Prevalence of antibiotics prescription amongst patients with and without COVID-19 in low- and middle-income countries: a systematic review and meta-analysis

References

• Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T Peer-Rev J Formul Manag. 2015;40:277–283.
   Google Scholar
• Murray CJ, Ikuta KS, Sharara F. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet Lond Engl. 2022;399:629–655.
   PubMed Web of Science ®Google Scholar
• Sartelli M, C Hardcastle T, Catena F, et al. Antibiotic use in low and middle-income countries and the challenges of antimicrobial resistance in surgery. Antibiotics. 2020;9:497.
   Google Scholar
• Tomas A, Aljadeeah S. The overlooked issue of outpatient combination antibiotic prescribing in low- and middle-income countries: an example from syria. Antibiotics. 2022;11:74.
   Google Scholar
• Pokharel S, Raut S, Adhikari B. Tackling antimicrobial resistance in low-income and middle-income countries. BMJ Glob Health. 2019;4:e002104.
   PubMed Web of Science ®Google Scholar
• Sulis G, Sayood S, Gandra S. Antimicrobial resistance in low- and middle-income countries: current status and future directions. Expert Rev Anti Infect Ther. 2022;20:147–160.
   PubMed Web of Science ®Google Scholar
• Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci USA. 2018;115:E3463–3470.
   PubMed Web of Science ®Google Scholar
• Wu S, Tannous E, Haldane V, et al. Barriers and facilitators of implementing interventions to improve appropriate antibiotic use in low- and middle-income countries: a systematic review based on the consolidated framework for implementation research. Implement Sci. 2022;17:30.
   PubMed Web of Science ®Google Scholar
• World Bank. Low & middle income | Data. 2022 [cited 2022 Dec 9]; Available from: https://data.worldbank.org/country/XO
   Google Scholar
• World Bank. Population, total | Data. 2022 [cited 2022 Dec 9]; Available from: https://data.worldbank.org/indicator/SP.POP.TOTL
   Google Scholar
• Adebisi YA, Jimoh ND, Ogunkola IO, et al. The use of antibiotics in COVID-19 management: a rapid review of national treatment guidelines in 10 African countries. Trop Med Health. 2021;49:51.
   PubMed Web of Science ®Google Scholar
• Dutta S, Kaur RJ, Bhardwaj P, et al. Demand of COVID-19 medicines without prescription among community pharmacies in Jodhpur, India: findings and implications. J Fam Med Prim Care. 2022;11:503–511.
   PubMedGoogle Scholar
• Jirjees F, Ahmed M, Sayyar S, et al. Self-medication with antibiotics during COVID-19 in the Eastern Mediterranean region countries: a review. Antibiotics. 2022;11:733.
   Google Scholar
• Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet Lond Engl. 2020;395:1054–1062.
   PubMed Web of Science ®Google Scholar
• Langford BJ, So M, Raybardhan S, et al. Bacterial coinfection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26:1622–1629.
   PubMed Web of Science ®Google Scholar
• Hoy D, Brooks P, Woolf A, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65:934–939.
   PubMed Web of Science ®Google Scholar
• Bajis S, Bernardo RS, Esmati S, et al. Antibiotic use in a district hospital in Kabul, Afghanistan: are we overprescribing? Public Health Action. 2014;4(4):259–264.
   PubMedGoogle Scholar
• Baltzell K, Kortz T, Scarr E, et al. “Not all fevers are malaria”: a mixed methods study of non-malarial fever management in rural southern Malawi. Rural Remote Health. 2019. DOI:10.22605/RRH4818
   PubMed Web of Science ®Google Scholar
• Bonniface M, Nambatya W, Rajab K. An evaluation of antibiotic prescribing practices in a rural refugee settlement district in Uganda. Antibiotics. 2021;10:172.
   Google Scholar
• Bunduki GK, Feasey N, Henrion MYR, et al. Healthcare-associated infections and antimicrobial use in surgical wards of a large urban central hospital in Blantyre, Malawi: a point prevalence survey. Infect Prev Pract. 2021;3:100163.
