Vitamin D modulates inflammatory response of DENV-2-infected macrophages by inhibiting the expression of inflammatory-liked miRNAs

References

• Halstead SB. Dengue. Lancet. 2007;370(9599):1644–1652.
   PubMed Web of Science ®Google Scholar
• (WHO) WHO. Dengue vaccine. Weekly Epidemiological Rec. 2016 July;2016(91):349–364. WHO position paper –.
   Google Scholar
• Guzman MG, Harris E. Dengue. Lancet. 2014;6736:1–13.
   Google Scholar
• Halstead SB. Recent advances in understanding dengue. F1000Res. 2019;8:1–12.
   Google Scholar
• Basu A, Chaturvedi UC. Vascular endothelium: the battlefield of dengue viruses. FEMS immunology and medical microbiology. FEMS Immunology and Medical Microbiology. 2008;53(3):287–299.
   PubMedGoogle Scholar
• Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus infection. Immunology. 2017;151(3):261–269.
   PubMed Web of Science ®Google Scholar
• White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76(9):3837–3843.
   PubMed Web of Science ®Google Scholar
• Verma R, Jung JH, Kim JY. 1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1. J Steroid Biochem Mol Biol. 2014;141:1–6.
   PubMed Web of Science ®Google Scholar
• Sadeghi K, Wessner B, Laggner U, et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006;36(2):361–370.
   PubMed Web of Science ®Google Scholar
• Jadhav NJ, Gokhale S, Seervi M, et al. Immunomodulatory effect of 1, 25 dihydroxy vitamin D3on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages. Int Immunopharmacol. 2018;62:237–243.
   PubMed Web of Science ®Google Scholar
• Puerta-Guardo H, Medina F, De la Cruz Hernández SI, et al. The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res. 2012;94(1):57–61.
   PubMed Web of Science ®Google Scholar
• Arboleda Alzate JF, Rodenhuis-Zybert IA, Hernández JC, et al. Human macrophages differentiated in the presence of vitamin D3restrict dengue virus infection and innate responses by downregulating mannose receptor expression. PLoS Negl Trop Dis. 2017;11(10):1–18.
   Web of Science ®Google Scholar
• Castillo JA, Giraldo DM, Hernandez JC, et al. Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2. PLoS Negl Trop Dis. 2021;15(10):e0009873.
   PubMed Web of Science ®Google Scholar
• Giraldo DM, Cardona A, Urcuqui-Inchima S. High-dose of vitamin D supplement is associated with reduced susceptibility of monocyte-derived macrophages to dengue virus infection and pro-inflammatory cytokine production: an exploratory study. Clin Chim Acta. 2018;478:140–151.
   PubMed Web of Science ®Google Scholar
• Martínez-Moreno J, Hernandez JC, Urcuqui-Inchima S. Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells. Mol Cell Biochem. 2019;464(1–2):169–180.
   PubMed Web of Science ®Google Scholar
• Yasmin R, Williams RM, Xu M, et al. Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer. J Biol Chem. 2005;280(48):40152–40160.
   PubMed Web of Science ®Google Scholar
• Hii CS, Ferrante A. The non-genomic actions of vitamin D. Nutrients. 2016;8(3):1–14.
   Web of Science ®Google Scholar
• Bartel DP. MicroRNA Target Recognition and Regulatory Functions. Cell. 2009;136(2):215–233.
   PubMed Web of Science ®Google Scholar
• Pedersen AW, Holmstrøm K, Jensen SS, et al. Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells. Clin Exp Immunol. 2009;157(1):48–59.
   PubMed Web of Science ®Google Scholar
• Karkeni E, Bonnet L, Marcotorchino J, et al. Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: a new mechanism for the regulation of inflammation by vitamin D. Epigenetics. 2018;13(2):156–162.
   PubMed Web of Science ®Google Scholar
• Chen Y, Liu W, Sun T, et al. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Iimmunol. 2013;190(7):3687–3695.
   PubMed Web of Science ®Google Scholar
• Arboleda JF, Fernandez GJ, Urcuqui-Inchima S. Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: implications for the cytokine response. Infect Genet Evol. 2019;69:12–21.
