An Analysis of Human Response to the Irritancy of Acetone Vapors

References

• Dalton, P., Wysocki, C.J., Brody, M.J., and Lawley, H.J., The influence of cognitive bias on the perceived odor, irritation and health symptoms from chemical exposure, Int. Arch. Occup. Environ. Health, 1997a; 69: 407–417.
   PubMed Web of Science ®Google Scholar
• Dalton, P., Wysocki, C.J., Brody, M.J., and Lawley, H.J., Perceived odor, irritation, and health symptoms following short-term expo- sure to acetone, Am. J. Ind. Med., 1997b; 31: 558–569.
   PubMed Web of Science ®Google Scholar
• Dick, R.B., Setzer, J.V., Taylor, B.J., and Shukla, R., Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone, Br. J. Ind. Med., 1989; 46: 111–121.
   PubMedGoogle Scholar
• Matsushita T., Yoshimune, A., Inoue, T., Yamada, S., and Suzuki, H., Experimental studies for determining the MAC value of acetone, I. Biological reactions in the “one- day exposure” to acetone (English transla- tion), Jpn. J. Ind. Health, 1969; 11: 477–485.
   Google Scholar
• Matsushita, T., Goshima, E., Miyagaki, H., Maeda, K., Takeuchi, Y., and Inoue, T., Ex- perimental studies for determining the MAC value of acetone. II. Biological reactions in the “six-day exposure” to acetone (English translation), Jpn. J. Ind. Health, 1969; 11: 507–518.
   Google Scholar
• Mitran E., Callender, T., Orha, B., Dragnea, P., and Botezatu, G., Neurotoxicity associ- ated with occupational exposure to acetone, methyl ethyl ketone, and cyclohexanone, Environ. Res., 1997; 73: 181–188.
   Google Scholar
• Nelson, K.W., Ege, J.F., Ross, M., Woodman, L.E., and Silverman, L., Sensory response to certain industrial solvent vapors, J. Ind. Hyg. Toxicol., 1943; 25: 282–285.
   Google Scholar
• Parmeggiani, L. and Sassi, C., Occupational poisoning from acetone: clinical symptoms, work environment studies and physiopatho- logical research (English translation), Med. Lavoro, 1954; 45: 431– 468.
   Google Scholar
• Raleigh, R.L. and McGee, W.A., Effects of short, high-concentration exposures to acetone as determined by observations in the work area, J. Occup. Med., 1972; 14: 607–610.
   Google Scholar
• Ruth, J.H., Odor thresholds and irritation lev- els of several chemical substances: a review, Am. Ind. Hyg. Assoc. J., 1986; 47: A142– A151.
   PubMedGoogle Scholar
• Satoh, T., Omae, K., Nakashima, H., Takebayashi, T., Matsumura, H., Kawai, T., Nakaza, M., and Sakurai, H., Relationship between acetone exposure concentration and health effects in acetate fiber plant workers, Int. Arch. Occup. Environ. Health, 1996; 68: 147–153.
   Google Scholar
• Seeber, A, Kiesswetter, E., and Blaszkewicz, M., Correlations between subjective distur- bances due to acute exposure to organic sol- vents and internal dose. In: Mutti, A., Costa, L.G., Manzo, L., and Cranmer, J.M., Eds. Current Issues in Neurotoxicology, Little Rock, Arkansas USA: Intox Press Inc., 1991a, 265–269.
   Google Scholar
• Seeber, A., Kiesswetter, E., Giller, D., Vangala, R.R., Blaszkewicz, M., Golka, K., and Bolt, H.M., Wirkungen akuter Exposi- tion gegen¸ber Aceton und Ethylacetat im MAK-Bereich, Verh. Dt. Ges. Arbeitsmed., 1991b; 31: 415–418.
   Google Scholar
• Seeber, A., Kiesswetter, E., Vangala, R.R., Blaszkewicz, M., and Golka, K., Combined exposure to organic solvents: An experimen- tal approach using acetone and ethylacetate, Appl. Psychol. International Review, 1992a; 41: 281–292.