   PubMedGoogle Scholar
• Chaw PS, Schlinkmann KM, Raupach-Rosin H, et al. Antibiotic use on paediatric inpatients in a teaching hospital in the Gambia, a retrospective study. Antimicrob Resist Infect Control. 2018;7:82.
   PubMed Web of Science ®Google Scholar
• Jackson M, Namuwenge, Okure G, et al. Over-the-counter suboptimal dispensing of antibiotics in Uganda. J Multidiscip Healthc. 2013;303. DOI:10.2147/JMDH.S49075.
   PubMedGoogle Scholar
• Worku F, Tewahido D. Retrospective assessment of antibiotics prescribing at public primary healthcare facilities in addis Ababa, Ethiopia. Interdiscip Perspect Infect Dis. 2018;1–9.
   Google Scholar
• Yebyo H, Medhanyie AA, Spigt M, et al. C-reactive protein point-of-care testing and antibiotic prescribing for acute respiratory tract infections in rural primary health centres of North Ethiopia: a cross-sectional study. NPJ Prim Care Respir Med. 2016;26:15076.
   PubMed Web of Science ®Google Scholar
• Yousif BME, Supakankunti S. General practitioners’ prescribing patterns at primary healthcare centers in national health insurance, Gezira, Sudan. Drugs Real World Outcomes. 2016;3:327–332.
   PubMedGoogle Scholar
• Fink G, D’Acremont V, Leslie HH, et al. Antibiotic exposure among children younger than 5 years in low-income and middle-income countries: a cross-sectional study of nationally representative facility-based and household-based surveys. Lancet Infect Dis. 2020;20:179–187.
   PubMed Web of Science ®Google Scholar
• Abdulah R, Insani WN, Putri NE, et al. Pattern of medication use in geriatric patients at primary healthcare facilities in Karawang, Indonesia. Drug Healthc Patient Saf. 2019;11:1–5.
   PubMed Web of Science ®Google Scholar
• Abubakar U. Antibiotic use among hospitalized patients in northern Nigeria: a multicenter point-prevalence survey. BMC Infect Dis. 2020;20:86.
   PubMed Web of Science ®Google Scholar
• Adisa R, Orherhe OM, Fakeye TO. Evaluation of antibiotic prescriptions and use in under-five children in Ibadan, SouthWestern Nigeria. Afr Health Sci. 2018;18:1189.
   PubMed Web of Science ®Google Scholar
• Ahiabu M-A, Tersbøl BP, Biritwum R, et al. A retrospective audit of antibiotic prescriptions in primary healthcare facilities in Eastern Region, Ghana. Health Policy Plan. 2016;31:250–258.
   PubMed Web of Science ®Google Scholar
• Ahmadi F, Zarei E. Prescribing patterns of rural family physicians: a study in Kermanshah Province, Iran. BMC Public Health. 2017;17:908.
   PubMed Web of Science ®Google Scholar
• Ahmed S, Korpe P, Ahmed T, et al. Burden and risk factors of antimicrobial use in children less than 5 years of age with diarrheal illness in rural Bangladesh. Am J Trop Med Hyg. 2018;98:1571–1576.
   PubMed Web of Science ®Google Scholar
• Alkaff RN, Kamigaki T, Saito M, et al. Use of antibiotics for common illnesses among children aged under 5 years in a rural community in Indonesia: a cross-sectional study. Trop Med Health. 2019;47:45.
   PubMed Web of Science ®Google Scholar
• Andrajati R, Tilaqza A, Supardi S. Factors related to rational antibiotic prescriptions in community health centers in Depok city, Indonesia. J Infect Public Health. 2017;10:41–48.
   PubMed Web of Science ®Google Scholar
• Ankrah D, Owusu H, Aggor A, et al. Point prevalence survey of antimicrobial utilization in ghana’s premier hospital: implications for antimicrobial stewardship. Antibiotics. 2021;10:1528.
