Advanced search
Publication Cover
Journal of Extracellular Vesicles Volume 8, 2019 - Issue 1
Journal homepage
7,147
Views
70
CrossRef citations to date
0
Altmetric
Research Article

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer

Aizea Morales-KastresanaVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAORCID Iconhttps://orcid.org/0000-0003-1401-9805View further author information
ORCID Icon,
Thomas A. MusichVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Joshua A. WelshVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA;Laboratory of Pathology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAORCID Iconhttps://orcid.org/0000-0002-1097-9756View further author information
ORCID Icon,
William TelfordExperimental Immunology and Transplantation Branch, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Thorsten DembergVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
James C. S. WoodWake Forest School of Medicine Flow Cytometry Core, Winston Salem, NC, USAView further author information
,
Marty BigosStanford University School of Medicine, Stanford, CA, USAView further author information
,
Carley D. RossBeckman Coulter, Fort Collins, CO, USAView further author information
,
Aliaksander KachynskiBeckman Coulter, Fort Collins, CO, USAView further author information
,
Alan DeanBeckman Coulter, Fort Collins, CO, USAView further author information
,
Edward J. FeltonBeth Israel Deaconess Medical Center, Boston, MA, USAView further author information
,
Jonathan Van DykeUniversity of California, Davis, Sacramento, CA, USAView further author information
,
John TiggesBeth Israel Deaconess Medical Center, Boston, MA, USAView further author information
,
Vasilis ToxavidisBeth Israel Deaconess Medical Center, Boston, MA, USAView further author information
,
David R. ParksStanford University School of Medicine, Stanford, CA, USAView further author information
,
W. Roy OvertonQuantaCyte Corporation, NJ, USAView further author information
,
Aparna H. KesarwalaRadiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Gordon J. FreemanDana-Farber Cancer Institute, Boston, MA, USAView further author information
,
Ariel RosnerVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Stephen P. PerfettoVaccine Research Center, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, USAView further author information
,
Lise PasquetVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Masaki TerabeVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Katherine McKinnonVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Veena KapoorExperimental Immunology and Transplantation Branch, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Jane B. TrepelDevelopmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Anu PuriBasic Research Lab, National Cancer Institute, NIH, Frederick, MD, USAView further author information
,
Hisataka KobayashiMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Bryant YungTheranostic Nanomedicine Section, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USAORCID Iconhttps://orcid.org/0000-0003-2690-6778View further author information
ORCID Icon,
Xiaoyuan ChenTheranostic Nanomedicine Section, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USAORCID Iconhttps://orcid.org/0000-0002-9622-0870View further author information
ORCID Icon,
Peter GuionRadiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Peter ChoykeMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USAView further author information
,
Susan J. KnoxStanford University School of Medicine, Stanford, CA, USAView further author information
,
Ionita GhiranBeth Israel Deaconess Medical Center, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0001-6655-3298View further author information
ORCID Icon,
Marjorie Robert-GuroffVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
,
Jay A. BerzofskyVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USAView further author information
&
Jennifer C. JonesVaccine Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA;Laboratory of Pathology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9488-7719View further author information
ORCID Icon show all
Article: 1597603 | Received 20 Jun 2017, Accepted 23 Jan 2019, Published online: 19 Jun 2019