   Google Scholar
• Seeber, A., Kiesswetter, E., and Blaszkewicz, M., Correlations between subjective distur- bances due to acute exposure to organic sol- vents and internal dose, Neurotoxicology, 1992b; 13: 265–270.
   PubMed Web of Science ®Google Scholar
• Seeber, A., Blaszkewicz, M., Golka, K., Kiesswetter, E., Vangala, RR., and Bolt, H.M., Exposure to acetone and neurobehavioural effects: comparison of two experiments and a field study, 24th International Congress on Occupational Health, Nizza, 1993a, 1–9.
   Google Scholar
• Seeber, A., Blaszkewicz, M., Kiesswetter, E., and Vangala, R.R., Untersuchungsbericht zum Einfluss von Aceton auf das Befinden von Schichtmitarbeitern im Werk Freiburg der Rhone-Poulenc Rhodia AG, Report of the Institute for Work Physiology, University of Dortmund, Germany, February, 1993b.
   Google Scholar
• Seeber, A., Blaszkewicz, M., Golka, K., and Kiesswetter, E., Solvent exposure and ratings of well-being: Dose-effect relationships and consistency of data, Environm. Res., 1997; 73: 81–91.
   Google Scholar
• Douglas, R.B., Human reflex bronchoconstriction as an adjunct to conjunctival sensitivity in defin- ing the threshold limit values of irritant gases and vapours. Ph.D. Thesis, London University, 1975.
   Google Scholar
• Oglesby, F.L., Williams, J.L., and Fassett, D.W., Eighteen-year experience with acetone. Annual Meeting of the American Industrial Hygiene Association, Detroit, Michigan, 1949.
   Google Scholar
• Cometto-Muñiz, J.E. and Cain, W.S., Effi- cacy of volatile organic compounds in evok- ing nasal pungency and odor, Arch. Environ. Health, 1993; 48: 309–314.
   PubMed Web of Science ®Google Scholar
• Cometto-Muñiz, J.E., Odor and nasal pun- gency (irritation) thresholds (personal communcation to L.J. van Gemert), 1994.
   Google Scholar
• Cometto-Muñiz, J.E. and Cain, W.S., Rela- tive sensitivity of the ocular trigeminal, nasal trigeminal and olfactory systems to airborne chemicals, Chem. Senses, 1995; 20: 191–198.
   PubMed Web of Science ®Google Scholar
• Wysocki, C.J., Dalton, P., Brody, M.J., and Lawley, H.J., Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupa- tionally non-exposed) subjects, Am. Ind. Hyg. Assoc. J., 1997; 58: 704–712.
   PubMed Web of Science ®Google Scholar
• WHO, Environmental Health Criteria 207, Acetone, International Programme on Chemi- cal Safety, World Health Organization, Geneva, Switzerland, 1998; 159 pp.
   Google Scholar
• Pozzani, U.C., Weil, C.S. and Carpenter, C.P., The toxicological basis of thresh- old limit values: 5. The experimental in- halation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am. Ind. Hyg. Assoc. J., 1959; 20: 364–369.
   PubMedGoogle Scholar
• De Ceaurriz, J.C., Micillino, J.C., Bonnet, P., and Guenier, J.P., Sensory irritation caused by various industrial airborne chemicals, Toxicol. Lett., 1981; 9: 137–143.
   PubMed Web of Science ®Google Scholar
• Schaper, M., Development of a database for sensory irritants and its use in establishing occupational exposure limits, Am. Ind. Hyg. Assoc. J., 1993; 54: 488–544.
   PubMed Web of Science ®Google Scholar
• Kane, L.E., Dombroske, R. and Alarie, Y., Evaluation of sensory irritation from some common industrial solvents, Am. Ind. Hyg. Assoc. J., 1980; 41: 451–455.
   PubMed Web of Science ®Google Scholar
• Bruckner, J.V. and Peterson, R.J., Evaluation of toluene and acetone inhalation abuse: II. Model development and toxicology, Toxicol. Appl. Pharmacol. 1981; 61: 302–312.
