298
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Protective effect of telomerase-based 16-mer peptide vaccine (GV1001) on inferior epigastric island skin flap survivability in ischaemia-reperfusion injury rat model

, , , &
Pages 210-216 | Received 19 May 2016, Accepted 05 Sep 2016, Published online: 27 Sep 2016

References

  • Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. Microsurgery 2004;24:468–75.
  • Lutz J, Thurmel K, Heemann U. Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation. J Inflamm (Lond) 2010;7:27.
  • Tatlidede SH, Murphy AD, McCormack MC, et al. Improved survival of murine island skin flaps by prevention of reperfusion injury. Plast Reconstr Surg 2009;123:1431–9.
  • Zhao L, Wang YB, Qin SR, et al. Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B 2013;14:382–91.
  • Koo TY, Yan JJ, Yang J. Protective effect of peptide GV1001 against renal ischemia-reperfusion injury in mice. Transplant Proc 2014;46:1117–22.
  • Van Ye TM, Roza AM, Pieper GM, et al. Inhibition of intestinal lipid peroxidation does not minimize morphologic damage. J Surg Res 1993;55:553–8.
  • Khalil AA, Aziz FA, Hall JC. Reperfusion injury. Plast Reconstr Surg 2006;117:1024–33.
  • Askar I, Oktay MF, Gurlek A, Bac B. Protective effects of some antineoplastic agents on ischemia-reperfusion injury in epigastric island skin flaps. Microsurgery 2006;26:193–9.
  • Cetin C, Kose AA, Aral E, et al. Protective effect of fucoidin (a neutrophil rolling inhibitor) on ischemia reperfusion injury: experimental study in rat epigastric island flaps. Ann Plast Surg 2001;47:540–6.
  • Wang W, Liu CZ, Jin B, et al. Alleviating the ischemia-reperfusion injury of donor liver by transfection of exogenous hTERT genes. Transplant Proc 2009;41:1499–503.
  • Carroll WR, Esclamado RM. Ischemia/reperfusion injury in microvascular surgery. Head Neck 2000;22:700–13.
  • Wang WZ, Baynosa RC, Zamboni WA. Update on ischemia-reperfusion injury for the plastic surgeon: 2011. Plast Reconstr Surg 2011;128:685e–92.
  • Park HH, Lee KY, Kim S, et al. Novel vaccine peptide GV1001 effectively blocks β-amyloid toxicity by mimicking the extra-telomeric functions of human telomerase reverse transcriptase. Neurobiol Aging 2014;35:1255–74.
  • Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. Br J Cancer 2008;98:677–83.
  • Chiodi I, Mondello C. Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. Front Oncol 2012;2:133.
  • Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995;19:1409–17.
  • Eskitascioglu T, Karaci S, Canoz O, et al. The impact of lidocaine on flap survival following reperfusion injury. J Surg Res 2011;167:323–8.
  • Bondke Persson A, Persson PB. Ischaemia, reperfusion, pre-and post-conditioning: telling friend from foe. Acta Physiol (Oxf) 2012;206:157–9.
  • Wang WZ, Anderson G, Firrell JC. Arteriole constriction following ischemia in denervated skeletal muscle. J Reconstr Microsurg 1995;11:99–106.
  • Wang WZ, Anderson GL. Intervention approaches against I/R-induced arterial insufficiency in reconstructive surgery. Hand Clin 2001;17:357–69, viii.
  • Wang WZ, Anderson G, Fleming JT, et al. Lack of nitric oxide contributes to vasospasm during ischemia/reperfusion injury. Plast Reconstr Surg 1997;99:1099–108.
  • Wang WZ, Fang XH, Stephenson LL, et al. Melatonin reduces ischemia/reperfusion-induced superoxide generation in arterial wall and cell death in skeletal muscle. J Pineal Res 2006;41:255–60.
  • Wang WZ, Fang XH, Stepheson LL, et al. NOS upregulation attenuates vascular endothelial dysfunction in the late phase of ischemic preconditioning in skeletal muscle. J Orthop Res 2004;22:578–85.
  • Xiao YD, Liu YQ, Li JL, et al. Hyperbaric oxygen preconditioning inhibits skin flap apoptosis in a rat ischemia-reperfusion model. J Surg Res 2015;199:732–9.
  • Wang WZ, Fang XH, Stephenson LL, et al. Ischemia-reperfusion-induced apoptotic endothelial cells isolated from rat skeletal muscle. Plast Reconstr Surg 2009;123:131S–8S.
  • Muneuchi G, Hossain A, Yamaguchi F, et al. The rare sugar D-allose has a reducing effect against ischemia-reperfusion injury on the rat abdominal skin island flap model. J Surg Res 2013;183:976–81.
  • Ozkan O, Ozkan O, Bektas G, et al. The relationship between ischemia time and mucous secretion in vaginal reconstruction with the jejunal free flap: an experimental study on the rat jejunum. Ann Plast Surg 2015;75:98–101.
  • Hatoko M, Tanaka A, Kuwahara M, Yurugi S. Molecular response to ischemia-reperfusion of rat skin: study of expression of p53, p21WAF-1, and Bax proteins, and apoptosis. Ann Plast Surg 2001;47:425–30.
  • Cordeiro PG, Lee JJ, Mastorakos D, et al. Prevention of ischemia-reperfusion injury in a rat skin flap model: the role of mast cells, cromolyn sodium, and histamine receptor blockade. Plast Reconstr Surg 2000;105:654–9.
  • Cordeiro PG, Mastorakos DP, Hu QY, Kirschner RE. The protective effect of L-arginine on ischemia-reperfusion injury in rat skin flaps. Plast Reconstr Surg 1997;100:1227–33.
  • Kayiran O, Cuzdan SS, Uysal A, Kocer U. Tadalafil significantly reduces ischemia reperfusion injury in skin island flaps. Indian J Plast Surg 2013;46:75–81.
  • Morris SF, Pang CY, Zhong A, et al. Assessment of ischemia-induced reperfusion injury in the pig latissimus dorsi myocutaneous flap model. Plast Reconstr Surg 1993;92:1162–72.
  • Shaw VE, Naisbitt DJ, Costello E, et al. Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. Expert Rev Vaccines 2010;9:1007–16.
  • Inderberg-Suso EM, Trachsel S, Lislerud K, et al. Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001. Oncoimmunology 2012;1:670–86.
  • Choi J, Kim H, Kim Y, et al. The anti-inflammatory effect of GV1001 mediated by the downregulation of ENO1-induced pro-inflammatory cytokine production. Immune Netw 2015;15:291–303.
  • Isomaki P, Junttila I, Vidqvist KL, et al. The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels. Rheumatology (Oxford) 2015;54:1103–13.
  • Nishimoto N, Kishimoto T. Humanized antihuman IL-6 receptor antibody, tocilizumab. Handb Exp Pharmacol 2008;181:151–60.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.