397
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Point prevalence survey of antibiotics use among hospitalised neonates and children in Saudi Arabia: findings and implications

, , , , , , , , , , , , & show all
Article: 2371411 | Received 17 Apr 2024, Accepted 18 Jun 2024, Published online: 12 Jul 2024

References

  • Akbari, R., Javaniyan, M., Fahimi, A., & Sadeghi, M. (2017). Renal function in patients with diabetic foot infection; does antibiotherapy affect it? Journal of Renal Injury Prevention, 6(2), 117–121. https://doi.org/10.15171/jrip.2017.23
  • Al-Obeid, S., Jabri, L., Al-Agamy, M., Al-Omari, A., & Shibl, A. (2015). Epidemiology of extensive drug resistant acinetobacter baumannii (XDRAB) at security forces hospital (SFH) in Kingdom of Saudi Arabia (KSA). Journal of Chemotherapy, 27(3), 156–162. https://doi.org/10.1179/1973947815Y.0000000019
  • Al-Tawfiq, J. A., & Al-Homoud, A. H. (2020). Pattern of systemic antibiotic use among hospitalized patients in a general hospital in Saudi Arabia. Travel Medicine and Infectious Disease, 36, 101605. https://doi.org/10.1016/j.tmaid.2020.101605
  • AlMahasnah, R., AlQassim, H., AlQaysum, I., Atta, M., AlRashidi, F., Abufara, H., Hashhoush, M., AlAjmi, N., & AlJishi, Y. (2023). Point prevalence survey on antimicrobial appropriateness in a tertiary care hospital in Saudi Arabia. Open Forum Infectious Diseases.
  • Al Matar, M., Enani, M., Binsaleh, G., Roushdy, H., Alokaili, D., Al Bannai, A., Khidir, Y., & Al-Abdely, H. (2019). Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016. Journal of Infection and Public Health, 12(1), 77–82. https://doi.org/10.1016/j.jiph.2018.09.003
  • Almughais, E. S., Alreshidi, F. F., & Ahmed, H. G. (2023). Prevalence of antibiotic misuse in cases of pneumonia and diarrhea in Saudi Arabia. Drug Target Insights, 17, 114–119. https://doi.org/10.33393/dti.2023.2614
  • Amadeo, B., Zarb, P., Muller, A., Drapier, N., Vankerckhoven, V., Rogues, A.-M., Davey, P., & Goossens, H. (2010). European surveillance of antibiotic consumption (ESAC) point prevalence survey 2008: Paediatric antimicrobial prescribing in 32 hospitals of 21 European countries. Journal of Antimicrobial Chemotherapy, 65(10), 2247–2252. https://doi.org/10.1093/jac/dkq309
  • Ambreen, S., Safdar, N., Ikram, A., Baig, M. Z. I., Farooq, A., Amir, A., … Zafar, A. (2023). Point prevalence survey of antimicrobial use in selected tertiary care hospitals of Pakistan using WHO methodology: Results and inferences. Medicina, 59(6), 1102. https://doi.org/10.3390/medicina59061102
  • Arif, S., Sadeeqa, S., & Saleem, Z. (2021). Patterns of antimicrobial use in hospitalized children: A repeated point prevalence survey from Pakistan. Journal of the Pediatric Infectious Diseases Society, 10(10), 970–974. https://doi.org/10.1093/jpids/piab026
  • Aslam, B., Wang, W., Arshad, M. I., Khurshid, M., Muzammil, S., Rasool, M. H., Nisar, M. A., Alvi, R. F., Aslam, M. A., & Qamar, M. U. (2018). CDATA[antibiotic resistance: A rundown of a global crisis]. CDATA[Infection and Drug Resistance], 1645–1658. https://doi.org/10.2147/IDR.S173867
  • Bazaid, A. S., Punjabi, A. A., Aldarhami, A., Qanash, H., Alsaif, G., Gattan, H., Barnawi, H., Alharbi, B., Alrashidi, A., & Alqadi, A. (2022). Bacterial infections among patients with chronic diseases at a tertiary care hospital in Saudi Arabia. Microorganisms, 10(10), 1907. https://doi.org/10.3390/microorganisms10101907
  • Chan, S., Ng, S., Chan, H. P., Pascoe, E. M., Playford, E. G., Wong, G., … Isbel, N. M. (2020). Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients. Cochrane Database of Systematic Reviews (8), CD013209.