   Google Scholar
• Ross, D.G., Acute acetone intoxication in- volving eight male workers, Am. Occup. Hyg. J., 1973; 16: 73–75.
   PubMedGoogle Scholar
• Finelli, P.F. and Mair, R.G., Disturbances of taste and smell. In: Neurology in Clinical Prac- tice, Bradley W.G. et al. (Eds.), Butterworth and Heinemann, Boston, 1991; 209–216.
   Google Scholar
• Engen, T., Perception of odor and irritation, Environ Intern., 1986; 12: 177–187.
   Google Scholar
• Alarie, Y., Sensory irritation of the upper airways by airborne chemicals, Tox. Appl. Pharmacol., 1973; 24: 279–297.
   PubMed Web of Science ®Google Scholar
• Cain, W.S. and Cometto-Muñiz, J.E., Irrita- tion and odor as indicators of indoor pollu- tion, Occ. Med., 1995; 10: 133–145.
   Google Scholar
• Cain, W.S., Gent, J., Catalanotto, F.A., and Goodspeed, R.B., Clinical evaluation of ol- faction, Am. J. Otolaryngol., 1983; 4: 252– 256.
   PubMed Web of Science ®Google Scholar
• Dalton, P., Odor perception and beliefs about risk, Chem. Senses, 1996; 21: 447–458.
   PubMed Web of Science ®Google Scholar
• Kiesswetter, E., Blaszkewicz, M., Vangala, R.R., and Seeber, A., Acute exposure to ac- etone in a factory and ratings of well-being, Neurotoxicology, 1994; 15: 597–602.
   Google Scholar
• Berglund, B., Berglund, U., Ekman, G., and Engen, T., Individual psychofysical functions for 28 odorants, Percept. Psychophys., 1971; 9: 379–384.
   Web of Science ®Google Scholar
• Berglund, B. and Olsson, M.J., Odor-inten- sity interaction in binary and ternary mix- tures, Percept. Psychophys., 1993; 53: 475– 482.
   PubMedGoogle Scholar
• Blondheim, S.H. and Reznik, L., The thresh- old for the smell of acetone and its relation-ship to the ability to taste phenylthiocarbamate, Experienta, 1971; 27: 1282–1283.
   Google Scholar
• Dalton, P. and Wysocki, C.J., The nature and duration of adaptation following long-term exposure to odors, Percept. Psychophys., 1996; 58: 781–792.
   PubMed Web of Science ®Google Scholar
• Devos, M., Patte, F., Rouault, J., Laffort, P., and van Gemert, L.J., Standardized Human Olfactory Thresholds. Oxford: IRL Press, 1990, p. 165.
   Google Scholar
• Forrai, G., Szabados, T., Papp, E.Sz., and Bánkövi, G., Studies on the sense of smell to ketone compounds in a Hungarian popula- tion, Humangenetik, 1970; 8: 348–353.
   Google Scholar
• Gagnon, P., Mergler, D., and Lapare, S., Ol- factory adaptation, threshold shift and recov- ery at low levels of exposure to methyl isobu- tyl ketone (MIBK), Neurotoxicology, 1994; 15: 637–642.
   Google Scholar
• Mergler, D. and Beauvais, B., Olfactory thresh- old shift following controlled 7–hour exposure to toluene and/or xylene, Neurotoxicology, 1992; 13: 211–216.
   Google Scholar
• Odeigah, P.G.C., Smell acuity for acetone and its relationship to taste ability to phe- nylthiocarbamide in a Nigerian population, E. Afr. Med. J., 1994; 71: 462–466.
   PubMedGoogle Scholar
• Patte, F., Etcheto, M., and Laffort, P., Selected and standardized values of suprathreshold odor intensities for 110 substances, Chem. Senses Flav., 1975; 1: 283–305.
