1,645
Views
18
CrossRef citations to date
0
Altmetric
Review

The regulatory role of miRNAs on VDR in breast cancer

& ORCID Icon
Pages 232-241 | Received 30 Mar 2017, Accepted 05 Apr 2017, Published online: 25 Jul 2017

References

  • Adams BD, Kasinski AL, Slack FJ. Aberrant regulation and function of microRNAs in cancer. Curr Biol 2014; 24(16):R762-R776; PMID:25137592; https://doi.org/10.1016/j.cub.2014.06.043
  • Adams BD, Parsons C, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest 2017; 127(3):761-771; https://doi.org/10.1172/JCI84424
  • Aguilea O, Pena C, Garcia JM, Larriba MJ, Ordonez- Moran P, Navarro D, Barbachano A, Lopez de Silanes I, Ballestar E, Fraga MF et al. The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25- dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis 2007; 28:1877-1884; PMID:17449905; https://doi.org/10.1093/carcin/bgm094
  • Allimirah F, Vaishnav A, McCormick M, Echchgadda I, Chatterjee B, Mehta RG, Peng X. Functionality of unliganded VDR in breast cancer cells: repressive action on CYP24 basal transcription. Mol Cell Biochem. 2010; 342(1–2): 143-150; https://doi.org/10.1007/s11010-010-0478-6
  • Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007 ;167(16):1730-1737; PMID:17846391; https://doi.org/10.1001/archinte.167.16.1730
  • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297; PMID:14744438; https://doi.org/10.1016/S0092-8674(04)00045-5
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136(2):215-233; PMID:19167326; https://doi.org/10.1016/j.cell.2009.01.002
  • Berger U, Wilson P, McClelland RA, Colston K, Haussler MR, Pike JW, Coombes RC. Immunocytochemical detection of 1,25-dihydroxyvitamin D3 receptor in breast cancer. Cancer Res 1987; 47:6793-6799; PMID:2824042
  • Bianchini G, Qi Y, Alvarez RH, Iwamoto T, Coutant C, Ibrahim NK, Valero V, Cristofanilli M, Green MC, Radvanyi L et al. Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers. J Clin Oncol 2010; 28:4316-4323; PMID:20805453; https://doi.org/10.1200/JCO.2009.27.2419
  • Chen S, Bu D, Ma Y, Zhu J, Chen G, Sun L, Zuo S, Li T, Pan Y, Wang X, Liu Y, Wang P. H19 overexpression induces resistance to 1,25(OH)2D by targeting VDR through miR-675-5p in colon cancer cells. Neoplasia 19(3):226-236; PMID:28189050; https://doi.org/10.1016/j.neo.2016.10.007
  • Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhatter R. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005; 436(7051):740-744; PMID:15973356; https://doi.org/10.1038/nature03868
  • Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci USA 2004; 101(20):7711-7715; PMID:15128933
  • Li YC, Chen Y, Liu W, and Thadhani R. MicroRNA-mediated mechanism of vitamin D regulation of innate immune response. J Steroid Biochem Mol Biol 2014 144(Pt A):81-86; PMID:24103701; https://doi.org/10.1016/j.jsbmb.2013.09.014
  • Crespo A, Filla MB, Russell SW, Murphy WJ. Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta. Biochem J 2000; 349:99-104; PMID:10861216; https://doi.org/10.1042/bj3490099
  • Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P, Narod SA (2007) Triple- negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13(15 Pt 1):4429-4434;; https://doi.org/10.1158/1078-0432.CCR-06-3045
  • Desmedt C, Haibe-Kains B, Wirapati P, Buyse M, Larsimont D, Bontempi G, Delorenzi M, Piccart M, Sotiriou C. Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res 2008; 14:5158-5165; PMID:18698033; https://doi.org/10.1158/1078-0432.CCR-07-4756
  • Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immune-modulator. Immunology 2011 134(2): 123-139; PMID:21896008; https://doi.org/10.1111/j.1365-2567.2011.03482.x
  • Ditsch N, Toth B, Mayr D, Lenhard M, Gallwas J, Weissenbacher T, Dannecker C, Friese K, Jeschke U. The association between vitamin D receptor expression and prolonged overall survival in breast cancer. J Histochem Cytochem 2012; 60(2):121-129; PMID:22108646; https://doi.org/10.1369/0022155411429155
  • Jensen EV. On the mechanism of estrogen action. Perspect Biol Med 1962; 6:47-59; PMID:13957617
  • Jensen EV, Block GE, Smith S, Kyser K, DeSombre ER. Estrogen receptors and breast cancer response to adrenalectomy. Natl Cancer Inst Monogr 1971; 34:55-70; PMID:5140877
  • Filipowicz W, Bhattacharyya SN, Sonenber N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9(2):102-114; PMID:18197166; https://doi.org/10.1038/nrg2290
  • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391(6669):806-811; PMID:9486653; https://doi.org/10.1038/35888
  • Frampton RJ, Suva LJ, Eisman JA, Findlay DM, Moore GE, Moseley JM, Martin TJ. Presence of 1,25-dihydrxyvitamin D3 receptors in established human cancer cell lines in culture. Cancer Res 1982; 42(3):1116-1119; PMID:6277475.
