Fusobacteria modulate oral carcinogenesis and promote cancer progression

References

• Messadi DV. Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci. 2013 Jun;5:59–12.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020 Jan;70:7–30.
   PubMed Web of Science ®Google Scholar
• Bremmer JF, Brakenhoff RH, Broeckaert MA, et al. Prognostic value of DNA ploidy status in patients with oral leukoplakia. Oral Oncol. 2011 Oct;47:956–960.
   Web of Science ®Google Scholar
• Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006 Jan 21;12:354–362.
   PubMed Web of Science ®Google Scholar
• Mager DL. Bacteria and cancer: cause, coincidence or cure? A review. J Transl Med. 2006 Mar 28;4:14.
   PubMed Web of Science ®Google Scholar
• D’Aiuto F, Parkar M, Andreou G, et al. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res. 2004 Feb;83:156–160.
   PubMed Web of Science ®Google Scholar
• Perera M, Al-Hebshi NN, Speicher DJ, et al. Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria. J Oral Microbiol. 2016;8:32762.
   PubMed Web of Science ®Google Scholar
• Tezal M, Sullivan MA, Reid ME, et al. Chronic periodontitis and the risk of tongue cancer. Arch Otolaryngol Head Neck Surg. 2007 May;133:450–454.
   PubMedGoogle Scholar
• Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol. 2005 Mar;76:406–410.
   PubMed Web of Science ®Google Scholar
• Meyer MS, Joshipura K, Giovannucci E, et al. A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control. 2008 Nov;19:895–907.
   PubMed Web of Science ®Google Scholar
• Ye L, Jiang Y, Liu W, et al. Correlation between periodontal disease and oral cancer risk: a meta-analysis. J Cancer Res Ther. 2016 Dec;12:C237–C40.
   Web of Science ®Google Scholar
• Holmes S. The oral complications of specific anticancer therapy. Int J Nurs Stud. 1991;28:343–360.
   Web of Science ®Google Scholar
• Bolz J, Dosa E, Schubert J, et al. Bacterial colonization of microbial biofilms in oral squamous cell carcinoma. Clin Oral Investig. 2014 Mar;18:409–414.
   Web of Science ®Google Scholar
• Yost S, Stashenko P, Choi Y, et al. Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses. Int J Oral Sci. 2018 Nov 12;10:32.
   PubMed Web of Science ®Google Scholar
• Oji C, Chukwuneke F. Poor oral hygiene may be the sole cause of oral cancer. J Maxillofac Oral Surg. 2012 Dec;11:379–383.
   Google Scholar
• Yu T, Guo F, Yu Y, et al. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell. 2017 Jul 27;170:548–63 e16.
   PubMed Web of Science ®Google Scholar
• Rubinstein MR, Baik JE, Lagana SM, et al. promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Rep. 2019 Apr;20. DOI:https://doi.org/10.15252/embr.201847638
   Google Scholar
• Ha NH, Park DG, Woo BH, et al. Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs. Cytokine. 2016 10;86:64–72.
   PubMed Web of Science ®Google Scholar
• Jung HM, Phillips BL, Patel RS, et al. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 2012 Aug 24;287:29261–29272.
   PubMed Web of Science ®Google Scholar
• Jung HM, Patel RS, Phillips BL, et al. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions. Mol Biol Cell. 2013 Jun;24:1638–48, S1–7.
   Web of Science ®Google Scholar
• Park YP, Jin L, Bennett KB, et al. CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma. Oral Oncol. 2018 Mar;78:145–150.
   PubMed Web of Science ®Google Scholar
• Chukkapalli SS, Velsko IM, Rivera-Kweh MF, et al. Polymicrobial oral infection with four periodontal bacteria orchestrates a distinct inflammatory response and atherosclerosis in apoe null mice. PLoS One. 2015;10:e0143291.
   PubMed Web of Science ®Google Scholar
• Harrandah AM, Fitzpatrick SG, Smith MH, et al. MicroRNA-375 as a biomarker for malignant transformation in oral lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Dec;122:743–52 e1.
   PubMed Web of Science ®Google Scholar
• Shirogane T, Fukada T, Muller JM, et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity. 1999 Dec;11:709–719.
