Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

References

• Yamaguchi Y, Kurita-Ochiai T, Kobayashi R, et al. Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm Res. 2017;66(1):59–12.
   Web of Science ®Google Scholar
• Weber A, Bittner ZA, Shankar S, et al. Recent insights into the regulatory networks of NLRP3 inflammasome activation. J Cell Sci. 2020;133(23):23.
   Web of Science ®Google Scholar
• de Alencar JB, Zacarias J, Tsuneto PY, et al. Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility. PLoS One. 2020;15(1):e0227905.
   PubMed Web of Science ®Google Scholar
• Lian D, Dai L, Xie Z, et al. Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide. Mol Immunol. 2018;103:209–219.
   Web of Science ®Google Scholar
• García-Hernández AL, Áe M-S, González-Alva P, et al. Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes. Oral Dis. 2019;25(2):596–608.
   Web of Science ®Google Scholar
• Tan Y, Chen J, Jiang Y, et al. The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. Arch Oral Biol. 2020;114:104692.
   Web of Science ®Google Scholar
• Li C, Yin W, Yu N, et al. miR-155 promotes macrophage pyroptosis induced by Porphyromonas gingivalis through regulating the NLRP3 inflammasome. Oral Dis. 2019;25(8):2030–2039.
   PubMed Web of Science ®Google Scholar
• Huang C, Zhang C, Yang P, et al. Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway. Drug Des Devel Ther. 2020;14:4901–4913.
   PubMed Web of Science ®Google Scholar
• Luan X, Zhou X, Naqvi A, et al. MicroRNAs and immunity in periodontal health and disease. Int J Oral Sci. 2018 Aug 6;10(3):24.
   PubMedGoogle Scholar
• Konermann A, Stabenow D, Knolle PA, et al. Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation. Innate Immun. 2012 Oct;18(5):745–752.
   PubMed Web of Science ®Google Scholar
• Chi D, Lin X, Meng Q, et al. Real-time induction of macrophage apoptosis, pyroptosis, and necroptosis by enterococcus faecalis OG1RF and two root canal isolated strains. Front Cell Infect Microbiol. 2021;11:720147.
   PubMed Web of Science ®Google Scholar
• Liu W, Liu J, Wang W, et al. NLRP6 induces pyroptosis by activation of caspase-1 in gingival fibroblasts. J Dent Res. 2018 Nov;97(12):1391–1398.
   Web of Science ®Google Scholar
• Shi J, Li J, Su W, et al. Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. Sci Rep. 2019 Feb 27;9(1):2902.
   Google Scholar
• Wang Q, Wu J, Zeng Y, et al. Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease. Clin Chim Acta. 2020 Nov;510:62–72.
   PubMed Web of Science ®Google Scholar
• Trinczek B, Brajenovic M, Ebneth A, et al. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. J Biol Chem. 2004;279(7):5915–5923.
   Web of Science ®Google Scholar
• Clement M, Chen X, Chenoweth HL, et al. MARK4 (Microtubule Affinity-Regulating Kinase 4)-dependent inflammasome activation promotes atherosclerosis-brief report. Arterioscler Thromb Vasc Biol. 2019;39(8):1645–1651.
   PubMed Web of Science ®Google Scholar
• Misawa T, Takahama M, Kozaki T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14(5):454–460.
   PubMed Web of Science ®Google Scholar
• Zeng QZ, Yang F, Li CG, et al. Paclitaxel enhances the innate immunity by promoting NLRP3 inflammasome activation in macrophages. Front Immunol. 2019;10:72.
   Web of Science ®Google Scholar
• Naqvi A, Jairajpuri DS, Noman O, et al. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: towards therapeutic management of Alzheimer’s disease. J Biomol Struct Dyn. 2020;38(13):3892–3907.
   PubMed Web of Science ®Google Scholar
• Naz F, Anjum F, Islam A, et al. Microtubule affinity-regulating kinase 4: structure, function, and regulation. Cell Biochem Biophys. 2013;67(2):485–499.
   Web of Science ®Google Scholar
• Li X, Thome S, Ma X, et al. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017;8(1):15986.
   Google Scholar
• Akira S, Misawa T, Satoh T, et al. Macrophages control innate inflammation. Diabetes Obes Metab. 2013;15(Suppl 3):10–18.
