Severe depression is associated with decreased levels of serum brain-derived neurotrophic factor in type 2 diabetes patients in Ghana

References

• Ducat L, Philipson LH, Anderson BJ. The mental health comorbidities of diabetes. JAMA. 2014;312(7):691–692. doi: 10.1001/jama.2014.8040
   PubMed Web of Science ®Google Scholar
• Gaynes BN, Akiba CF, Hosseinipour MC, et al. The sub-saharan Africa regional partnership (SHARP) for mental health capacity-building scale-up trial: study design and protocol. Psychiatric Serv. 2021;72(7):812–821. doi: 10.1176/appi.ps.202000003
   PubMed Web of Science ®Google Scholar
• Agyekum JA, Gyamfi T, Yeboah K. Depression, poor sleep quality, and diabetic control in type 2 diabetes patients at Sunyani Regional Hospital, Ghana: a case–control study. Middle East Current Psychiatry. 2023;30(1):45. doi: 10.1186/s43045-023-00317-1
   Google Scholar
• Chen S, Zhang Q, Dai G, et al. Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis. Endocrine. 2016;53(1):35–46. doi: 10.1007/s12020-016-0869-x
   PubMed Web of Science ®Google Scholar
• Khaledi M, Haghighatdoost F, Feizi A, et al. The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies. Acta Diabetol. 2019;56(6):631–650. doi: 10.1007/s00592-019-01295-9
   PubMed Web of Science ®Google Scholar
• Paile‐Hyvärinen M, Räikkönen K, Forsén T, et al. Depression and its association with diabetes, cardiovascular disease, and birth weight. Ann Med. 2007;39(8):634–640. doi: 10.1080/07853890701545722
   PubMed Web of Science ®Google Scholar
• Huang B, Huang Z, Tan J, et al. The mediating and interacting role of physical activity and sedentary behavior between diabetes and depression in people with obesity in United States. J Diabetes Complications. 2021;35(1):107764. doi: 10.1016/j.jdiacomp.2020.107764
   PubMed Web of Science ®Google Scholar
• Daneshzad E, Keshavarz S-A, Qorbani M, et al. Dietary total antioxidant capacity and its association with sleep, stress, anxiety, and depression score: a cross-sectional study among diabetic women. Clin Nutr ESPEN. 2020;37:187–194. doi: 10.1016/j.clnesp.2020.03.002
   PubMed Web of Science ®Google Scholar
• Rozanska O, Uruska A, Zozulinska-Ziolkiewicz D. Brain-derived neurotrophic factor and diabetes. Int J Mol Sci. 2020;21(3):841. doi: 10.3390/ijms21030841
   PubMed Web of Science ®Google Scholar
• Jaggar M, Fanibunda SE, Ghosh S, et al. Chapter 6 - the neurotrophic hypothesis of depression revisited: new insights and therapeutic implications. In: Quevedo J Carvalho A, editors. Neurobiology of depression. Zarate CA: Academic Press; 2019. p. 43–62.
   Google Scholar
• Klein AB, Williamson R, Santini MA, et al. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol. 2011;14(3):347–353. doi: 10.1017/S1461145710000738
   PubMed Web of Science ®Google Scholar
• Kallies G, Rapp MA, Fydrich T, et al. Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder. Psychoneuroendocrinology. 2019;102:212–215. doi: 10.1016/j.psyneuen.2018.12.015
   PubMed Web of Science ®Google Scholar
• Morichi S, Kashiwagi Y, Takekuma K, et al. Expressions of brain-derived neurotrophic factor (BDNF) in cerebrospinal fluid and plasma of children with meningitis and Encephalitis/Encephalopathy. Int J Neurosci. 2012;123(1):17–23. doi: 10.3109/00207454.2012.721829
   Web of Science ®Google Scholar
• Wang C-P, Lorenzo C, Habib SL, et al. Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. J Diabetes Complications. 2017;31(4):679–686. doi: 10.1016/j.jdiacomp.2017.01.013
   PubMed Web of Science ®Google Scholar
• Davarpanah M, Shokri-Mashhadi N, Ziaei R, et al. A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile. Sci Rep. 2021;11(1):13773. doi: 10.1038/s41598-021-93271-z
   PubMedGoogle Scholar
• Krabbe KS, Nielsen AR, Krogh-Madsen R, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50(2):431–438. doi: 10.1007/s00125-006-0537-4
   PubMed Web of Science ®Google Scholar
