Update on SARS-CoV-2 infection in children

References

• Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733.
   Google Scholar
• Wang C, Horby PW, Hayden FG, et al. A novel coronavirus outbreak of global health concern. Lancet. 2020;395:470–473.
   Google Scholar
• World Health Organization. Director-General’s statement on IHR Emergency Committee on Novel Coronavirus (2019-nCoV). 2020. [Accessed on 2020 Sep 1]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov).
   Google Scholar
• Gupta S, Malhotra N, Gupta N, et al. The curious case of coronavirus disease 2019 (COVID-19) in children. J Pediatr. 2020;222:258–259.
   Google Scholar
• Buonsenso D, Sali M, Pata D, et al. Children and COVID-19: microbiological and immunological insights. Pediatr Pulmonol. 2020;55:2547–2555.
   Google Scholar
• Guo C-X, He L, Yin J-Y, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Med. 2020;18:250.
   Google Scholar
• Lu Y, Wen H, Rong D, et al. Clinical characteristics and radiological features of children infected with the 2019 novel coronavirus. Clin Radiol. 2020;75:520–525.
   Google Scholar
• Kilani MM, Odeh MM, Shalabi M, et al. Clinical and laboratory characteristics of SARS-CoV2-infected paediatric patients in Jordan: serial RT-PCR testing until discharge. Paediatr Int Child Health. 2020. DOI:10.1080/20469047.2020.1804733.
   Google Scholar
• Zhen-Dong Y, Gao-Jun Z, Run-Ming J, et al. Clinical and transmission dynamics characteristics of 406 children with coronavirus disease 2019 in China: a review. J Infect.. 2020;37:e11–e15.
   Google Scholar
• Götzinger F, Santiago-García B, Noguera-Julián A, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4:653–661.
   Google Scholar
• Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol. 2020;55:1169–1174.
   Google Scholar
• Shelmerdine SC, Lovrenski J, Caro-Domínguez P, et al. Coronavirus disease 2019 (COVID-19) in children: a systematic review of imaging findings. Pediatr Radiol. 2020;50:1217–1230.
   Google Scholar
• Zhang L, Peres TG, Silva MVF, et al. What we know so far about coronavirus disease 2019 in children: a meta-analysis of 551 laboratory-confirmed cases. Pediatr Pulmonol. 2020;55:2115–2127.
   Google Scholar
• Prata-Barbosa A, Lima-Setta F, Dos Santos GR, et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. J Pediatr. 2020. Available from. DOI:10.1016/j.jpedp.2020.07.002.
   Google Scholar
• Parri N, Lenge M, Cantoni B, et al. COVID-19 in 17 Italian pediatric emergency departments. Pediatrics. 2020 e20201235 10.1542/peds.2020-1235
   Google Scholar
• Mak PQ, Chung K-S, Wong JS-C, et al. Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents. Pediatr Infect Dis J. 2020;39:e199–e200.
   Google Scholar
• Wood R, Thomson EC, Galbraith R, et al. Sharing a household with children and risk of COVID-19: a study of over 300,000 adults living in healthcare worker households in Scotland. medRxiv. 2020. Available from: doi:10.1101/2020.09.21.20196428
   Google Scholar
• Lu Y, Li Y, Deng W, et al. Symptomatic infection is associated with prolonged duration of viral shedding in mild coronavirus disease 2019: a retrospective study of 110 children in Wuhan. Pediatr Infect Dis J. 2020;39:e95–e99.
   Google Scholar
• Kim L, Whitaker M, O’Halloran A, et al. Hospitalization rates and characteristics of children aged <8 years hospitalized with laboratory-confirmed covid-19 – covid-net, 14 states, march 1-july 25, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1081–1088.
   Google Scholar
• Melgosa M, Madrid A, Alvárez O, et al. SARS-CoV-2 infection in Spanish children with chronic kidney pathologies. Pediatr Nephrol. 2020;35:1521–1524.
   Google Scholar
• Heilbronner C, Berteloot L, Tremolieres P, et al. Patients with sickle cell disease and suspected COVID-19 in a paediatric intensive care unit. Br J Haematol. 2020;190:e21–24.
   Google Scholar
• Turner D, Huang Y, Martín-de-Carpi J, et al. Corona virus disease 2019 and paediatric inflammatory bowel diseases: global experience and provisional guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, hepatology, and nutrition. J Pediatr Gastroenterol Nutr. 2020;70:727–733.
   Google Scholar
• International Society of Pediatric and Adolescent Diabetes  (ISPAD). Summary of recommendations regarding COVID-19 in children with diabetes: keep calm and mind your diabetes care and public health advice. Pediatr Diabetes 2020; 21: 413–414
   Google Scholar
• Marlais M, Wlodkowski T, Vivarelli M, et al. The severity of COVID-19 in children on immunosuppressive medication. Lancet Child Adolesc Health. 2020;4:e17–e18.