  • Friedrich M, Axt-Fliedner R, Villena-Heinsen C, Tilgen W, Schmidt W, Reichrath J. Analysis of vitamin D-receptor (VDR) and retionoid X-receptor α in breast cancer. Histochem J 2002; 34(1–2):35-40; PMID:12365798; https://doi.org/10.1023/A:1021343825552
  • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19:92-105; PMID:18955434; https://doi.org/10.1101/gr.082701.108
  • Giangreco AA, Nonn L. The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D2 metabolites. J Steroid Biochem Mol Biol 2013 136:86-93; PMID:23333596; https://doi.org/10.1016/j.jsbmb.2013.01.001
  • Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch Intern Med 2009; 169:626-632; PMID:19307527; https://doi.org/10.1001/archinternmed.2008.604
  • Gulliford T, English J, Colston KW, Menday P, Moller S, Coombes RC. A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer. Br J Cancer 1998; 78(1):6-13; PMID:9662243; https://doi.org/10.1038/bjc.1998.434
  • Haffty BG, Yang Q, Reiss M, Kearney T, Higgins SA, Weidhaas J, Harris L, Hait W, Toppmeyer D. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 2006; 24(36):5652-5657; PMID:17116942; https://doi.org/10.1200/JCO.2006.06.5664
  • Hammond SM, Bernstein E, Beach D, Hannon GJ. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000; 404(6775):293-296; PMID:10749213; https://doi.org/10.1038/35005107
  • Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 1995; 377:397-404; PMID:7566114; https://doi.org/10.1038/377397a0
  • Huang F-Yu, Wong DK, Seto WK, Lai CL, Yuen MF. Estradiol induces apoptosis via activation of miRNA-23a and p53: Implication for gender difference in liver cancer development. Oncotarget 2015; 6(33):34941-34952; PMID:26439986; https://doi.org/10.18632/oncotarget.5472
  • Jacobson EA, James KA, Newmark HL, Carroll KK. Effects of dietary fat, calcium, and vitamin D on growth and mammary tumorigenesis induced by 7,12-dimethylbenz(a)-anthracene in female Sprague-Dawley rats. Cancer Res 1989; 49:6300-6303; PMID:2509066.
  • Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998; 78:1193-11231; PMID:9790574.
  • Johnson AL, Zinser GM, Waltz SE. Vitamin D3-depdnent VDR signaling delays ron-mediated tumorigenesis through suppression of β-catenin activity. Oncotarget 2015; 6(18):16304-16320; PMID:26008979; https://doi.org/10.18632/oncotarget.4059
  • Kato M, Slack FJ. microRNAs: small molecules with big roles — C. elegans to human cancer. Biol Cell 2008; 100(2):71-81; PMID:18199046; https://doi.org/10.1042/BC20070078
  • Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D. The human genome browser at UCSC. Genome Res 2002; 12(6):996-1006; PMID:12045153; https://doi.org/10.1101/gr.229102
  • Kretschmann KL, Eyob H, Buys SS, Welm AL. The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression. Curr Drug Targets 2010; 11:1157-1168; PMID:20545605; https://doi.org/10.2174/138945010792006825
  • Krishnan AV, Trump DL, Johnson CS, Feldman D. The role of vitamin D in cancer prevention and treatment. Endocrinol Metab Clin N Am 2010; 39(2):401-418; PMID:20511060; https://doi.org/10.1016/j.ecl.2010.02.011
  • Kurihara N, Fan K, Thaler HT, Yang K, Lipkin M. Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice. J Med Food 2008; 11:201-206; PMID:18358070; https://doi.org/10.1089/jmf.2007.619
  • Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007; 85(6):1586-1591; PMID:17556697.
