Neuroblastoma-secreted exosomes carrying miR‐375 promote osteogenic differentiation of bone-marrow mesenchymal stromal cells

References

• Brodeur GM, Pritchard J, Berthold F, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11(8):1466–18.
   PubMed Web of Science ®Google Scholar
• Ren G, Esposito M, Kang Y. Bone metastasis and the metastatic niche. J Mol Med. 2015;93(11):1203–1212.
   Web of Science ®Google Scholar
• Méndez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829–834.
   PubMed Web of Science ®Google Scholar
• Kakonen SM, Mundy GR. Mechanisms of osteolytic bone metastases in breast carcinoma. Cancer. 2003;97:834–839.
   PubMed Web of Science ®Google Scholar
• Roodman GD. Role of the bone marrow micro-environment in multiple myeloma. J Bone Miner Res. 2002;17:1921–1925.
   PubMed Web of Science ®Google Scholar
• Krzeszinski JY, Wei W, Huynh H, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature. 2014 Aug 28;512(7515):431–435..
   PubMed Web of Science ®Google Scholar
• Brian E, Yibin K. MicroRNAs as regulators of bone homeostasis and bone metastasis. Bonekey Rep. 2014;3:549.
   Google Scholar
• Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 1989;8:98–101.
   PubMed Web of Science ®Google Scholar
• Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–659.
   PubMed Web of Science ®Google Scholar
• Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov 19;527(7578):329–335..
   PubMed Web of Science ®Google Scholar
• Fong MY, Zhou W, Liu L, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb;17(2):183–194..
   PubMed Web of Science ®Google Scholar
• Granchi D, Amato I, Battistelli L, et al. In vitro blockade of receptor activator of nuclear factor-kappaB ligand prevents osteoclastogenesis induced by neuroblastoma cells. Int J Cancer. 2004;111:829–838.
   PubMed Web of Science ®Google Scholar
• Redini F, Heymann D. Bone tumor environment as a potential therapeutic target in ewing sarcoma. Front Oncol. 2015;5:279.
   Web of Science ®Google Scholar
• Tumilowicz JJ, Nichols WW, Cholon JJ, et al. Definition of a continuous human cell line derived from neuroblastoma. Cancer Res. 1970;30(8):2110–2118.
   Web of Science ®Google Scholar
• Vassal G, Terrier-Lacombe MJ, Bissery MC, et al. Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br J Cancer. 1996;74(4):537–545.
   Web of Science ®Google Scholar
• Biedler JL, Helson L, Spengler BA. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res. 1973;33(11):2643–2652.
   PubMed Web of Science ®Google Scholar
• Barnes EN, Biedler JL, Spengler BA, et al. The fine structure of continuous human neuroblastoma lines SK-N-SH, SK -N-BE(2), and SK-N-MC. InVitro. 1981;17:619–630.
   Google Scholar
• Seeger RC, Rayner SA, Banerjee A, et al. Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines. Cancer Res. 1977;37(5):1364–1371.
   Web of Science ®Google Scholar
• Ferrandis E, Da Silva J, Riou G, et al. Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse. Cancer Res. 1994;54(8):2256–2261.
   Web of Science ®Google Scholar
• Thery C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (misev2018): A position statement of the international society for extracellular vesicles and update of the misev2014 guidelines. J Extracell Vesicles. 2018;7:1535750.
   PubMed Web of Science ®Google Scholar
• Colletti M, Petretto A, Galardi A, et al. proteomic analysis of neuroblastoma-derived exosomes: new insights into a metastatic signature. Proteomics. 2017 Dec;17(2324):23–24..
   Google Scholar
• Da Huang W, BT S, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
   PubMed Web of Science ®Google Scholar
• HaDuong JH, Blavier L, Baniwal SK, et al. Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer. 2015;137(4):797–809.
   Web of Science ®Google Scholar
• Akhtari M, Mansuri J, Newman KA, et al. Biology of breast cancer bone metastasis. Cancer Biol Ther. 2008;7(1):3–9.
   PubMed Web of Science ®Google Scholar
• Sait S, Modak S. Anti-GD2 immunotherapy for neuroblastoma. Expert Rev Anticancer Ther. 2017;17(10):889–904.
   PubMed Web of Science ®Google Scholar
• Nakata R, Shimada H, Fernandez GE, et al. Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. J Extracell Vesicles. 2017;6(1):1332941.
   PubMed Web of Science ®Google Scholar
• Fonseka P, Liem M, Ozcitti C, et al. Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity. J Extracell Vesicles. 2019;8(1):1597614.
   PubMed Web of Science ®Google Scholar
• Wang Y, Lieberman R, Pan J, et al. miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. Mol Cancer. 2016;15(1):70.
   PubMedGoogle Scholar
• Kang W, Huang T, Zhou Y, et al. miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis. Cell Death Dis. 2018;9(2):92.
