Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing

References

• Mak K, Manji A, Gallant-Behm C, et al. Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model. J Dermatol Sci. 2009;56:168–16.
   Web of Science ®Google Scholar
• Board-Davies E, Moses R, Sloan A, et al. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Transl Med. 2015;4:1283–1293.
   Web of Science ®Google Scholar
• Khurshid Z, Naseem M, Sheikh Z, et al. Oral antimicrobial peptides: types and role in the oral cavity. Saudi Pharm J. 2016;24:515–524.
   Web of Science ®Google Scholar
• Leavitt T, Hu MS, Marshall CD, et al. Scarless wound healing: finding the right cells and signals. Cell Tissue Res. 2016;365:483–493.
   PubMed Web of Science ®Google Scholar
• Viklund P, Lindblad M, Lu M, et al. Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden. Ann Surg. 2006;243:204–211.
   PubMed Web of Science ®Google Scholar
• Ohki T, Yamato M, Murakami D, et al. Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model. Gut. 2006;55:1704–1710.
   PubMed Web of Science ®Google Scholar
• Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology. 2012;143:582–588.e2.
   PubMed Web of Science ®Google Scholar
• Yamaguchi N, Isomoto H, Kobayashi S, et al. Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation. Sci Rep. 2017;7:1–12.
   Web of Science ®Google Scholar
• Jonas E, Sjöqvist S, Elbe P, et al. Transplantation of tissue-engineered cell sheets for stricture prevention after endoscopic submucosal dissection of the oesophagus. United Eur Gastroenterol J. 2016;4:741–753.
   PubMed Web of Science ®Google Scholar
• Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4:214–222.
   PubMed Web of Science ®Google Scholar
• Tan JL, Lau SN, Leaw B, et al. Amnion epithelial cell-derived exosomes restrict lung injury and enhance endogenous lung repair. Stem Cells Transl Med. 2018;7:180–196.
   Web of Science ®Google Scholar
• Tsujii Y, Hayashi Y, Kawai N, et al. Risk of perforation in balloon dilation associated with steroid injection for preventing esophageal stricture after endoscopic submucosal dissection. Endosc Int Open. 2017;5:E573–E579.
   Web of Science ®Google Scholar
• Larjava, H,Wiebe C, Gallant-Behm C, et al. Exploring scarless healing of oral soft tissues. J Can Dent Assoc (Tor). 2011;77:1–5.
   Web of Science ®Google Scholar
• Dereli M, Krazinski BE, Ayvaz S, et al. A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis. Folia Histochem Cytobiol. 2014;52:29–35.
   Web of Science ®Google Scholar
• Kerwin LY, El Tal AK, Stiff MA, et al. Scar prevention and remodeling: A review of the medical, surgical, topical and light treatment approaches. Int J Dermatol. 2014;53:922–936.
   PubMed Web of Science ®Google Scholar
• Chhabra S, Chhabra N, Kaur A, et al. Wound healing concepts in clinical practice of OMFS. J Maxillofac Oral Surg. 2016;16:403–423.
   Web of Science ®Google Scholar
• Hans M, Madaan Hans V. Epithelial antimicrobial Peptides: guardian of the oral cavity. Int J Pept. 2014;2014:1–13.
   Google Scholar
• Isakson M, de Blacam C, Whelan D, et al. Mesenchymal stem cells and cutaneous wound healing: current evidence and future potential. Stem Cells Int. 2015;2015:831095.
   PubMed Web of Science ®Google Scholar
• Ringdén O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation. 2006;81:1390–1397.
   PubMed Web of Science ®Google Scholar
• Augustine S, Avey MT, Harrison B, et al. Mesenchymal stromal cell therapy in bronchopulmonary dysplasia: systematic review and meta-analysis of preclinical studies. Stem Cells Transl Med. 2017;6:2079–2093.
   PubMed Web of Science ®Google Scholar
• Wang L, Hu L, Zhou X, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep. 2017;7:1–12.
   PubMed Web of Science ®Google Scholar
• Kordelas L, Rebmann V, Ludwig AK, et al. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia. 2014;28:970–973.
   PubMed Web of Science ®Google Scholar
• Willis GR, Fernandez-Gonzalez A, Anastas J, et al. Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation. Am J Respir Crit Care Med. 2018;197:104–116.
   PubMed Web of Science ®Google Scholar
• Yamato M, Okano T. Cell sheet engineering. Mater Today. 2004;7:42–47.
   Web of Science ®Google Scholar
• Nishida K, Yamato M, Hayashida Y, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med. 2004;351:1187–1196.
   PubMed Web of Science ®Google Scholar
• Iwata T, Yamato M, Washio K, et al. Periodontal regeneration with autologous periodontal ligament-derived cell sheets – a safety and efficacy study in ten patients. Regener Ther. 2018;9:38–44.
   PubMed Web of Science ®Google Scholar
• Sato M, Yamato M, Hamahashi K, et al. Articular cartilage regeneration using cell sheet technology. Anat Rec. 2014;297:36–43.
   Google Scholar
• Lötvall J Hill AF, Hochberh F, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles. J Extracell Vesicles. 2014;3:26913.
   PubMedGoogle Scholar
• Tkach M, Théry C. Communication by extracellular vesicles: where we are and where we need to go. Cell. 2016;164:1226–1232.
   PubMed Web of Science ®Google Scholar
• Van Deun J, Mestdagh P, Agostinis P, et al. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods. 2017;14:228–232.
   PubMed Web of Science ®Google Scholar
• Bhatnagar V, Kumar A. Topical application of mitomycin-C in corrosive esophageal strictures. J Indian Assoc Pediatr Surg. 2005;10:25.
   Google Scholar
• Yu Y, Gool E, Berckmans RJ, et al. Extracellular vesicles from human saliva promote hemostasis by delivering coagulant tissue factor to activated platelets. J Thromb Haemost. 2018;16:1153–1163.
   Web of Science ®Google Scholar