   Google Scholar
• Bixler D, Miller AD, Mattison CP, et al. SARS-CoV-2-associated deaths among persons aged <21 years – United States, February 12 – July 31, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1324–1329.
   Google Scholar
• Liguoro I, Pilotto C, Bonanni M, et al. SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr. 2020;179:1029–1046.
   Google Scholar
• Henry BM, Benoit SW, de Oliveira MHS, et al. Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): a pooled analysis and review. Clin Biochem. 2020;81:1–8.
   Google Scholar
• Wang Y, Zhu F, Wang C, et al. Children hospitalized with severe COVID-19 in Wuhan. Pediatr Infect Dis J. 2020;39:e91–e94.
   Google Scholar
• Antunez-Montes OY, Escamilla MI, Figueroa-Uribe AF. COVID-19 and multisystem inflammatory syndrome in Latin American children: a multinational study. Pediatr Infect Dis J. 2020. DOI:10.1097/INF.0000000000002949
   Google Scholar
• Xu CLH, Raval M, Schnall JA, et al. Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data. Pediatr Infect Dis J. 2020;39:e249–e256.
   Google Scholar
• Chao JY, Derespina KR, Herold BC, et al. Clinical characteristics and outcomes of hospitalized and critically ill children and adolescents with coronavirus disease 2019 at a tertiary care medical center in New York City. J Pediatr. 2020;223:14–19.e2.
   Google Scholar
• Oualha M, Bendavid M, Berteloot L, et al. Severe and fatal forms of COVID-19 in children. Arch Pediatr. 2020;27:235–238.
   Google Scholar
• Sanna G, Serrau G, Bassareo PP, et al. Children’s heart and COVID-19: up-to-date evidence in the form of a systematic review. Eur J Pediatr. 2020;179:1079–1087.
   Google Scholar
• Trogen B, Gonzalez FJ, Shust GF. COVID-19-associated myocarditis in an adolescent. Pediatr Infect Dis J. 2020;39:e204–205.
   Google Scholar
• Gefen AM, Palumbo N, Nathan SK, et al. Pediatric COVID-19-associated rhabdomyolysis: a case report. Pediatr Nephrol. 2020;35:1517–1520.
   Google Scholar
• Torrelo A, Andina D, Santonja C, et al. Erythema multiforme-like lesions in children and COVID-19. Pediatr Dermatol. 2020;37:442–446.
   Google Scholar
• Shah SK, Munoz AC. Multisystem inflammatory syndrome in children in COVID-19 pandemic. Indian J Pediatr. 2020;87:671–673.
   Google Scholar
• Ouldali N, Pouletty M, Mariani P, et al. Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis. Lancet Child Adolesc Health. 2020;4:662–668.
   Google Scholar
• Davies P, Evans C, Kanthimathinathan HK, et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health. 2020;4:669–677.
   Google Scholar
• Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;6736:1–8.
   Google Scholar
• Belot A, Antona D, Renolleau S, et al. SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020. Euro Surveill. 2020;22:2001010.
   Google Scholar
• Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383:334–346.
   Google Scholar
• World Health Organization. Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19. Geneva: WHO. 2020. [Accessed on 2020 Sep 1]. Available from: https://www.who.int/news-room/commentaries/detail/multis%0Dystem-inflammatory-syndrome-in-children-and-adolescents-with-covid–19
   Google Scholar
• European Centre for Disease and Control. Paediatric Inflammatory Multisystem Syndrome and SARS-CoV-2 Infection in Children. Stockholm: The Centre: 2020. [Accessed on 2020 Sep 1]. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/covid-19-risk-assessment-paediatric-inflammatory-multisystem-syndrome-15-May-2020.pdf
   Google Scholar
• Centers for Disease Control and Prevention, Health Alert Network. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). 2020. Report No: 0432. [Accessed on 2020 Sep 1]. Available from: https://emergency.cdc.gov/han/2020/%0Dhan00432.asp
   Google Scholar
• Buonsenso D, Di Sante G, Sali M. Cytokine profile in an adolescent with pediatric multisystem inflammatory syndrome temporally related to COVID-19. Pediatr Infect Dis J.. 2020;39:e213–215.
   Google Scholar
• Cabrero-Hernández M, García-Salido A, Leoz-Gordillo I, et al. Severe SARS-CoV-2 infection in children with suspected acute abdomen: a case series from a tertiary hospital in Spain. Pediatr Infect Dis J.. 2020;39:e195–198.
   Google Scholar
• Pouletty M, Borocco C, Ouldali N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort. Ann Rheum Dis.. 2020;79:999–1006.
   Google Scholar
• Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094.
   Google Scholar
• Bapst T, Romano F, Müller M, et al. Special dermatological presentation of paediatric multisystem inflammatory syndrome related to COVID-19: erythema multiforme. BMJ Case Rep. 2020;13:e236986.