   PubMed Web of Science ®Google Scholar
• Zaidi SK, Sullivan AJ, Medina R, et al. Tyrosine phosporilation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. Embo J. 2004;23(4):790–799.
   PubMed Web of Science ®Google Scholar
• Pocaterra A, Romani P, Dupont S. YAP/TAZ functions and their regulation at a glance. J Cell Sci. 2020;133(2):ii: jcs23042.
   Web of Science ®Google Scholar
• Catena V, Fanciulli M. Deptor: not only a mTOR inhibitor. J Exp Clin Cancer Res. 2017;36(1):12.
   Google Scholar
• Zimmerman MW, Liu Y, He S, et al. MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification. Cancer Discov. 2018 Mar;8(3):320–335..
   Web of Science ®Google Scholar
• Berrettoni BA, Carter JR. Mechanisms of cancer metastasis to bone. The Journal of Bone & Joint Surgery. 1986;68(2):308–312.
   Google Scholar
• Sohara Y, Shimada H, Scadeng M, et al. Lytic bone lesions in human neuroblastoma xenograft involve osteoclast recruitment and are inhibited by bisphosphonate. Cancer Res. 2003;63(12):3026–3031.
   Web of Science ®Google Scholar
• Michigami T, Ihara-Watanabe M, Yamazaki M, et al. Receptor activator of Nuclear factor kB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma. Cancer Res. 2001;61:1637–1644.
   PubMed Web of Science ®Google Scholar
• Ara T, Song L, Shimada H, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009 Jan 1;69(1):329–337..
   PubMed Web of Science ®Google Scholar
• Mussano F, Genova T, Corsalini M, et al. Cytokine, chemokine, and growth factor profile characterization of undifferentiated and osteoinduced human adipose-derived stem cells. Stem Cells Int. 2017;2017:6202783.
   Web of Science ®Google Scholar
• Aveic S, Davtalab R, Vogt M, et al. Calcium phosphate scaffolds with defined interconnecting channel structure provide a mimetic 3D niche for bone marrow metastasized tumor cell growth. Acta Biomater. 2019;88:527–539..
   Web of Science ®Google Scholar
• Zhang JF, Fu WM, He ML, et al. MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling. RNA Biol. 2011;8:829–838.
   PubMed Web of Science ®Google Scholar
• Valencia K, Luis-Ravelo D, Bovy N, et al. miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization. Mol Oncol. 2014;8:689–703.
   PubMed Web of Science ®Google Scholar
• Zhang X, Sai B, Wang F, et al. Zheng L Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT. Mol Cancer. 2019;13(18):40.
   Google Scholar
• Kinoshita T, Hanazawa T, Nohata N, et al. The functional significance of microRNA-375 in human squamous cell carcinoma: aberrant expression and effects on cancer pathways. J Hum Genet. 2012;57:556–653.
   PubMed Web of Science ®Google Scholar
• Li SL, An N, Liu B, et al. Exosomes from LNCaP cells promote osteoblast activity through miR-375 transfer. Oncol Lett. 2019;17(5):4463–4473.
   Web of Science ®Google Scholar
• Si C, Lingfei J, Shan Z, et al. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis. Stem Cell Res Ther. 2018;9:185.
   Web of Science ®Google Scholar
• Chen S, Zheng Y, Zhang S, et al. Promotion effects of miR-375 on the osteogenic differentiation of human adipose-derived mesenchymal stem cells. Stem Cell Reports. 2017;8(3):773–786.
   PubMed Web of Science ®Google Scholar
• Yan JW, Lin JS, He XX. The emerging role of miR-375 in cancer. Int J Cancer. 2014;135:1011–1018.
   PubMed Web of Science ®Google Scholar
• Madhavan D, Peng C, Wallwiener M, et al. Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis. 2016;37:461–470.
   PubMed Web of Science ®Google Scholar
• Nam RK, Wallis CJD, Amemiya Y, et al. Identification of a novel MicroRNA panel associated with metastasis following radical prostatectomy for prostate cancer. Anticancer Res. 2018;38:5027–5034.
   Web of Science ®Google Scholar
• Porzycki P, Ciszkowicz E, Semik M, et al. Combination of three miRNA (miR-141, miR-21, and miR-375) as potential diagnostic tool for prostate cancer recognition. Int Urol Nephrol. 2018;50(9):1619–1626.
   PubMed Web of Science ®Google Scholar
• Singh I, Swami R, Pooja D, et al. Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting. J Drug Target. 2016;24(3):212–223.
   PubMed Web of Science ®Google Scholar
• Russell HV, Groshen SG, Ara T, et al. A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: a new approaches to neuroblastoma therapy (NANT) study. Pediatr Blood Cancer. 2011 Aug;57(2):275–282..
   PubMed Web of Science ®Google Scholar
• Canon JR, Roudier M, Bryant R, et al. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin Exp Metastasis. 2008;25(2):119–129.
   PubMed Web of Science ®Google Scholar