151
Views
3
CrossRef citations to date
0
Altmetric
Clinical feature - Original research

Evaluation of aerosolized epoprostenol for hypoxemia in non-intubated patients with coronavirus disease 2019

ORCID Icon, , , &
Pages 118-123 | Received 01 Oct 2021, Accepted 16 Feb 2022, Published online: 10 Mar 2022

References

  • Wunsch H. Mechanical ventilation in COVID-19: interpreting the current epidemiology. Am J Respir Crit Care Med. 2020;202(1):1–21.
  • Ranney M, Griffeth V, Jha A. Critical supply shortage- the need for ventilators and personal protective equipment during the covid-19 pandemic. N Engl J Med. 2020;382(18):e41.
  • COVID-19 treatment guidelines panel. coronavirus disease 2019 (COVID-19) treatment guidelines. Retrieved 10 October 2021. National Institutes of Health. Available at: https://www.covid19treatmentguidelines.nih.gov/critical-care/
  • Waleed A, Laura E, Fayez A, et al. Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: first update. Crit Care Med. 2021;49(3):e219–e234.
  • The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with covid-19. N Engl J Med. 2021;384(8): 693–704.
  • The RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial. Lancet. 2021;397(10285):1637–1645.
  • REMAP-CAP Investigators. Interleukin-6 receptor antagonists in critically Ill patients with COVID-19. N Engl J Med. 2021;384(16):1491–1502. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa2100433
  • Flolan (epoprostenol sodium) [package insert]. Triangle Pack (NC): GlaxoSmithKline; 2015.
  • Searcy RJ, Morales JR, Ferreira JA, et al. The role of inhaled prostacyclin in treating acute respiratory distress syndrome. Ther Adv Respir Dis. 2015;9(6):302–312.
  • Fuller BM, Mohr NM, Skrupky L, et al. The use of inhaled prostaglandins in patients with ARDS: a systematic review and meta-analysis. Chest. 2015;147(6):1510–1522.
  • Li J, Gurnani PK, Roberts KM, et al. The clinical impact of flow titration on epoprostenol delivery via high flow nasal cannula for ICU patients with pulmonary hypertension or right ventricular dysfunction: a retrospective cohort comparison study. J Clin Med. 2020;9(2):464.
  • Li J, Harnois LJ, Markos B, et al. Epoprostenol delivered via high flow nasal cannula for ICU subjects with severe hypoxemia comorbid with pulmonary hypertension or right heart dysfunction. Pharmaceutics. 2019;11(6):281.
  • Ammar MA, Sasidhar M, Lam SW. Inhaled epoprostenol through noninvasive routes of ventilator support systems. Ann Pharmacother. 2018;52(12):1173–1181.
  • Dondorp A, Hayat M, Aryal D, et al. Schultz M. respiratory support in COVID-19 patients, with a focus on resource-limited settings. Am J Trop Med Hyg. 2020;102(6):1191–1197.
  • Ehrmann S, Li J, Ibarra-Estrada M, et al. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomized, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021;9(12):1387–1395.
  • The National Heart. Lung, and blood institute acute respiratory distress syndrome (ards) clinical trials network. comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354(24): 2564–2575.
  • Collins JA, Rudenski A, Gibson J, et al. Relating oxygen partial pressure, saturation, and content: the haemoglobin-oxygen dissociation curve. Breathe. 2015;11(3):194–201.
  • Sonti R, Pike W, Cobb N. Responsiveness of inhaled epoprostenol in respiratory failure due to COVID-19. J Intensive Care Med. 2020;36(3):327–333.
  • Li J, Gong L, Fink J. The ratio of nasal cannula gas flow to patient inspiratory flow on trans-nasal pulmonary aerosol delivery for adults: an in vitro study. Pharmaceutics. 2019;11(5):225.
  • Li J, Fink J, MacLoughlin R, et al. Review on trans-nasal pulmonary aerosol delivery. Crit Care. 2020;24:506.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.