   Google Scholar
• Cometto-Muñiz, J.E. and Cain, W.S., Influ- ence of airborne contaminants on olfaction and the common chemical sense. In: Getschell, T.V., et al. Ed. Smell and Taste in Health and Disease, 1991, 765–785.
   Google Scholar
• Cometto-Muñiz, J.E. and Cain, W.S., Ago- nistic sensory effects of airbrne chemicals in mixtures: Odor, nasal pungency, and eye irri- tation, Percept. Psychophys., 1997; 59: 665– 674.
   PubMed Web of Science ®Google Scholar
• Doty, R.L., Intranasal trigeminal detection of chemical vapors by humans, Physiol.Behav., 1975; 14: 855–859.
   PubMed Web of Science ®Google Scholar
• Doty, R.L., Brugger, W.E., Jurs, P.C., Orndorff, M.A., Snyder, P.J., and Lowry, L.D., Intranasal trigeminal stimulation from odor- ous volatiles: psychometric responses from anosmic and normal humans, Physiol. Behav., 1978; 20: 175–185.
   PubMed Web of Science ®Google Scholar
• Kobal, G., Toller, S. van., and Hummel T., Is there directional smelling? Experientia. Basel: Birkhauser Verlag, 1989; 45: 130–132.
   Google Scholar
• Roscher, S., Mohammadian, P., Schneider, A., Wendler, J., Hummel, T., and Kobal, G., Ol- factory input facilitates trigeminal chemosen- sitivity, ECRO Abstracts, 1996.
   Google Scholar
• Hummel, T., Barz, S., Lötsch, J., Roscher, S., Kettenmann, B., and Kobal, G., Loss of ol- factory function leads to a decrease of trigemi- nal sensitivity, Chem. Senses, 1996; 21: 75– 79.
   PubMed Web of Science ®Google Scholar
• Kobal, G., Hummel, T., and Toller, S. van, Differences in human chemosensory evoked potentials to olfactory and somatosensory chemical stimuli presented to left and right nostrils, Chem. Senses, 1992; 17: 233–244.
   Web of Science ®Google Scholar
• Thürauf, N., Hummel, T., Kettenmann, B., and Kobal, G., Nociceptive and reflexive re- sponses recorded from the human nasal mu- cosa, Brain Res., 1993; 629: 293–299.
   PubMed Web of Science ®Google Scholar
• Kobal, G. and Hummel, T., Scalp distribution of chemosensory evoked potentials elicited by trigeminal and olfactory stimuli. Chem. Senses, 1989; 14: 190.
   Google Scholar
• Sobel, N., Prabhakaran, V., Desmond, J.E., Glover, G.H., Goode, R.L., Sullivan, E.V., and Gabrieli, J.D., Sniffing and smelling: sepa- rate subsystems in the human olfactory cor- tex. Nature, 1998; 392: 282–286.
   PubMed Web of Science ®Google Scholar
• Finger, T.E., Getschell, M.L, Getschell, T.V., and Kinnamon, J.C., Affector and effector functions of peptidergic innervation of the nasal cavity. In: Green, B.G., Mason, J.R., and Kare, M.R., Eds. Chemical Senses; vol 2: Irritation. New York: Marcel Dekker, 1990, 1–20.
   Google Scholar
• Getschell, M.L., Bouvet, J.F., Finger, T.E., Holley, A., and Getschell, T.V., Peptidergic regulation of secretory activity in the olfac- tory mucosa of the tiger salamander: immu- nocytochemistry and pharmacology, Cell Tiss. Res., 1989; 256: 381–389.
   Google Scholar
• Cometto-Muñiz, J.E. and Cain, W.S., Thres- holds for odor and nasal pungency, Physiol. Behav., 1990; 48: 719–725.
   PubMed Web of Science ®Google Scholar
• DiVincenzo, G.D., Yanno, F.J., and Astill, B.D., Exposure of man and dog to low con- centrations of acetone vapor, Am. Ind. Hyg. Assoc. J., 1973; 34: 329–336.
