References

• Acheson, D., Feifel, D., Wilde, S., McKinney, R., Lohr, J., & Risbrough, V. (2013). The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology, 229(1), 199–13. PubMed PMID: 89657567.
   PubMed Web of Science ®Google Scholar
• American Psychological Association. (2013). Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Pub.
   Google Scholar
• American Psychological Association. (2017). Clinical practice guideline for the treatment of Posttraumatic Stress Disorder (PTSD) in adults. American Psychological Association guideline development panel for the treatment of PTSD in adults. Retrieved from https://www.apa.org/ptsd-guideline/ptsd.pdf
   Google Scholar
• Askovic, M., Watters, A. J., Aroche, J., & Harris, A. W. F. (2017). Neurofeedback as an adjunct therapy for treatment of chronic posttraumatic stress disorder related to refugee trauma and torture experiences: Two case studies. Australasian Psychiatry, 25(4), 358–363.
   Web of Science ®Google Scholar
• Asmundson, G. J., Fetzner, M. G., DeBoer, L. B., Powers, M. B., Otto, M. W., & Smits, J. A. (2013). Let’s get physical: A contemporary review of the anxiolytic effects of exercise for anxiety and its disorders. Depression and Anxiety, 30(4), 362–373.
   PubMed Web of Science ®Google Scholar
• Batten, S. V., Drapalski, A. L., Decker, M. L., DeViva, J. C., Morris, L. J., Mann, M. A., & Dixon, L. B. (2009). Veteran interest in family involvement in PTSD treatment. Psychological Services, 6(3), 184.
   PubMed Web of Science ®Google Scholar
• Bellomo, R., Warrillow, S. J., & Reade, M. C. (2009). Why we should be wary of single-center trials. Critical Care Medicine, 37(12), 3114–3119.
   PubMed Web of Science ®Google Scholar
• Bentz, D., Michael, T., de Quervain, D. J. F., & Wilhelm, F. H. (2010). Enhancing exposure therapy for anxiety disorders with glucocorticoids: From basic mechanisms of emotional learning to clinical applications. Journal of Anxiety Disorders, 24, 223–230.
   PubMed Web of Science ®Google Scholar
• Bisson, J. I., Ehlers, A., Matthews, R., Pilling, S., Richards, D., & Turner, S. (2007). Psychological treatments for chronic post-traumatic stress disorder - Systematic review and meta-analysis. British Journal of Psychiatry, 190, 97–104.
   PubMed Web of Science ®Google Scholar
• Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005). A multidimensional meta-analysis of psychotherapy for PTSD. American Journal of Psychiatry, 162(2), 214–227.
   PubMed Web of Science ®Google Scholar
• Bürkner, P.-C., Bittner, N., Holling, H., Buhlmann, U., & Hashimoto, K. (2017). D-cycloserine augmentation of behavior therapy for anxiety and obsessive-compulsive disorders: A meta-analysis. PloS One, 12(3), 1–19.
   Web of Science ®Google Scholar
• Campbell, M., Decker, K. P., Kruk, K., & Deaver, S. P. (2016). Art therapy and cognitive processing therapy for combat-related PTSD: A randomized controlled trial. Art Therapy, 33(4), 169–177.
   Web of Science ®Google Scholar
• Cardeña, E., Maldonado, J., van der Hart, O., & Spiegel, D. (2000). Hypnosis. In E. B. Foa, T. M. Keane, & M. J. Friedman (Eds.), Effective treatments for PTSD (pp. 247–279). NewYork: Guilford.
   Google Scholar
• Carpenter, J. K., Andrews, L. A., Witcraft, S. M., Powers, M. B., Smits, J. A. J., & Hofmann, S. G. (2018). Cognitive behavioral therapy for anxiety and related disorders: A meta‐analysis of randomized placebo‐controlled trials. Depression and Anxiety, 35(6), 502–514.
   PubMed Web of Science ®Google Scholar
• Chapman, J. J., Coombes, J. S., Brown, W. J., Khan, A., Chamoli, S., Pachana, N. A., & Burton, N. W. (2017). The feasibility and acceptability of high-intensity interval training for adults with mental illness: A pilot study. Mental Health and Physical Activity, 13, 40–48.
   Web of Science ®Google Scholar
• Collie, K., Backos, A., Malchiodi, C., & Spiegel, D. (2006). Art therapy for combat-related PTSD: Recommendations for research and practice. Art Therapy, 23(4), 157–164.
