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Eukaryotic transcription initiation machinery visualized at molecular level

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Pages 203-208 | Received 31 Aug 2016, Accepted 12 Sep 2016, Published online: 22 Sep 2016

References

  • Lee TI, Young RA. Transcriptional regulation and its misregulation in disease. Cell 2013; 152:1237-1251; PMID:23498934; http://dx.doi.org/10.1016/j.cell.2013.02.014
  • Roeder RG, Rutter WJ. Multiple forms of DNA–dependent RNA polymerase in eukaryotic organisms. Nature 1969; 224:234-237; PMID:5344598; http://dx.doi.org/10.1038/224234a0
  • Schneider DA. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Gene 2012; 493:176-184 PMID:21893173; http://dx.doi.org/10.1016/j.gene.2011.08.006
  • Roeder R. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci 1996; 21:327-335; PMID:8870495; http://dx.doi.org/10.1016/S0968-0004(96)10050-5
  • Schramm L, Hernandez N. Recruitment of RNA polymerase III to its target promoters. Genes Dev 2002; 16:2593-2620; PMID:12381659; http://dx.doi.org/10.1101/gad.1018902
  • Vannini A, Cramer P. Conservation between the RNA Polymerase I, II, and III transcription initiation machineries. Mole Cell 2012; 45:439-446; http://dx.doi.org/10.1016/j.molcel.2012.01.023
  • Grünberg S, Warfield L, Hahn S. Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP–dependent promoter opening. Nat Struct Mol Biol 2012; 19:788-796; PMID:22751016; http://dx.doi.org/10.1038/nsmb.2334
  • He Y, Fang J, Taatjes DJ, Nogales E. Structural visualization of key steps in human transcription initiation. Nature 2013; 495:481-486; PMID:23446344; http://dx.doi.org/10.1038/nature11991
  • Kim TK, Ebright RH, Reinberg D. Mechanism of ATP-dependent promoter melting by transcription factor IIH. Science 2000; 288:1418-1422; PMID:10827951; http://dx.doi.org/10.1126/science.288.5470.1418
  • Fishburn J, Tomko E, Galburt E, Hahn S. Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation. PNAS 2015; 112:3961-3966; PMID:25775526; http://dx.doi.org/10.1073/pnas.1417709112
  • He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E. Near-atomic resolution visualization of human transcription promoter opening. Nature 2016; 533:359-365; PMID:27193682; http://dx.doi.org/10.1038/nature17970
  • Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P. Transcription initiation complex structures elucidate DNA opening. Nature 2016; 533:353-358; PMID:27193681; http://dx.doi.org/10.1038/nature17990
  • Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD. Structure of an RNA polymerase II preinitiation complex. PNAS 2015; 112:13543-13548; PMID:26483468; http://dx.doi.org/10.1073/pnas.1518255112
  • Goodrich JA, Cutler G, Tjian R. Contacts in Context: promoter specificity and macromolecular interactions in transcription. Cell 1996; 84:825-830; PMID:8601306; http://dx.doi.org/10.1016/S0092-8674(00)81061-2
  • Boeger H, Bushnell DA, Davis R, Griesenbeck J, Lorch Y, Strattan JS, Westover KD, Kornberg RD. Structural basis of eukaryotic gene transcription. FEBS Letters 2004; 579:899-903; http://dx.doi.org/10.1016/j.febslet.2004.11.027
  • Buratowski S, Hahn S, Guarente L, Sharp PA. Five intermediate complexes in transcription initiation by RNA polymerase II. Cell 1989; 56:549-561; PMID:2917366; http://dx.doi.org/10.1016/0092-8674(89)90578-3
  • Kim JL, Nikolov DB, Burley SK. Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature 1993; 365:520-527; PMID:8413605; http://dx.doi.org/10.1038/365520a0
  • Kim Y, Geiger JH, Hahn S, Sigler PB. Crystal structure of a yeast TBP/TATA-box complex. Nature 1993; 365:512-520; PMID:8413604; http://dx.doi.org/10.1038/365512a0
  • Buratowski S, Sopta M, Greenblatt J, Sharp PA. RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex. Proc Natl Acad Sci USA 1991; 88:7509-7513; PMID:1881889; http://dx.doi.org/10.1073/pnas.88.17.7509
  • Struhl K. Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast. Cell 1987; 49:295-297; PMID:2882858; http://dx.doi.org/10.1016/0092-8674(87)90277-7
  • Goodrich JA, Tjian R. Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II. Cell 1994; 77:145-156; PMID:8156590; http://dx.doi.org/10.1016/0092-8674(94)90242-9
