Kazinol C from Broussonetia kazinoki stimulates autophagy via endoplasmic reticulum stress-mediated signaling

References

• Bae S, Kim MK, Kim HS, Moon YA. 2020. Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells. Animal Cells Syst. 24(5):260–266.
   PubMed Web of Science ®Google Scholar
• Bae UJ, Jang HY, Lim JM, Hua L, Ryu JH, Park BH. 2015. Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes. Exp Mol Med. 47:e160.
   PubMed Web of Science ®Google Scholar
• Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 415(6867):92–96.
   PubMed Web of Science ®Google Scholar
• Deng S, Shanmugam MK, Kumar AP, Yap CT, Sethi G, Bishayee A. 2019. Targeting autophagy using natural compounds for cancer prevention and therapy. Cancer. 125(8):1228–1246.
   PubMed Web of Science ®Google Scholar
• Dikic I, Elazar Z. 2018. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 19(6):349–364.
   PubMed Web of Science ®Google Scholar
• Ding WX, Ni HM, Gao W, Hou YF, Melan MA, Chen X, Stolz DB, Shao ZM, Yin XM. 2007. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem. 282(7):4702–4710.
   PubMed Web of Science ®Google Scholar
• Doherty J, Baehrecke EH. 2018. Life, death and autophagy. Nat Cell Biol. 20(10):1110–1117.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, et al. 2017. Molecular definitions of autophagy and related processes. EMBO J. 36(13):1811–1836.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillon J, Lo Iacono O, Corazzari M, Fimia GM, et al. 2014. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 5:e1179.
   PubMed Web of Science ®Google Scholar
• Hetz C. 2012. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 13(2):89–102.
   PubMed Web of Science ®Google Scholar
• Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G. 2019. Iron overload inhibits late stage autophagic flux leading to insulin resistance. EMBO Rep. 20(10):e47911.
   PubMed Web of Science ®Google Scholar
• Kim HS, Lim J, Lee DY, Ryu JH, Lim JS. 2015. Kazinol c from Broussonetia kazinoki activates AMP-activated protein kinase to induce antitumorigenic effects in HT-29 colon cancer cells. Oncol Rep. 33(1):223–229.
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 13(2):132–141.
   PubMed Web of Science ®Google Scholar
• Kim J, Yang G, Kim Y, Kim J, Ha J. 2016. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med. 48:e224.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 17(1):1–382.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, et al. 2021. Autophagy in major human diseases. EMBO J. 40(19):e108863.
   PubMed Web of Science ®Google Scholar
• Kong Q, Zhang Z, Liang Z. 2020. Upregulating miR-637 aggravates endoplasmic reticulum stress-induced apoptosis in gastric cancer cells by suppressing Calreticulin. Animal Cells Syst. 24(5):267–274.
   PubMed Web of Science ®Google Scholar
• Kwon J, Lee Y, Jeong JH, Ryu JH, Kim KI. 2020. Inhibition of autophagy sensitizes lignan-induced endoplasmic reticulum stress-mediated cell death. Biochem Biophys Res Commun. 526(2):300–305.
   PubMed Web of Science ®Google Scholar
• Longatti A, Orsi A, Tooze SA. 2010. Autophagosome formation: not necessarily an inside job. Cell Res. 20(11):1181–1184.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B. 2020. Autophagy in human diseases. N Engl J Med. 383(16):1564–1576.
   PubMed Web of Science ®Google Scholar
• Moreau K, Ravikumar B, Renna M, Puri C, Rubinsztein DC. 2011. Autophagosome precursor maturation requires homotypic fusion. Cell. 146(2):303–317.
   PubMed Web of Science ®Google Scholar
• Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, et al. 2006. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol. 26(24):9220–9231.
   PubMed Web of Science ®Google Scholar
• Schwarz DS, Blower MD. 2016. The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci. 73(1):79–94.
   PubMed Web of Science ®Google Scholar
• Settembre C, Ballabio A. 2011. TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes. Autophagy. 7(11):1379–1381.
   PubMed Web of Science ®Google Scholar
• Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, et al. 2011. TFEB links autophagy to lysosomal biogenesis. Science. 332(6036):1429–1433.
   PubMed Web of Science ®Google Scholar
• Shin HJ, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH. 2016. AMPK-SKP2-CARM1 signaling cascade in transcriptional regulation of autophagy. Nature. 534(7608):553–557.
   PubMed Web of Science ®Google Scholar
• Smith M, Wilkinson S. 2017. ER homeostasis and autophagy. Essays Biochem. 61(6):625–635.
   PubMed Web of Science ®Google Scholar
• Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, et al. 2011. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 7(1):40–50.
   PubMed Web of Science ®Google Scholar
• Zecchini S, Proietti Serafini F, Catalani E, Giovarelli M, Coazzoli M, Di Renzo I, De Palma C, Perrotta C, Clementi E, Buonanno F, et al. 2018. Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells. Cell Death Dis. 10(1):10.
   PubMed Web of Science ®Google Scholar