Potential implications of SARS-CoV-2 oral infection in the host microbiota

References

• Carvalho T. COVID-19 research in brief: december, 2019 to June, 2020. Nat Med. 2020;26:1152–6.
   Web of Science ®Google Scholar
• Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12:1–5.
   PubMed Web of Science ®Google Scholar
• Patel J, Sampson V. The role of oral bacteria in COVID-19. Lancet Microbe. 2020;1:e105.
   Google Scholar
• Kitamoto S, Nagao-Kitamoto H, Jiao Y, et al. The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis. Cell. 2020;182:447–462.
   PubMed Web of Science ®Google Scholar
• Lan L, Xu D, Ye G, et al. Positive RT-PCR test results in patients recovered from COVID-19. JAMA. 2020;323:1502.
   PubMed Web of Science ®Google Scholar
• Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382:970–971.
   PubMed Web of Science ®Google Scholar
• Zhou X, Li Y, Li T, et al. Follow-up of asymptomatic patients with SARS-CoV-2 infection. Clin Microbiol Infect. 2020;26:957–959.
   Web of Science ®Google Scholar
• Yan R, Zhang Y, Li Y, et al. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367:1444–1448.
   PubMed Web of Science ®Google Scholar
• Xu J, Li Y, Gan F, et al. Salivary glands: potential reservoirs for COVID-19 asymptomatic infection. J Dent Res. 2020;99:989.
   Web of Science ®Google Scholar
• Pascolo L, Zupin L, Melato M, et al. TMPRSS2 and ACE2 coexpression in SARS-CoV-2 salivary glands infection. J Dent Res. 2020;99:1120–1121.
   Web of Science ®Google Scholar
• Liu L, Wei Q, Alvarez X, et al. Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of Rhesus Macaques. J Virol. 2011;85:4025–4030.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhao J, Peng J, et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients. Cell Prolif. 2020. DOI:https://doi.org/10.1111/cpr.12923
   Google Scholar
• Fisher J, Monette DL, Patel KR, et al. COVID-19 associated parotitis: a case report. Am J Emerg Med. 2020. DOI:https://doi.org/10.1016/j.ajem.2020.06.059
   Google Scholar
• Chern A, Famuyide AO, Moonis G, et al. Sialadenitis: a possible early manifestation of COVID −19. Laryngoscope. 2020;130:2595–2597.
   Web of Science ®Google Scholar
• To KK, Tsang OT-Y, Yip CC-Y, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020;71:841–843.
   PubMed Web of Science ®Google Scholar
• Chen D, Xu W, Lei Z, et al. Recurrence of positive SARS-CoV-2 RNA in COVID-19: A case report. Int J Infect Dis. 2020;93:297–299.
   PubMed Web of Science ®Google Scholar
• da Silva Pedrosa M, Sipert CR, Nogueira FN. Are the salivary glands the key players in spreading COVID-19 asymptomatic infection in dental practice? J Med Virol. 2020. DOI:https://doi.org/10.1002/jmv.26316
   Google Scholar
• Lechien JR, Chiesa-Estomba CM, Hans S, et al. Loss of smell and taste in 2013 European patients with mild to moderate COVID-19. Ann Int Med. 2020;173:672–675.
   Web of Science ®Google Scholar
• Cooper KW, Brann DH, Farruggia MC, et al. COVID-19 and the chemical senses: supporting players take center stage. Neuron. 2020;107(2):219–233.
   PubMed Web of Science ®Google Scholar
• Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral mucosal lesions in a COVID-19 patient: new signs or secondary manifestations? Int J Infect Dis. 2020;97:326–328.
   PubMed Web of Science ®Google Scholar
• Zhong M, Lin B, Gao H, et al. Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry. bioRxiv 2020. DOI:https://doi.org/10.1101/2020.04.18.047951
   Google Scholar
• Gomes-Filho IS, Cruz SSD, Trindade SC, et al. Periodontitis and respiratory diseases: A systematic review with meta-analysis. Oral Dis. 2020;26:439–446.
