rocchetti G, Callegari ML, Lucini L, Morelli L. Linoleic acid induces metabolic stress in the intestinal microorganism Bifidobacterium breve DSM 20213. Sci Rep. 2020;10(1):5997. doi:10.1038/s41598-020-62897-w.
   PubMed Web of Science ®Google Scholar
• Li W, Hang S, Fang Y, Bae S, Zhang Y, Zhang M, Wang G, McCurry MD, Bae M, Paik D, et al. A bacterial bile acid metabolite modulates T(reg) activity through the nuclear hormone receptor NR4A1. Cell Host & Microbe. 2021;29(9):1366–1377.e9. doi:10.1016/j.chom.2021.07.013.
   PubMed Web of Science ®Google Scholar
• Hang S, Paik D, Yao L, Kim E, Trinath J, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576(7785):143–148. doi:10.1038/s41586-019-1785-z.
   PubMed Web of Science ®Google Scholar
• Meng D, Sommella E, Salviati E, Campiglia P, Ganguli K, Djebali K, Zhu W, Walker WA. Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine. Pediatr Res. 2020;88(2):209–17. doi:10.1038/s41390-019-0740-x.
   PubMed Web of Science ®Google Scholar
• Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, et al. Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. BMC Microbiol. 2020;20(1):357. doi:10.1186/s12866-020-02023-y.
   PubMed Web of Science ®Google Scholar
• Fang Z, Pan T, Li L, Wang H, Zhu J, Zhang H, Zhao J, Chen W, Lu W. Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes. 2022;14(1):14. doi:10.1080/19490976.2022.2044723.
   Web of Science ®Google Scholar
• Shen J, Yang L, You K, Chen T, Su Z, Cui Z, Wang M, Zhang W, Liu B, Zhou K, et al. Indole-3-acetic acid alters intestinal microbiota and alleviates ankylosing spondylitis in mice. Front Immunol. 2022;13:762580. doi:10.3389/fimmu.2022.762580.
   PubMed Web of Science ®Google Scholar
• Wang T, Gnanaprakasam JNR, Chen X, Kang S, Xu X, Sun H, Liu L, Rodgers H, Miller E, Cassel TA, et al. Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction. Nat Metab. 2020;2(7):635–47. doi:10.1038/s42255-020-0219-4.
   PubMedGoogle Scholar
• Mager LF, Burkhard R, Pett N, Cooke NCA, Brown K, Ramay H, Paik S, Stagg J, Groves RA, Gallo M, et al. Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Sci. 2020;369(6510):1481–1489. doi:10.1126/science.abc3421.
   PubMed Web of Science ®Google Scholar
• Carafa I, Masuero D, Vrhovsek U, Bittante G, Franciosi E, Tuohy KM Production of conjugated linoleic acid (CLA): effect of inulin on microbial composition and CLA concentration in a human intestinal model. Proceedings of the Nutrition Society 2020; 79.
   Google Scholar
• Laursen MF, Sakanaka M, von Burg N, Morbe U, Andersen D, Moll JM, Pekmez CT, Rivollier A, Michaelsen KF, Mølgaard C, et al. Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut. Nat microbiol. 2021;6(11):1367–1382. doi:10.1038/s41564-021-00970-4.
   PubMed Web of Science ®Google Scholar
• Zelante T, Iannitti RG, Cunha C, De Luca A, Giovannini G, Pieraccini G, Zecchi R, D’Angelo C, Massi-Benedetti C, Fallarino F, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013;39(2):372–385. doi:10.1016/j.immuni.2013.08.003.
   PubMed Web of Science ®Google Scholar
• Natividad JM, Agus A, Planchais J, Lamas B, Jarry AC, Martin R, Michel M-L, Chong-Nguyen C, Roussel R, Straube M, et al. Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome. Cell Metab. 2018;28(5):737–749.e4. doi:10.1016/j.cmet.2018.07.001.
   PubMed Web of Science ®Google Scholar
• Gao K, Mu CL, Farzi A, Zhu WY. Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr. 2020;11(3):709–23. doi:10.1093/advances/nmz127.
   PubMed Web of Science ®Google Scholar
• Modoux M, Rolhion N, Lefevre JH, Oeuvray C, Nadvornik P, Illes P, Emond P, Parc Y, Mani S, Dvorak Z, et al. Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands. Gut Microbes. 2022;14(1):2105637. doi:10.1080/19490976.2022.2105637.
   PubMed Web of Science ®Google Scholar
• Bender MJ, McPherson AC, Phelps CM, Pandey SP, Laughlin CR, Shapira JH, Medina Sanchez L, Rana M, Richie TG, Mims TS, et al. Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Cell. 2023;186(9):1846–1862.e26. doi:10.1016/j.cell.2023.03.011.
   PubMed Web of Science ®Google Scholar
• LeBlanc JG, Milani C, de Giori GS, Sesma F, van Sinderen D, Ventura M. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol. 2013;24(2):160–168. doi:10.1016/j.copbio.2012.08.005.
