The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication

References

• Hang LE, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, Lobachev K, Branzei D, Feng W, Zhao X. Rtt107 is a multi-functional scaffold supporting replication progression with partner SUMO and ubiquitin ligases. Mol Cell 2015; 60:268-79; PMID:26439300; http://dx.doi.org/10.1016/j.molcel.2015.08.023
   PubMed Web of Science ®Google Scholar
• Rouse J. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J 2004; 23:1188-97; PMID:14988729; http://dx.doi.org/10.1038/sj.emboj.7600129
   PubMed Web of Science ®Google Scholar
• Chin J, Bashkirov V, Heyer W, Romesberg F. Esc4/Rtt107 and the control of recombination during replication. DNA Repair 2006; 5:618-28; PMID:16569515; http://dx.doi.org/10.1016/j.dnarep.2006.02.005
   PubMed Web of Science ®Google Scholar
• Roberts T, Kobor M, Bastin-Shanower S, Ii M, Horte SA, Gin JW, Emili A, Rine J, Brill SJ, Brown GW. Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell 2006; 17:539-48; PMID:16267268; http://dx.doi.org/10.1091/mbc.E05-08-0785
   PubMed Web of Science ®Google Scholar
• Zappulla DC, Maharaj ASR, Connelly JJ, Jockusch RA, Sternglanz R. Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs. BMC Mol Biol 2006; 7:40; PMID:17094803; http://dx.doi.org/10.1186/1471-2199-7-40
   PubMed Web of Science ®Google Scholar
• Koonin EV, Altschul SF, Bork P. BRCA1 protein products. Functional motifs. Nat Genet 1996; 13:266-8; PMID:8673121; http://dx.doi.org/10.1038/ng0796-266
   PubMed Web of Science ®Google Scholar
• Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J 1997; 11:68-76; PMID:9034168
   PubMed Web of Science ®Google Scholar
• Gerloff DL, Woods NT, Farago AA, Monteiro ANA. BRCT domains: A little more than kin, and less than kind. FEBS Lett 2012; 586:2711-6; PMID:22584059; http://dx.doi.org/10.1016/j.febslet.2012.05.005
   PubMed Web of Science ®Google Scholar
• Woods NT, Mesquita RD, Sweet M, Carvalho MA, Li X, Liu Y, Nguyen H, Thomas CE, Iversen ES, Jr, Marsillac S, et al. Charting the landscape of tandem BRCT domain-mediated protein interactions. Sci Sign 2012; 5:rs6
   PubMed Web of Science ®Google Scholar
• Leung CCY, Glover JNM. BRCT domains: easy as one, two, three. Cell Cycle 2011; 10:2461-70; PMID:21734457; http://dx.doi.org/10.4161/cc.10.15.16312
   PubMed Web of Science ®Google Scholar
• Li X, Liu K, Li F, Wang J, Huang H, Wu J, Shi Y. Structure of the C-terminal tandem BRCT repeats of Rtt107 reveals a critical role in the interaction with H2A during DNA damage repair. J Biol Chem 2012; 287:9137-46; PMID:22262834; http://dx.doi.org/10.1074/jbc.M111.311860
   PubMed Web of Science ®Google Scholar
• Ohouo PY, Bastos de Oliveira FM, Almeida BS, Smolka MB. DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response. Mol Cell 2010; 39:300-6; PMID:20670896; http://dx.doi.org/10.1016/j.molcel.2010.06.019
   PubMed Web of Science ®Google Scholar
• Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS. Rtt107 is required for recruitment of the Smc5/6 complex to DNA double strand breaks. J Biol Chem 2011; 286:26250-7; PMID:21642432; http://dx.doi.org/10.1074/jbc.M111.235200
   PubMed Web of Science ®Google Scholar
• Mimura S, Yamaguchi T, Ishii S, Noro E, Katsura T, Obuse C, Kamura T. Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J Biol Chem 2010; 285:9858-67; PMID:20139071; http://dx.doi.org/10.1074/jbc.M109.082107
   PubMed Web of Science ®Google Scholar
• Zaidi IW, Rabut G, Poveda A, Scheel H, Malmstrom J, Ulrich H, Hofmann K, Pasero P, Peter M, Luke B. Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. EMBO Reports 2008; 9:1034-40; PMID:18704118; http://dx.doi.org/10.1038/embor.2008.155
   PubMed Web of Science ®Google Scholar