   Google Scholar
• Cusack, K., Jonas, D. E., Forneris, C. A., Wines, C., Sonis, J., Middleton, J. C., … Gaynes, B. N. (2016). Psychological treatments for adults with posttraumatic stress disorder: A systematic review and meta-analysis. Clinical Psychology Review, 43, 128–141.
   PubMed Web of Science ®Google Scholar
• Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006). Review: Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biological Psychiatry, 60, 369–375.
   PubMed Web of Science ®Google Scholar
• de Kleine, R. A., Hendriks, G.-J., Kusters, W. J., Broekman, T. G., & van Minnen, A. (2012). A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biological Psychiatry, 71(11), 962–968.
   PubMed Web of Science ®Google Scholar
• de Quervain, D., Schwabe, L., & Roozendaal, B. (2017). Stress, glucocorticoids and memory: Implications for treating fear-related disorders. Nature Reviews Neuroscience, 18(1), 7.
   PubMed Web of Science ®Google Scholar
• de Quervain, D. J. F., Bentz, D., Michael, T., Bolt, O. C., Wiederhold, B. K., Margraf, J., & Wilhelm, F. H. (2011). Glucocorticoids enhance extinction-based psychotherapy. Proceedings of the National Academy of Sciences, 108(16), 6621–6625. PubMed PMID: edsbas.6C0FDA32
   PubMed Web of Science ®Google Scholar
• Difede, J., Cukor, J., Wyka, K., Olden, M., Hoffman, H., Lee, F. S., & Altemus, M. (2014). D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial. Neuropsychopharmacology, 39(5), 1052–1058.
   Web of Science ®Google Scholar
• Ehlers, A., Clark, D. M., Hackmann, A., McManus, F., & Fennell, M. (2005). Cognitive therapy for post-traumatic stress disorder: Development and evaluation. Behaviour Research and Therapy, 43(4), 413–431.
   PubMed Web of Science ®Google Scholar
• Engel, C. C., Cordova, E. H., Benedek, D. M., Liu, X., Gore, K. L., Goertz, C., … Ursano, R. J. (2014). Randomized effectiveness trial of a brief course of acupuncture for posttraumatic stress disorder. Medical Care, 52(12), S57–S64.
   Web of Science ®Google Scholar
• Fetzner, M. G., & Asmundson, G. J. G. (2015). Aerobic exercise reduces symptoms of posttraumatic stress disorder: A randomized controlled trial. Cognitive Behaviour Therapy, 44(4), 301–313.
   PubMed Web of Science ®Google Scholar
• Flanagan, J. C., Sippel, L. M., Wahlquist, A., Moran-Santa Maria, M. M., & Back, S. E. (2018). Augmenting prolonged exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial. Journal of Psychiatric Research, 98, 64–69.
   PubMed Web of Science ®Google Scholar
• Flatten, G., Gast, U., Hofmann, A., Knaevelsrud, C., Lampe, A., Liebermann, P., ... Wöller, W. (2013). Posttraumatische Belastungsstörung: S3-Leitlinie und Quellentexte (pp. 147). Stuttgart: Schattauer.
   Google Scholar
• Foa, E. B., Hembree, E. A., & Rothbaum, B. O. (2007). Prolonged exposure therapy for PTSD: Emotional processing of traumatic experiences; therapist guide (pp. 2007). Oxford: Oxford University Press.
   Google Scholar
• Forbes, D., Creamer, M., Phelps, A., Bryant, R., McFarlane, A., Devilly, G. J., … Newton, S. (2007). Australian guidelines for the treatment of adults with acute stress disorder and post-traumatic stress disorder. The Australian and New Zealand Journal of Psychiatry, 41(8), 637–648.
   PubMed Web of Science ®Google Scholar
• Galovski, T. E., Harik, J. M., Blain, L. M., Elwood, L., Gloth, C., & Fletcher, T. D. (2016). Augmenting cognitive processing therapy to improve sleep impairment in PTSD: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 84(2), 167.
   PubMed Web of Science ®Google Scholar
• Gapen, M., van der Kolk, B. A., Hamlin, E., Hirshberg, L., Suvak, M., & Spinazzola, J. (2016). A pilot study of neurofeedback for chronic PTSD. Applied Psychophysiology and Biofeedback, 41(3), 251–261.
   PubMed Web of Science ®Google Scholar
• Glynn, S. M., Eth, S., Randolph, E. T., Foy, D. W., Leong, G. B., Paz, G. G., ... Katzman. (1995). Behavioral family therapy for Vietnam combat veterans with posttraumatic stress disorder. The Journal of Psychotherapy Practice and Research, 4(3), 214.