   PubMed Web of Science ®Google Scholar
• Israeli, R., Zoref, Y., Tessler, Z., and Braver, J., Reaktionszeit als Mittel zur Aceton-TLV- (MAK)-Wertbestimmung, Zbl. Arbeitsmed., 1977; 8: 197–199.
   Google Scholar
• Kawai, T., Yasugi, T., Uchida, Y., Iwami, O., and Ikeda, M., Urinary excretion of unmetabolized acetone as an indicator of occupational exposure to acetone, Int. Arch. Occup. Environ. Health, 1990; 62: 165–169.
   PubMed Web of Science ®Google Scholar
• Pezzagno, G., Imbriani, M., Ghittori, S., Capodaglio, E., and Huang, J., Urinary elimi- nation of acetone in experimental and occu- pational exposure, Scand. J. Work Environ. Health, 1986; 12: 603–608.
   PubMed Web of Science ®Google Scholar
• Stewart, R.D., Hake, C.L., Wu, A., Graff, S.A., Forster, H.V., Keeler, W.H., Lebrun, A.J., Newton, P.E., and Soto, R.J., Acetone: Devel- opment of a Biologic Standard for the Indus- trial Worker by Breath Analysis. Milwaukee: Medical Coll. Wisconsin, Inc., NIOSH (Cin- cinnati, OH) PB82–172917), 1975.
   Google Scholar
• Hernberg, S., Introduction to Occupational Epidemiology. Lewis Publ. Inc., 1992.
   Google Scholar
• Sietman, B. and Seeber, A., Irritation and annoyance experience when exposed to ac- etone. A statistical re-analysis of two lab ex- periments and a field study as a result of the research project “Irritation and annoyance experience of exposure to acetone” with Rho^ ne-Poulenc Rhodia AG, Freiburg. Insti- tute for Work Physiology, University of Dortmund, Germany, September 1996.
   Google Scholar
• Hudnell, H.K., Otto, D.A., House, D.E., and Molhave, L., Exposure of humans to a vola- tile organic mixture. II Sensory, Arch. Environ. Health, 1992; 47: 31–38.
   PubMed Web of Science ®Google Scholar
• Amoore, J.E. and Hautala, E., Odor as an aid to chemical safety: odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water di- lution, J. Appl. Toxicol., 1983; 3: 272–290.
   PubMed Web of Science ®Google Scholar
• Artho, A. and Koch, R., Charactérisation olfactive des composés de la fumée de ciga- rettes, A. du Tabac, Sect.; 1–11–Paris-Seita, 1973, 37–43.
   Google Scholar
• Feldman, Y.G., Data for determining the maxi- mum permissible concentration of acetone in the atmosphere (in Russ.), Gig. Sanit., 1960; 25: 3–10.
   Google Scholar
• Gemert, L.J. van, Compilations of Odour Threshold Values in Air and Water, Boelens Aroma Chemical Information Services (BACIS), Huizen, The Netherlands, 1999, p. 91.
   Google Scholar
• Hartung, L.D., Hammond, E.G., and Miner, J.R., Identification of carbonyl compounds in a swine-building atmosphere, Livest. Waste Manage. Pollut. Abatement, Proc. Int. Symp., 1971, 105–106.
   Google Scholar
• Kittel, G., Die moderne Olfaktometrie und Odorimetrie. Azetonschwellenuntersuchungen, Z. Laryngol. Rhinol. Otol., 1968; 47: 893–903.
   Google Scholar
• Kittel, G. and Wendelstein, P.J.G., Zur Differenzierung der Olfactiven Wahrnehmungs- und Erkennungsschwelle, Arch. Klin. Exp. Ohren Nasen Kehlkopfheilkunde, 1971; 199: 683–687.
   Google Scholar
• Pogosyan, U.G., The effect on man of the combined action of small concentrations of acetone and phenol in the atmosphere, Hyg. Sanit., 1965; 30: 1–9.
   Google Scholar
• Tkach, N.Z. Combined effect of acetone and acetophenone in the atmosphere, Hyg. Sanit., 1965; 30: 179–185.