  • Cooper, L., Sneddon, J., Afriyie, D. K., Sefah, I. A., Kurdi, A., Godman, B., & Seaton, R. A. (2020). Supporting global antimicrobial stewardship: Antibiotic prophylaxis for the prevention of surgical site infection in low- and middle-income countries (LMICs): A scoping review and meta-analysis. JAC-Antimicrobial Resistance, 2(3), dlaa070. https://doi.org/10.1093/jacamr/dlaa070
  • Dadgostar, P. (2019). CDATA[antimicrobial resistance: Implications and costs]. CDATA[Infection and Drug Resistance], 3903–3910. https://doi.org/10.2147/IDR.S234610
  • D’Amore, C., Ciofi degli Atti, M. L., Zotti, C., Prato, R., Guareschi, G., Spiazzi, R., … Raponi, M. (2021). Use of multiple metrics to assess antibiotic use in Italian children’s hospitals. Scientific Reports, 11(1), 3543. https://doi.org/10.1038/s41598-021-83026-1
  • Gandra, S., Alvarez-Uria, G., Murki, S., Singh, S. K., Kanithi, R., Jinka, D. R., Chikkappa, A. K., Subramanian, S., Sharma, A., & Dharmapalan, D. (2018). Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India: 2016. International Journal of Infectious Diseases, 71, 20–24. https://doi.org/10.1016/j.ijid.2018.03.017
  • Gaynes, R. (2017). The discovery of penicillin – New insights after more than 75 years of clinical use. Emerging Infectious Diseases, 23(5), 849–853. https://doi.org/10.3201/eid2305.161556
  • Gkentzi, D., Kortsalioudaki, C., Cailes, B. C., Zaoutis, T., Kopsidas, J., Tsolia, M., Spyridis, N., Siahanidou, S., Sarafidis, K., & Heath, P. T. (2019). Epidemiology of infections and antimicrobial use in Greek neonatal units. Archives of Disease in Childhood - Fetal and Neonatal Edition, 104(3), F293–F297. https://doi.org/10.1136/archdischild-2018-315024
  • Godman, B., Egwuenu, A., Haque, M., Malande, O. O., Schellack, N., Kumar, S., Saleem, Z., Sneddon, J., Hoxha, I., & Islam, S. (2021). Strategies to improve antimicrobial utilization with a special focus on developing countries. Life (chicago, Ill), 11(6), 528. https://doi.org/10.3390/life11060528
  • Gupta, A., Ampofo, K., Rubenstein, D., & Saiman, L. (2003). Extended spectrum β lactamase-producing klebsiella pneumoniae infections: A review of the literature. Journal of Perinatology, 23(6), 439–443. https://doi.org/10.1038/sj.jp.7210973
  • Haseeb, A., Abuhussain, S. S. A., Alghamdi, S., Bahshwan, S. M., Mahrous, A. J., Alzahrani, Y. A., … Naji, A. S. (2023). Point prevalence survey of antimicrobial use and resistance during the COVID-19 era among hospitals in Saudi Arabia and the implications. Antibiotics, 12(11), 1609. https://doi.org/10.3390/antibiotics12111609
  • Haseeb, A., Faidah, H. S., Algethamy, M., Alghamdi, S., Alhazmi, G. A., Alshomrani, A. O., Alqethami, B. R., Alotibi, H. S., Almutiri, M. Z., & Almuqati, K. S. (2022). Antimicrobial usage and resistance in makkah region hospitals: A regional point prevalence survey of public hospitals. International Journal of Environmental Research and Public Health, 19(1), 254. https://doi.org/10.3390/ijerph19010254
  • Ho, T., Buus-Frank, M. E., Edwards, E. M., Morrow, K. A., Ferrelli, K., Srinivasan, A., … Pursley, D. M. (2018). Adherence of newborn-specific antibiotic stewardship programs to CDC recommendations. Pediatrics, 142(6), e20174322.
