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Research Article

Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset

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Article: 1657756 | Received 26 Jun 2019, Accepted 15 Aug 2019, Published online: 22 Aug 2019

References

  • Rosak C, Mertes G. Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations. Diabetes Metab Syndr Obes. 2012;5:1–8. PubMed PMID: 23093911; PubMed Central PMCID: PMC3476372.
  • Strong R, Miller RA, Antebi A, et al. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. 2016;15(5):872–884. PubMed PMID: 27312235.
  • Harrison DE, Strong R, Allison DB, et al. Acarbose, 17-alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014;13(2):273–282. PubMed PMID: 24245565; PubMed Central PMCID: PMC3954939.
  • Cusi K, DeFronzo RA. Metformin: a review of its metabolic effects. Diabetes Rev. 1998;6(2): 89–131. PubMed PMID: WOS:000077170200002.
  • Hundal RS, Krssak M, Dufour S, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes. 2000;49(12):2063–2069. PubMed PMID: WOS:000165573500013.
  • Martin-Montalvo A, Mercken EM, Mitchell SJ, et al. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013;4:2192. PubMed PMID: 23900241; PubMed Central PMCID: PMC3736576.
  • Justice JN, Ferrucci L, Newman AB, et al. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience. 2018. PubMed PMID: 30151729. DOI:10.1007/s11357-018-0042-y.
  • Barzilai N, Crandall JP, Kritchevsky SB, et al. Metformin as a tool to target aging. Cell Metab. 2016;236:1060–1065. PubMed PMID: WOS:000378000600018.
  • Tardif SD, Mansfield KG, Ratnam R, et al. The marmoset as a model of aging and age-related disease. Inst Lab Anim Res J. 2011;52(1):54–65.
  • Tardif S, Ross C, Bergman P, et al. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci. 2015;70(5):577–587. PubMed PMID: 25038772; PubMed Central PMCID: PMC4400395.
  • Lin JH. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab Dispos. 1998;26(12): 1202–1212. PubMed PMID: WOS:000077689700010.
  • Decensi A, Puntoni M, Goodwin P, et al. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res. 2010;3(11):1451–1461. PubMed PMID: 20947488.
  • Zhang ZJ, Bi Y, Li S, et al. Reduced risk of lung cancer with metformin therapy in diabetic patients: a systematic review and meta-analysis. Am J Epidemiol. 2014;180(1):11–14. PubMed PMID: 24920786.
  • Lin Y, Wang K, Ma C, et al. Evaluation of metformin on cognitive improvement in patients with non-dementia vascular cognitive impairment and abnormal glucose metabolism. Front Aging Neurosci. 2018;10:227. PubMed PMID: 30100873; PubMed Central PMCID: PMC6074058.
  • Holman RR, Coleman RL, Chan JCN, et al. Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017 Nov;5:877–886. PubMed PMID: 28917545.
  • Hsu PF, Sung SH, Cheng HM, et al. Cardiovascular benefits of acarbose versus sulfonylureas in type 2 diabetic patients treated with metformin. J Clin Endocrinol Metab. 2018;103:3611–3619. PubMed PMID: 30113697.
  • Chan KC, Yu MH, Lin MC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016;6:38642. PubMed PMID: 27924924; PubMed Central PMCID: PMC5141573.
  • Minatoguchi S, Zhang Z, Bao N, et al. Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits. J Cardiovasc Pharmacol. 2009;54(1):25–30. PubMed PMID: 19487955.
  • Chao CT, Wang J, Huang JW, et al. Acarbose use and liver injury in diabetic patients with severe renal insufficiency and hepatic diseases: a propensity score-matched cohort study. Front Pharmacol. 2018;9. PubMed PMID: WOS:000441016700001. DOI:10.3389/Fphar.2018.00860
  • Gu Y, Wang X, Li J, et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nat Commun. 2017;8(1):1785. PubMed PMID: 29176714; PubMed Central PMCID: PMC5702614.
