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Research Article

Association of overexpressed carboxyl-terminal amyloid precursor protein in brains with altered glucose metabolism and liver toxicity

, ORCID Icon &
Pages 103-111 | Received 02 Nov 2022, Accepted 28 Mar 2023, Published online: 04 Apr 2023

References

  • An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, et al. 2018. Evidence for brain glucose dysregulation in Alzheimer’s disease. Alzheimer’s & Dementia. 14:318–329. Epub 2017/10/23.
  • Andres-Blasco I, Herrero-Cervera A, Vinue A, Martinez-Hervas S, Piqueras L, Sanz MJ, Burks DJ, Gonzalez-Navarro H. 2015. Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis. J Endocrinol. 227:179–191. Epub 2015/10/02.
  • Babu RO, Lui VCH, Chen Y, Yiu RSW, Ye Y, Niu B, Wu Z, Zhang R, Yu MON, Chung PHY, et al. 2020. Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia. J Hepatol. 73:1391–1403. Epub 2020/06/20.
  • Bartoov-Shifman R, Hertz R, Wang H, Wollheim CB, Bar-Tana J, Walker MD. 2002. Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4α. J Biol Chem. 277:25914–25919. Epub 2002/05/08.
  • Bassendine MF, Taylor-Robinson SD, Fertleman M, Khan M, Neely D. 2020. Is Alzheimer’s disease a liver disease of the brain? J Alzheimers Dis. 75:1–14. Epub 2020/04/07.
  • Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A. 2012. The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol. 56:952–964. Epub 2011/12/17.
  • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. 2006. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 5:64–74. Epub 2005/12/20.
  • Calsolaro V, Edison P. 2016. Alterations in glucose metabolism in Alzheimer’s disease. Recent Pat Endocr Metab Immune Drug Discov. 10:31–39. Epub 2016/06/17.
  • Carbonell F, Zijdenbos AP, Bedell BJ. 2020. Alzheimer’s disease neuroimaging I. 2020. Spatially distributed amyloid-beta reduces glucose metabolism in mild cognitive impairment. J Alzheimers Dis. 73:543–557. Epub 2019/12/05.
  • Cariello M, Piccinin E, Moschetta A. 2021. Transcriptional regulation of metabolic pathways via lipid-sensing nuclear receptors PPARs, FXR, and LXR in NASH. Cell Mol Gastroenterol Hepatol. 11:1519–1539. Epub 2021/02/06.
  • Chitraju C, Walther TC, Farese RV, Jr. 2019. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 60:1112–1120. Epub 2019/04/03.
  • Choi SH, Park CH, Koo JW, Seo JH, Kim HS, Jeong SJ, Lee JH, Kim SS, Suh YH. 2001. Memory impairment and cholinergic dysfunction by centrally administered Aβ and carboxyl-terminal fragment of Alzheimer’s APP in mice. FASEB J. 15:1816–1818. Epub 2001/08/02.
  • de la Monte SM. 2019. The full spectrum of Alzheimer’s disease is rooted in metabolic derangements that drive type 3 diabetes. Adv Exp Med Biol.1128:45-83. Epub 2019/05/08.
  • Estrada LD, Ahumada P, Cabrera D, Arab JP. 2019. Liver dysfunction as a novel player in Alzheimer’s progression: looking outside the brain. Front Aging Neurosci. 11:174. Epub 2019/08/06.
  • Fontbonne A, Berr C, Ducimetiere P, Alperovitch A. 2001. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects. Diabetes Care. 24:366–370. Epub 2001/02/24.
  • Fraser SP, Suh YH, Chong YH, Djamgoz MB. 1996. Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the β-amyloid precursor protein. J Neurochem. 66:2034–2040. Epub 1996/05/01.
  • Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, et al. 2019. Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Mol Cell Neurosci. 99:103390. Epub 2019/07/06.
  • Gee MS, Son SH, Jeon SH, Do J, Kim N, Ju YJ, Lee SJ, Chung EK, Inn KS, Kim NJ, et al. 2020. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 12:45. Epub 2020/04/23.
  • Grimm MO, Grimm HS, Hartmann T. 2007. Amyloid beta as a regulator of lipid homeostasis. Trends Mol Med. 13:337–344. Epub 2007/07/24.
