Extracellular microRNAs in blood differentiate between ischaemic and haemorrhagic stroke subtypes

References

• Tymianski M. Stroke in 2013: disappointments and advances in acute stroke intervention. Nat Rev Neurol. 2014;10(2):66–12.
   Web of Science ®Google Scholar
• Kwiatkowski TG, Libman RB, Frankel M, et al. Effects of tissue plasminogen activator for acute ischemic stroke at one year. national institute of neurological disorders and stroke recombinant tissue plasminogen activator stroke study group. N Engl J Med. 1999;340(23):1781–1787.
   PubMed Web of Science ®Google Scholar
• National Institute of Neurological D, Stroke rt PASSG. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24):1581–1587.
   PubMed Web of Science ®Google Scholar
• Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708–718.
   PubMed Web of Science ®Google Scholar
• Dmytriw AA, Zhang Y, Mendes Pereira V. Mechanical thrombectomy and the future of acute stroke treatment. Eur J Radiol. 2019;112:214–221.
   Web of Science ®Google Scholar
• Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11–21.
   PubMed Web of Science ®Google Scholar
• Saenger AK, Christenson RH. Stroke biomarkers: progress and challenges for diagnosis, prognosis, differentiation, and treatment. Clin Chem. 2010;56(1):21–33.
   PubMed Web of Science ®Google Scholar
• Hunter MP, Ismail N, Zhang X, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One. 2008;3(11):e3694.
   PubMed Web of Science ®Google Scholar
• Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–659.
   PubMed Web of Science ®Google Scholar
• Li M, Zhang J. Circulating microRNAs: potential and emerging biomarkers for diagnosis of cardiovascular and cerebrovascular diseases. Biomed Res Int. 2015;2015:730535.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li S, Li L, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 2015;13(1):17–24.
   PubMed Web of Science ®Google Scholar
• Rosell R, Wei J, Taron M. Circulating microRNA signatures of tumor-derived exosomes for early diagnosis of non-small-cell lung cancer. Clin Lung Cancer. 2009;10(1):8–9.
   PubMed Web of Science ®Google Scholar
• Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470–1476.
   PubMed Web of Science ®Google Scholar
• Vaksman O, Trope C, Davidson B, et al. Exosome-derived miRNAs and ovarian carcinoma progression. Carcinogenesis. 2014;35(9):2113–2120.
   PubMed Web of Science ®Google Scholar
• Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012;109(31):E2110–6.
   PubMed Web of Science ®Google Scholar
• De Smaele E, Ferretti E, Gulino A. MicroRNAs as biomarkers for CNS cancer and other disorders. Brain Res. 2010;1338:100–111.
   PubMed Web of Science ®Google Scholar
• Burgos K, Malenica I, Metpally R, et al. Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathology. PLoS One. 2014;9(5):e94839.
   PubMed Web of Science ®Google Scholar
• Dewdney B, Trollope A, Moxon J, et al. Circulating microRNAs as biomarkers for acute ischemic stroke: a systematic review. J Stroke Cerebrovasc Dis. 2018;27(3):522–530.
   PubMed Web of Science ®Google Scholar
• Eyileten C, Wicik Z, De Rosa S, et al. MicroRNAs as diagnostic and prognostic biomarkers in ischemic Stroke-A comprehensive review and bioinformatic analysis. Cells. 2018;7(12):249.
   Web of Science ®Google Scholar
• Gui Y, Xu Z, Jin T, et al. Using extracellular circulating microRNAs to classify the etiological subtypes of ischemic stroke. Transl Stroke Res. 2018;10(4):352–361.
   Web of Science ®Google Scholar
• Leung LY, Chan CP, Leung YK, et al. Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke. Clin Chim Acta. 2014;433:139–144.
   PubMed Web of Science ®Google Scholar
• Liu DZ, Tian Y, Ander BP, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30(1):92–101.
   PubMed Web of Science ®Google Scholar
• Modak JM, Roy-O’Reilly M, Zhu L, et al. Differential microribonucleic acid expression in cardioembolic stroke. J Stroke Cerebrovasc Dis. 2019;28(1):121–124.
   Web of Science ®Google Scholar
• Mick E, Shah R, Tanriverdi K, et al. Stroke and circulating extracellular RNAs. Stroke. 2017;48(4):828–834.