   PubMed Web of Science ®Google Scholar
• Milani C, Katayama MLH, De Lyra EC, et al. Transcriptional effects of 1,25 dihydroxyvitamin D3 physiological and supra-physiological concentrations in breast cancer organotypic culture. BMC Cancer. 2013;13(1):1–15.
   PubMedGoogle Scholar
• Smith DC, Johnson CS, Freeman CC, et al. A phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy. Clin Cancer Res. 1999;5(6):1339–1345.
   PubMed Web of Science ®Google Scholar
• Shu P, Chang S, and Kuo Y, et al. Development of group- and serotype-specific one-step SYBR green i-based real-time reverse transcription-PCR assay for dengue virus. Journal of Clinical Microbiology. 2003;41(6):2408–2416.
   PubMed Web of Science ®Google Scholar
• a SL, Schnurr D, Yagi S, et al. Quantitative real-time PCR for rhinovirus, and its use in determining the relationship between TCID50 and the number of viral particles. J Virol Methods. 2011;171(1):212–218.
   PubMed Web of Science ®Google Scholar
• Fernandez GJ, Castillo JA, Giraldo DM, et al. Vitamin D regulates the expression of immune and stress response genes in dengue virus-infected macrophages by inducing specific microRNAs. Microrna. 2021;10(4):240–249.
   PubMedGoogle Scholar
• Duan X, Li Y, Chen S, et al. Vitamin D potentiates the inhibitory effect of MicroRNA-130a in hepatitis C virus replication independent of type I interferon signaling pathway. Mediators Inflamm. 2015;2015:1–6.
   Web of Science ®Google Scholar
• Diao W, Lu L, Li S, et al. MicroRNA-125b-5p modulates the inflammatory state of macrophages via targeting B7-H4. Biochem Biophys Res Commun. 2017;491(4):912–918.
   PubMed Web of Science ®Google Scholar
• Song L, Li M, Li J, et al. TGF- b induces miR-182 to sustain NF- k B activation in glioma subsets Find the latest version : TGF- β induces miR-182 to sustain NF- κ B activation in glioma subsets. 2012;122(10):3563–3578.
   Google Scholar
• Wu S, He L, Li Y, et al. MiR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6. J Infect. 2013;67(4):329–341.
   PubMed Web of Science ®Google Scholar
• Giangreco AA, Vaishnav A, Wagner D, et al. Tumor suppressor microRNAs, miR-100 and −125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. Cancer Prev Res. 2013;6(5):483–494.
   PubMed Web of Science ®Google Scholar
• Qin C-F, Zhao H, Liu Z-Y, et al. Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response. Mol Biol Rep. 2011;38(6):3867–3873.
   PubMed Web of Science ®Google Scholar
• Nasirudeen a MA, Wong HH, Thien P, et al. MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PLoS Negl Trop Dis. 2011;5(1):1–11.
   Web of Science ®Google Scholar
• Tsai Y-T, Chang S-Y, Lee C-N, et al. Human TLR3 recognizes dengue virus and modulates viral replication in vitro. Cell Microbiol. 2009;11(4):604–615.
   PubMed Web of Science ®Google Scholar
• Wang JP, Liu P, and Latz E. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition , et al. Journal of immunology. 2006, 1950; 177, 7114–7121.
   Google Scholar
• Whyte CS, Bishop ET, Ruckerl D, et al. Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol. 2011;90(5):845–854.
   PubMed Web of Science ®Google Scholar
• Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D 3. FASEB J. 2005;19(9):1067–1077.
   PubMed Web of Science ®Google Scholar
• Li Y, Tan J, and Miao Y MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia. cell death discovery, et al. Cell death Discovery. 2021; 7(1) . DOI:10.1038/s41420-021-00670-2.