   Google Scholar
• Glynn, S. M., Eth, S., Randolph, E. T., Foy, D. W., Urbaitis, M., Boxer, L., … Crothers, J. (1999). A test of behavioral family therapy to augment exposure for combat-related posttraumatic stress disorder. Journal of Consulting and Clinical Psychology, 67(2), 243–251.
   Web of Science ®Google Scholar
• Goldstein, L. A., Mehling, W. E., Metzler, T. J., Cohen, B. E., Barnes, D. E., Choucroun, G. J., … Neylan, T. C. (2018). Veterans group exercise: A randomized pilot trial of an integrative exercise program for veterans with posttraumatic stress. Journal of Affective Disorders, 227, 345–352.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Lima, F., & Bruchey, A. K. (2004). Extinction memory by the metabolic enhancer improvement methylene blue. Learning & Memory, 11(5), 633–640.
   Web of Science ®Google Scholar
• Grant, S., Colaiaco, B., Motala, A., Shanman, R., Sorbero, M., & Hempel, S. (2018). Acupuncture for the treatment of adults with posttraumatic stress disorder: A systematic review and meta-analysis. Journal of Trauma & Dissociation, 19(1), 39–58.
   PubMed Web of Science ®Google Scholar
• Habetha, S., Bleich, S., Weidenhammer, J., & Fegert, J. M. (2012). A prevalence-based approach to societal costs occurring in consequence of child abuse and neglect. Child and Adolescent Psychiatry and Mental Health, 6(1), 35.
   Google Scholar
• Hackney, A. C. (2006). Stress and the neuroendocrine system: The role of exercise as a stressor and modifier of stress. Expert Review of Endocrinology & Metabolism, 1(6), 783–792.
   PubMedGoogle Scholar
• Higgins, J. P., & Green, S. (2011, March). Cochrane handbook for systematic review of interventions version 5.1. The Cochrane Collaboration. Retrieved from https://training.cochrane.org/handbook
   Google Scholar
• Hilton, L., Maher, A. R., Colaiaco, B., Apaydin, E., Sorbero, M. E., Booth, M., … Hempel, S. (2017). Meditation for posttraumatic stress: Systematic review and meta-analysis. Psychological Trauma: Theory, Research, Practice, and Policy, 9(4), 453–460.
   PubMed Web of Science ®Google Scholar
• Hofmann, S. G., & Smits, J. A. J. (2008). Cognitive-behavioral therapy for adult anxiety disorders: A meta-analysis of randomized placebo-controlled trials. Journal of Clinical Psychiatry, 69(4), 621–632.
   PubMed Web of Science ®Google Scholar
• Hoge, C. W., & Chard, K. M. (2018). A window into the evolution of trauma-focused psychotherapies for posttraumatic stress disorder. JAMA, 319(4), 343–345.
   PubMed Web of Science ®Google Scholar
• Lande, R. G., Williams, L. B., Francis, J. L., Gragnani, C., & Morin, M. L. (2010). Efficacy of biofeedback for post-traumatic stress disorder. Complementary Therapies in Medicine, 18(6), 256–259.
   PubMed Web of Science ®Google Scholar
• Lass-Hennemann, J., & Michael, T. (2014). Endogenous cortisol levels influence exposure therapy in spider phobia. Behaviour Research and Therapy, 60, 39–45.
   Web of Science ®Google Scholar
• Lehrer, P. M., & Gevirtz, R. (2014). Heart rate variability biofeedback: How and why does it work? Frontiers in Psychology, 5, 756.
   PubMed Web of Science ®Google Scholar
• Litz, B. T., Salters-Pedneault, K., Steenkamp, M. M., Hermos, J. A., Bryant, R. A., Otto, M. W., & Hofmann, S. G. (2012). A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder. Journal of Psychiatric Research, 46(9), 1184–1190.
   PubMed Web of Science ®Google Scholar
• Malchiodi, C. (2015). Neurobiology, creative interventions, and childhood trauma. In C. A. Malchiodi (Ed.), Creative interventions with traumatized children, 2nd ed. (pp. 3–23). New York, NY: Guilford Press.
   Google Scholar
• Marin, M.-F., Lonak, S. F., & Milad, M. R. (2015). Augmentation of evidence-based psychotherapy for PTSD with cognitive enhancers. Current Psychiatry Reports, 17(6), 39.
   Web of Science ®Google Scholar
• Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011). The safety and efficacy of (plus minus) 3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439.
