Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats

References

• Bixter MT, Blocker KA, Rogers WA. Enhancing the social engagement of older adults through technology. Author links open overlay panels. Aging, Technology, and Health; 2018. p. 179–214.
   Google Scholar
• Mula M. Cognitive dysfunction in patients with epilepsy: focus on clinical variables. Future Neurol. 2015;10(1):41–48.
   Google Scholar
• Landi S, Petrucco L, Sicca F, et al. Transient cognitive impairment in epilepsy. Front Mol Neurosci. 2019;11:458.
   Web of Science ®Google Scholar
• Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011;4(6):385–407.
   PubMedGoogle Scholar
• Akinsomisoye OS, Owolabi AR, Adeyeye OB, et al. Effects of vigabatrin, carbamazepine, or its combination on the pituitary-gonadal axis in male Wistar rats. Res J Health Sci. 2017;5(4):194–203.
   Google Scholar
• Osuntokun OS, Adedokun KI, Oladokun OO, et al. Carbamazepine alone induced more severe ataxic movement and cerebellar toxicity than gabapentin or carbamazepine-gabapentin. UNIOSUN J Sci. 2018;3(2):122–131.
   Google Scholar
• Prunetti P, Perucca E. New and forthcoming anti-epileptic drugs. Curr Opin Neurol. 2011;24(2):159–164.
   Web of Science ®Google Scholar
• Bialer M. Why are antiepileptic drugs used for nonepileptic conditions? Epilepsia. 2012;53(7):26–33.
   PubMedGoogle Scholar
• Lowry JA, Vandover JC, DeGreeff J, et al. Unusual presentation of iatrogenic phenytoin toxicity in a newborn. J Med Toxicol. 2005;1(1):26–29.
   Google Scholar
• Gupta V, Yadav TP, Yadav A. Phenytoin toxicity presenting as acute meningoencephalitis in children. Neurol India. 2011;59(1):66–67.
   Web of Science ®Google Scholar
• Lukyanetz EA, Shkryl VM, Kostyuk PG. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 2002;43(1):9–18.
   PubMed Web of Science ®Google Scholar
• Swaroop HS, Ananya C, Nithin K, et al. Levetiracetam: a Review of its use in the treatment of epilepsy. Int J Med Biomed Res. 2013;2(3):166–172.
   Google Scholar
• Rachamallu V, Song MM, Reed JM, et al. Levetiracetam-induced transaminitis in a young male with traumatic brain injury. Oxf Med Case Reports. 2017;2017(11):omx067.
   PubMedGoogle Scholar
• Brown C. Pharmacological management of epilepsy. Prog Neurol Psychiatry. 2018;20(2):27–34.
   Web of Science ®Google Scholar
• Matagne AC, Baltes E, Coupez R. Levetiracetam enhances markedly the seizure suppression of other antiepileptic drugs in audiogenic susceptible mice. Epilepsia. 2001;42:82.
   Google Scholar
• Czubak A, Nowakowska E, Kus K, et al. Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life. Hum Exp Toxicol. 2001;27(12):883–894.
   Google Scholar
• Olaibi OK, Osuntokun OS, Ijomone OM. Effects of chronic administration of gabapentin and carbamazepine on the histomorphology of the hippocampus and striatum. Ann Neurosci. 2014;21(2):57–61.
   Google Scholar
• Witt JA, Helmstaedter C. Monitoring the cognitive effects of antiepileptic pharmacotherapy – approaching the individual patient. Epilepsy Behav. 2013;26(3):450–456.
   PubMed Web of Science ®Google Scholar
• Soysal H, Unur E, Duzler A, et al. Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus. Seizure. 2011;20(3):187–193.
   Web of Science ®Google Scholar
• Talos D, Chang M, Kosaras B. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013;73(1):24–30.
   Web of Science ®Google Scholar
• Brioni JD, Hock FJ, Mcgaugh JL. Drug effects on learning and memory. In: Vogel HG, Vogel WH, editors. Drug discovery and evaluation. 2nd ed. Philadephia: Springer; 2002. p. 619–622.
   Google Scholar
• Ogundele OM, Adeniyi PA, Ajonijeb DC, et al. Motor and memory function in rat models of cyanide toxicity and vascular occlusion induced ischemic injury. Pathophysiology. 2014;21(3):191–198.
   PubMedGoogle Scholar
• Seibenhener ML, Wooten MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. JoVE. 2015;6 (96):e52434.
   Google Scholar
• Hayashi K, Furuya A, Sakamaki Y, et al. The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS One. 2017;12(3):e0173175. .
   Web of Science ®Google Scholar
• Tsakiris S, Schulpis KH, Marinou K, et al. Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+-ATPase and Mg2+-ATPase activities induced by the in vitro galactosemia. Pharmacol Res. 2004;49(5):475–479.
   Web of Science ®Google Scholar
• Sally AE, Gehad AAJ, Dalia OS. Alleviation of haloperidol-induced oxidative stress in rats: effects of sucrose vs grape seed extract. Bull Faculty Pharm Cairo Univ. 2015;53(1):29–35.