   Google Scholar
• Ansar A, Iftikhar S, Mir WA, et al. Original article drug prescription pattern in a tertiary care hospital in Pakistan. Med Forum. 2017;28:4.
   Google Scholar
• Atif M, Azeem M, Saqib A, et al. Investigation of antimicrobial use at a tertiary care hospital in Southern Punjab, Pakistan using WHO methodology. Antimicrob Resist Infect Control. 2017;6:41.
   PubMed Web of Science ®Google Scholar
• Bediako-Bowan AAA, Owusu E, Labi A-K, et al. Antibiotic use in surgical units of selected hospitals in Ghana: a multi-centre point prevalence survey. BMC Public Health. 2019;19:797.
   PubMed Web of Science ®Google Scholar
• Boone K, Morris SK, Doshi S, et al. Antimicrobial prescribing during infant hospital admissions in a birth Cohort in Dhaka. Bangladesh J Trop Pediatr. 2021;67:fmaa093.
   PubMed Web of Science ®Google Scholar
• Chaudhary P, Bahl A, Kumar A. Trends of prescribing and utilization of antibiotics in the paediatric outpatient population of a secondary care hospital in Gurgaon, India. Indian J Med Spec. 2014;5:93–96.
   Google Scholar
• Chem ED, Anong DN, J-FKT A. Prescribing patterns and associated factors of antibiotic prescription in primary health care facilities of Kumbo East and Kumbo West health districts, North West Cameroon. PLoS ONE. 2018;13:e0193353.
   PubMed Web of Science ®Google Scholar
• Dat VQ, Dat TT, Hieu VQ, et al. Antibiotic use for empirical therapy in the critical care units in primary and secondary hospitals in Vietnam: a multicenter cross-sectional study. Lancet Reg Health - West Pac. 2022;18:100306.
   PubMedGoogle Scholar
• Dodoo CC, Orman E, Alalbila T, et al. Antimicrobial prescription pattern in ho teaching hospital, Ghana: seasonaL determination using a point prevalence survey. Antibiotics. 2021;10:199.
   Google Scholar
• Fahimzad A, Eydian Z, Karimi A, et al. Surveillance of antibiotic consumption point prevalence survey 2014: antimicrobial prescribing in pediatrics wards of 16 Iranian hospitals Arch Iran Med. 2016;19(3):204–209.
   PubMed Web of Science ®Google Scholar
• Gandra S, Alvarez-Uria G, Murki S, et al. Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India: 2016. Int J Infect Dis. 2018;71:20–24.
   PubMed Web of Science ®Google Scholar
• Jose J. Paediatric prescription analysis in a primary health care institution. J Clin Diagn Res. 2016. DOI:10.7860/JCDR/2016/22350.8797
   Google Scholar
• Mekuria LA, de Wit TF, Spieker N, et al. Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: a mixed-methods study. PLoS ONE. 2019;14:e0222651.
   PubMed Web of Science ®Google Scholar
• Mustafa ZU, Kow CS, Salman M, et al. Pattern of medication utilization in hospitalized patients with COVID-19 in three district headquarters hospitals in the Punjab province of Pakistan. Explor Res Clin Soc Pharm. 2022;5:100101.
   PubMedGoogle Scholar
• Ndhlovu M, Nkhama E, Miller JM, et al. Antibiotic prescribing practices for patients with fever in the transition from presumptive treatment of malaria to ‘confirm and treat’ in Zambia: a cross-sectional study. Trop Med Int Health. 2015;20:1696–1706.
   PubMed Web of Science ®Google Scholar
• Nepal A, Hendrie D, Robinson S, et al. Analysis of patterns of antibiotic prescribing in public health facilities in Nepal. J Infect Dev Ctries. 2020;14:18–27.
   PubMed Web of Science ®Google Scholar
• Raza UA, Khursheed, T, Irfan, M. et al. Prescription patterns of general practitioners in Peshawar, Pakistan. Pak J Med Sci. 2014;30:462–465.