   Web of Science ®Google Scholar
• Pallos D, Ruivo GF, Ferrari‐Junior SH, et al. Periodontal disease and detection of human herpesviruses in saliva and gingival crevicular fluid of chronic kidney disease patients. J Periodontol. 2020;91:1139–1147.
   Web of Science ®Google Scholar
• Chen C, Feng P, Slots J, et al. Herpesvirus-bacteria synergistic interaction in periodontitis. Periodontol 2000. 2020;82:42–64.
   Web of Science ®Google Scholar
• Grenier G, Gagnon G, Grenier D, et al. Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment. Oral Microbiol Immunol. 2009;24:506–509.
   PubMedGoogle Scholar
• Gupta S, Mohindra R, Chauhan PK, et al. SARS-CoV-2 detection in gingival crevicular fluid. J Dent Res. 2020;002203452097053. DOI:https://doi.org/10.1177/0022034520970536
   Google Scholar
• Badran Z, Gaudin A, Struillou X, et al. Periodontal pockets: A potential reservoir for SARS-CoV-2? Med Hypotheses. 2020;143:109907.
   Web of Science ®Google Scholar
• Shenoy MK, Iwai S, Lin DL, et al. Immune response and mortality risk relate to distinct lung microbiomes in patients with HIV and pneumonia. Am J Respir Crit Care Med. 2017;195:104–114.
   PubMed Web of Science ®Google Scholar
• Kalantar-Zadeh K, Ward SA, Kalantar-Zadeh K, et al. Considering the effects of microbiome and diet on SARS-CoV-2 infection: nanotechnology roles. ACS Nano. 2020;14:5179–5182.
   PubMed Web of Science ®Google Scholar
• Leung RK, Zhou JW, Guan W, et al. Modulation of potential respiratory pathogens by pH1N1 viral infection. Clin Microbiol Infect. 2013;19:930–935.
   PubMed Web of Science ®Google Scholar
• Moore SC, Penrice-Randal R, Alruwaili M, et al. Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. medRxiv. 2020. DOI:https://doi.org/10.1101/2020.03.05.20032011
   Google Scholar
• Cox MJ, Loman N, Bogaert D, et al. Co-infections: potentially lethal and unexplored in COVID-19. Lancet Microbe. 2020;1:e11.
   PubMedGoogle Scholar
• Zhang G, Hu C, Luo L, et al. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. J Clin Virol. 2020;127:104364.
   PubMed Web of Science ®Google Scholar
• Garcia-Vidal C, Sanjuan G, Moreno-García E, et al. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin Microbiol Infect. 2020. DOI:https://doi.org/10.1016/j.cmi.2020.07.041
   Google Scholar
• Blanco JL, Ambrosioni J, Garcia F, et al. COVID-19 in patients with HIV: clinical case series. Lancet HIV. 2020;7:e314–e316.
   PubMed Web of Science ®Google Scholar
• Ai J, Zhang H, Xu T,et al. Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China. medRxiv. 2020. DOI:https://doi.org/10.1101/2020.02.13.20022673
   Google Scholar
• Libertucci J, Young VB. The role of the microbiota in infectious diseases. Nat Microbiol. 2019;4:35–45.
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9:313–323.
   PubMed Web of Science ®Google Scholar
• Yu G, Gail MH, Consonni D, et al. Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features. Genome Biol. 2016;17:163.
   PubMed Web of Science ®Google Scholar
• Chakraborty S. SARS-Cov2 enables anaerobic bacteria (Prevotella, et al) to colonize the lungs disrupting homeostasis, causing long-drawn chronic symptoms, and acute severe symptoms (ARDS, septic shock, clots, arterial stroke) which finds resonance, with key differences, in the ‘forgotten disease’ Lemierre Syndrome, enabled by Epstein Barr Virus. Open Science Framework. 2020. DOI:https://doi.org/10.31219/osf.io/usztn
   Google Scholar
• Martinez-Guryn K, Leone V, Chang EB, et al. Regional diversity of the gastrointestinal microbiome. Cell Host Microbe. 2019;26:314–324.