   Web of Science ®Google Scholar
• Zingale VD, Gugliandolo A, Mazzon E. Mir‐155: an important regulator of neuroinflammation. International Journal of Molecular Sciences. MDPI. 2022; DOI:10.3390/ijms23010090
   Google Scholar
• Zeljic K, Supic G, and Magic Z. New insights into vitamin Danticancer properties: focus on miRNA modulation. Molecular genetics and genomics. Molecular genetics and genomics. 2017;292(3): 511–524. Doi:10.1007/s00438-017-1301-9.
   PubMed Web of Science ®Google Scholar
• Green S, Vaughn DW, and Kalayanarooj S, et al. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. The Journal of Infectious Diseases. 1999;179(4): 755–762. Available: https://academic.oup.com/jid/article/179/4/755/888053
   PubMed Web of Science ®Google Scholar
• Inyoo S, Suttitheptumrong A, Pattanakitsakul SN. Synergistic effect of TNF-α and dengue virus infection on adhesion molecule reorganization in human endothelial cells. Jpn J Infect Dis. 2017;70(2):186–191.
   PubMed Web of Science ®Google Scholar
• Suttitheptumrong A, Mahutchariyakul T, Rawarak N, et al. Altered moesin and actin cytoskeleton protein rearrangements affect transendothelial permeability in human endothelial cells upon dengue virus infection and tnf-α treatment. Viruses. 2021;14(1):13.
   PubMedGoogle Scholar
• Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol. 2006;6(11):823–835.
   PubMed Web of Science ®Google Scholar
• Lai J, Wang M, Huang C, et al. Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells. EMBO Rep. 2018;19(8):e46182.
   PubMed Web of Science ®Google Scholar
• O’Connell RM, Taganov KD, and Boldin MP, et al. MicroRNA-155 is induced during the macrophage inflammatory response Proceedings of the national academy of sciences. 2007;104(5):1604–1609. doi: 10.1073/pnas.0610731104.
   PubMed Web of Science ®Google Scholar
• Wang Z, Filgueiras LR, Wang S, et al. Leukotriene B 4 enhances the generation of proinflammatory microRNAs to promote MyD88-Dependent macrophage activation. J Immunol. 2021;192(5):2349–2356.
   Google Scholar
• Androulidaki A, Iliopoulos D, Arranz A, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 2009;31(2):220–231.
   PubMed Web of Science ®Google Scholar
• Saini J, Bandyopadhyay B, Pandey AD, et al. High-Throughput RNA sequencing analysis of plasma samples reveals circulating microRNA signatures with biomarker potential in dengue disease progression. mSystems. 2020;5. DOI:10.1128/msystems.00724-20.
   Web of Science ®Google Scholar
• Tambyah PA, Ching CS, Sepramaniam S, et al. microRNA expression in blood of dengue patients. Ann Clin Biochem. 2016;53(4):466–476.
   PubMed Web of Science ®Google Scholar
• de Oliveira LF, de Andrade AAS, Pagliari C, et al. Differential expression analysis and profiling of hepatic miRNA and isomiRNA in dengue hemorrhagic fever. Sci Rep. 2021;11(1):1–9.
   PubMed Web of Science ®Google Scholar
• Newton K, Dixit VM. Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol. 2012;4. 10.1101/cshperspect.a006049
   Web of Science ®Google Scholar
• Gao Z, Dou Y, Chen Y, et al. MicroRNA roles in the NF-κB signaling pathway during viral infections. Biomed Res Int. 2014;2014:19–21.
   Web of Science ®Google Scholar
• Zhang Y, Wei W, Cheng N, et al. Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology. 2012;56(5):1631–1640.
   PubMed Web of Science ®Google Scholar
• Ceppi M, Pereira AM, and Dunand-Sauthier I, et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proceedings of the national academy of sciences.2009;106(8):2735–2740. doi: 10.1073/pnas.0811073106.
   PubMed Web of Science ®Google Scholar
• Mann M, Mehta A, Zhao JL, et al. An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun. 2017;8(1):8.
   PubMedGoogle Scholar
• Zitman-Gal T, Green J, Pasmanik-Chor M, et al. Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment. Cardiovasc Diabetol. 2014;13(1):8.
