Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36

References

• Tuttle KR, Bakris GL, Bilous RW, et al. Diabetic kidney disease: a report from an ADA Consensus Conference. Am J Kidney Dis. 2014;64(4):1–12.
   Web of Science ®Google Scholar
• Pavenstädt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003;83(1):253–307.
   PubMed Web of Science ®Google Scholar
• Stitt-Cavanagh E, MacLeod L, Kennedy C. The podocyte in diabetic kidney disease. ScientificWorldJournal. 2009;9:1127–1139.
   PubMedGoogle Scholar
• Adler S. Diabetic nephropathy: linking histology, cell biology, and genetics. Kidney Int. 2004;66(5):2095–2106.
   PubMed Web of Science ®Google Scholar
• Maezawa Y, Takemoto M, Yokote K. Cell biology of diabetic nephropathy: roles of endothelial cells, tubulointerstitial cells and podocytes. J Diabetes Investig. 2015;6(1):3–15.
   PubMed Web of Science ®Google Scholar
• Najafian B, Alpers CE, Fogo AB. Pathology of human diabetic nephropathy. Contrib Nephrol. 2011;170:36–47.
   PubMed Web of Science ®Google Scholar
• Najafian B, Kim Y, Crosson JT, et al. Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy. J Am Soc Nephrol. 2003;14(4):908–917.
   PubMed Web of Science ®Google Scholar
• Gilbert RE, Cooper ME. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int. 1999;56(5):1627–1637.
   PubMed Web of Science ®Google Scholar
• Qian Y, Feldman E, Pennathur S, et al. From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes. 2008;57(6):1439–1445.
   PubMed Web of Science ®Google Scholar
• Gorriz JL, Martinez-Castelao A. Proteinuria: detection and role in native renal disease progression. Transplant Rev (Orlando). 2012;26(1):3–13.
   Google Scholar
• Keener J, Sneyd J. Intercellular communication. In: Keener J, Sneyd J, editors. Mathematical physiology: I: cellular physiology. New York, NY: Springer New York; 2009. p. 347–384.
   Google Scholar
• Erdbrugger U, Le TH. Extracellular vesicles in renal diseases: more than novel biomarkers? J Am Soc Nephrol. 2015;27(1):12-26.
   Web of Science ®Google Scholar
• Mause SF, Weber C. Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res. 2010;107(9):1047–1057.
   PubMed Web of Science ®Google Scholar
• Hugel B, Martínez MC, Kunzelmann C, et al. Membrane microparticles: two sides of the coin. Physiology (Bethesda). 2005;20:22–27.
   PubMed Web of Science ®Google Scholar
• Burger D, Montezano AC, Nishigaki N, et al. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/Rho kinase pathways targeted to lipid rafts. Arterioscler Thromb Vasc Biol. 2011;31(8):1898–1907.
   PubMed Web of Science ®Google Scholar
• Brodsky SV, Zhang F, Nasjletti A, et al. Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol. 2004;286(5):H1910–H1915.
   PubMed Web of Science ®Google Scholar
• Burger D, Kwart DG, Montezano AC, et al. Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. J Am Heart Assoc. 2012;1(3):e001842.
   PubMed Web of Science ®Google Scholar
• Burger D, Turner M, Munkonda MN, et al. Endothelial microparticle-derived reactive oxygen species: role in endothelial signaling and vascular function. Oxid Med Cell Longev. 2016;2016:5047954.
   Web of Science ®Google Scholar
• Niessen A, Heyder P, Krienke S, et al. Apoptotic-cell-derived membrane microparticles and IFN-alpha induce an inflammatory immune response. J Cell Sci. 2015;128(14):2443–2453.
   Web of Science ®Google Scholar
• Burger D, Schock S, Thompson CS, et al. Microparticles: biomarkers and beyond. Clin Sci (Lond). 2013;124(7):423–441.
   PubMed Web of Science ®Google Scholar
• Gyorgy B, Szabo TG, Pasztoi M, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68(16):2667–2688.
   PubMed Web of Science ®Google Scholar
• Morel O, Toti F, Bakouboula B, et al. Procoagulant microparticles: ‘criminal partners’ in atherothrombosis and deleterious cellular exchanges. Pathophysiol Haemost Thromb. 2006;35(1–2):15–22.
   Google Scholar
• Wang Y, Chen L-M, Liu M-L. Microvesicles and diabetic complications [mdash] novel mediators, potential biomarkers and therapeutic targets. Acta Pharmacol Sin. 2014;35(4):433–443.
   Web of Science ®Google Scholar
• Burger D, Thibodeau J-F, Holterman CE, et al. Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury. J Am Soc Nephrol. 2014;25(7):1401–1407.
   Web of Science ®Google Scholar
• Lytvyn Y, Xiao F, Kennedy CR, et al. Assessment of urinary microparticles in normotensive patients with type 1 diabetes. Diabetologia. 2017;60(3):581–584.
   Web of Science ®Google Scholar
• Saleem MA, O’Hare MJ, Reiser J, et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol. 2002;13(3):630–638.
   PubMed Web of Science ®Google Scholar
• Burger D, Oleynik P. Isolation and characterization of circulating microparticles by flow cytometry. Methods Mol Biol. 2017;1527:271–281.
   Google Scholar
• Viñas JL, Burger D, Zimpelmann J, et al. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury. Kidney Int. 2016;90(6):1238–1250.
   Web of Science ®Google Scholar
• Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-β signaling in fibrosis. Growth Factors. 2011;29(5):196–202.
   PubMed Web of Science ®Google Scholar
• Pohlers D, Brenmoehl J, Löffler I, et al. TGF-beta and fibrosis in different organs - molecular pathway imprints. Biochim Biophys Acta. 2009;1792(8):746–756.