  • Horumpende, P. G., Mshana, S. E., Mouw, E. F., Mmbaga, B. T., Chilongola, J. O., & de Mast, Q. (2020). Point prevalence survey of antimicrobial use in three hospitals in north-eastern Tanzania. Antimicrobial Resistance & Infection Control, 9(1), 1–6. https://doi.org/10.1186/s13756-020-00809-3
  • Hsia, Y., Lee, B. R., Versporten, A., Yang, Y., Bielicki, J., Jackson, C., Newland, J., Goossens, H., Magrini, N., & Sharland, M. (2019). Use of the WHO access, watch, and reserve classification to define patterns of hospital antibiotic use (AWaRe): An analysis of paediatric survey data from 56 countries. The Lancet Global Health, 7(7), e861–e871. https://doi.org/10.1016/S2214-109X(19)30071-3
  • Hufnagel, M., Versporten, A., Bielicki, J., Drapier, N., Sharland, M., & Goossens, H. (2019). High rates of prescribing antimicrobials for prophylaxis in children and neonates: Results from the antibiotic resistance and prescribing in European children point prevalence survey. Journal of the Pediatric Infectious Diseases Society, 8(2), 143–151. https://doi.org/10.1093/jpids/piy019
  • Jing, F.-H., Wang, Q., He, T.-J., Xin, N., Wang, Y.-W., Han, Y., Wang, X., & Li, Z. (2024). Three-year point prevalence survey of antimicrobial use in a Chinese university hospital. Canadian Journal of Infectious Diseases and Medical Microbiology, 1, 6698387. https://doi.org/10.1155/2024/6698387
  • Laxminarayan, R., Van Boeckel, T., Frost, I., Kariuki, S., Khan, E. A., Limmathurotsakul, D., Larsson, D. J., Levy-Hara, G., Mendelson, M., & Outterson, K. (2020). The Lancet infectious diseases commission on antimicrobial resistance: 6 years later. The Lancet Infectious Diseases, 20(4), e51–e60. https://doi.org/10.1016/S1473-3099(20)30003-7
  • Levy Hara, G., Rojas-Cortés, R., Molina León, H. F., Dreser Mansilla, A., Alfonso Orta, I., Rizo-Amezquita, J. N., Santos Herrera, R. G., Mendoza de Ayala, S., Arce Villalobos, M., & Mantilla Ponte, H. (2022). Point prevalence survey of antibiotic use in hospitals in Latin American countries. Journal of Antimicrobial Chemotherapy, 77(3), 807–815. https://doi.org/10.1093/jac/dkab459
  • Lobanovska, M., & Pilla, G. (2017). Focus: Drug development: Penicillin’s discovery and antibiotic resistance: Lessons for the future? The Yale Journal of Biology and Medicine, 90(1), 135–145.