   PubMed Web of Science ®Google Scholar
• Safaeian L, Salami S, Pakmehr F, et al. Seasonality and physician-related factors associated with antibiotic prescribing: a cross-sectional study in Isfahan, Iran. Int J Prev Med. 2015;6:1.
   PubMedGoogle Scholar
• Sarwar MR, Saqib A, Iftikhar S, et al. Antimicrobial use by WHO methodology at primary health care centers: a cross sectional study in Punjab, Pakistan. BMC Infect Dis. 2018;18:492.
   PubMed Web of Science ®Google Scholar
• Saweri OPM, Hetzel MW, Mueller I, et al. The treatment of non-malarial febrile illness in Papua New Guinea: findings from cross sectional and longitudinal studies of health worker practice. BMC Health Serv Res. 2017;17:10.
   PubMed Web of Science ®Google Scholar
• Suranadi IW, IMAK S, Fatmawati NND, et al. A retrospective analysis of the bacterial infections, antibiotic use, and mortality predictors of COVID-19 patients. Int J Gen Med. 2022;15:3591–3603.
   PubMed Web of Science ®Google Scholar
• At Thobari J, Satria CD, Ridora Y, et al. Antimicrobial use in an Indonesian community cohort 0-18 months of age. PLoS ONE. 2019;14:e0219097.
   PubMed Web of Science ®Google Scholar
• Ababneh MA, Al-Azzam SI, Ababneh R, et al. Antibiotic prescribing for acute respiratory infections in children in Jordan. Int Health. 2017;9:124–130.
   PubMed Web of Science ®Google Scholar
• Ababneh MA, Jaber M, Rababa’h A, et al. Prevalence of antimicrobial use in a tertiary academic hospital: a venue for antimicrobial stewardship programs. Expert Rev Anti Infect Ther. 2021;19:1047–1051.
   PubMed Web of Science ®Google Scholar
• Aksoy M, Isli F, Kadi E, et al. Evaluation of more than one billion outpatient prescriptions and eight‐year trend showing a remarkable reduction in antibiotic prescription in Turkey: a success model of governmental interventions at national level. Pharmacoepidemiol Drug Saf. 2021;30:1242–1249.
   PubMed Web of Science ®Google Scholar
• Alkhaldi SM, Yaseen NA, Bataineh EA, et al. Patterns of antibiotic prescribing and appropriateness for respiratory tract infections in a teaching hospital in Jordan. Int J Clin Pract. 2021;75. DOI:10.1111/ijcp.14113.
   PubMed Web of Science ®Google Scholar
• Al‐shatnawi SF, Al‐hosban SY, Altawalbeh SM, et al. Antibiotic prescribing patterns for childhood infections in ambulatory settings in Jordan. Int J Clin Pract. 2021;75. DOI:10.1111/ijcp.14740.
   Web of Science ®Google Scholar
• Bozic B, Bajcetic M. Use of antibiotics in paediatric primary care settings in Serbia. Arch Dis Child. 2015;100:966–969.
   PubMed Web of Science ®Google Scholar
• Cao B, Wang Y, Wen D, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787–1799.
   PubMed Web of Science ®Google Scholar
• Chautrakarn S, Anugulruengkitt S, Puthanakit T, et al. Antimicrobial prescription patterns in a tertiary‐care pediatric unit in Thailand. Pediatr Int. 2020;62:683–687.
   PubMed Web of Science ®Google Scholar
• Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;m1091. DOI:10.1136/bmj.m1091.
   PubMed Web of Science ®Google Scholar
• Sánchez Choez X, Armijos Acurio ML, Jimbo Sotomayor RE. Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador. BMC Pharmacol Toxicol. 2018;19:46.
   PubMed Web of Science ®Google Scholar
• Ergül AB, İ G, Çelik T, et al. Assessment of inappropriate antibiotic use in pediatric patients: point-prevalence study. Turk Arch Pediatr Pediatri Arş. 2018;53:17–23.