  • Larriba MJ, Gonzalez-Sancho JM, Barbachano A, Niell N, Ferrer-Mayorga G, Munoz A. Vitamin D is a multilevel repressor of Wnt/b-catenin signaling in cancer cells. Cancers 2013; 5:1242-1260; PMID:24202444; https://doi.org/10.3390/cancers5041242
  • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121:2750-2767; PMID:21633166; https://doi.org/10.1172/JCI45014
  • Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P. Germline mutation of MicroRNA-125a is associated with breast cancer. J Med Genet 2009 46(5):358-360; PMID:19411564; https://doi.org/10.1136/jmg.2008.063123
  • Liu CG, Calin GA, Volinia S, Croce CM. MicroRNA expression profiling using microarrays. Nat Protoc 2008; 3:563-78; PMID:18388938; https://doi.org/10.1038/nprot.2008.14
  • Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S et al. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood 2017; 129(11):1491-1502; PMID:28053194; https://doi.org/10.1182/blood-2016-06-721027
  • Long MD, Sucheston-Campbell LE, Campbell MJ. Vitmin D receptor and RXR in the post-genomic era. J Cell Physiol 2015 230(4):758-766; PMID:25335912; https://doi.org/10.1002/jcp.24847
  • MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 1998; 50:151-196; PMID:9647865
  • Masuyama H, Brownfield CM, St-Arnaud R, MacDonald PN. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol Endocrinol 1997; 11:1507-1517; PMID:9280066; https://doi.org/10.1210/mend.11.10.9990
  • Mehta RG, Peng X, Alimirah F, Murillo G, Mehta R. Vitamin D and breast cancer: emerging concepts. Cancer Lett 2013; 334(1):95-100; https://doi.org/10.1016/j.canlet.2012.10.034
  • Mendell JT, Olson EN. MicroRNAs in stress signaling and human disease. Cell 2012; 148(6):1172-1187; PMID:22424228; https://doi.org/10.1016/j.cell.2012.02.005
  • Mohri T, Nakajima M, Takagi S, Komagata S, Yokoi T. MicroRNA regulates human vitamin D receptor. Int J Cancer 2009; 125(6) 1328-1333; PMID:19437538; https://doi.org/10.1002/ijc.24459
  • Nayeri S, Danielsson C, Kahlen JP, Schrader M, Mathiasen IS, Binderup L, Carlberg C. The anti-proliferative effect of vitamin D3 analogues is not mediated by inhibition of the AP-1 pathway, but may be related to promoter selectivity. Oncogene 1995; 11(9):1853-1858; PMID:7478614
  • Nesby-O'Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, Allen C, Doughertly C, Gunter EW, Bowman BA. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 2002; 76:187-192; PMID:12081833
  • Nishikawa J, Kitaura M, Matsumoto M, Imagawa M, Nishihara T. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer. Nucleic Acids Res 1994; 22(15):2902-2907; PMID:8065900; https://doi.org/10.1093/nar/22.15.2902
  • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010; 10:111-122; PMID:20098459; https://doi.org/10.1038/nri2708
  • Padi SK, Zhang Q, Rustum YM, Morrison C, Guo B. MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. Gastroenterology 2013; 145:437-446; PMID:23619147; https://doi.org/10.1053/j.gastro.2013.04.012
  • Perou C, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA et al. Molecular portraits of human breast tumours. Nature 2000; 406:747-752; PMID:10963602; https://doi.org/10.1038/35021093
  • Prat, A, Adamo B, Cheang MC, Anders CK, Carey LA, Perou CM. Molecular characterization of basal-like and non-basal-like triple-negative breast cancer. Oncology 2013; 18; 123-133; https://doi.org/10.1634/theoncologist.2012-0397
  • Prüfer K, Barsony J. Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor. Mol Endocrinol 2006; 16:1738-1751; https://doi.org/10.1210/me.2001-0345
  • Prüfer K, Racz A, Lin GC, Barsony J. Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors. J Biol Chem 2000;275:41114-41123; PMID:11001945; https://doi.org/10.1074/jbc.M003791200
  • Pulito C, Terrenato I, Di Benedetto A, Korita E, Goeman F, Sacconi A, Biagioni F, Blandino G, Strano S, Muti P, Mottolese M, Falvo E. Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas. PLoS One 2015; 10:1-18; PMID:25849303; https://doi.org/10.1371/journal.pone.0124894