   Web of Science ®Google Scholar
• Tiedt S, Prestel M, Malik R, et al. RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke. Circ Res. 2017;121(8):970–980.
   PubMed Web of Science ®Google Scholar
• Martinez B, Peplow PV. Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury. Neural Regen Res. 2016;11(9):1375–1378.
   PubMed Web of Science ®Google Scholar
• Ouyang YB, Stary CM, Yang GY, et al. microRNAs: innovative targets for cerebral ischemia and stroke. Curr Drug Targets. 2013;14(1):90–101.
   PubMed Web of Science ®Google Scholar
• Lotvall J, Hill AF, Hochberg F, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles. J Extracell Vesicles. 2014;3:26913.
   PubMedGoogle Scholar
• Thery C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.
   PubMed Web of Science ®Google Scholar
• Saugstad JA, Lusardi TA, Van Keuren-Jensen KR, et al. Analysis of extracellular RNA in cerebrospinal fluid. J Extracell Vesicles. 2017;6(1):1317577.
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Yeri A, Cheah PS, et al. Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell. 2019;177(2):446–62 e16.
   PubMed Web of Science ®Google Scholar
• Giraldez MD, Spengler RM, Etheridge A, et al. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018;36(8):746–757.
   PubMed Web of Science ®Google Scholar
• Yeri A, Courtright A, Danielson K, et al. Evaluation of commercially available small RNASeq library preparation kits using low input RNA. BMC Genomics. 2018;19(1):331.
   PubMed Web of Science ®Google Scholar
• Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.
   PubMed Web of Science ®Google Scholar
• Goeman JJ. L1 penalized estimation in the Cox proportional hazards model. Biom J. 2010;52(1):70–84.
   PubMed Web of Science ®Google Scholar
• Reeves MJ, Bushnell CD, Howard G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7(10):915–926.
   PubMed Web of Science ®Google Scholar
• Enderle D, Spiel A, Coticchia CM, et al. Characterization of RNA from exosomes and other extracellular vesicles isolated by a novel spin column-based method. PLoS One. 2015;10(8):e0136133.
   PubMed Web of Science ®Google Scholar
• Tang YT, Huang YY, Zheng L, et al. Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum. Int J Mol Med. 2017;40(3):834–844.
   PubMed Web of Science ®Google Scholar
• Burgos KL, Javaherian A, Bomprezzi R, et al. Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing. RNA. 2013;19(5):712–722.
   PubMed Web of Science ®Google Scholar
• Burgos KL, Van Keuren-Jensen K. RNA isolation for small RNA next-generation sequencing from acellular biofluids. Methods Mol Biol. 2014;1182:83–92.
   Google Scholar
• Cheng X, Kan P, Ma Z, et al. Exploring the potential value of miR-148b-3p, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke. Biosci Rep. 2018;38(6):BSR20181033
   Web of Science ®Google Scholar
• Liao J, Liu Y, Wang J. Identification of more objective biomarkers for blood-stasis syndrome diagnosis. BMC Complement Altern Med. 2016;16(1):371.
   Web of Science ®Google Scholar
• Arata H, Hosokawa K, Maeda M. Rapid sub-attomole microRNA detection on a portable microfluidic chip. Anal Sci. 2014;30(1):129–135.
   Web of Science ®Google Scholar
• Dave VP, Ngo TA, Pernestig AK, et al. MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics. Lab Invest. 2018;99(4):452–469.
   Web of Science ®Google Scholar
• Godoy PM, Bhakta NR, Barczak AJ, et al. Large differences in small RNA composition between human biofluids. Cell Rep. 2018;25(5):1346–1358.
   PubMed Web of Science ®Google Scholar
• Beck TF, Mullikin JC, Program NCS, et al. Systematic evaluation of Sanger validation of next-generation sequencing variants. Clin Chem. 2016;62(4):647–654.
   PubMed Web of Science ®Google Scholar
• Mestdagh P, Hartmann N, Baeriswyl L, et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods. 2014;11(8):809–815.
   PubMed Web of Science ®Google Scholar
• Mateescu B, Kowal EJ, van Balkom BW, et al. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. J Extracell Vesicles. 2017;6(1):1286095.
   PubMed Web of Science ®Google Scholar