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Steroid hormone receptors silence genes by a chromatin-targeted mechanism similar to those used for gene activation

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Pages 15-20 | Received 06 Sep 2016, Accepted 23 Sep 2016, Published online: 20 Oct 2016

References

  • Acevedo ML, Kraus WL. Transcriptional activation by nuclear receptors. Essays Biochem 2004; 40:73-88; PMID:15242340; http://dx.doi.org/10.1042/bse0400073
  • Ballare C, Castellano G, Gaveglia L, Althammer S, Gonzalez-Vallinas J, Eyras E, Le Dily F, Zaurin R, Soronellas D, Vicent GP et al. Nucleosome-driven transcription factor binding and gene regulation. Mol Cell 2013; 49:67-79; PMID:23177737; http://dx.doi.org/10.1016/j.molcel.2012.10.019
  • Buser AC, Obr AE, Kabotyanski EB, Grimm SL, Rosen JM, Edwards DP. Progesterone receptor directly inhibits beta-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications. Mol Endocrinol 2011; 25:955-968; PMID:21527503; http://dx.doi.org/10.1210/me.2011-0064
  • Fan Y, Sirotkin A, Russell RG, Ayala J, Skoultchi AI. Individual somatic H1 subtypes are dispensable for mouse development even in mice lacking the H1(0) replacement subtype. Mol Cell Biol 2001; 21:7933-7943; PMID:11689686; http://dx.doi.org/10.1128/MCB.21.23.7933-7943.2001
  • Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP. Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology 2008; 149:6236-6250; PMID:18687774; http://dx.doi.org/10.1210/en.2008-0768
  • Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L et al. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 2007; 128:505-518; PMID:17289570; http://dx.doi.org/10.1016/j.cell.2006.12.038
  • Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Progress Hormone Res 1999; 54:291-313; discussion 313-294; PMID:10548881
  • Grewal SI, Jia S. Heterochromatin revisited. Nat Rev Genet 2007; 8:35-46; PMID:17173056; http://dx.doi.org/10.1038/nrg2008
  • Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 2011; 43:27-33; PMID:21151129; http://dx.doi.org/10.1038/ng.730
  • Kariagina A, Aupperlee MD, Haslam SZ. Progesterone receptor isoform functions in normal breast development and breast cancer. Crit Rev Eukaryot Gene Expr 2008; 18:11-33; PMID:18197783; http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v18.i1.20
  • Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH. Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell 2012; 151:1608-1616; PMID:23260146; http://dx.doi.org/10.1016/j.cell.2012.11.018
  • Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, Gunther T, Buettner R, Schule R. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005; 437:436-439; PMID:16079795; http://dx.doi.org/10.1038/nature04020
  • Nacht AS, Pohl A, Zaurin R, Soronellas D, Quilez J, Sharma P, Wright RH, Beato M, Vicent GP. Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters. EMBO J 2016; 35:1822-1843; PMID:27390128; http://dx.doi.org/10.15252/embj.201593260
  • Obr AE, Edwards DP. The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol 2012; 357:4-17; PMID:22193050; http://dx.doi.org/10.1016/j.mce.2011.10.030
  • Ooi L, Wood IC. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet 2007; 8:544-554; PMID:17572692; http://dx.doi.org/10.1038/nrg2100
  • Perissi V, Jepsen K, Glass CK, Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet 2010; 11:109-123; PMID:20084085; http://dx.doi.org/10.1038/nrg2736
  • Pflum MK, Tong JK, Lane WS, Schreiber SL. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem 2001; 276:47733-47741; PMID:11602581; http://dx.doi.org/10.1074/jbc.M105590200
  • Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell 2006; 22:669-679; PMID:16762839; http://dx.doi.org/10.1016/j.molcel.2006.04.019
  • Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J Biol Chem 2002; 277:5209-5218; PMID:11717311; http://dx.doi.org/10.1074/jbc.M110090200
  • Sancho M, Diani E, Beato M, Jordan A. Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth. PLoS Genet 2008; 4:e1000227; PMID:18927631; http://dx.doi.org/10.1371/journal.pgen.1000227
  • Santos GM, Fairall L, Schwabe JW. Negative regulation by nuclear receptors: a plethora of mechanisms. Trends Endocrinol Metab 2011; 22:87-93; PMID:21196123; http://dx.doi.org/10.1016/j.tem.2010.11.004
  • Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, Li M, Chambon P. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 2011; 145:224-241; PMID:21496643; http://dx.doi.org/10.1016/j.cell.2011.03.027
  • Tsai SC, Seto E. Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem 2002; 277:31826-31833; PMID:12082111; http://dx.doi.org/10.1074/jbc.M204149200
  • Vicent GP, Ballare C, Nacht AS, Clausell J, Subtil-Rodriguez A, Quiles I, Jordan A, Beato M. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell 2006; 24:367-381; PMID:17081988; http://dx.doi.org/10.1016/j.molcel.2006.10.011
  • Vicent GP, Nacht AS, Zaurin R, Font-Mateu J, Soronellas D, Le Dily F, Reyes D, Beato M. Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes. Genes Dev 2013; 27:1179-1197; PMID:23699411; http://dx.doi.org/10.1101/gad.215293.113
  • Vicent GP, Zaurin R, Nacht AS, Li A, Font-Mateu J, Le Dily F, Vermeulen M, Mann M, Beato M. Two chromatin remodeling activities cooperate during activation of hormone responsive promoters. PLoS Genet 2009; 5:e1000567; PMID:19609353; http://dx.doi.org/10.1371/journal.pgen.1000567
  • Wisniewski JR, Zougman A, Kruger S, Mann M. Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue. Mol Cell Proteomics 2007; 6:72-87; PMID:17043054; http://dx.doi.org/10.1074/mcp.M600255-MCP200
  • Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP et al. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 2016; 352:1221-1225; PMID:27257257; http://dx.doi.org/10.1126/science.aad9335
  • Yoshinaga SK, Peterson CL, Herskowitz I, Yamamoto KR. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Science 1992; 258:1598-1604; PMID:1360703; http://dx.doi.org/10.1126/science.1360703
  • Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev 2011; 25:2227-2241; PMID:22056668; http://dx.doi.org/10.1101/gad.176826.111
  • Zhang Y, Cheng MB, Zhang YJ, Zhong X, Dai H, Yan L, Wu NH, Zhang Y, Shen YF. A switch from hBrm to Brg1 at IFNgamma-activated sequences mediates the activation of human genes. Cell Res 2010; 20:1345-1360; PMID:21079652; http://dx.doi.org/10.1038/cr.2010.155

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