   PubMed Web of Science ®Google Scholar
• Yoshii K, Hosomi K, Sawane K, Kunisawa J. Metabolism of dietary and microbial vitamin B family in the regulation of host immunity. Front Nutr. 2019;6:48. doi:10.3389/fnut.2019.00048.
   PubMed Web of Science ®Google Scholar
• Woo V, Eshleman EM, Hashimoto-Hill S, Whitt J, Wu SE, Engleman L, Rice T, Karns R, Qualls JE, Haslam DB, et al. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host & Microbe. 2021;29(12):1744–1756.e5. doi:10.1016/j.chom.2021.09.010.
   PubMed Web of Science ®Google Scholar
• Bonakdar M, Czuba LC, Han G, Zhong G, Luong H, Isoherranen N, Vaishnava S. Gut commensals expand vitamin a metabolic capacity of the mammalian host. Cell Host & Microbe. 2022;30(8):1084–1092.e5. doi:10.1016/j.chom.2022.06.011.
   PubMed Web of Science ®Google Scholar
• Hall JA, Grainger JR, Spencer SP, Belkaid Y. The role of retinoic acid in tolerance and immunity. Immunity. 2011;35(1):13–22. doi:10.1016/j.immuni.2011.07.002.
   PubMed Web of Science ®Google Scholar
• Duriancik DM, Lackey DE, Hoag KA. Vitamin A as a regulator of antigen presenting cells. J Nutr. 2010;140(8):1395–1399. doi:10.3945/jn.110.124461.
   PubMed Web of Science ®Google Scholar
• Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011;17(12):1519–28. doi:10.3748/wjg.v17.i12.1519.
   PubMed Web of Science ®Google Scholar
• Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480):446–450. doi:10.1038/nature12721.
   PubMed Web of Science ®Google Scholar
• Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin W-B, Guo C-J, Violante S, et al. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020;581(7809):475–479. doi:10.1038/s41586-020-2193-0.
   PubMed Web of Science ®Google Scholar
• Kriaa A, Bourgin M, Potiron A, Mkaouar H, Jablaoui A, Gerard P, Maguin E, Rhimi M. Microbial impact on cholesterol and bile acid metabolism: current status and future prospects. J Lipid Res. 2019;60(2):323–32. doi:10.1194/jlr.R088989.
   PubMed Web of Science ®Google Scholar
• Begley M, Hill C, Gahan CG. Bile salt hydrolase activity in probiotics. Appl Environ Microbiol. 2006;72(3):1729–1738. doi:10.1128/AEM.72.3.1729-1738.2006.
   PubMed Web of Science ®Google Scholar
• Zhang M, Wang H, Tracey KJ. Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit Care Med. 2000;28(Supplement):N60–6. doi:10.1097/00003246-200004001-00007.
   PubMedGoogle Scholar
• Zhang M, Caragine T, Wang H, Cohen PS, Botchkina G, Soda K, Bianchi M, Ulrich P, Cerami A, Sherry B, et al. Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. J Exp Med. 1997;185(10):1759–1768. doi:10.1084/jem.185.10.1759.
   PubMed Web of Science ®Google Scholar
• Riviere A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front Microbiol. 2016;7:979. doi:10.3389/fmicb.2016.00979.
   PubMed Web of Science ®Google Scholar
• Staley C, Weingarden AR, Khoruts A, Sadowsky MJ. Interaction of gut microbiota with bile acid metabolism and its influence on disease states. Appl Microbiol Biotechnol. 2017;101(1):47–64. doi:10.1007/s00253-016-8006-6.
   PubMed Web of Science ®Google Scholar
• Shapiro H, Thaiss CA, Levy M, Elinav E. The cross talk between microbiota and the immune system: metabolites take center stage. Curr Opin Immunol. 2014;30:54–62. doi:10.1016/j.coi.2014.07.003.
   PubMed Web of Science ®Google Scholar
• Paik D, Yao L, Zhang Y, Bae S, D’Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, et al. Human gut bacteria produce ΤΗ17-modulating bile acid metabolites. Nature. 2022;603(7903):907–12. doi:10.1038/s41586-022-04480-z.
   PubMed Web of Science ®Google Scholar
• Hu J, Wang C, Huang X, Yi S, Pan S, Zhang Y, Yuan G, Cao Q, Ye X, Li H, et al. Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling. Cell Rep. 2021;36(12):109726. doi:10.1016/j.celrep.2021.109726.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Morotomi M. Absence of cholic acid 7α-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994;77(11):3275–3286. doi:10.3168/jds.S0022-0302(94)77268-4.
   PubMed Web of Science ®Google Scholar
• Proietti E, Rossini S, Grohmann U, Mondanelli G. Polyamines and Kynurenines at the intersection of immune modulation. Trends Immunol. 2020;41(11):1037–1050. doi:10.1016/j.it.2020.09.007.
   PubMed Web of Science ®Google Scholar
• Carriche GM, Almeida L, Stuve P, Velasquez L, Dhillon-LaBrooy A, Roy U, Lindenberg M, Strowig T, Plaza-Sirvent C, Schmitz I, et al. Regulating T-cell differentiation through the polyamine spermidine. J Allergy Clin Immunol. 2021;147(1):335–348.e11. doi:10.1016/j.jaci.2020.04.037.