   Web of Science ®Google Scholar
• Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine, 151(4), 264–269.
   PubMed Web of Science ®Google Scholar
• Morina, N., Maier, T., Bryant, R., Knaevelsrud, C., Wittmann, L., Rufer, M., … Müller, J. (2012). Combining biofeedback and Narrative Exposure Therapy for persistent pain and PTSD in refugees: A pilot study. European Journal of Psychotraumatology, 3, 17660.
   PubMed Web of Science ®Google Scholar
• National Collaborating Centre for Mental Health. (2005). Post-traumatic stress disorder: The management of PTSD in adults and children in primary and secondary care. Leicester (UK): Gaskell.
   Google Scholar
• Orwin, R., Cooper, H., & Hedges, L. (1994). The handbook of research synthesis (pp. 139–162). New York, NY: Russell Sage Foundation.
   Google Scholar
• Pacella, M. L., Hruska, B., & Delahanty, D. L. (2013). The physical health consequences of PTSD and PTSD symptoms: A meta-analytic review. Journal of Anxiety Disorders, 27(1), 33–46.
   PubMed Web of Science ®Google Scholar
• Pallmann, P., Bedding, A. W., Choodari-Oskooei, B., Dimairo, M., Flight, L., Hampson, L. V., … Jaki, T. (2018). Adaptive designs in clinical trials: Why use them, and how to run and report them. BMC Medicine, 16–29.
   Web of Science ®Google Scholar
• Peake, J. M., Tan, S. J., Markworth, J. F., Broadbent, J. A., Skinner, T. L., & Cameron-Smith, D. (2014). Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise. American Journal of Physiology-Heart and Circulatory Physiology, 307(7), E539–E552.
   Google Scholar
• Polak, A. R., Witteveen, A. B., Denys, D., & Olff, M. (2015). Breathing biofeedback as an adjunct to exposure in cognitive behavioral therapy hastens the reduction of PTSD symptoms: A pilot study. Applied Psychophysiology and Biofeedback, 40(1), 25–31.
   PubMed Web of Science ®Google Scholar
• Powers, M. B., Medina, J. L., Burns, S., Kauffman, B. Y., Monfils, M., Asmundson, G. J. G., … Smits, J. A. J. (2015). Exercise augmentation of exposure therapy for PTSD: Rationale and pilot efficacy data. Cognitive Behaviour Therapy, 44(4), 314–327.
   PubMed Web of Science ®Google Scholar
• Reiter, K., Andersen, S. B., & Carlsson, J. (2016). Neurofeedback treatment and posttraumatic stress disorder effectiveness of neurofeedback on posttraumatic stress disorder and the optimal choice of protocol. Journal of Nervous and Mental Disease, 204(2), 69–77.
   PubMed Web of Science ®Google Scholar
• Resick, P. A., & Schnicke, M. (1993). Cognitive processing therapy for rape victims: A treatment manual. Newbury Park: Sage Publications.
   Google Scholar
• Riha, P. D., Rojas, J. C., & Gonzalez-Lima, F. (2011). Beneficial network effects of methylene blue in an amnestic model. Neuroimage, 54(4), 2623–2634.
   PubMed Web of Science ®Google Scholar
• Rosenbaum, S., Sherrington, C., & Tiedemann, A. (2015). Exercise augmentation compared with usual care for post‐traumatic stress disorder: A randomized controlled trial. Acta Psychiatrica Scandinavica, 131(5), 350–359.
   PubMed Web of Science ®Google Scholar
• Rothbaum, B. O., Price, M., Jovanovic, T., Norrholm, S. D., Gerardi, M., Dunlop, B., … Ressler, K. J. (2014). A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans. The American Journal of Psychiatry, 171(6), 640–648.
   PubMed Web of Science ®Google Scholar
• Schnurr, P. P., Friedman, M. J., Engel, C. C., Foa, E. B., Shea, M. T., Chow, B. K., … Bernardy, N. (2007). Cognitive behavioral therapy for posttraumatic stress disorder in women: A randomized controlled trial. JAMA, 297(8), 820–830.
   PubMed Web of Science ®Google Scholar
• Schottenbauer, M. A., Glass, C. R., Arnkoff, D. B., Tendick, V., & Gray, S. H. (2008). Nonresponse and dropout rates in outcome studies on PTSD: Review and methodological considerations. Psychiatry: Interpersonal and Biological Processes, 71(2), 134–168.