   PubMed Web of Science ®Google Scholar
• Samarakoon R, Overstreet JM, Higgins SP, et al. TGF-beta1  → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res. 2012;347(1):117–128.
   Web of Science ®Google Scholar
• Vallon V. The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol. 2011;300(5):R1009–R1022.
   PubMed Web of Science ®Google Scholar
• Adhikary L, Chow F, Nikolic-Paterson DJ, et al. Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy. Diabetologia. 2004;47(7):1210–1222.
   PubMed Web of Science ®Google Scholar
• Nishida M, Okumura Y, Sato H, et al. Delayed inhibition of p38 mitogen-activated protein kinase ameliorates renal fibrosis in obstructive nephropathy. Nephrol Dial Transplant. 2008;23(8):2520–2524.
   PubMed Web of Science ®Google Scholar
• Stambe C, Atkins RC, Hill PA, et al. Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. Kidney Int. 2003;64(6):2121–2132.
   Web of Science ®Google Scholar
• Nicholson AC, Han J, Febbraio M, et al. Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis. Ann N Y Acad Sci. 2001;947:224–228.
   Web of Science ®Google Scholar
• Park YM. CD36, a scavenger receptor implicated in atherosclerosis. Exp Mol Med. 2014;46:e99.
   PubMed Web of Science ®Google Scholar
• Lopez-Vilchez I, Diaz-Ricart M, Galan AM, et al. Internalization of tissue factor-rich microvesicles by platelets occurs independently of GPIIb-IIIa, and involves CD36 receptor, serotonin transporter and cytoskeletal assembly. J Cell Biochem. 2016;117(2):448–457.
   Web of Science ®Google Scholar
• Ranghino A, Dimuccio V, Papadimitriou E, et al. Extracellular vesicles in the urine: markers and mediators of tissue damage and regeneration. Clin Kidney J. 2015;8(1):23–30.
   Web of Science ®Google Scholar
• Eyre J, Burton JO, Saleem MA, et al. Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes. Nephron Exp Nephrol. 2011;119(3):e58–e66.
   Google Scholar
• Fernandez-Martínez AB, Torija AV, Carracedo J, et al. Microparticles released by vascular endothelial cells increase hypoxia inducible factor expression in human proximal tubular HK-2 cells. Int J Biochem Cell Biol. 2014;53:334–342.
   Web of Science ®Google Scholar
• Zhou Y, Xiong M, Fang L, et al. miR-21-containing microvesicles from injured tubular epithelial cells promote tubular phenotype transition by targeting PTEN protein. Am J Pathol. 2013;183(4):1183–1196.
   PubMed Web of Science ®Google Scholar
• Povero D, Panera N, Eguchi A, et al. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cells via microRNA targeting peroxisome proliferator-activated receptor-γ. Cell Mol Gastroenterol Hepatol. 2015;1(6):646–663.e644.
   PubMed Web of Science ®Google Scholar
• Susztak K, Ciccone E, McCue P, et al. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2005;2(2):e45.
   PubMed Web of Science ®Google Scholar
• Yang Y-L, Lin S-H, Chuang L-Y, et al. CD36 is a novel and potential anti-fibrogenic target in albumin-induced renal proximal tubule fibrosis. J Cell Biochem. 2007;101(3):735–744.
   Web of Science ®Google Scholar
• Okamura DM, Pennathur S, Pasichnyk K. López-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA. CD36 Regulates Oxidative Stress and Inflammation in Hypercholesterolemic CKD. J Am Soc Nephrol: JASN. 2009;20(3):495–505.
   PubMed Web of Science ®Google Scholar
• Souza AC, Bocharov AV, Baranova IN, et al. Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation. Kidney Int. 2016;89(4):809–822.
   Web of Science ®Google Scholar
• Burch ML, Ballinger ML, Yang SNY, et al. Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor. J Biol Chem. 2010;285(35):26798–26805.
   Web of Science ®Google Scholar
• Chung H, Ramachandran R, Hollenberg MD, et al. Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-beta receptor signaling pathways contributes to renal fibrosis. J Biol Chem. 2013;288(52):37319–37331.
   PubMed Web of Science ®Google Scholar
• Barteneva NS, Fasler-Kan E, Bernimoulin M, et al. Circulating microparticles: square the circle. BMC Cell Biol. 2013;14:23.
   PubMed Web of Science ®Google Scholar
• Morel O, Jesel L, Freyssinet J-M, et al. Cellular mechanisms underlying the formation of circulating microparticles. Arterioscler Thromb Vasc Biol. 2011;31(1):15–26.
   PubMed Web of Science ®Google Scholar
• Burger D, Turner M, Xiao F, et al. High glucose increases the formation and pro-oxidative activity of endothelial microparticles. Diabetologia. 2017;60:1791–1800.
   PubMed Web of Science ®Google Scholar
• Jansen F, Yang X, Franklin BS, et al. High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovasc Res. 2013;98(1):94–106.
   PubMed Web of Science ®Google Scholar
• Taft JL, Nolan CJ, Yeung SP, et al. Clinical and histological correlations of decline in renal function in diabetic patients with proteinuria. Diabetes. 1994;43(8):1046–1051.
   Web of Science ®Google Scholar
• Bohle A, Christ H, Grund KE, et al. The role of the interstitium of the renal cortex in renal disease. Contrib Nephrol. 1979;16:109–114.
   PubMedGoogle Scholar
• Brosius FC 3rd. New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy. Rev Endocr Metab Disord. 2008;9(4):245–254.
   PubMed Web of Science ®Google Scholar