  • Grimm MO, Grimm HS, Patzold AJ, Zinser EG, Halonen R, Duering M, Tschape JA, De Strooper B, Muller U, Shen J, et al. 2005. Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin. Nat Cell Biol. 7:1118–1123. Epub 2005/10/18.
  • Grimm MO, Tschape JA, Grimm HS, Zinser EG, Hartmann T. 2006. Altered membrane fluidity and lipid raft composition in presenilin-deficient cells. Acta Neurol Scand Suppl. 185:27–32. Epub 2006/07/27.
  • Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF. 2003. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J Biol Chem. 278:6803–6808. Epub 2002/11/28.
  • Hardy J, Selkoe DJ. 2002. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science. 297:353–356. Epub 2002/07/20.
  • Hartell NA, Suh YH. 2000. Peptide fragments of β-amyloid precursor protein: effects on parallel fiber-purkinje cell synaptic transmission in Rat cerebellum. J Neurochem. 74:1112–1121. Epub 2000/02/29.
  • Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. 2001. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 21:1393–1403. Epub 2001/02/07.
  • Herholz K. 2010. Cerebral glucose metabolism in preclinical and prodromal Alzheimer’s disease. Expert Rev Neurother. 10:1667–1673. Epub 2010/10/28.
  • Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, et al. 2004. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease. FASEB J. 18:902–904. Epub 2004/03/23.
  • Hoekstra M, Kruijt JK, Van Eck M, Berkel V, J T. 2003. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J Biol Chem. 278:25448–25453. Epub 2003/04/22.
  • Hooijmans CR, Graven C, Dederen PJ, Tanila H, van Groen T, Kiliaan AJ. 2007. Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice. Brain Res. 1181:93–103. Epub 2007/10/06.
  • Hunt A, Schonknecht P, Henze M, Seidl U, Haberkorn U, Schroder J. 2007. Reduced cerebral glucose metabolism in patients at risk for Alzheimer’s disease. Psychiatry Res. 155:147–154. Epub 2007/05/26.
  • Jang MG, Oh JM, Ko HC, Kim JW, Baek S, Jin YJ, Hur SP, Kim SJ. 2021. Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats. Anim Cells Syst (Seoul). 25:396–404. Epub 2022/01/22.
  • Jones JG. 2016. Hepatic glucose and lipid metabolism. Diabetologia. 59:1098–1103. Epub 2016/04/07.
  • Kedia N, Almisry M, Bieschke J. 2017. Glucose directs amyloid-beta into membrane-active oligomers. Phys Chem Chem Phys. 19:18036–18046. Epub 2017/07/04.
  • Kim SH, Suh YH. 1996. Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer’s amyloid precursor protein. J Neurochem. 67:1172–1182. Epub 1996/09/01.
  • Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV, Jr. 2010. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest. 120:756–767. Epub 2010/02/04.
  • Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, et al. 2006. PPARδ regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 103:3444–3449. Epub 2006/02/24.
  • Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O’Brien PC, Palumbo PJ. 1997. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol. 145:301–308. Epub 1997/02/15.
  • Lim HJ, Cho JS, Oh JH, Shim SB, Hwang DY, Jee SW, Lee SH, Sheen YY, Lee SH, Kim YK. 2005. NSE-Controlled carboxyl-terminus of APP gene over-expressing in transgenic mice induces altered expressions in behavior, Aβ-42, and GSK3β binding proteins. Cell Mol Neurobiol. 25:833–850. Epub 2005/09/01.
  • Lim HJ, Shim SB, Jee SW, Lee SH, Lim CJ, Hong JT, Sheen YY, Hwang DY. 2013. Green tea catechin leads to global improvement among Alzheimer’s disease-related phenotypes in NSE/hAPP-C105 Tg mice. J Nutr Biochem. 24:1302–1313. Epub 2013/01/22.
  • Liu CC, Hu J, Tsai CW, Yue M, Melrose HL, Kanekiyo T, Bu G. 2015. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. J Neurosci. 35:5851–5859. Epub 2015/04/10.
  • Lloyd LJ, Langley-Evans SC, McMullen S. 2010. Childhood obesity and adult cardiovascular disease risk: a systematic review. Int J Obes (Lond). 34:18–28. Epub 2009/05/13.