• Cavaleri D, Moretti F, Bartoccetti A, et al. The role of BDNF in major depressive disorder, related clinical features, and antidepressant treatment: insight from meta-analyses. Neuroscience & Biobehavioral Reviews. 2023;149:105159. doi: 10.1016/j.neubiorev.2023.105159
   PubMed Web of Science ®Google Scholar
• Mondal AC, Fatima M. Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment. Int J Neurosci. 2019;129(3):283–296. doi: 10.1080/00207454.2018.1527328
   PubMed Web of Science ®Google Scholar
• Iannitelli A, Tirassa P, Fiore M, et al. Gender differences in ultradian serum levels of NGF and BDNF correlate with psychophysical traits in healthy humans. Riv Psichiatr. 2021;56(6):314–320. doi: 10.1708/3713.37045
   PubMed Web of Science ®Google Scholar
• Christian LM, Mitchell AM, Gillespie SL, et al. Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: associations with race, depressive symptoms, and low birth weight. Psychoneuroendocrinology. 2016;74:69–76. doi: 10.1016/j.psyneuen.2016.08.025
   PubMed Web of Science ®Google Scholar
• Fazeli PL, Woods SP, Lambert CC, et al. Differential associations between BDNF and Memory Across Older black and white adults with HIV disease. J Acquir Immune Defic Syndr. 2022;89(2):129–135. doi: 10.1097/QAI.0000000000002831
   PubMed Web of Science ®Google Scholar
• Weobong B, Akpalu B, Doku V, et al. The comparative validity of screening scales for postnatal common mental disorder in Kintampo, Ghana. J Affective Disorders. 2009;113(1):109–117. doi: 10.1016/j.jad.2008.05.009
   PubMed Web of Science ®Google Scholar
• Makhubela M, Khumalo IP. Psychometric evaluation of the PHQ-9 in university students: factorial validity and measurement equivalence across three African countries. Current Psychol. 2022;42(21):18061–18069. doi: 10.1007/s12144-022-02997-0
   Web of Science ®Google Scholar
• Cichoń E, Kiejna A, Kokoszka A, et al. People with diabetes need a lower cut-off than others for depression screening with PHQ-9. PLoS One. 2020;15(10):e0240209. doi: 10.1371/journal.pone.0240209
   PubMed Web of Science ®Google Scholar
• Mitchell AJ, Yadegarfar M, Gill J, et al. Case finding and screening clinical utility of the patient health questionnaire (PHQ-9 and PHQ-2) for depression in primary care: a diagnostic meta-analysis of 40 studies. BJPsych Open. 2016;2(2):127–138. doi: 10.1192/bjpo.bp.115.001685
   PubMed Web of Science ®Google Scholar
• Naegelin Y, Dingsdale H, Säuberli K, et al. Measuring and validating the levels of brain-derived neurotrophic factor in human serum. eNeuro. 2018;5(2):ENEURO.0419–17.2018. doi: 10.1523/ENEURO.0419-17.2018
   PubMed Web of Science ®Google Scholar
• Li B, Lang N, Cheng Z-F. Serum levels of brain-derived neurotrophic factor are associated with diabetes risk, complications, and obesity: a cohort study from Chinese patients with type 2 diabetes. Mol Neurobiol. 2016;53(8):5492–5499. doi: 10.1007/s12035-015-9461-2
   PubMed Web of Science ®Google Scholar
• He M, Wang J. Decreased serum brain-derived neurotrophic factor in Chinese patients with type 2 diabetes mellitus. Acta Biochim Biophys Sin. 2014;46(5):426–427. doi: 10.1093/abbs/gmu008
   Google Scholar
• Dias BG, Banerjee SB, Duman RS, et al. Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology. 2003;45(4):553–563. doi: 10.1016/S0028-3908(03)00198-9
   PubMed Web of Science ®Google Scholar
• Berton O, McClung CA, DiLeone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006;311(5762):864–868. doi: 10.1126/science.1120972
   PubMed Web of Science ®Google Scholar
• Boyuk B, Degirmencioglu S, Atalay H, et al. Relationship between levels of brain-derived neurotrophic factor and metabolic parameters in patients with type 2 diabetes mellitus. J Diabetes Res. 2014;2014:1–6. doi: 10.1155/2014/978143
   Web of Science ®Google Scholar
• Yamanaka M, Itakura Y, Tsuchida A, et al. Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice. Diabetes Obesity Metab. 2007;9(6):879–888. doi: 10.1111/j.1463-1326.2006.00675.x
   PubMed Web of Science ®Google Scholar
• Lee B-H, Kim Y-K. Reduced platelet BDNF level in patients with major depression. Prog Neuro Psychopharmacol Biol Psychiatry. 2009;33(5):849–853. doi: 10.1016/j.pnpbp.2009.04.002