  • Liu X, Bushnell DA, Wang D, Calero G, Kornberg RD. Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism. Science 2010; 327:206-209; PMID:19965383; http://dx.doi.org/10.1126/science.1182015
  • Kostrewa D, Zeller ME, Armache KJ, Seizl M, Leike K, Thomm M, Cramer P. RNA polymerase II–TFIIB structure and mechanism of transcription initiation. Nature 2009; 462:323-330; PMID:19820686; http://dx.doi.org/10.1038/nature08548
  • Plaschka C, Larivière L, Wenzeck L, Seizl M, Hemann M, Tegunov D, Petrotchenko EV, Borchers CH, Baumeister W, Herzog F et al. Architecture of the RNA polymerase II-Mediator core initiation complex. Nature 2015; 518:376-380; PMID:25652824; http://dx.doi.org/10.1038/nature14229
  • Čabart P, ∨jvári A, Pal M, Luse DS. Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes. PNAS 2011; 108:15786-15791; PMID:21896726; http://dx.doi.org/10.1073/pnas.1104591108
  • Bernecky C, Herzog F, Baumeister W, Plitzko JM, Cramer P. Structure of transcribing mammalian RNA polymerase II. Nature 2016; 529:551-554; PMID:26789250; http://dx.doi.org/10.1038/nature16482
  • Assfalg R, Lebedev A, Gonzalez OG, Schelling A, Koch S, Iben S. TFIIH is an elongation factor of RNA polymerase I. Nucleic Acids Res 2012; 40:650-659; PMID:21965540; http://dx.doi.org/10.1093/nar/gkr746
  • Knutson BA, Knutson BA, Luo J, Ranish J, Hahn S. Architecture of the Saccharomyces cerevisiae RNA polymerase I core factor complex. Nat Struct Mol Biol 2014; 21:810-816; PMID:25132180; http://dx.doi.org/10.1038/nsmb.2873
  • Fernández-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NMI, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Müller CW. Crystal structure of the 14-subunit RNA polymerase I. Nature 2013; 502:644-649; http://dx.doi.org/10.1038/nature12636
  • Engel C, Sainsbury S, Cheung AC, Kostrewa D, Cramer P. RNA polymerase I structure and transcription regulation. Nature 2013; 502:650-655; PMID:24153182; http://dx.doi.org/10.1038/nature12712
  • Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P. Structure of the initiation-competent RNA polymerase I and its implication for transcription. Nat Commun 2016; 7:12126; PMID:27418187; http://dx.doi.org/10.1038/ncomms12126
  • Engel C, Plitzko J, Cramer P. RNA polymerase I–Rrn3 complex at 4.8 Å resolution. Nat Commun 2016; 7:12129; PMID:27418309; http://dx.doi.org/10.1038/ncomms12129
  • Hoffmann NA, Jakobi AJ, Moreno-Morcillo M, Glatt S, Kosinski J, Hagen WJH, Sachse C, Müller CW. Molecular structures of unbound and transcribing RNA polymerase III. Nature 2015; 528:231-236; PMID:26605533; http://dx.doi.org/10.1038/nature16143
  • Blattner C, Jennebach S, Herzog F, Mayer A, Cheung ACM, Witte G, Lorenzen K, Hopfner KP, Heck AJR, Aebersold R et al. Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev 2011; 25:2093-2105; PMID:21940764; http://dx.doi.org/10.1101/gad.17363311
  • Knutson BA, Hahn S. Yeast Rrn7 and human TAF1B Are TFIIB-related RNA polymerase I general transcription factors. Science 2011; 333:1637-1640; PMID:21921198; http://dx.doi.org/10.1126/science.1207699
  • Naidu S, Friedrich JK, Russell J, Zomerdijk JCBM. TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. Science 2011; 333:1640-1642; PMID:21921199; http://dx.doi.org/10.1126/science.1207656
  • Khoo SK, Wu CC, Lin YC, Lee JC, Chen HT. Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex. Mol Cell Biol 2014; 34:551-559; PMID:24277937; http://dx.doi.org/10.1128/MCB.00910-13
  • Hu HL, Wu CC, Lee JC, Chen HT. A Region of Bdp1 necessary for transcription initiation that is located within the RNA polymerase III active site cleft. Mol Cell Biol 2015; 35:2831-2840; PMID:26055328; http://dx.doi.org/10.1128/MCB.00263-15
  • Male G, Appen von A, Glatt S, Taylor NMI, Cristovao M, Groetsch H, Beck M, Müller CW. Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Nat Commun 2015; 6:7387; PMID:26060179; http://dx.doi.org/10.1038/ncomms8387
  • Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 2016; 531:604-609; PMID:27007846; http://dx.doi.org/10.1038/nature17394

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