  • Mark RJ, Pang Z, Geddes JW, Uchida K, Mattson MP. 1997. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci. 17:1046–1054. Epub 1997/02/01.
  • Mosconi L. 2005. Brain glucose metabolism in the early and specific diagnosis of Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 32:486–510. Epub 2005/03/05.
  • Nagai N, Ito Y, Sasaki H. 2016. Hyperglycemia enhances the production of amyloid β1–42in the lenses of otsuka long-evans tokushima fatty rats, a model of human type 2 diabetes. Invest Ophthalmol Vis Sci. Mar. 57:1408–1417. Epub 2016/03/31.
  • Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. 2017. DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Dev Cell. 42:9–21 e25. Epub 2017/07/12.
  • Nho K, Kueider-Paisley A, Ahmad S, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, et al. 2019. Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers. JAMA Netw Open. 2:e197978. Epub 2019/08/01.
  • Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. 1999. Diabetes mellitus and the risk of dementia: the rotterdam study. Neurology. 53:1937–1937. Epub 1999/12/22.
  • Park S, Williams KW, Sohn JW. 2022. Leptin-inhibited neurons in the lateral parabrachial nucleus do not alter food intake or glucose balance. Anim Cells Syst (Seoul).26:92-98. Epub 2022/07/06.
  • Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, et al. 2001. A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer’s disease. Neurobiol Dis. 8:890–899. Epub 2001/10/11.
  • Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J. 2004. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci U S A. 101:284–289. Epub 2003/12/23.
  • Roberts KF, Elbert DL, Kasten TP, Patterson BW, Sigurdson WC, Connors RE, Ovod V, Munsell LY, Mawuenyega KG, Miller-Thomas MM, et al. 2014. Amyloid-β efflux from the central nervous system into the plasma. Ann Neurol. 76:837–844. Epub 2014/09/11.
  • Sagare AP, Deane R, Zlokovic BV. 2012. Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 136:94–105. Epub 2012/07/24.
  • Shepardson NE, Shankar GM, Selkoe DJ. 2011. Cholesterol level and statin use in Alzheimer disease: I. Review of Epidemiological and Preclinical Studies. Arch Neurol. 68:1239–1244. Epub 2011/10/12.
  • Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC. 2002. Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice. Neuroreport. 13:455–459. Epub 2002/04/04.
  • Sparks DL. 2007. Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver. Curr Alzheimer Res. 4:165–169. Epub 2007/04/14.
  • Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo EH, Dickstein DL. 2012. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci. 51:43–52. Epub 2012/08/14.
  • Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al. 1999. Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:735–741. Epub 1999/10/26.
  • Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. 2002. Cholesterol-Dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis. 9:11–23. Epub 2002/02/19.
  • Walton RG, Zhu B, Unal R, Spencer M, Sunkara M, Morris AJ, Charnigo R, Katz WS, Daugherty A, Howatt DA, et al. 2015. Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity. J Biol Chem. 290:11547–11556. Epub 2015/03/19.
  • Wang YR, Wang QH, Zhang T, Liu YH, Yao XQ, Zeng F, Li J, Zhou FY, Wang L, Yan JC, et al. 2017. Associations between hepatic functions and plasma amyloid-beta levels—implications for the capacity of liver in peripheral amyloid-beta clearance. Mol Neurobiol. 54:2338–2344. Epub 2016/03/10.
  • Wani A, Gupta M, Ahmad M, Shah AM, Ahsan AU, Qazi PH, Malik F, Singh G, Sharma PR, Kaddoumi A, et al. 2019. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 15:1810–1828. Epub 2019/03/22.
  • Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. 1997. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 337:869–873. Epub 1997/09/26.
  • Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, Zhu XY, Giunta B, Tan J, Song WH, et al. 2015. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease. Acta Neuropathol. 130:487–499. Epub 2015/09/14.
  • Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R. 2002. Alzheimer’s beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci. 22:RC221. Epub 2002/05/15.
  • Yang L, Seki E. 2012. Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol. 3:138. Epub 2012/06/05.
  • Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, Le Y, Zhai Q. 2013. Amyloid-β induces hepatic insulin resistance In vivo via JAK2. Diabetes. 62:1159–1166. Epub 2012/12/12.