• Jeppsson K, Kanno T, Shirahige K, Sjögren C. The maintenance of chromosome structure: positioning and functioning of SMC complexes. Nat Rev Mol Cell Biol 2014; 15:601-14; PMID:25145851; http://dx.doi.org/10.1038/nrm3857
   PubMed Web of Science ®Google Scholar
• Rouse J. Control of genome stability by SLX protein complexes. Biochem Soc Trans 2009; 37:495-510; PMID:19442243; http://dx.doi.org/10.1042/BST0370495
   PubMed Web of Science ®Google Scholar
• Scholes DT, Banerjee M, Bowen B, Curcio MJ. Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 2001; 159:1449-65; PMID:11779788
   PubMed Web of Science ®Google Scholar
• Prakash L, Prakash S. Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 1977; 86:33-55; PMID:195865
   PubMed Web of Science ®Google Scholar
• Ohouo PY, de Oliveira FMB, Liu Y, Ma CJ, Smolka MB. DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9. Nature 2012; 493:120-4; PMID:23160493; http://dx.doi.org/10.1038/nature11658
   PubMed Web of Science ®Google Scholar
• Cussiol JR, Jablonowski CM, Yimit A, Brown GW, Smolka MB. Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions. EMBO J 2015; 34(12):1704-17; PMID:25896509; http://dx.doi.org/10.15252/embj.201490834
   PubMed Web of Science ®Google Scholar
• Dibitetto D, Ferrari M, Rawal CC, Balint A, Kim T, Zhang Z, Smolka MB, Brown GW, Marini F, Pellicioli A. Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks. Nucleic Acids Res 2015; 44(2):669-82: gkv1080; PMID:26490958; http://dx.doi.org/10.1093/nar/gkv1080
   PubMed Web of Science ®Google Scholar
• Jablonowski CM, Cussiol JR, Oberly S, Yimit A, Balint A, Kim T, Zhang Z, Brown GW, Smolka MB. Termination of replication stress signaling via concerted action of the Slx4 scaffold and the PP4 phosphatase. Genetics 2015; 201:937-49; PMID:26362319; http://dx.doi.org/10.1534/genetics.115.181479
   PubMed Web of Science ®Google Scholar
• Gritenaite D, Princz LN, Szakal B, Bantele SCS, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, et al. A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev 2014; 28:1604-19; PMID:25030699; http://dx.doi.org/10.1101/gad.240515.114
   PubMed Web of Science ®Google Scholar
• Driscoll R, Hudson A, Jackson SP. Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science 2007; 315:649-52; PMID:17272722; http://dx.doi.org/10.1126/science.1135862
   PubMed Web of Science ®Google Scholar
• Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z. Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science 2007; 315:653-5; PMID:17272723; http://dx.doi.org/10.1126/science.1133234
   PubMed Web of Science ®Google Scholar
• Han J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell 2013; 155:817-29; PMID:24209620; http://dx.doi.org/10.1016/j.cell.2013.10.014
   PubMed Web of Science ®Google Scholar
• Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A. The sirtuins Hst3 and Hst4p preserve genome integrity by controlling histone H3 lysine 56 deacetylation. Curr Biol 2006; 16:1280-9; PMID:16815704; http://dx.doi.org/10.1016/j.cub.2006.06.023
   PubMed Web of Science ®Google Scholar
• Maas NL, Miller KM, DeFazio LG, Toczyski DP. Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol cell 2006; 23:109-19; PMID:16818235; http://dx.doi.org/10.1016/j.molcel.2006.06.006
   PubMed Web of Science ®Google Scholar
• Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, et al. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 2007; 446:806-10; PMID:17314980; http://dx.doi.org/10.1038/nature05649
   PubMed Web of Science ®Google Scholar
• Roberts T, Zaidi I, Vaisica J, Peter M, Brown G. Regulation of Rtt107 recruitment to stalled DNA replication forks by the cullin Rtt101 and the Rtt109 acetyltransferase. Mol Biol Cell 2008; 19:171; PMID:17978089; http://dx.doi.org/10.1091/mbc.E07-09-0961
   PubMed Web of Science ®Google Scholar
