Advanced search
Publication Cover
Pathobiology of Aging & Age-related Diseases Volume 9, 2019 - Issue 1
Journal homepage
1,258
Views
2
CrossRef citations to date
0
Altmetric
Technical Report

Cross species application of quantitative neuropathology assays developed for clinical Alzheimer’s disease samples

Silvan R. UrferDepartment of Pathology, University of Washington, Seattle, WA, USAORCID Iconhttps://orcid.org/0000-0002-3722-0731View further author information
ORCID Icon,
Caitlin S. LatimerDepartment of Pathology, University of Washington, Seattle, WA, USAView further author information
,
Warren LadigesDepartment of Comparative Medicine, University of Washington, Seattle, WA, USAView further author information
,
C. Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USAView further author information
,
Sarah BenbowDepartment of Medicine, University of Washington, Seattle, WA, USA;Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA;Veterans Affairs Geriatric Research Education and Clinical Center, Seattle, WA, USAView further author information
,
Benjamin HarrisonDepartment of Pathology, University of Washington, Seattle, WA, USAView further author information
,
Daniel E.L. PromislowDepartment of Pathology, University of Washington, Seattle, WA, USAView further author information
,
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA, USAView further author information
,
Brian C KraemerDepartment of Pathology, University of Washington, Seattle, WA, USA;Department of Medicine, University of Washington, Seattle, WA, USA;Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA;Veterans Affairs Geriatric Research Education and Clinical Center, Seattle, WA, USAView further author information
,
Adrienne WangDepartment of Biology, Western Washington University, Bellingham, WA, USAView further author information
,
Franco GuscettiInstitute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, SwitzerlandORCID Iconhttps://orcid.org/0000-0002-3173-4811View further author information
ORCID Icon &
Martin DarvasDepartment of Pathology, University of Washington, Seattle, WA, USACorrespondence[email protected]
View further author information
 show all
Article: 1657768 | Received 12 Jun 2019, Accepted 16 Aug 2019, Published online: 03 Sep 2019

References

  • A. Alzheimer's. Alzheimer's disease facts and figures, Alzheimer's & dementia: the journal of the Alzheimer's Association. 2016; 12 (2016): 459–509.
  • Hyman BT, Phelps CH, Beach TG, et al. National institute on aging-Alzheimer’s association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement. 2012;8(1):1–6.
  • Keene CD, Darvas M, Kraemer B, et al. Neuropathological assessment and validation of mouse models for Alzheimer’s disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016;6:32397.
  • Keene CD,  Wilson AM, Kilgore MD et al. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab. Invest. 2019; 99(7): 1056–1067.
  • Jankowsky JL, Fadale DJ, Anderson J, et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004;13(2):159–170.
  • Fonte V, Dostal V, Roberts CM, et al. A glycine zipper motif mediates the formation of toxic beta-amyloid oligomers in vitro and in vivo. Mol Neurodegener. 2011;6(1):61.
  • Wittmann CW, Wszolek MF, Shulman JM, et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001;293(5530):711–714.
  • Finelli A, Kelkar A, Song H-J, et al. A model for studying Alzheimer’s Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci. 2004;26(3):365–375.
  • Yoshiyama Y, Higuchi M, Zhang B, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007;53(3):337–351.
  • Kraemer BC, Zhang B, Leverenz JB, et al. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc Natl Acad Sci U S A. 2003;100(17):9980–9985.
  • Taylor LM, McMillan PJ, Liachko NF, et al. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Mol Neurodegener. 2018;13(1):7.
  • Latimer CS, Shively CA, Keene CD, et al. A nonhuman primate model of early Alzheimer’s disease pathologic change: Implications for disease pathogenesis. Alzheimers Dement. 2019;15(1):93–105.
  • Schmidt F, Boltze J, Jäger C, et al. detection and quantification of beta-amyloid, pyroglutamyl Abeta, and Tau in aged canines. J Neuropathol Exp Neurol. 2015;74(9):912–923.
  • Smolek T, Madari A, Farbakova J, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524(4):874–895.
  • Yu C-H, Song G-S, Yhee J-Y, et al. Histopathological and immunohistochemical comparison of the brain of human patients with Alzheimer’s disease and the brain of aged dogs with cognitive dysfunction. J Comp Pathol. 2011;145(1):45–58.
  • Wegiel J, Wisniewski HM, Soltysiak Z. Region- and cell-type-specific pattern of tau phosphorylation in dog brain. Brain Res. 1998;802(1–2):259–266.
  • Schütt T, Helboe L, Pedersen LØ, et al. Dogs with cognitive dysfunction as a spontaneous model for early Alzheimer’s disease: a translational study of neuropathological and inflammatory markers. J Alzheimers Dis. 2016;52(2):433–449.
  • Walker LC, Jucker M. The exceptional vulnerability of humans to Alzheimer’s disease. Trends Mol Med. 2017;23(6):534–545.
  • Sharma G, Huo A, Kimura T, et al. Tau isoform expression and phosphorylation in marmoset brains. J Biol Chem. 2019;294(30):11433–11444.
  • Chambers JK, Tokuda T, Uchida K, et al. The domestic cat as a natural animal model of Alzheimer’s disease. Acta Neuropathol Commun. 2015;3:78.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.