   PubMed Web of Science ®Google Scholar
• Lee B-H, Kim Y-K. BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide. J Affective Disorders. 2010;125(1):369–373. doi: 10.1016/j.jad.2010.01.074
   PubMed Web of Science ®Google Scholar
• Molendijk ML, Spinhoven P, Polak M, et al. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry. 2014;19(7):791–800. doi: 10.1038/mp.2013.105
   PubMed Web of Science ®Google Scholar
• Lee B-H, Kim Y-K. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investigation. 2010;7(4):231. doi: 10.4306/pi.2010.7.4.231
   PubMed Web of Science ®Google Scholar
• Gonul AS, Akdeniz F, Taneli F, et al. Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci. 2005;255(6):381–386. doi: 10.1007/s00406-005-0578-6
   PubMed Web of Science ®Google Scholar
• Karege F, Bondolfi G, Gervasoni N, et al. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biological Psychiatry. 2005;57(9):1068–1072. doi: 10.1016/j.biopsych.2005.01.008
   PubMed Web of Science ®Google Scholar
• Karege F, Perret G, Bondolfi G, et al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109(2):143–148. doi: 10.1016/S0165-1781(02)00005-7
   PubMed Web of Science ®Google Scholar
• Emon MPZ, Das R, Nishuty NL, et al. Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case–control study with or without antidepressant therapy. BMC Res Notes. 2020;13(1):1–6. doi: 10.1186/s13104-020-04952-3
   PubMed Web of Science ®Google Scholar
• Lee B-H, Park Y-M, Hwang J-A, et al. Variable alterations in plasma erythropoietin and brain-derived neurotrophic factor levels in patients with major depressive disorder with and without a history of suicide attempt. Prog Neuro Psychopharmacol Biol Psychiatry. 2021;110:110324. doi: 10.1016/j.pnpbp.2021.110324
   PubMed Web of Science ®Google Scholar
• Rasmussen P, Brassard P, Adser H, et al. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009;94(10):1062–1069. doi: 10.1113/expphysiol.2009.048512
   PubMed Web of Science ®Google Scholar
• Kackley ML, Buga A, Crabtree CD, et al. Influence of nutritional ketosis achieved through various methods on plasma concentrations of brain derived neurotropic factor. Brain Sci. 2022;12(9):1143. doi: 10.3390/brainsci12091143
   PubMed Web of Science ®Google Scholar
• Golden E, Emiliano A, Maudsley S, et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore longitudinal study of aging. PLoS One. 2010;5(4):e10099. doi: 10.1371/journal.pone.0010099
   PubMed Web of Science ®Google Scholar
• Kulaksizoglu S, Kulaksizoglu B. The relationship between metabolic syndrome, BDNF, and vitamin D in patients with schizophrenia. Neurochem J. 2017;11(1):104–111. doi: 10.1134/S1819712417010056
   Google Scholar
• Amoureux S, Lorgis L, Sicard P, et al. Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension. Fundam Clin Pharmacol. 2012;26(2):227–234. doi: 10.1111/j.1472-8206.2010.00912.x
   PubMed Web of Science ®Google Scholar
• Smith AJ, Malan L, Uys AS, et al. Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study. J Hum Hypertens. 2015;29(1):33–39. doi: 10.1038/jhh.2014.39
   PubMed Web of Science ®Google Scholar
• Nakagomi A, Okada S, Yokoyama M, et al. Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. NP J Aging Mech Dis. 2015;1(1):15009. doi: 10.1038/npjamd.2015.9
   PubMedGoogle Scholar
• Spagnuolo MS, Donizetti A, Iannotta L, et al. Brain-derived neurotrophic factor modulates cholesterol homeostasis and apolipoprotein E synthesis in human cell models of astrocytes and neurons. J Cell Physiol. 2018;233(9):6925–6943. doi: 10.1002/jcp.26480
   PubMed Web of Science ®Google Scholar
• Fujimura H, Altar CA, Chen R, et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost. 2002;87(4):728–734. doi: 10.1055/s-0037-1613072
   PubMed Web of Science ®Google Scholar
• Michalski B, Fahnestock M. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease. Mol Brain Res. 2003;111(1):148–154. doi: 10.1016/S0169-328X(03)00003-2
   PubMedGoogle Scholar