  • Michael, C. A., Dominey-Howes, D., & Labbate, M. (2014). The antimicrobial resistance crisis: Causes, consequences, and management. Frontiers in Public Health, 2, 110657. https://doi.org/10.3389/fpubh.2014.00145
  • Ministry of Health. (2017). Kingdom Saudi Arabia national action plan on combating antimicrobial resistance. Retrieved November 17, 2023, from https://cdn.who.int/media/docs/default-source/antimicrobial-resistance/amr-spc-npm/nap-library/national-action-plan-on-combating-amr-(saudi-arabia.pdf?sfvrsn = 41521791)
  • Muller-Pebody, B., Johnson, A., Heath, P., Gilbert, R., Henderson, K., Sharland, M., & Group, i. (2011). Empirical treatment of neonatal sepsis: Are the current guidelines adequate? Archives of Disease in Childhood – Fetal and Neonatal Edition, 96(1), F4–F8. https://doi.org/10.1136/adc.2009.178483
  • Murray, C. J., Ikuta, K. S., Sharara, F., Swetschinski, L., Aguilar, G. R., Gray, A., Han, C., Bisignano, C., Rao, P., & Wool, E. (2022). Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. The Lancet, 399(10325), 629–655. https://doi.org/10.1016/S0140-6736(21)02724-0
  • Mustafa, Z. U., Khan, A. H., Harun, S. N., Salman, M., & Godman, B. (2023). Antibiotic overprescribing among neonates and children hospitalized with COVID-19 in Pakistan and the implications. Antibiotics, 12(4), 646. https://doi.org/10.3390/antibiotics12040646
  • Mustafa, Z. U., Khan, A. H., Salman, M., Syed Sulaiman, S. A., & Godman, B. (2022a). Antimicrobial utilization among neonates and children: A multicenter point prevalence study from leading children’s hospitals in punjab, Pakistan. Antibiotics, 11(8), 1056. https://doi.org/10.3390/antibiotics11081056
  • Mustafa, Z. U., Salman, M., Yasir, M., Godman, B., Majeed, H. A., Kanwal, M., Iqbal, M., Riaz, M. B., Hayat, K., & Hasan, S. S. (2022b). Antibiotic consumption among hospitalized neonates and children in punjab province, Pakistan. Expert Review of Anti-Infective Therapy, 20(6), 931–939. https://doi.org/10.1080/14787210.2021.1986388
  • Mwita, J. C., Ogunleye, O. O., Olalekan, A., Kalungia, A. C., Kurdi, A., Saleem, Z., Sneddon, J., & Godman, B. (2021). Key issues surrounding appropriate antibiotic use for prevention of surgical site infections in low- and middle-income countries: A narrative review and the implications. CDATA[International Journal of General Medicine], 515–530. https://doi.org/10.2147/IJGM.S253216
  • Nebot, S. S., López-Ramos, M. G., Velasco-Arnaiz, E., Jordan, I., Fortuny, C., & Noguera-Julian, A. (2022). Impact and quality of antimicrobial use in a referral pediatric intensive care unit. Enfermedades Infecciosas y Microbiología Clínica, 40(2), 78–81.
  • Neyaz, Y., Khoja, T., Qureshi, N., Magzoub, M., Hoycox, A., & Walley, T. (2011). Medication prescribing pattern in primary care in Riyadh City, Saudi Arabia. Eastern Mediterranean Health Journal, 17(2), 149–155. https://doi.org/10.26719/2011.17.2.149
  • Olwi, R. I., & Olwi, D. I. (2021). Trends in the use of antibiotics for pharyngitis in Saudi Arabia. The Journal of Infection in Developing Countries, 15(03), 415–421. https://doi.org/10.3855/jidc.12822
  • Omulo, S., Oluka, M., Achieng, L., Osoro, E., Kinuthia, R., Guantai, A., Opanga, S. A., Ongayo, M., Ndegwa, L., & Verani, J. R. (2022). Point-prevalence survey of antibiotic use at three public referral hospitals in Kenya. PLoS One, 17(6), e0270048. https://doi.org/10.1371/journal.pone.0270048
  • O’Neill, J. (2016). Tackling drug-resistant infections globally: Final report and recommendations – The review on antimicrobial re-sistance. Retrieved November 17, 2023, from https://amrreview.org/sites/default/files/160525_Final%20paper_with%20cover.pdf
  • Osowicki, J., Gwee, A., Noronha, J., Britton, P. N., Isaacs, D., Lai, T. B., Nourse, C., Avent, M., Moriarty, P., & Francis, J. R. (2015). Australia-wide point prevalence survey of antimicrobial prescribing in neonatal units. Pediatric Infectious Disease Journal, 34(8), e185–e190. https://doi.org/10.1097/INF.0000000000000719
  • Paramadhas, A., Tiroyakgosi, B. D., Mpinda-Joseph, C., Morokotso, P., Matome, M., Sinkala, M., Gaolebe, F., Malone, M., Molosiwa, B., Shanmugam, E., & G, M. (2019). Point prevalence study of antimicrobial use among hospitals across Botswana; Findings and implications. Expert Review of Anti-Infective Therapy, 17(7), 535–546. https://doi.org/10.1080/14787210.2019.1629288
  • Pauwels, I., Versporten, A., Drapier, N., Vlieghe, E., & Goossens, H. (2021). Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): Results from a worldwide point prevalence survey in 69 countries. Journal of Antimicrobial Chemotherapy, 76(6), 1614–1624. https://doi.org/10.1093/jac/dkab050
  • Prestinaci, F., Pezzotti, P., & Pantosti, A. (2015). Antimicrobial resistance: A global multifaceted phenomenon. Pathogens and Global Health, 109(7), 309–318. https://doi.org/10.1179/2047773215Y.0000000030
  • Prusakov, P., Goff, D. A., Wozniak, P. S., Cassim, A., Scipion, C. E., Urzúa, S., Ronchi, A., Zeng, L., Ladipo-Ajayi, O., & Aviles-Otero, N. (2021). A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study. EClinicalMedicine, 32.