   PubMedGoogle Scholar
• Gasson J, Blockman M, Willems B. Antibiotic prescribing practice and adherence to guidelines in primary care in the Cape town metro District, South Africa. S Afr Med J. 2018;108:304.
   PubMed Web of Science ®Google Scholar
• Greer RC, Intralawan D, Mukaka M, et al. Retrospective review of the management of acute infections and the indications for antibiotic prescription in primary care in northern Thailand. BMJ Open. 2018;8:e022250.
   PubMed Web of Science ®Google Scholar
• Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720.
   PubMed Web of Science ®Google Scholar
• He Y, Li W, Wang Z, et al. Nosocomial infection among patients with COVID-19: a retrospective data analysis of 918 cases from a single center in Wuhan, China. Infect Control Hosp Epidemiol. 2020;41:982–983.
   PubMed Web of Science ®Google Scholar
• Kalkan İA, Çinar G, PehliVanli A, et al. Pattern of systemic antibiotic use and potential drug interactions: evaluations through a point prevalence study in Ankara University Hospitals. Turk J Med Sci. 2021;51(2):523–529.
   PubMed Web of Science ®Google Scholar
• Lima MG, Dutra KR, Martins UCM. Prescribing indicators in primary health care in Belo Horizonte, Brazil: associated factors. Int J Clin Pharm. 2017;39:913–918.
   PubMed Web of Science ®Google Scholar
• Liu C, Liu C, Wang D, et al. Intrinsic and external determinants of antibiotic prescribing: a multi-level path analysis of primary care prescriptions in Hubei, China. Antimicrob Resist Infect Control. 2019;8:132.
   PubMed Web of Science ®Google Scholar
• Mashalla Y, Setlhare V, Massele A, et al. Assessment of prescribing practices at the primary healthcare facilities in Botswana with an emphasis on antibiotics: findings and implications. Int J Clin Pract. 2017;71:e13042.
   Web of Science ®Google Scholar
• Ab Rahman N, Teng CL, Sivasampu S. Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. BMC Infect Dis. 2016;16:208.
   PubMed Web of Science ®Google Scholar
• Şencan İ, Çağ Y, Karabay O, et al. Antibiotic use and influencing factors among hospitalized patients with COVID-19: a multicenter point-prevalence study from Turkey. Balk Med J. 2022;39:209–217.
   PubMed Web of Science ®Google Scholar
• Sun Q, Dyar OJ, Zhao L, et al. Overuse of antibiotics for the common cold – attitudes and behaviors among doctors in rural areas of Shandong Province, China. BMC Pharmacol Toxicol. 2015;16:6.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang P, Wang X, et al. Use and prescription of antibiotics in primary health care settings in China. JAMA Intern Med. 2014;174:1914.
   PubMed Web of Science ®Google Scholar
• Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323:1061.
   PubMed Web of Science ®Google Scholar
• Wang D, Yin Y, Hu C, et al. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. crit care. 2020;24:188.
   PubMed Web of Science ®Google Scholar
• Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8:475–481.
   PubMed Web of Science ®Google Scholar
• Yin J, Dyar OJ, Yang P, et al. Pattern of antibiotic prescribing and factors associated with it in eight village clinics in rural Shandong Province, China: a descriptive study. Trans R Soc Trop Med Hyg. 2019;113:714–721.
   PubMed Web of Science ®Google Scholar
• Zhan Q, Wang YL, Chen X. Evaluation of antibacterial use in outpatients of township and community primary medical institutions in a district of Sichuan Province, China. J Glob Antimicrob Resist. 2019;19:201–206.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Hu Y, Zou G, et al. Antibiotic prescribing for upper respiratory infections among children in rural China: a cross-sectional study of outpatient prescriptions. Glob Health Action. 2017;10:1287334.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Using indicators to measure country pharmaceutical situations: fact book on WHO level I and level II monitoring indicators. Geneva: World Health Organization; 2006.
   Google Scholar
• Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. Lancet Lond Engl. 2016;387:168–175.
   PubMed Web of Science ®Google Scholar