Hesperidin depolarizes the pacemaker potentials through 5-HT₄ receptor in murine small intestinal interstitial cells of Cajal

References

• Arai M, Matsumura T, Tsuchiya N, Sadakane C, Inami R, Suzuki T, Yoshikawa M, Imazeki F, Yokosuka O. 2012. Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin. Hepato-Gastroenterology. 59:62–66.
   PubMed Web of Science ®Google Scholar
• Baker DE. 2005. Rationale for using serotonergic agents to treat irritable bowel syndrome. Am J Health Syst Pharm. 62:700–711. doi: 10.1093/ajhp/62.7.700
   PubMed Web of Science ®Google Scholar
• Bock C, Waldmann KH, Ternes W. 2008. Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract. Nutr Res. 28:879–891. doi: 10.1016/j.nutres.2008.08.001
   PubMed Web of Science ®Google Scholar
• Cho J, Kweon H, Huh S, Sadra A. 2018. Augmented reduction in colonic inflammatory markers of dextran sulfate sodium induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflate. Anim Cells Syst. 22:189–196. doi: 10.1080/19768354.2018.1476409
   PubMed Web of Science ®Google Scholar
• Chung HJ, Noh Y, Kim MS, Jang A, Lee CE, Myung SC. 2018. Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells. Anim Cells Syst. 22:407–414. doi: 10.1080/19768354.2018.1494628
   PubMed Web of Science ®Google Scholar
• Der T, Bercik P, Donnelly G, Jackson T, Berezin I, Collins SM, Huizinga JD. 2000. Interstitial cells of Cajal and inflammation-induced motor dysfunction in the mouse small intestine. Gastroenterology. 119:1590–1599. doi: 10.1053/gast.2000.20221
   PubMed Web of Science ®Google Scholar
• El-Serag HB, Talley NJ. 2003. Health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther. 18:387–393. doi: 10.1046/j.1365-2036.2003.01706.x
   PubMed Web of Science ®Google Scholar
• Epperson A, Hatton WJ, Callaghan B, Doherty P, Walker RL, Sanders KM, Ward SM, Horowitz B. 2000. Molecular markers expressed in cultured and freshly isolated interstitial cells of Cajal. Am J Physiol Cell Physiol. 279:C529–C539. doi: 10.1152/ajpcell.2000.279.2.C529
   PubMed Web of Science ®Google Scholar
• Garg A, Garg S, Zaneveld LJ, Singla AK. 2001. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res. 15:655–669. doi: 10.1002/ptr.1074
   PubMed Web of Science ®Google Scholar
• Gershon MD, Tack J. 2007. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 132:397–414. doi: 10.1053/j.gastro.2006.11.002
   PubMed Web of Science ®Google Scholar
• Hirst GD, Dickens EJ, Edwards FR. 2002. Pacemaker shift in the gastric antrum of guinea-pigs produced by excitatory vagal stimulation involves intramuscular interstitial cells. J Physiol. 541:917–928. doi: 10.1113/jphysiol.2002.018614
   PubMed Web of Science ®Google Scholar
• Hou M, Man M, Man W, Zhu W, Hupe M, Park K, Crumrine D, Elias PM, Man MQ. 2012. Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin. Exp Dermatol. 21:337–340. doi: 10.1111/j.1600-0625.2012.01455.x
   PubMed Web of Science ®Google Scholar
• Huizinga JD, Chang G, Diamant NE, El-Sharkawy TY. 1984. Electrophysiological basis of excitation of canine colonic circular muscle by cholinergic agents and substance P. J Pharmacol Exp Ther. 231:692–699.
   PubMed Web of Science ®Google Scholar
• Huizinga JD, Thuneberg L, Kluppel Malysz MJ, Mikkelsen HB, Bernstein A. 1995. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature. 373:347–349. doi: 10.1038/373347a0
   PubMed Web of Science ®Google Scholar
• Inoue R, Chen S. 1993. Physiology of muscarinic receptor operated nonselective cation channels in guinea-pig ileal smooth muscle. Exs. 66:261–268.