   Google Scholar
• Heidemann SM, Tilford B, Bauerfeld C, et al. Three cases of pediatric multisystem inflammatory syndrome associated with COVID-19 due to SARS-CoV-2. Am J Case Rep. 2020;21:e925779.
   Google Scholar
• Godfred-Cato S, Bryant B, Leung J, et al. COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020. MMWR Morbid Mortal Wkly Rep. 69;2020 1074–1080
   Google Scholar
• Dufort EM, Koumans EH, Chow EJ, et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med. 2020;383:347–358.
   Google Scholar
• Chiotos K, Bassiri H, Behrens EM, et al. Multisystem inflammatory syndrome in children during the coronavirus 2019 pandemic: a case series. J Pediatric Infect Dis Soc. 2020;9:393–398.
   Google Scholar
• Regev T, Antebi M, Eytan D, et al. Pediatric inflammatory multisystem syndrome with central nervous system involvement and hypocomplementemia following SARS-COV-2 infection. Pediatr Infect Dis J. 2020;39:e206–207.
   Google Scholar
• Singh-Grewal D, Lucas R, McCarthy K, et al. Update on the COVID-19-associated inflammatory syndrome in children and adolescents; paediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2. J Paediatr Child Health. 2020;56:1173–1177.
   Google Scholar
• Lee WS, Margolskee E. Leukoerythroblastosis and plasmacytoid lymphocytes in a child with SARS-CoV-2-associated multisystem inflammatory syndrome. Blood. 2020;136:914.
   Google Scholar
• Rowley AH. Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat Rev Immunol.. 2020;20:453–454.
   Google Scholar
• Ebina-Shibuya R, Namkoong H, Shibuya Y, et al. Multisystem inflammatory syndrome in children (MIS-C) with COVID-19: insights from simultaneous familial Kawasaki disease cases. Int J Infect Dis. 2020;97:371–373.
   Google Scholar
• Kim YJ, Park H, Choi YY, et al. Defining association between COVID-19 and the multisystem inflammatory syndrome in children through the pandemic. J. Korean Med Sci. 2020;35:e204.
   Google Scholar
• Buonsenso D, Riitano F, Valentini P. Pediatric inflammatory multisystem syndrome temporally related with SARS-CoV-2: immunological similarities with acute rheumatic fever and toxic shock syndrome. Front Pediatr. 2020;8:574.
   Google Scholar
• Consiglio C, Cotugno N, Sardh F, et al. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020;183:968–981.
   Google Scholar
• Henderson LA, Canna SW, Friedman KG, et al. American College of Rheumatology Clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV-2 and hyperinflammation in pediatric COVID-19: version 1. Arthritis Rheumatol.. 2020;72:1791–1805.
   Google Scholar
• Jiang L, Tang K, Levin M, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020;20:e276–e288.
   Google Scholar
• Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun.. 2020;11:5164.
   Google Scholar
• McCarty KL, Tucker M, Lee G, et al. Fetal inflammatory response syndrome associated with maternal SARS-CoV-2 infection. Pediatrics. 2020;e2020010132 DOI: 10.1542/peds.2020-010132
   Google Scholar
• Coronado Munoz A, Nawaratne U, McMann D, et al. Late-onset neonatal sepsis in a patient with covid-19. N Engl J Med. 2020;382:e49.
   Google Scholar
• Needleman JS, Hanson AE. COVID-19-associated apnea and circumoral cyanosis in a 3-week-old. BMC Pediatr.. 2020;20:382.
   Google Scholar
• Mullins E, Evans D, Viner RM, et al. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol.. 2020;55:586–592.
   Google Scholar
• Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr.. 2020;174:722–725.
   Google Scholar
• Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020;223:e14.
   Google Scholar
• Khoury R, Bernstein PS, Debolt C, et al. Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers. Obstet Gynecol. 2020;136:273–282.
   Google Scholar
• Delahoy MJ, Whitaker M, O’Halloran A, et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020. MMWRMorbid Mortal Wkly Rep.. 2020;69:1347–1354.
   Google Scholar
• Dumitriu D, Emeruwa UN, Hanft E, et al. Outcomes of neonates born to mothers with severe acute respiratory syndrome coronavirus 2 infection at a large medical center in New York city. JAMA Pediatr. 2021;175(2):157-167. e204298.
   Google Scholar
• Karami P, Naghavi M, Feyzi A, et al. WITHDRAWN: mortality of a pregnant patient diagnosed with COVID-19: a case report with clinical, radiological, and histopathological findings. Travel Med Infect Dis.; 2020. p. 101665. DOI:10.1016/j.tmaid.2020.101665.
   Google Scholar
• Liu Y, Chen H, Tang K, et al. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020. DOI:10.1016/j.jinf.2020.02.028.