  • Rehman, I. U., Asad, M. M., Bukhsh, A., Ali, Z., Ata, H., Dujaili, J. A., Blebil, A. Q., & Khan, T. M. (2018). Knowledge and practice of pharmacists toward antimicrobial stewardship in Pakistan. Pharmacy, 6(4), 116. https://doi.org/10.3390/pharmacy6040116
  • Saleem, Z., Hassali, M. A., Godman, B., Versporten, A., Hashmi, F. K., Saeed, H., Saleem, F., Salman, M., Rehman, I. U., & Khan, T. M. (2020). Point prevalence surveys of antimicrobial use: A systematic review and the implications. Expert Review of Anti-Infective Therapy, 18(9), 897–910. https://doi.org/10.1080/14787210.2020.1767593
  • Sharland, M., Pulcini, C., Harbarth, S., Zeng, M., Gandra, S., Mathur, S., & Magrini, N. (2018). Classifying antibiotics in the WHO essential medicines list for optimal use – Be AWaRe. The Lancet Infectious Diseases, 18(1), 18–20. https://doi.org/10.1016/S1473-3099(17)30724-7
  • Skosana, P., Schellack, N., Godman, B., Kurdi, A., Bennie, M., Kruger, D., & Meyer, J. (2022). A national, multicentre, web-based point prevalence survey of antimicrobial use and quality indices among hospitalised paediatric patients across South Africa. Journal of Global Antimicrobial Resistance, 29, 542–550. https://doi.org/10.1016/j.jgar.2021.12.003
  • Taibah, H., Arlikatti, S., Andrew, S. A., Maghelal, P., & DelGrosso, B. (2020). Health information, attitudes and actions at religious venues: Evidence from Hajj pilgrims. International Journal of Disaster Risk Reduction, 51, 101886. https://doi.org/10.1016/j.ijdrr.2020.101886
  • Tayebati, S. K., Nittari, G., Mahdi, S. S., Ioannidis, N., Sibilio, F., & Amenta, F. (2017). Identification of world health organisation ship’s medicine chest contents by anatomical therapeutic chemical (ATC) classification codes. International Maritime Health, 68(1), 39–45. https://doi.org/10.5603/IMH.2017.0007
  • Tersigni, C., Montagnani, C., D’Argenio, P., Duse, M., Esposito, S., Hsia, Y., Sharland, M., & Galli, L. (2019). Antibiotic prescriptions in Italian hospitalised children after serial point prevalence surveys (or pointless prevalence surveys): Has anything actually changed over the years? Italian Journal of Pediatrics, 45(1), 1–4. https://doi.org/10.1186/s13052-019-0722-y
  • Thomas, K., & Vassilopoulos, D. (2020). Infections in patients with rheumatoid arthritis in the era of targeted synthetic therapies. Mediterranean Journal of Rheumatology, 31(Suppl 1), 129–136. https://doi.org/10.31138/mjr.31.1.129
  • Touboul-Lundgren, P., Jensen, S., Drai, J., & Lindbæk, M. (2015). Identification of cultural determinants of antibiotic use cited in primary care in Europe: A mixed research synthesis study of integrated design “culture is all around us”. BMC Public Health, 15(1), 1–9. https://doi.org/10.1186/s12889-015-2254-8
  • Tripathi, N., Cotten, C. M., & Smith, P. B. (2012). Antibiotic use and misuse in the neonatal intensive care unit. Clinics in Perinatology, 39(1), 61–68. https://doi.org/10.1016/j.clp.2011.12.003
  • Ventola, C. L. (2015). The antibiotic resistance crisis: Part 1: Causes and threats. Pharmacy and Therapeutics, 40(4), 277–283.