   Google Scholar
• Davis, R.G., Olfactory psychophysical pa- rameters in man, rat, dog and pigeon, J. Comp. Physiol. Psychol., 1973; 85: 221–232.
   Google Scholar
• Marshall, D.A. and Moulton, D.G., Olfactory sensitivity to alpha-ionone in humans and dogs, Chem. Senses, 1981; 6: 53–61.
   Google Scholar
• Marshall, D.A., Blumer, L., and Moulton, D.G., Odor detection curves for n-pentanoic acid in dogs and humans, Chem. Senses, 1981; 6: 445–453.
   Google Scholar
• Bartley, D.L., Woebkenberg, M.L., and Posner, J.C., Performance of thick-sorbent diffusive samplers, Ann. Occup. Hyg., 1988; 32: 333–343.
   PubMedGoogle Scholar
• Burnett, R.D., Evaluation of charcoal sam- pling tubes, Am. Ind. Hyg. Assoc. J., January 1976, 37–45.
   Google Scholar
• Campbell, D.N. and Moore, R,H., The quan- titative determination of acrylonitrile, acrolein, acetonitrile and acetone in workplace air, Ind. Hyg. Assoc. J., 1979; 40: 904–909.
   PubMed Web of Science ®Google Scholar
• Fujino, A., Satoh, T., Takebayashi, T., Nakashima, H., Sakurai, H., Higashi, T., Matumura, H., Minaguchi, H., and Kawai, T., Biological monitoring of workers exposed to acetone in acetate fibre plants, Br. J. Ind. Med., 1992; 49: 654–657.
   Google Scholar
• Groves, W.A. and Zellers, E.T., Investigation of organic vapor losses to condensed water vapor in Tedlar bags used for exhaled-breath sampling, Am. Ind. Hyg. Assoc. J., 1996; 57: 257–263.
   PubMed Web of Science ®Google Scholar
• Harper, M., Kimberland, M.L., Orr, R.J., and Guild, L.V., An evaluation of sorbents for sampling ketones in workplace air, Appl. Occup. Environ Hyg., 1993; 8: 293–304.
   Google Scholar
• Harper, M. and Guild, L.V., Experience in the use of the NIOSH diffusive sampler evalu- ation protocol, Am. Ind. Hyg. Assoc. J., 1996; 57: 1115–1123.
   PubMed Web of Science ®Google Scholar
• Kawai, T., Yasugi, T., Uchida, Y., and Ikeda, M., A personal diffusive sampler for occupa- tional acetone vapor exposure monitoring, Toxicol. Lett., 1991; 55: 295–302.
   Google Scholar
• Lautenberger, W.J., Kring, E.V., and Mo- rello, J.A., A new personal badge monitor for organic vapors, Am. Ind. Hyg. Assoc. J., 1980; 41: 737–747.
   PubMed Web of Science ®Google Scholar
• Levin, J.O. and Carleborg, L., Evaluation of solid sorbents for sampling ketones in work- room air, Ann. Occup. Hyg., 1987; 31: 31–38.
   Google Scholar
• Stark, M. and Hietkamp, G., Laborbericht Nr Fo-C 107/94, 1994 (Confidential).
   Google Scholar
• Stark, M., Untersuchungsbericht: FE-TA 1 /95. Rho^ ne-Poulenc Rhodia AG, Germany, 1995.
   Google Scholar
• Vangala, R.R., Blaszkewicz, M., Bolt, H.M., Golka, K., Kiesswetter, E., and Seeber, A., Acute experimental exposures to acetone and ethyl acetate. In: Recent developments in Toxicology: Trends, Methods and Problems, Arch. Toxicol., 1991; Suppl. 14: 259–262.
   Google Scholar
• Xiao, H., Levine, S.P., Nowak, J., Puskar, M., and Spear, R.C., Analysis of organic va- pors in the workplace by remote sensing fourier transform infrared spectroscopy, Am. Ind. Hyg. Assoc. J., 1993; 54: 545–556.
   PubMed Web of Science ®Google Scholar