   PubMed Web of Science ®Google Scholar
• Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, et al. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021;184(16):4186–4202.e20. doi:10.1016/j.cell.2021.06.007.
   PubMed Web of Science ®Google Scholar
• Michonneau D, Latis E, Curis E, Dubouchet L, Ramamoorthy S, Ingram B, de Latour RP, Robin M, de Fontbrune FS, Chevret S, et al. Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites. Nat Commun. 2019;10(1):5695. doi:10.1038/s41467-019-13498-3.
   PubMed Web of Science ®Google Scholar
• Henrick BM, Chew S, Casaburi G, Brown HK, Frese SA, Zhou Y, Underwood MA, Smilowitz JT. Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants. Pediatr Res. 2019;86(6):749–57. doi:10.1038/s41390-019-0533-2.
   PubMed Web of Science ®Google Scholar
• Casaburi G, Frese SA. Colonization of breastfed infants by Bifidobacterium longum subsp. infantis EVC001 reduces virulence gene abundance. Human Microbiome J. 2018;9:7–10. doi:10.1016/j.humic.2018.05.001.
   Google Scholar
• Dikopoulos N, Bertoletti A, Kroger A, Hauser H, Schirmbeck R, Reimann J. Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells. J Immunol. 2005;174(1):99–109. doi:10.4049/jimmunol.174.1.99.
   PubMed Web of Science ®Google Scholar
• Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O’Neil DA, Macfarlane GT. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut. 2005;54(2):242–9. doi:10.1136/gut.2004.044834.
   PubMed Web of Science ®Google Scholar
• Imaoka A, Shima T, Kato K, Mizuno S, Uehara T, Matsumoto S, Setoyama H, Hara T, Umesaki Y. Anti-inflammatory activity of probiotic Bifidobacterium: enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells. World J Gastroenterol. 2008;14(16):2511–6. doi:10.3748/wjg.14.2511.
   PubMed Web of Science ®Google Scholar
• Steed H, Macfarlane GT, Blackett KL, Bahrami B, Reynolds N, Walsh SV, Cummings JH, Macfarlane S. Clinical trial: the microbiological and immunological effects of synbiotic consumption – a randomized double-blind placebo-controlled study in active Crohn’s disease. Aliment Pharmacol Ther. 2010;32(7):872–83. doi:10.1111/j.1365-2036.2010.04417.x.
   PubMed Web of Science ®Google Scholar
• Groeger D, O’Mahony L, Murphy EF, Bourke JF, Dinan TG, Kiely B, Shanahan F, Quigley EMM. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325–39. doi:10.4161/gmic.25487.
   PubMed Web of Science ®Google Scholar
• Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF. The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients. Sci. 2018;359(6371):104–8. doi:10.1126/science.aao3290.
   PubMed Web of Science ®Google Scholar
• Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Man Lei Y, Jabri B, Alegre M-L, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Sci. 2015;350(6264):1084–9. doi:10.1126/science.aac4255.
   PubMed Web of Science ®Google Scholar
• Yoon Y, Kim G, Jeon BN, Fang S, Park H. Bifidobacterium strain-specific enhances the efficacy of cancer therapeutics in tumor-bearing mice. Cancers Basel. 2021;13(5):957. doi:10.3390/cancers13050957.
   PubMed Web of Science ®Google Scholar
• Yang J, Wu Z, Chen Y, Hu C, Li D, Chen Y, Imani S, Wen Q, Fu S, Wu J, et al. Pre-treatment with Bifidobacterium infantis and its specific antibodies enhance targeted radiosensitization in a murine model for lung cancer. J Cancer Res Clin Oncol. 2021;147(2):411–422. doi:10.1007/s00432-020-03434-0.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Cai J, Hou W, Xu K, Wu X, Song Y, Bai C, Mo Y-Y, Zhang Z. Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice. Gut Microbes. 2023;15(1):2166700. doi:10.1080/19490976.2023.2166700.
   PubMed Web of Science ®Google Scholar
• Li Q, Li Y, Wang Y, Xu L, Guo Y, Wang Y, Wang L, Guo C. Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12. Oncoimmunology. 2021;10(1):1868122. doi:10.1080/2162402X.2020.1868122.
   PubMed Web of Science ®Google Scholar
• Wang F, Yin Q, Chen L, Davis MM Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. Proceedings of the National Academy of Sciences of the United States of America 2018; 115:157–61.
   Google Scholar
• Galeano Nino JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E, et al. Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature. 2022;611(7937):810–817. doi:10.1038/s41586-022-05435-0.
   PubMed Web of Science ®Google Scholar
• Uniken Venema WTC, Ramirez-Sanchez AD, Bigaeva E, Withoff S, Jonkers I, McIntyre RE, Ghouraba M, Raine T, Weersma RK, Franke L, et al. Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels. Sci Rep. 2022;12(1):9897. doi:10.1038/s41598-022-13812-y.
   PubMed Web of Science ®Google Scholar