  • Versporten, A., Zarb, P., Caniaux, I., Gros, M.-F., Drapier, N., Miller, M., Jarlier, V., Nathwani, D., Goossens, H., & Koraqi, A. (2018). Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: Results of an internet-based global point prevalence survey. The Lancet Global Health, 6(6), e619–e629. https://doi.org/10.1016/S2214-109X(18)30186-4
  • Walsh, T. R., Gales, A. C., Laxminarayan, R., & Dodd, P. C. (2023). Antimicrobial resistance: Addressing a global threat to humanity (Vol. 20, pp. e1004264). Public Library of Science.
  • Wang, C.-n., Tong, J., Yi, B., Huttner, B. D., Cheng, Y., Li, S., … Zhao, S. (2021). Antibiotic use among hospitalized children and neonates in China: Results from quarterly point prevalence surveys in 2019. Frontiers in Pharmacology, 12, 601561. https://doi.org/10.3389/fphar.2021.601561
  • Woll, C., Neuman, M. I., Pruitt, C. M., Wang, M. E., Shapiro, E. D., Shah, S. S., McCulloh, R. J., Nigrovic, L. E., Desai, S., & DePorre, A. G. (2018). Epidemiology and etiology of invasive bacterial infection in infants ≤60 days old treated in emergency departments. The Journal of Pediatrics, 200, 210–217.e1. https://doi.org/10.1016/j.jpeds.2018.04.033
  • World Bank Group. (2019). Pulling together to beat superbugs knowledge and implementation gaps in addressing antimicrobial resistance. Retrieved November 17, 2023, from https://openknowledge.worldbank.org/bitstream/handle/10986/32552/PullingTogether-to-Beat-Superbugs-Knowledge-and-Implementation-Gaps-in-Addressing-Antimicrobial-Resistance.pdf?sequence = 1&isAllowed = y
  • World Health Organization (WHO). (2018). Essential medicines and health products. WHO methodology for point prevalence survey on antibiotic use in hospitals. Retrieved November 17, 2023, from https://www.who.int/medicines/access/antimicrobial_resistance/WHOEMP-IAU-2018_01/en/
  • World Health Organization (WHO). (2020). Antimicrobial Resistance (AMR); World Health Organization: Geneva, Switzerland. Retrieved December 1, 2023, from https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
  • Youngster, I., Avorn, J., Belleudi, V., Cantarutti, A., Díez-Domingo, J., Kirchmayer, U., Park, B.-J., Peiró, S., Sanfélix-Gimeno, G., & Schröder, H. (2017). Antibiotic use in children – A cross-national analysis of 6 countries. The Journal of Pediatrics, 182, 239–244.e1. https://doi.org/10.1016/j.jpeds.2016.11.027
  • Zhang, J., Lin, L., Lu, G., Wu, K., Tian, D., Tang, L., Ma, X., Wang, Y., Liu, G., & Li, Y. (2024). Changes in the intrinsic severity of severe acute respiratory syndrome coronavirus 2 according to the emerging variant: A nationwide study from February 2020 to June 2022, including comparison with vaccinated populations. BMC Infectious Diseases, 24(1), 1–10. https://doi.org/10.1186/s12879-023-08869-7
  • Zhang, J., Ma, X., Tang, L., Tian, D., Lin, L., Li, Y., … Qian, J. (2022). Pattern of antibiotic prescriptions in Chinese children, a cross-sectional survey from 17 hospitals located across 10 provinces of China. Frontiers in Pediatrics, 10, 857945. https://doi.org/10.3389/fped.2022.857945