1,504
Views
1
CrossRef citations to date
0
Altmetric
Neuroscience

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

&
Pages 174-182 | Received 16 Dec 2021, Accepted 04 Jul 2022, Published online: 19 Aug 2022

References

  • Albarakati AJA, Baty RS, Aljoudi AM, Habotta OA, Elmahallawy EK, Kassab RB, Abdel Moneim AE. 2020. Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways. Mol Biol Rep. 47:2591–2603.
  • Berger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, Figueira I. 2009. Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 33:169–180.
  • Careaga MBL, Girardi CEN, Suchecki D. 2016. Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation. Neurosci Biobehav Rev. 71:48–57.
  • Chen Y, Sun XB, Lu HE, Wang F, Fan XH. 2017. Effect of luteoin in delaying cataract in STZ-induced diabetic rats. Arch Pharm Res. 40:88–95.
  • Cohen H, Kozlovsky N, Savion N, Natar MA, Loewenthal U, Loewenthal N, Zohar J, Kaplan Z. 2009. An association between stress-induced disruption of the hypothalamic-pituitary-adrenal axis and disordered glucose metabolism in an animal model of post-traumatic stress disorder. J Neuroendocrinol. 21:898–909.
  • Corley MJ, Caruso MJ, Takahashi LK. 2012. Stress-induced enhancement of fear conditioning and sensitization facilitates extinction-resistant and habituation-resistant fear behaviors in a novel animal model of posttraumatic stress disorder. Physiol Behav. 105:408–416.
  • Dong J, Xu O, Wang J, Shan C, Ren X. 2021. Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-kappaB pathway in allergic rhinitis rats. Immunopharmacol Immunotoxicol. 43:319–327.
  • Faye C, Mcgowan JC, Denny CA, David DJ. 2018. Neurobiological mechanisms of stress resilience and implications for the aged population. Curr Neuropharmacol. 16:234–270.
  • Feng JH, Sim SM, Park JS, Hong JS, Suh HW. 2021. Modulation of corticosterone and changes of signal molecules in the HPA axis after cold water swimming stress. Anim Cells Syst. 25:37–45.
  • Fokkens AS, Groothoff JW, van der Klink JJ, Popping R, Stewart RE, van de Ven L, Brouwer S, Tuinstra J. 2015. The mental disability military assessment tool: a reliable tool for determining disability in veterans with post-traumatic stress disorder. J Occup Rehabil. 25:569–576.
  • Francati V, Vermetten E, Bremner J. 2007. Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings. Depress Anxiety. 24:202–218.
  • Gao ZW, Ju RL, Luo M, Wu SL, Zhang WT. 2019. The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD. Psychiatry Res. 279:130–137.
  • Guo DJ, Li F, Yu PHF, Chan SW. 2013. Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells. Pharm Biol. 51:190–196.
  • Han F, Ding JL, Shi YX. 2014. Expression of amygdala mineralocorticoid receptor and glucocorticoid receptor in the single prolonged stress rats. BMC Neurosci. 77:1471–2202.
  • Hytti M, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Kauppinen A. 2016. Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation. Sci Rep. 5:17645.
  • Jang M, Jung T, Kang M, Kim J, Noh J. 2021. Oxytocin-induced anxiogenic behavior in juvenile male rats. Anim Cells Syst. 25:369–376.
  • Kim JS, Kwon CS, Son KH. 2000. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci Biotechnol Biochem. 64:2458–2461.
  • Kirkpatrick HA, Heller GM. 2014. Post-traumatic stress disorder: theory and treatment update. Int J Psychiatry Med. 47:337–346.
  • Krishnamurthy S, Garabadu D, Joy KP. 2013. Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. Neuropharmacology. 75:62–77.
  • Krystal JH, Neumeister A. 2009. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Res. 1293:13–23.
  • Lee B, Sur B, Oh S. 2020. Neuroprotective effect of Korean red ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression. J Gin Res. 44:644–654.
  • Li L, Luo W, Qian Y, Zhu W, Qian J, Li J, Jin Y, Xu X, Liang G. 2019. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-kappaB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine. 59:152774.
  • Rajapriya S, Geetha AJ. 2021. Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-kappaB in rats subjected to experimental pancreatitis – influence of HSP70. Basic Clin Physiol Pharmacol. 24:1–10.
  • Schöner J, Heinz A, Endres M, Gertz K, Kronenberg G. 2017. Post-traumatic stress disorder and beyond: an overview of rodent stress models. J Cell Mol Med. 21:2248–2256.
  • Sherin JE, Nemeroff CB. 2011. Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin Neurosci. 13:263–278.
  • Walker DL, Miles LA, Davis M. 2009. Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry. 33:1291–1308.
  • Wang H, Wang H, Cheng H, Che Z. 2016. Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model. Mol Med Rep. 13:4215–4220.
  • Wang SC, Lin CC, Chen CC, Tzeng NS, Liu YP. 2018. Effects of oxytocin on fear memory and neuroinflammation in a rodent model of posttraumatic stress disorder. Int J Mol Sci. 19:3848–3858.
  • Xiong J, Wang K, Yuan C, Xing R, Ni J, Hu G, Chen F, Wang X. 2017. Luteolin protects mice from severe acute pancreatitis by exerting HO1-mediated anti-inflammatory and antioxidant effects. Int J Mol Med. 39:113–125.
  • Yao ZH, Yao XL, Zhang Y, Zhang SF, Hu JC. 2018. Luteolin could improve cognitive dysfunction by inhibiting neuroinflammation. Neurochem Res. 43:806–820.
  • Zhang JX, Xing JG, Wang LL, Jiang HL, Guo SL, Liu R. 2017. Luteolin inhibits fibrillary beta-amyloid(1-40)-induced inflammation in a human blood-brain barrier model by suppressing the p38 MAPK-mediated NF-kappaB signaling pathways. Molecules. 22:334–344.