   Web of Science ®Google Scholar
• Wang J, Shen X, Liu J, et al. High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression. Cell Death Dis. 2020;11(5):383.
   PubMed Web of Science ®Google Scholar
• Muller J, Bolomsky A, Dubois S, et al. Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity in multiple myeloma bone disease. Haematologica. 2018;103(8):1359–1368.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhou X, Li Y, et al. Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia. Oncogene. 2018;37(41):5520–5533.
   PubMed Web of Science ®Google Scholar
• Jeddo S, Wei X, Li K, et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma. Oncol Rep. 2020;44(3):1037–1048.
   Web of Science ®Google Scholar
• Guarda G, Dostert C, Staehli F, et al. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature. 2009;460(7252):269–273.
   PubMed Web of Science ®Google Scholar
• Shen X, Liu X, Wan S, et al. Discovery of coumarin as microtubule affinity-regulating kinase 4 inhibitor that sensitize hepatocellular carcinoma to paclitaxel. Front Chem. 2019;7:366.
   PubMed Web of Science ®Google Scholar
• Chiu HC, Lan GL, Chiang CY, et al. Upregulation of heme oxygenase-1 expression in gingiva after cyclosporin A treatment. J Periodontol. 2008;79(11):2200–2206.
   Web of Science ®Google Scholar
• Lucas H, Bartold PM, Dharmapatni AA, et al. Inhibition of apoptosis in periodontitis. J Dent Res. 2010;89(1):29–33.
   Web of Science ®Google Scholar
• Curtis MA, Diaz PI, Van Dyke TE. The role of the microbiota in periodontal disease. Periodontol 2000. 2020;83(1):14–25.
   PubMed Web of Science ®Google Scholar
• Ding PH, Yang MX, Wang NN, et al. Porphyromonas gingivalis-Induced NLRP3 inflammasome activation and its downstream interleukin-1β release depend on caspase-4. Front Microbiol. 2020;11:1881.
   Web of Science ®Google Scholar
• Zang Y, Song JH, Oh SH, et al. Targeting NLRP3 inflammasome reduces age-related experimental alveolar bone loss. J Dent Res. 2020;99(11):1287–1295.
   Web of Science ®Google Scholar
• Phillips JR, Nadim HS, Layman DL. Alterations in cell morphology and cytoskeletal proteins in gingival fibroblasts exposed to a Bacteroides gingivalis extract. J Periodontal Res. 1990;25(6):339–346.
   Web of Science ®Google Scholar
• Qiu Q, Zhang F, Wu J, et al. Gingipains disrupt F-actin and cause osteoblast apoptosis via integrin β1. J Periodontal Res. 2018;53(5):762–776.
   PubMed Web of Science ®Google Scholar
• Kinane JA, Benakanakere MR, Zhao J, et al. Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis. Cell Microbiol. 2012;14(7):1085–1096.
   Web of Science ®Google Scholar
• Isowa N, Xavier AM, Dziak E, et al. LPS-induced depolymerization of cytoskeleton and its role in TNF-alpha production by rat pneumocytes. Am J Physiol. 1999;277(3):L606–15.
   Google Scholar
• St-Pierre J, Moreau F, Cornick S, et al. The macrophage cytoskeleton acts as a contact sensor upon interaction with Entamoeba histolytica to trigger IL-1β secretion. PLoS Pathog. 2017 Aug;13(8):e1006592.
   Web of Science ®Google Scholar
• Luo Y, Huang Z, Mou T, et al. SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway. Life Sci. 2021;273:119286.
   PubMed Web of Science ®Google Scholar
• Portran D, Schaedel L, Xu Z, et al. Tubulin acetylation protects long-lived microtubules against mechanical ageing. Nat Cell Biol. 2017 Apr;19(4):391–398.
   PubMed Web of Science ®Google Scholar
• Naz F, Shahbaaz M, Bisetty K, et al. Designing new kinase inhibitor derivatives as therapeutics against common complex diseases: structural basis of microtubule affinity-regulating kinase 4 (MARK4) inhibition. OMICS. 2015 Nov;19(11):700–711.
   PubMed Web of Science ®Google Scholar
• Chung S, Nakamura Y. MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells. Cell Cycle. 2013 Jun 1;12(11):1655–1656.
   PubMed Web of Science ®Google Scholar