  • Santagata S, Thakkar A, Ergonul A, Wang B, Woo T, Hu R, Harrell JC, McNamara G, Schwede M, Culhane AC et al. Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J Clin Investig 2014; 124(2):859-870; PMID:24463450; https://doi.org/10.1172/JCI70941
  • Sasaki H, Harada H, Handa Y, Morino H, Suzawa M, Shimpo E, Katsumata T, Masuhiro Y, Matsuda K, Ebihara K et al. Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression. Biochemistry 1995; 34(1):370-377; PMID:7819220; https://doi.org/10.1021/bi00001a045
  • Shaffer PL, Gewirth DT. Structural analysis of RXR-VDR interactions on DR3 DNA. J Steroid Biochem Mol Biol 2004; 89–90(1–5):215-219; PMID:15225774; https://doi.org/10.1016/j.jsbmb.2004.03.084
  • Singh PK, Van den Berg, PR, Long MD, Vreugdenhil A, Grieshober L, Ochs-Balcom HM, Wang J, Delcambre S, Heikkinen S, Carlberg C et al. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics 2017; 18:132; PMID:24583788; https://doi.org/10.1186/s12864-017-3481-4
  • Singh PK, Preus L, Hu Q, Yan L, Long MD, Morrison CD, Nesline M, Johnson CS, Koochekpour S, Kohli M et al. Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients. Oncotarget 2014; 5:824-840; PMID:24583788; https://doi.org/10.18632/oncotarget.1776
  • Sone T, Kerner S, Pike JW. Vitamin D receptor interaction with specific DNA. Association as a 1, 25-dihydroxyvitamin D3-modulated heterodimer. J Biol Chem 1991; 266:23296-23305; PMID:1660470
  • Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98; 10869-10874; PMID:17121939; https://doi.org/10.1073/pnas.191367098
  • Tashiro K, Ishii C, Ryoji M. Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene. Biochem Biophys Res Commun 2007; 358:259-265; PMID:17475215; https://doi.org/10.1016/j.bbrc.2007.04.103
  • Thakkar A, Wang B, Picon-Ruiz, Buchwald P, Ince, TA. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat 2016; 157:77-90; PMID:27120467; https://doi.org/10.1007/s10549-016-3807-y
  • Ting HJ, Messing J, Yasmin-Karim S, Lee YF. Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D. J Bio Chem 2013; 288:1-9; PMID:23188821; https://doi.org/10.1074/jbc.M112.395947
  • Tolón RM, Castillo AI, Jiménez-Lara AM, Aranda A. Association with Ets-1 causes ligand- and AF2-independent activation of nuclear receptors. Mol Cell Biol 2000; 20:8793-8802; PMID:11073980; https://doi.org/10.1128/MCB.20.23.8793-8802.2000
  • Tsang WP, Ng EK, Ng SS, Jin H, Yu J, Sung JJ, Kwok TT, Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis 2010; 31(3):350-358; PMID:19926638; https://doi.org/10.1093/carcin/bgp181
  • Tuoresmaki P, Vaisanen S, Neme A, Heikkinen S, Carlberg C. Patterns of genome-wide VDR locations. PLoS One 2014;9(4), e96105; PMID:24787735; https://doi.org/10.1371/journal.pone.0096105
  • Waterham HR, Wanders RJ. Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome. Biochim Biophys Acta 2000; 1529(1–3):340-356; PMID:11111101; https://doi.org/10.1016/S1388-1981(00)00159-1
  • Wejse C, Olesen R, Rabna P, Kaestel P, Gustafson P, Aaby P, Andersen PL, Glerup H, Sodemann M. Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls. Am J Clin Nutr 2007; 86:1376-1383; PMID:17991649.
  • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009; 11:228-234; PMID:19255566; https://doi.org/10.1038/ncb0309-228
  • Weigelt B, Reis-Filho, JS. Histological and molecular types of breast cancer: is there a unifying taxonomy? Nat Rev Clin Oncol 2009; 6:718-730; PMID:19942925; https://doi.org/10.1038/nrclinonc.2009.166
  • Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524; PMID:16141061; https://doi.org/10.1126/science.1111444
  • Zhang F, Wang B, Houlong L, Jingkui Yu, Feng Li, Haitao Hou, Qifeng Yang. Decreased MiR-124-3p expression prompted breast cancer cell progression mainly by targeting Beclin-1. Clin Lab 2013; 62(6):1139-1145; PMID:27468577
  • Zhou J, Ng SB, Cheng WJ. LIN28/LIN28B: an emerging oncogenic driver in cancer stem cells. Int J Biochem Cell Biol 2013; 45(5):973-978; PMID:23420006; https://doi.org/10.1016/j.biocel.2013.02.006

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.