• Murray JM, Carr AM. Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol 2008; 9:177-82; PMID:18059412; http://dx.doi.org/10.1038/nrm2309
   PubMed Web of Science ®Google Scholar
• Chen YH, Choi K, Szakal B, Arenz J, Duan X, Ye H, Branzei D, Zhao X. Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair. Proc Natl Acad Sci USA 2009; 106:21252-7; PMID:19995966; http://dx.doi.org/10.1073/pnas.0908258106
   PubMed Web of Science ®Google Scholar
• Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, Sanchez H, Wyman C, Niu H, Zhao X, et al. Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell 2014; 56:436-45; PMID:25439736; http://dx.doi.org/10.1016/j.molcel.2014.09.013
   PubMed Web of Science ®Google Scholar
• Wardlaw CP, Carr AM, Oliver AW. TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair 2014; 22:165-74; PMID:25087188; http://dx.doi.org/10.1016/j.dnarep.2014.06.004
   PubMed Web of Science ®Google Scholar
• Lindroos HB, Strom L, Itoh T, Katou Y, Shirahige K, Sjogren C. Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol Cell 2006; 22:755-67; PMID:16793545; http://dx.doi.org/10.1016/j.molcel.2006.05.014
   PubMed Web of Science ®Google Scholar
• Buser R, Kellner V, Melnik A, Wilson-Zbinden C, Schellhaas R, Kastner L, Piwko W, Dees M, Picotti P, Maric M, et al. The replisome-coupled E3 ubiquitin ligase Rtt101-Mms22 counteracts Mrc1 function to tolerate genotoxic stress. PLoS Genetics 2016; 12:e1005843; PMID:26849847; http://dx.doi.org/10.1371/journal.pgen.1005843
   PubMedGoogle Scholar
• Balint A, Kim T, Gallo D, Cussiol JR, Bastos de Oliveira FM, Yimit A, Ou J, Nakato R, Gurevich A, Shirahige K, et al. Assembly of Slx4 signaling complexes behind DNA replication forks. EMBO J 2015; 34(16):2182-97; PMID:26113155; http://dx.doi.org/10.15252/embj.201591190
   PubMed Web of Science ®Google Scholar
• Vázquez MV, Rojas V, Tercero JA. Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA. DNA Repair 2008; 7:1693-704; http://dx.doi.org/10.1016/j.dnarep.2008.06.014
   PubMed Web of Science ®Google Scholar
• Crabbe L, Thomas A, Pantesco V, De Vos J, Pasero P, Lengronne A. Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response. Nat Struct Mol Biol 2010; 17:1391-7; PMID:20972444; http://dx.doi.org/10.1038/nsmb.1932
   PubMed Web of Science ®Google Scholar
• Paciotti V, Clerici M, Scotti M, Lucchini G, Longhese MP. Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway. Mol Cell Biol 2001; 21:3913-25; PMID:11359899; http://dx.doi.org/10.1128/MCB.21.12.3913-3925.2001
   PubMed Web of Science ®Google Scholar
• Tercero JA, Longhese MP, Diffley JF. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11:1323-36; PMID:12769855; http://dx.doi.org/10.1016/S1097-2765(03)00169-2
   PubMed Web of Science ®Google Scholar
• Zhong Y, Nellimoottil T, Peace JM, Knott SRV, Villwock SK, Yee JM, Jancuska JM, Rege S, Tecklenburg M, Sclafani RA, et al. The level of origin firing inversely affects the rate of replication fork progression. J Cell Biol 2013; 201:373-83; PMID:23629964; http://dx.doi.org/10.1083/jcb.201208060
   PubMed Web of Science ®Google Scholar
• Theis JF, Irene C, Dershowitz A, Brost RL, Tobin ML, di Sanzo FM, Wang JY, Boone C, Newlon CS. The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. PLoS Genetics 2010; 6:e1001227; PMID:21151954; http://dx.doi.org/10.1371/journal.pgen.1001227
   PubMedGoogle Scholar
• Theis JF, Dershowitz A, Irene C, Maciariello C, Tobin ML, Liberi G, Tabrizifard S, Korus M, Fabiani L, Newlon CS. Identification of mutations that decrease the stability of a fragment of Saccharomyces cerevisiae chromosome III lacking efficient replicators. Genetics 2007; 177:1445-58; PMID:17720931; http://dx.doi.org/10.1534/genetics.107.074690
   PubMed Web of Science ®Google Scholar