References
- Willis JR, Gabaldon T. The human oral microbiome in health and disease: from sequences to ecosystems. Microorganisms. 2020;8:308.
- Paster BJ, Olsen I, Aas JA, et al. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol. 2006;42:80–12. 2000.
- Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.
- Bosshardt DD. The periodontal pocket: pathogenesis, histopathology and consequences. Periodontol. 2018;76:43–50. 2000.
- Lasserre JF, Brecx MC, Toma S. Oral microbes, biofilms and their role in periodontal and peri-implant diseases. Materials. 2018;11:1802.
- Abusleme L, Hoare A, Hong BY, et al. Microbial signatures of health, gingivitis, and periodontitis. Periodontol. 2021;86:57–78. 2000.
- Lamont RJ, Hajishengallis G. Polymicrobial synergy and dysbiosis in inflammatory disease. Trends Mol Med. 2015;21:172–183.
- Koivisto L, Bi J, Hakkinen L, et al. Integrin alphavbeta6: structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186–196.
- Bi J, Koivisto L, Pang A, et al. Suppression of alphavbeta6 integrin expression by polymicrobial oral biofilms in gingival epithelial cells. Sci Rep. 2017;7:4411.
- Ghannad F, Nica D, Fulle MI, et al. Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease. Am J Pathol. 2008;172:1271–1286.
- Huang XZ, Wu JF, Cass D, et al. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996;133:921–928.
- Yang Z, Mu Z, Dabovic B, et al. Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol. 2007;176:787–793.
- Knight PA, Wright SH, Brown JK, et al. Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol. 2002;161:771–779.
- Mohammed J, Beura LK, Bobr A, et al. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-beta. Nat Immunol. 2016;17:414–421.
- Bi J, Dai J, Koivisto L, et al. Inflammasome and cytokine expression profiling in experimental periodontitis in the integrin beta6 null mouse. Cytokine. 2019a;114:135–142.
- Hu S, Peng L, Kwak Y-T, et al. The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense. Cell Rep. 2015;13(9):1922–1936.
- Mohazab L, Koivisto L, Jiang G, et al. Critical role for alphavbeta6 integrin in enamel biomineralization. J Cell Sci. 2013;126:732–744.
- Velsko IM, Chukkapalli SS, Rivera-Kweh MF, et al. Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in alphavbeta6 integrin-deficient mice. Infect Immun. 2015;83:4582–4593.
- Bi J, Koivisto L, Dai J, et al. Epidermal growth factor receptor signaling suppresses alphavbeta6 integrin and promotes periodontal inflammation and bone loss. J Cell Sci. 2019b;133:jcs236588.
- Ansar M, Jan A, Santos-Cortez RL, et al. Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability. Eur J Hum Genet. 2016;24:1223–1227.
- Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest. 1976;34(3):235–249.
- Haapasalmi K, Makela M, Oksala O, et al. Expression of epithelial adhesion proteins and integrins in chronic inflammation. Am J Pathol. 1995;147:193–206.
- Chang AM, Liu Q, Hajjar AM, et al. Toll-like receptor-2 and −4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota. J Periodontol. 2019;90:1202–1212.
- Kim J, An JU, Kim W, et al. Differences in the gut microbiota of dogs (Canis lupus familiaris) fed a natural diet or a commercial feed revealed by the Illumina MiSeq platform. Gut Pathog. 2017;9:68.
- Kolenbrander PE, Palmer RJsJr., Rickard AH, et al. Bacterial interactions and successions during plaque development. Periodontol. 2006;42:47–79. 2000.
- Joseph S, Aduse-Opoku J, Hashim A, et al. A 16S rRNA gene and draft genome database for the murine oral bacterial community. mSystems. 2021;6. DOI:10.1128/mSystems.01222-20
- Abusleme L, O’Gorman H, Dutzan N, et al. Establishment and stability of the murine oral microbiome. J Dent Res. 2020;99:721–729.
- Hernandez-Arriaga A, Baumann A, Witte OW, et al. Changes in oral microbial ecology of C57BL/6 mice at different ages associated with sampling methodology. Microorganisms. 2019;7:283.
- Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014;16:1024–1033.
- Segata N, Haake SK, Mannon P, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012;13:R42.
- Gohler A, Hetzer A, Holtfreter B, et al. Quantitative molecular detection of putative periodontal pathogens in clinically healthy and periodontally diseased subjects. PLoS One. 2014;9:e99244.
- Hyvarinen K, Laitinen S, Paju S, et al. Detection and quantification of five major periodontal pathogens by single copy gene-based real-time PCR. Innate Immun. 2009;15:195–204.
- Galimanas V, Hall MW, Singh N, et al. Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators. Microbiome. 2014;2:32.
- Wei Y, Shi M, Zhen M, et al. Comparison of subgingival and buccal mucosa microbiome in chronic and aggressive periodontitis: a pilot study. Front Cell Infect Microbiol. 2019;9:53.
- Fine DH, Patil AG, Velusamy SK. Aggregatibacter actinomycetemcomitans (Aa) under the radar: myths and misunderstandings of aa and its role in aggressive periodontitis. Front Immunol. 2019;10:728.
- Javurek AB, Suresh D, Spollen WG, et al. Gut dysbiosis and neurobehavioral alterations in rats exposed to silver nanoparticles. Sci Rep. 2017;7:2822.
- Petriz BA, Castro AP, Almeida JA, et al. Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats. BMC Genomics. 2014;15:511.
- Yang L, Liu C, Zhao W, et al. Impaired autophagy in intestinal epithelial cells alters gut microbiota and host immune responses. Appl Environ Microbiol. 2018;84. DOI:10.1128/AEM.00880-18.
- Benjamin JL, Sumpter RsJr., Levine B, et al. Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe. 2013;13:723–734.
- Cadwell K, Stappenbeck TS, Virgin HW. Role of autophagy and autophagy genes in inflammatory bowel disease. Curr Top Microbiol Immunol. 2009;335:141–167.
- Bauche D, Marie JC. Transforming growth factor beta: a master regulator of the gut microbiota and immune cell interactions. Clin Transl Immunology. 2017;6:e136.
- Watanabe D, Guo Y, Kamada N. Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease. EMBO Mol Med. 2021;13:e13452.