   PubMed Web of Science ®Google Scholar
• Schmidt TS, Hayward MR, Coelho LP, et al. Extensive transmission of microbes along the gastrointestinal tract. eLife. 2019;8:e42693.
   Web of Science ®Google Scholar
• Li B, Ge Y, Cheng L, et al. Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice. Int J Oral Sci. 2019;11:10.
   PubMed Web of Science ®Google Scholar
• Flemer B, Warren RD, Barrett MP, et al. The oral microbiota in colorectal cancer is distinctive and predictive. Gut. 2018;67:1454–1463.
   PubMed Web of Science ®Google Scholar
• Xun Z, Zhang Q, Xu T, et al. Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles. Front Microbiol. 2018;9:1136.
   PubMed Web of Science ®Google Scholar
• Dinakaran V, Mandape SN, Shuba K, et al. Identification of specific oral and gut pathogens in full thickness colon of colitis patients: implications for colon motility. Front Microbiol. 2019;9:3220.
   Web of Science ®Google Scholar
• Schirmer M, Franzosa EA, Lloyd-Price J, et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat Microbiol. 2018;3:337–346.
   PubMed Web of Science ®Google Scholar
• Zuo T, Zhan H, Zhang F, et al. Alterations in fecal fungal microbiome of patients with COVID-19 during time of hospitalization until discharge. Gastroenterology. 2020. DOI:https://doi.org/10.1053/j.gastro.2020.06.048
   Google Scholar
• Gu S, Chen Y, Wu Z, et al. Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis. 2020. DOI:https://doi.org/10.1093/cid/ciaa709
   Google Scholar
• Gaeckle NT, Pragman AA, Pendleton KM, et al. The oral-lung axis: the impact of oral health on lung health. Respir Care. 2020;65:1211–1220.
   Web of Science ®Google Scholar
• Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med. 2011;184:957–963.
   PubMed Web of Science ®Google Scholar
• Simon-Soro A, Sohn MB, McGinniss JE, et al. Upper respiratory dysbiosis with a facultative-dominated ecotype in advanced lung disease and dynamic change after lung transplant. Ann Am Thorac Soc. 2019;16:1383–1391.
   Web of Science ®Google Scholar
• Winning L, Patterson CC, Cullen KM, et al. Chronic periodontitis and reduced respiratory function. J Clin Periodontol. 2019;46:266–275.
   Web of Science ®Google Scholar
• Kumar PS. From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease. J Physiol. 2017;595:465–476.
   PubMed Web of Science ®Google Scholar
• Bahrani-Mougeot FK, Paster BJ, Coleman S, et al. Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia. J Clin Microbiol. 2007;45:1588–1593.
   PubMed Web of Science ®Google Scholar
• Horváth G, Sorscher EJ. Luminal fluid tonicity regulates airway ciliary beating by altering membrane stretch and intracellular calcium. Cell Motil Cytoskeleton. 2008;65:469–475.
   Web of Science ®Google Scholar
• Chakraborty S. Metagenome of SARS-Cov2 patients in Shenzhen with travel to Wuhan shows a wide range of species-Lautropia, Cutibacterium, Haemophilus being most abundant and Campylobacter explaining diarrhea. Open Science Framework. 2020. DOI:https://doi.org/10.31219/osf.io/jegwq
   Google Scholar
• Bao L, Zhang C, Dong J, et al. Oral microbiome and SARS-CoV-2: beware of lung co-infection. Front Microbiol. 2020;11:1840.
   PubMed Web of Science ®Google Scholar
• Lamont RJ, Koo H, Hajishengallis G, et al. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;16:745–759.
   PubMed Web of Science ®Google Scholar