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Open Peer Commentaries

Efficacy Testing as a Primary Purpose of Phase 1 Clinical Trials: Is it Applicable to First-in-Human Bionics and Optogenetics Trials?

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Pages 20-22 | Published online: 18 Apr 2012

REFERENCES

  • Bi , A. 2006 . Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration . Neuron , 50 ( 1 ) : 23 – 33 .
  • Bretzner , F. , Gilbert , F. , Baylis , F. and Brownstone , R. 2011 . Target populations for first-in-human embryonic stem cell research in spinal cord injury . Cell Stem Cell , 8 : 468 – 475 .
  • Edwards , S. J. 2005 . Research participation and the right to withdraw . Bioethics , 19 ( 2 ) : 112 – 130 .
  • Gilbert , F . 2009 . Geron's hESC trial for spinal cord injury: The risk of therapeutic misconception . Forum Bioethics, The Hastings Center , Epub April 17 Available at: http://www.thehastingscenter.org/bioethicsforum/post.aspx?id=3370&blogid=140
  • Hess , P. 2012 . Intracranial stem cell-based transplantation: Reconsidering the ethics of phase 1 clinical trials in light of irreversible intervention in the brain . AJOB Neuroscience , 3 ( 2 ) : 3 – 13 .
  • Hodgetts , S. I. , Davies , M. , Smythe , G. M. , Fan , Y. , Beilharz , M. W. and Grounds , M. D. 1998 . Quantitation of donor male myoblast survival in cell transplantation experiments in dystrophic mice . Muscle & Nerve Suppl , 7 : S126
  • Jia , Z. 2011 . Stimulating cardiac muscle by light: Cardiac optogenetics by cell delivery . Circulation: Arrhythmia and Electrophysiology , 4 : 753 – 760 .
  • Yizhar , O. 2011 . Optogenetics in neural systems . Neuron , 71 ( 1 ) : 9 – 34 .

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