   Google Scholar
• Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand.. 2020;383:823–865.
   Google Scholar
• Della Gatta AN, Rizzo R, Pilu G, et al. Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obstet Gynecol.. 2020;136:36–41.
   Google Scholar
• GC de M, KCGM de A. COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis. Cad Saude Publica. 2020;36:e00087320.
   Google Scholar
• WB de C, Gibelli MAC, Krebs VLJ, et al. Neonatal SARS-CoV-2 infection. Clinics (Sao Paulo). 2020;75:e1996.
   Google Scholar
• Alzamora MC, Paredes T, Caceres D, et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37:861–865.
   Google Scholar
• Alberca RW, Pereira NZ, Oliveira LMDS, et al. Pregnancy, viral infection, and COVID-19. Front Immunol. 2020;11:1672.
   Google Scholar
• Sun M, Xu G, Yang Y, et al. Evidence of mother-to-newborn infection with COVID-19. Br J Anaesth. 2020;125:e245–e247.
   Google Scholar
• Lamouroux A, Attie-Bitach T, Martinovic J, et al. Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. Am J Obstet Gynecol. 2020;223:91.e1-91.e4.
   Google Scholar
• Hu X, Gao J, Luo X, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vertical transmission in neonates born to mothers with coronavirus disease 2019 (COVID-19) pneumonia. Obstet Gynecol. 2020;136:65–67.
   Google Scholar
• Demirjian A, Singh C, Tebruegge M, et al. Probable vertical transmission of SARS-CoV-2 infection. Pediatr Infect Dis J. 2020;39:e257–e260.
   Google Scholar
• Sisman J, Jaleel MA, Moreno W, et al. Intrauterine transmission of SARS-COV-2 infection in a preterm infant. Pediatr Infect Dis J. 2020;39:e265–e267.
   Google Scholar
• Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11:3572.
   Google Scholar
• Yang P, Wang X, Liu P, et al. Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. J Clin Virol. 2020;127:104356.
   Google Scholar
• Buonsenso D, Costa S, Sanguinetti M, et al. Neonatal late onset infection with severe acute respiratory syndrome coronavirus 2. Am J Perinatol. 2020;37:869–872.
   Google Scholar
• Jain P, Thakur A, Kler N, et al. Manifestations in neonates born to COVID-19 positive mothers. Indian J Pediatr. 2020;87:644.
   Google Scholar
• Egloff C, Vauloup-Fellous C, Picone O, et al. Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2. J Clin Virology. 2020;11:104447.
   Google Scholar
• Egloff C, Picone O, Vauloup-Fellous C, et al. Mother to child SARS-CoV-2 transmission: fact or fantasy. Virologie (Montrouge). 2020;24:142–146.
   Google Scholar
• Yang Z, Liu Y. Vertical transmission of severe acute respiratory syndrome coronavirus 2: a systematic review. Am J Perinatol. 2020;37:1055–1060.
   Google Scholar
• Gao Y-J, Ye L, Zhang J-S, et al. Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infect Dis. 2020;20:564.
   Google Scholar
• Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, et al. Vertical transmission of coronavirus disease 19 (covid-19) from infected pregnant mothers to Neonates: a review. Fetal Pediatr Pathol. 2020;39:246–250.
   Google Scholar
• Liu P, Zheng J, Yang P, et al. The immunologic status of newborns born to SARS-CoV-2–infected mothers in Wuhan, China. J Allergy Clin Immunol. 2020;11:e1.
   Google Scholar
• Groß R, Conzelmann C, Müller JA, et al. Detection of SARS-CoV-2 in human breastmilk. Lancet. 2020;11:1757–1758.
   Google Scholar
• Costa S, Posteraro B, Marchetti S, et al. Excretion of SARS-CoV-2 in human breast milk. Clin Microbiol Infect. 2020;395:1430–1432.
   Google Scholar
• MÁ MG, Malalana Martínez AM, Marín Martínez ME, et al. Negative transmission of SARS-CoV-2 to hand-expressed colostrum from SARS-CoV-2-positive mothers. Breastfeed Med. 2020;15:492–494.
   Google Scholar
• Precit MR, Yee R, Anand V, et al. A case report of neonatal acute respiratory failure due to severe acute respiratory syndrome coronavirus-2. J Pediatr Infect Dis Soc. 2020;9:390–392.
   Google Scholar
• BHBM de F, de SM AMD, Gaíva MAM. Prevention and control measures for neonatal COVID-19 infection: a scoping review. Rev Bras Enferm. 2020;73:e20200467.
   Google Scholar
• World Health Organization. Clinical management of COVID-19. 2020. Geneva: WHO. WHO reference number: WHO/2019-nCoV/clinical/2020.5. [Accessed on 2020 Sep 1]. Available from: https://www.who.int/publications/i/item/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
   Google Scholar