References

  • van der Pol E, Coumans FAW, Grootemaat AE, et al. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost. 2014;12:1182–14.
  • van der Pol E, van Gemert MJ, Sturk A, et al. Single vs. swarm detection of microparticles and exosomes by flow cytometry. J Thromb Haemost. 2012;10:919–930.
  • Erdbrugger U, Lannigan J. Analytical challenges of extracellular vesicle detection: A comparison of different techniques. Cytometry A. 2016;89:123–134.
  • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200:373–383.
  • Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14:195–208.
  • Chalmin F, Ladoire S, Mignot G, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010;120:457–471.
  • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907–1920.
  • Zitvogel L, Regnault A, Lozier A, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med. 1998;4:594–600.
  • Viaud S, Théry C, Ploix S, et al. Dendritic cell-derived exosomes for cancer immunotherapy: what‘s next?. Cancer Res. 2010;70:1281–1285.
  • Shapiro HM. Practical Flow Cytometry. John Wiley & Sons; 2005.
  • van der Vlist EJ, Nolte-‘T Hoen EN, Stoorvogel W, et al. Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry. Nat Protoc. 2012;7:1311–1326.
  • Nolan JP, Stoner SA. A trigger channel threshold artifact in nanoparticle analysis. Cytometry A. 2013;83:301–305.
  • Stoner SA, Duggan E, Condello D, et al. High sensitivity flow cytometry of membrane vesicles. Cytometry A. 2016;89:196–206.
  • Arieli R, Marmur A. Dynamics of gas micronuclei formed on a flat hydrophobic surface, the predecessors of decompression bubbles. Resp Physiol Neurobi. 2013;185:647–652.
  • Morch KA. Cavitation inception from bubble nuclei. Interface Focus. 2015;5:20150006.
  • C., M.. MATLAB functions for Mie scattering and absorption. 2002–11.
  • Musich, T., Jones, J.C., Keele, B.F., et al. Flow virometric sorting and analysis of HIV quasispecies from plasma. JCI Insight. 2017;2:e90626.
  • Chang SS, Reuter VE, Heston WD, et al. Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res. 1999;59:3192–3198.
  • Vodicka MA, Goh WC, Wu LI, et al. Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology. 1997;233:193–198.
  • Lasser C, Eldh M, Lotvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp. 2012;59:e3037.
  • Higginbotham JN, Zhang Q, Jeppesen DK, et al. Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting. J Extracell Vesicles. 2016;5:29254.
  • Cao Z, Li C, Higginbotham JN, et al. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics. 2008;7:1651–1667.
  • Groot Kormelink T, Arkesteijn GJA, Nauwelaers FA, et al. Prerequisites for the analysis and sorting of extracellular vesicle subpopulations by high-resolution flow cytometry. Cytometry A. 2016;89:135–147.
  • Danielson KM, Estanislau J, Tigges J, et al. Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry. PLoS One. 2016;11:e0144678.
  • Morales-Kastresana A, Telford B, Musich TA, et al. Labeling extracellular vesicles for nanoscale flow cytometry. Sci Rep. 2017;7:1878.
  • Musich T, O’Connell O, Gonzalez-Perez MP, et al. HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages. Retrovirology. 2015;12:25.
  • Musich T, Peters PJ, Duenas-Decamp MJ, et al. A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection. J Virol. 2011;85:2397–2405.
  • Arakelyan A, Fitzgerald W, Margolis L, et al. Nanoparticle-based flow virometry for the analysis of individual virions. J Clin Invest. 2013;123:3716–3727.
  • Welsh JA, Kepley J, Rosner A, et al. Prospective use of high-refractive index materials for single molecule detection in flow cytometry. Sensors. (Basel, Switzerland). 2018;18(8):pii: E2461.
  • Im H, Shao H, Park YI, et al. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014;32:490–495.
  • Jeong S, Park J, Pathania D, et al. Integrated magneto-electrochemical sensor for exosome analysis. ACS Nano. 2016;10:1802–1809.
  • Zhu S, Ma L, Wang S, et al. Light-scattering detection below the level of single fluorescent molecules for high-resolution characterization of functional nanoparticles. Acs Nano. 2014;8:10998–11006.
  • Hulett HR, Bonner WA, Barrett J, et al. Cell sorting: automated separation of mammalian cells as a function of intracellular fluorescence. Science. 1969;166:747–749.
  • Parks DR, Bryan VM, Oi VT, et al. Antigen-specific identification and cloning of hybridomas with a fluorescence-activated cell sorter. Proc Natl Acad Sci U S A. 1979;76:1962–1966.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.