Porphyromonas gingivalis may interfere with conception in women

References

• Kassebaum NJ, Bernabé E, Dahiya M, et al. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93:1–6.
   Web of Science ®Google Scholar
• Scannapieco FA, Bush RB, Paju S. Periodontal disease as a risk factor for adverse pregnancy outcomes. A systematic review. Ann Periodontol. 2003;8:70–78.
   PubMedGoogle Scholar
• Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–1820.
   PubMed Web of Science ®Google Scholar
• Pussinen PJ, Paju S, Mäntylä P, et al. Serum microbial- and host-derived markers of periodontal diseases: a review. Curr Med Chem. 2007;14:2402–2412.
   Web of Science ®Google Scholar
• Pussinen PJ, Tuomisto K, Jousilahti P, et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol. 2007;27:1433–1439.
   Web of Science ®Google Scholar
• Hayashi C, Gudino CV, Gibson FC 3rd, et al. Review: pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010;25:305–316.
   PubMed Web of Science ®Google Scholar
• Turunen SP, Kummu O, Harila K, et al. Recognition of Porphyromonas gingivalis gingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein. PLoS One. 2012;7:e34910.
   Web of Science ®Google Scholar
• Wang C, Kankaanpää J, Kummu O, et al. Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans. Immunol Res. 2016;64:699–710.
   Web of Science ®Google Scholar
• Weiss G, Goldsmith LT, Taylor RN, et al. Inflammation in reproductive disorders. Reprod Sci. 2009;16:216–229.
   PubMed Web of Science ®Google Scholar
• Kavoussi SK, West BT, Taylor GW, et al. Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey. Fertil Steril. 2009;91:335–342.
   PubMed Web of Science ®Google Scholar
• Hart R, Doherty DA, Pennell CE, et al. Periodontal disease: a potential modifiable risk factor limiting conception. Hum Reprod. 2012;27:1332–1342.
   Web of Science ®Google Scholar
• Pavlatou A, Tsami A, Vlahos N, et al. The effect of in vitro fertilization on gingival inflammation according to women’s periodontal status: clinical data. J Int Acad Periodontol. 2013;15:36–42.
   Google Scholar
• Oittinen J, Kurki T, Kekki M, et al. Periodontal disease and bacterial vaginosis increase the risk for adverse pregnancy outcome. Infect Dis Obstet Gynecol. 2005;13:213–216.
   PubMedGoogle Scholar
• Könönen E, Paju S, Pussinen PJ, et al. Population-based study of salivary carriage of periodontal pathogens in adults. J Clin Microbiol. 2007;45:2446–2451.
   Web of Science ®Google Scholar
• Pussinen PJ, Vilkuna-Rautiainen T, Alfthan G, et al. Multiserotype enzyme-linked immunosorbent assay as a diagnostic aid for periodontitis in large-scale studies. J Clin Microbiol. 2002;40:512–518.
   PubMed Web of Science ®Google Scholar
• Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol. 1991;29:297–301.
   PubMed Web of Science ®Google Scholar
• Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994;5:78–111.
   PubMedGoogle Scholar
• Pussinen PJ, Könönen E, Paju S, et al. Periodontal pathogen carriage, rather than periodontitis, determines the serum antibody levels. J Clin Periodontol. 2011;38:405–411.
   PubMed Web of Science ®Google Scholar
• Beck JD, Eke P, Heiss G, et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation. 2005;112:19–24.
   PubMed Web of Science ®Google Scholar
• Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev. 1998;62:1244–1263.
   PubMed Web of Science ®Google Scholar
• Gnauck A, Lentle RG, Kruger MC. The characteristics and function of bacterial lipopolysaccharides and their endotoxic potential in humans. Int Rev Immunol. 2015;25:1–31.
   Google Scholar
• Hajishengallis G, Lamont RJ. Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol. 2014;44:328–338.
   PubMed Web of Science ®Google Scholar
• Ye C, Katagiri S, Miyasaka N, et al. The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth. Arch Gynecol Obstet. 2013;288:65–72.
   PubMed Web of Science ®Google Scholar
• Vanterpool SF, Been JV, Houben ML, et al. Porphyromonas gingivalis within placental villous mesenchyme and umbilical cord stroma is associated with adverse pregnancy outcome. PLoS One. 2016;11:e0146157. DOI:10.1371/journal.pone.0146157
   PubMed Web of Science ®Google Scholar
• Schenkein HA, Bradley JL, Purkall DB. Anticardiolipin in Porphyromonas gingivalis antisera causes fetal loss in mice. J Dent Res. 2013;92:814–818.
   Web of Science ®Google Scholar
• Ao M, Miyauchi M, Furusho H, et al. Dental infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One. 2015;10:e0137249. DOI:10.1371/journal.pone.0137249
   PubMed Web of Science ®Google Scholar
• Benedyk M, Mydel PM, Delaleu N, et al. Gingipains: critical factors in the development of aspiration pneumonia caused by Porphyromonas gingivalis. J Innate Immun. 2016;8:185–198.
   PubMed Web of Science ®Google Scholar
• Agarwal A, Mulgund A, Hamada A, et al. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. DOI:10.1186/s12958-015-0032-1
   PubMed Web of Science ®Google Scholar