   PubMedGoogle Scholar
• Kim BJ, Lim HH, Yang DK, Jun JY, Chang IY, Park CS, So I, Stanfield PR, Kim KW. 2005. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology. 129:1504–1517. doi: 10.1053/j.gastro.2005.08.016
   PubMed Web of Science ®Google Scholar
• Komori S, Kawai M, Takewaki T, Ohashi H. 1992. GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in Guinea-pig ileal muscle. J Physiol. 450:105–126. doi: 10.1113/jphysiol.1992.sp019118
   PubMed Web of Science ®Google Scholar
• Lacy BE, Crowell MD, Mathis C, Bauer D, Heinberg LJ. 2018. Gastroparesis: quality of life and health care utilization. J Clin Gastroenterol. 52:20–24. doi: 10.1097/MCG.0000000000000728
   PubMed Web of Science ®Google Scholar
• Lacy BE, Weiser K. 2006. Gastrointestinal motility disorders: an update. Dig Dis. 24:228–242. doi: 10.1159/000092876
   PubMed Web of Science ®Google Scholar
• Li C, Schluesener H. 2017. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 57:613–631. doi: 10.1080/10408398.2014.906382
   PubMed Web of Science ®Google Scholar
• Liu HN, Ohya S, Nishizawa Y, Sawamura YK, Iino S, Syed MM, Goto K, Imaizumi Y, Nakayama S. 2011. Serotonin augments gut pacemaker activity via 5-HT3 receptors. PLoS One. 6:e24928. doi: 10.1371/journal.pone.0024928
   PubMed Web of Science ®Google Scholar
• Ogata R, Inoue Y, Nakano H, Ito Y, Kitamura K. 1996. Oestradiol-induced relaxation of rabbit basilar artery by inhibition of voltage-dependent Ca channels through GTP-binding protein. Br J Pharmacol. 117:351–359. doi: 10.1111/j.1476-5381.1996.tb15198.x
   PubMed Web of Science ®Google Scholar
• Orallo F, Alvarez E, Basaran H, Lugnier C. 2004. Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclicnucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin. Naunyn Schmiedebergs Arch Pharmacol. 370:452–463. doi: 10.1007/s00210-004-0994-6
   PubMed Web of Science ®Google Scholar
• Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L. 2001. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol. 96:3130–3137. doi: 10.1111/j.1572-0241.2001.05259.x
   PubMed Web of Science ®Google Scholar
• Sanders KM. 1996. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology. 111:492–515. doi: 10.1053/gast.1996.v111.pm8690216
   PubMed Web of Science ®Google Scholar
• Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, Gemmen E, Shah S, Avdic A, Rubin R. 2002. The burden of selected digestives diseases in the United States. Gastroenterology. 122:1500–1511. doi: 10.1053/gast.2002.32978
   PubMed Web of Science ®Google Scholar
• Shahi PK, Choi S, Zuo DC, Yeum CH, Yoon PJ, Lee J, Kim YD, Park CG, Kim MY, Shin HR, et al. 2011. 5-hydroxytryptamine generates tonic inward currents on pacemaker activity of interstitial cells of cajal from mouse small intestine. Korean J Physiol Pharmacol. 15:129–135. doi: 10.4196/kjpp.2011.15.3.129
   PubMed Web of Science ®Google Scholar
• Stevens Y, Rymenant EV, Grootaert C, Camp JV, Possemiers S, Masclee A, Jonkers D. 2019. The intestinal fate of citrus flavanones and their effects on gastrointestinal health. Nutrients. 11:1464. doi: 10.3390/nu11071464
   Web of Science ®Google Scholar
• Suzuki H, Asakawa A, Kawamura N, Yagi T, Inui A. 2014. Hesperidin potentiates ghrelin signaling. Recent Pat Food Nutr Agric. 6:60–63. doi: 10.2174/2212798406666140825120623
   PubMedGoogle Scholar
• Takiguchi S, Hiura Y, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Miyata H, Mori M, Hosoda H, Kangawa K, et al. 2013. Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy. Gastric Cancer. 16:167–174. doi: 10.1007/s10120-012-0164-3
   PubMed Web of Science ®Google Scholar
• Wei J, Li N, Xia X, Chen X, Peng F, Besner GE, Feng J. 2014. Effects of lipopolysaccharide induced inflammation on the interstitial cells of Cajal. Cell Tissue Res. 356:29–37. doi: 10.1007/s00441-013-1775-7
   PubMed Web of Science ®Google Scholar
• Xiong YJ, Chu HW, Lin Y, Han F, Li YC, Wang AG, Wang FJ, Chen DP, Wang JY. 2016. Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation. Acta Pharmacol Sin. 37:1091–1100. doi: 10.1038/aps.2016.56
   PubMed Web of Science ®Google Scholar
• Zhu Y, Golden CM, Ye J, Wang XY, Akbarali HI, Huizinga JD. 2003. ERG k+ currents regulate pacemaker activity in ICC. Am J Physiol Gastrointest Liver Physiol. 285:G1249–G1258. doi: 10.1152/ajpgi.00149.2003
   PubMed Web of Science ®Google Scholar
• Zhu MH, Kim TW, Ro S, Yan W, Ward SM, Koh SD, Sanders KM. 2009. A Ca(2+)-activated Cl(−) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. J Physiol. 587:4905–4918. doi: 10.1113/jphysiol.2009.176206
   PubMed Web of Science ®Google Scholar