   Google Scholar
• Habila N, Inuwa HM, Aimola IA, et al. Correlation of acetylcholinesterase activity in the brain and blood of Wistar rats acutely infected with Trypanosoma Congolense. J Acute Dis. 2012;1(1):26–30.
   Google Scholar
• Onaolapo OJ, Onaolapo AY, Akanmu MA, et al. Evidence of alterations in brain structure and antioxidant status following ‘low dose’ monosodium glutamate ingestion. Pathophysiology. 2016;23(3):147–156.
   PubMedGoogle Scholar
• Czuczwar SJ, Borowicz KK. Polytherapy in epilepsy: the experimental evidence. Epilepsy Res. 2002;52(1):15–23.
   Web of Science ®Google Scholar
• Forcelli PA, Kozlowski R, Snyder C, et al. Effects of neonatal antiepileptic drug exposure on cognitive, emotional, and motor function in adult rats. J Pharmacol Exp Ther. 2012;340(3):558–566.
   Web of Science ®Google Scholar
• Zimcikova E, Simko J, Karesova I, et al. Behavioral effects of antiepileptic drugs in rats: are the effects on mood and behavior detectable in an open-field test? Seizure. 2017;52:35–40.
   PubMed Web of Science ®Google Scholar
• Shanmugam S, Daniel L, Ahamed J. A meta-analysis of antiepileptic drugs induced choreoathetosis in pediatric patients. Int J Med Rev Case Rep. 2017;1(3):49–52.
   Google Scholar
• Chindo BA, Adzu B, Gamaniel KS. Antiepileptic drug targets: an update on ion channels, epileptology - the modern state of science, Vladimir V. Kalinin, Intech Open; 2016. DOI:https://doi.org/10.5772/64455.
   Google Scholar
• Schipper S, Aalbers MW, Rijkers K, et al. Tonic GABAA receptors as potential target for the treatment of temporal lobe epilepsy. Mol Neurobiol. 2016;53(8):5252–5265.
   Web of Science ®Google Scholar
• Osuntokun OS, Olayiwola G, Oladele A, et al. Chronic administration of gabapentin and a gabapentin-carbamazepine combination reversibly suppress testicular function in male Wistar rats (Rattus norvegicus). Pathophysiology. 2017;24(2):63–69.
   PubMedGoogle Scholar
• Nachev P, Wydell H, O’Neill K, et al. The role of pre-supplementary motor areas in the control of the action. Neuroimage. 2007;36:3.
   Web of Science ®Google Scholar
• Sakurai Y, Furukawa E, Kurihara M, et al. Frontal phonological agraphia and acalculia with impaired verbal short-term memory due to left inferior precentral gyrus lesion. Case Rep Neurol. 2018;10(1):72–82.
   PubMed Web of Science ®Google Scholar
• Arora A, Mehta AK, Sharma KK, et al. Effects of carbamazepine and lamotrigine on cognitive function and oxidative stress in the brain during chemical epileptogenesis in rats. Basic Clin Pharmacol Toxicol. 2009;106(5):372–377.
   Web of Science ®Google Scholar
• Sembulingam K, Sembulingam P. Essential of medical physiology. Jaypee Brothers Medical Publishers(P) Ltd. 2012;12:884–889.
   Google Scholar
• Kersten M, Rabbe T, Blome R, et al. Novel object recognition in rats with NMDAR dysfunction in CA1 after stereotactic injection of anti-NMDAR encephalitis cerebrospinal fluid. Front Neurol. 2019;10(586):1–11.
   Google Scholar
• Maurer SV, Williams CL. The cholinergic system modulates memory and hippocampal plasticity via its interactions with non-neuronal cells. Front Immunol. 2017;8:1489.
   Web of Science ®Google Scholar
• Bookheimer SY. Precentral Gyrus. In: Volkmar FR, editor. Encyclopedia of autism spectrum disorders. New York, NY: Springer; 2013. DOI:https://doi.org/10.1007/978-1-4419-1698-3_203
   Google Scholar
• Morimoto M, Hashimoto T, Kitaoka T, et al. Impact of oxidative stress and newer antiepileptic drugs on the albumin and cortisol value in severe motor and intellectual disabilities with epilepsy. J Clin Med Res. 2018;10(2):137–145.
   Google Scholar
• Mahmoud AT, Tawfik MA, Abd-El-Aziz HAD. A study of DNZ damage in epileptic treated with valproic acid or carbamazepine. Menoufia Med J. 2019;32(3):1078–1082.
   Google Scholar
• Menon B, Ramalingam K, Kumar RV. Oxidative stress in patients with epilepsy is independent of antiepileptic drugs. Seizure. 2012;21(10):780–784.
   PubMed Web of Science ®Google Scholar
• Milligan TA, Hurwitz S, Bromfield EB. Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology. 2008;71(9):665–669.
   Web of Science ®Google Scholar