   PubMedGoogle Scholar
• Enquobahrie D, Williams M, Qiu C, et al. Global maternal early pregnacy peripheral blood mRNA and miRNA expression profiles according to plasma 25-hydroxyvitamin D concentrations. Journal Maternal Fetal Neonatal Medecine. 2012;100:130–134.
   Google Scholar
• Wilson HM. SOCS proteins in macrophage polarization and function. Front Immunol. 2014;5:1–5.
   PubMed Web of Science ®Google Scholar
• Chen R, Yang KD, Lee I, et al. Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever. J Infect. 2014;69(4):366–374.
   PubMed Web of Science ®Google Scholar
• oki IH, Tomari Y. The functions of microRNAs: mRNA decay and translational repression. Trends Cell Biol. 2015;25(11):651–665.
   PubMed Web of Science ®Google Scholar
• Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, et al. García-sastre adolfo. inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J Virol. 2005;79(13):8004–8013.
   PubMed Web of Science ®Google Scholar
• Morrison J, Laurent-Rolle M, Maestre AM, et al. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. PLoS Pathog. 2013;9(3):e1003265.
   PubMed Web of Science ®Google Scholar
• Girardi E, López P, Pfeffer S. On the importance of host MicroRNAs during viral infection. Front Genet. 2018;9:1–17.
   PubMed Web of Science ®Google Scholar
• Otsuka M, Jing Q, Georgel P, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007;27(1):123–134.
   PubMed Web of Science ®Google Scholar
• Frattari G, Aagaard L, Denton PW. The role of miR-29a in HIV-1 replication and latency. J Virus Erad. 2017;3(4):185–191.
   PubMed Web of Science ®Google Scholar
• Song L, Liu H, Gao S, et al. Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol. 2010;84(17):8849–8860.
   PubMed Web of Science ®Google Scholar
• Su YC, Huang YF, Wu YW, et al. MicroRNA-155 inhibits dengue virus replication by inducing heme oxygenase-1-mediated antiviral interferon responses. FASEB J. 2020;34(6):7283–7294.
   PubMed Web of Science ®Google Scholar
• Su C, Hou Z, Zhang C, et al. Ectopic expression of microRNA-155 enhances innate antiviral immunity against HBV infection in human hepatoma cells. Virol J. 2011;8(1):1–11.
   PubMedGoogle Scholar
• He X, Teng J, Cui C, et al. MicroRNA-182 inhibits HCMV replication through activation of type I IFN response by targeting FOXO3 in neural cells. Exp Cell Res. 2018;369(2):197–207.
   PubMed Web of Science ®Google Scholar
• Li S, Duan X, Li Y, et al. MicroRNA-130a inhibits HCV replication by restoring the innate immune response. J Viral Hepat. 2014;21(2):121–128.
   PubMed Web of Science ®Google Scholar
• Duan X, Liu X, Li W, et al. Microrna-130a downregulates HCV replication through an atg5-dependent autophagy pathway. Cells. 2019;8(4):338.
   PubMed Web of Science ®Google Scholar
• Huang JY, Chou SF, Lee JW, et al. MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ. Rna. 2015;21(3):385–400.
   PubMed Web of Science ®Google Scholar
• Huang CW, Tsai KN, Chen YS, et al. Differential mirna expression profiling reveals correlation of mir125b-5p with persistent infection of Japanese encephalitis virus. Int J Mol Sci. 2021;23(1):22.
   PubMedGoogle Scholar
• Huang J, Wang F, Argyris E, et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4 + T lymphocytes. Nat Med. 2007;13(10):1241–1247.
   PubMed Web of Science ®Google Scholar
• Mantri CK, Pandhare Dash J, Mantri JV, et al. Cocaine enhances HIV-1 replication in CD4+ T cells by down-regulating MiR-125b. PLoS ONE. 2012;7. DOI:10.1371/journal.pone.0051387
   Web of Science ®Google Scholar
• Castillo JA, Castrillón JC, Diosa-Toro M, et al. Complex interaction between dengue virus replication and expression of miRNA-133a. BMC Infect Dis. 2016;16(1):29.
   PubMedGoogle Scholar