   PubMed Web of Science ®Google Scholar
• Shapiro, F. (1995). Eye movement desensitization and reprocessing: Basic principles, protocols, and procedures (Vol. 3, pp. 1995). New York: Guilford. print.
   Google Scholar
• Sherman, M. D., Larsen, J., Straits-Troster, K., Erbes, C., & Tassey, J. (2015). Veteran-child communication about parental PTSD: A mixed methods pilot study. Journal of Family Psychology, 29(4), 595–603.
   PubMed Web of Science ®Google Scholar
• Sherman, M. D., & Larsen, J. L. (2018). Family-focused interventions and resources for veterans and their families. Psychological Services, 15(2), 146–153.
   Web of Science ®Google Scholar
• Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. (2015). Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacology & Therapeutics, 149, 150–190.
   PubMed Web of Science ®Google Scholar
• Soravia, L. M., Heinrichs, M., Winzeler, L., Fisler, M., Schmitt, W., Horn, H., … de Quervain, D. J.-F. (2014). Glucocorticoids enhance in vivo exposure‐based therapy of spider phobia. Depression & Anxiety, 31(5), 429–435.
   Web of Science ®Google Scholar
• Tan, G., Dao, T. K., Farmer, L., Sutherland, R. J., & Gevirtz, R. (2011). Heart Rate Variability (HRV) and Posttraumatic Stress Disorder (PTSD): A pilot study. Applied Psychophysiology and Biofeedback, 36(1), 27–35.
   PubMed Web of Science ®Google Scholar
• Telch, M. J., Bruchey, A. K., Rosenfield, D., Cobb, A. R., Smits, J., Pahl, S., & Gonzalez-Lima, F. (2014). Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia. The American Journal of Psychiatry, 171(10), 1091–1098.
   PubMed Web of Science ®Google Scholar
• Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., III, & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience & Biobehavioral Reviews, 36(2), 747–756.
   PubMed Web of Science ®Google Scholar
• Tolin, D. F. (2017). Can cognitive behavioral therapy for anxiety and depression be improved with pharmacotherapy? A meta-analysis. Psychiatric Clinics, 40(4), 715–738.
   Google Scholar
• Tuerk, P. W., Wangelin, B. C., Powers, M. B., Smits, J. A., Acierno, R., Myers, U. S., ... Hamner, M. B. (2018). Augmenting treatment efficiency in exposure therapy for PTSD: A randomized double-blind placebo-controlled trial of yohimbine HCl. Cognitive Behaviour Therapy, 14(5), 1–21.
   Google Scholar
• Whealin, J. M., Yoneda, A. C., Nelson, D., Hilmes, T. S., Kawasaki, M. M., & Yan, O. H. (2017). A culturally adapted family intervention for rural pacific Island veterans with PTSD. Psychological Services, 14(3), 295–306.
   Web of Science ®Google Scholar
• Wittchen, H. U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jonsson, B., … Steinhausen, H.-C. (2011). The size and burden of mental disorders and other disorders of the brain in Europe 2010. European Neuropsychopharmacology, 21(9), 655–679.
   PubMed Web of Science ®Google Scholar
• World Health Organization. (2013). Guidelines for the management of conditions specifically related to stress. Geneva, Switzerland: WHO.
   Google Scholar
• Wynn, G. H. (2015). Complementary and alternative medicine approaches in the treatment of PTSD. Current Psychiatry Reports, 17(8), 62.
   Web of Science ®Google Scholar
• Yehuda, R., Bierer, L. M., Pratchett, L. C., Lehrner, A., Koch, E. C., Van Manen, J. A., … Hildebrandt, T. (2015). Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and outcome. Psychoneuroendocrinology, 51, 589–597.
   PubMed Web of Science ®Google Scholar
• Zoellner, L. A., Telch, M., Foa, E. B., Farach, F. J., McLean, C. P., Gallop, R., … Gonzalez-Lima, F. (2017). Enhancing extinction learning in posttraumatic stress disorder with brief daily imaginal exposure and methylene blue: A randomized controlled trial. The Journal of Clinical Psychiatry, 78(7), E782–E789.
   Web of Science ®Google Scholar
• Zucker, T. L., Samuelson, K. W., Muench, F., Greenberg, M. A., & Gevirtz, R. N. (2009). The effects of respiratory sinus arrhythmia biofeedback on heart rate variability and posttraumatic stress disorder symptoms: A pilot study. Applied Psychophysiology and Biofeedback, 34(2), 135–143.
   PubMed Web of Science ®Google Scholar