  • Zhang X, Fang Z, Zhang C, et al. Effects of acarbose on the gut microbiota of prediabetic patients: a randomized, double-blind, controlled crossover trial. Diabetes Therapy. 2017;8(2):293–307. PubMed PMID: 28130771; PubMed Central PMCID: PMC5380489.
  • Garratt M, Bower B, Garcia GG, et al. Sex differences in lifespan extension with acarbose and 17-alpha estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell. 2017;166:1256–1266. PubMed PMID: 28834262; PubMed Central PMCID: PMC5676051.
  • Gibbs VK, Brewer RA, Miyasaki ND, et al. Sex-dependent differences in liver and gut metabolomic profiles with acarbose and calorie restriction in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2018;732:157–165. PubMed PMID: 28651373; PubMed Central PMCID: PMC5861978.
  • Sadagurski M, Cady G, Miller RA. Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner. Aging Cell. 2017;164:652–660. PubMed PMID: 28544365; PubMed Central PMCID: PMC5506421.
  • Weiss R, Fernandez E, Liu Y, et al. Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice. Aging (Albany NY). 2018;10:386–401. PubMed PMID: 29579736.
  • Ahr HJ, Boberg M, Krause HP, et al. Pharmacokinetics of acarbose .1. Absorption, concentration in plasma, metabolism and excretion after single administration of [C-14]acarbose to rats, dogs and man. Arzneimittel-Forsch. 1989;39-2(10):1254–1260. PubMed PMID: WOS:A1989AW02200017.
  • Yu MH, Lin MC, Huang CN, et al. Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling. Vascul Pharmacol. 2018;103–105:8–15. PubMed PMID: 29432898.
  • Sahdeo S, Tomilov A, Komachi K, et al. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014;17:116–125.
  • Rosen P, Osmers A. Oxidative stress in young Zucker rats with impaired glucose tolerance is diminished by acarbose. Horm Metab Res. 2006;389:575–580. PubMed PMID: WOS:000241498400005.
  • Chakraborty A, Chowdhury S, Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract. 2011;931:56–62. PubMed PMID: 21146883.
  • Andrzejewski S, Gravel SP, Pollak M, et al. Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab. 2014;2:12. PubMed PMID: 25184038; PubMed Central PMCID: PMC4147388.
  • Salmon AB. Moving toward ‘common’ use of the marmoset as a non-human primate aging model. Pathobiol Aging Age Relat Dis. 2016;6:32758. PubMed PMID: 27452489; PubMed Central PMCID: PMCPMC4958916.
  • Kaeberlein M. How healthy is the healthspan concept? GeroScience. 2018;40:361–364.
  • Lee HJ, Feliers D, Barnes JL, et al. Hydrogen sulfide ameliorates aging-associated changes in the kidney. GeroScience. 2018;40(2):163–176. PubMed PMID: 29717417; PubMed Central PMCID: PMC5964063.
  • Masser DR, Hadad N, Porter H, et al. Analysis of DNA modifications in aging research. Geroscience. 2018;40(1):11–29. PubMed PMID: 29327208; PubMed Central PMCID: PMC5832665.
  • An JY, Quarles EK, Mekvanich S, et al. Rapamycin treatment attenuates age-associated periodontitis in mice. GeroScience. 2017;39(4):457–463. PubMed PMID: PMC5636779.
  • Moore TL, Bowley B, Shultz P, et al. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017;39(5–6):571–584. PubMed PMID: WOS:000418822500006.
  • Kim S, Myers L, Wyckoff J, et al. The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. Geroscience. 2017;391:83–92. PubMed PMID: WOS:000401331200009.
  • Kane AE, Gregson E, Theou O, et al. The association between frailty, the metabolic syndrome, and mortality over the lifespan. Geroscience. 2017;392:221–229. PubMed PMID: WOS:000401636600008.
  • Snider TA, Richardson A, Stoner JA, et al. The geropathology grading platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging. GeroScience. 2018;402:97–103. PubMed PMID: PMC5964058.