   PubMed Web of Science ®Google Scholar
• Whitmore SE, Lamont RJ, Goldman WE. Oral bacteria and cancer. PLoS Pathog. 2014 Mar;10:e1003933.
   PubMed Web of Science ®Google Scholar
• Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013 Aug 14;14:195–206.
   PubMed Web of Science ®Google Scholar
• Mao S, Park Y, Hasegawa Y, et al. Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis. Cell Microbiol. 2007;9:1997–2007.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009 Jun;119:1420–1428.
   PubMed Web of Science ®Google Scholar
• Karlsson MC, Gonzalez SF, Welin J, et al. Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system. Mol Oncol. 2017 Jul;11:781–791.
   Web of Science ®Google Scholar
• Voulgari A, Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta. 2009 Dec;1796:75–90.
   PubMed Web of Science ®Google Scholar
• Franco C, Patricia HR, Timo S, et al. Matrix metalloproteinases as regulators of periodontal inflammation. Int J Mol Sci. 2017 Feb 17;18:440.
   Web of Science ®Google Scholar
• Sahibzada HA, Khurshid Z, Khan RS, et al. Salivary IL-8, IL-6 and TNF-alpha as potential diagnostic biomarkers for oral cancer. Diagnostics (Basel). 2017 Apr 9;7:37-43.
   Google Scholar
• Binder Gallimidi A, Fischman S, Revach B, et al. Periodontal pathogens porphyromonas gingivalis and fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015 Sep 8;6:22613–22623.
   PubMedGoogle Scholar
• Rossa C Jr., D’Silva NJ. Immune-relevant aspects of murine models of head and neck cancer. Oncogene. 2019 Jan 29;38:3973-3988.
   Web of Science ®Google Scholar
• Polak D, Wilensky A, Shapira L, et al. Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response. J Clin Periodontol. 2009 May;36:406–410.
   PubMed Web of Science ®Google Scholar
• Di Benedetto A, Gigante I, Colucci S, et al. Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol. 2013;2013:503754.
   PubMedGoogle Scholar
• Tezal M, Sullivan MA, Hyland A, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18:2406–2412.
   PubMed Web of Science ®Google Scholar
• Katz J, Onate MD, Pauley KM, et al. Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma. Int J Oral Sci. 2011 Oct;3:209–215.
   PubMed Web of Science ®Google Scholar
• Chang C, Geng F, Shi X, et al. The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma. Appl Microbiol Biotechnol. 2019 Feb;103:1393–1404.
   PubMed Web of Science ®Google Scholar
• Rao SK, Pavicevic Z, Du Z, et al. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem. 2010 Oct 15;285:32512–32521.
   PubMed Web of Science ®Google Scholar
• Han YW. Fusobacterium nucleatum: a commensal-turned pathogen. Curr Opin Microbiol. 2015 Feb;23:141–147.
   PubMed Web of Science ®Google Scholar
• Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012 Feb;22:299–306.
   PubMed Web of Science ®Google Scholar
• Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013 Aug 14;14:207–215.
   PubMed Web of Science ®Google Scholar
• McCoy AN, Araujo-Perez F, Azcarate-Peril A, et al. Fusobacterium is associated with colorectal adenomas. PLoS One. 2013 Jan 15;8:e53653.
   PubMed Web of Science ®Google Scholar
• Bullman S, Pedamallu CS, Sicinska E, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017 Dec 15;358:1443–1448.
   PubMed Web of Science ®Google Scholar
• Yang Y, Weng W, Peng J, et al. Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-kappaB, and up-regulating expression of microRNA-21. Gastroenterology. 2017 Mar;152:851–66 e24.
   PubMed Web of Science ®Google Scholar
• Yamamura K, Baba Y, Nakagawa S, et al. Human microbiome fusobacterium nucleatum in esophageal cancer tissue is associated with prognosis. Clin Cancer Res. 2016 Nov 15;22:5574–5581.
   PubMed Web of Science ®Google Scholar
• Hawkins BL, Heniford BW, Ackermann DM, et al. 4NQO carcinogenesis: a mouse model of oral cavity squamous cell carcinoma. Head Neck. 1994 Sep-Oct;16:424–432.
   PubMed Web of Science ®Google Scholar