529
Views
18
CrossRef citations to date
0
Altmetric
Original Research

Obesity, Dietary inflammation, and Frailty among Older Adults: Evidence from the National Health and Nutrition Examination Survey

, PhDORCID Icon, , Mph, , PhD, , PhDORCID Icon & , ScDORCID Icon

References

  • Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Ser A Biol Sci Med Sci. 2001;56(3):M146–M157. doi:10.1093/gerona/56.3.M146
  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/S0140-6736(12)62167-9
  • Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24(3):455–469. vi. doi:10.1016/j.cger.2008.03.004
  • Pijpers E, Ferreira I, Stehouwer CDA, Nieuwenhuijzen Kruseman A. The frailty dilemma. Review of the predictive accuracy of major frailty scores. Eur J Intern Med. 2012;23(2):118–123. doi:10.1016/j.ejim.2011.09.003
  • Fried LP, Ferrucci L, Darer J, Williamson J, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol Ser A Biol Sci Med Sci. 2004;59(3):255–263.
  • Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2009;65(4):377–381. doi:10.1093/gerona/glp186
  • Strandberg TE, Stenholm S, Strandberg AY, Salomaa VV, Pitkälä KH, Tilvis RS. Original contribution the “obesity paradox, “frailty, disability, and mortality in older men: a prospective, longitudinal cohort study. Am J Epidemiol. 2013;178(9):1452–1460. doi:10.1093/aje/kwt157
  • Mezuk B, Lohman MC, Rock AK, Payne ME. Trajectories of body mass indices and development of frailty: evidence from the health and retirement study. Obesity. 2016;24(8):1643–1647. doi:10.1002/oby.21572
  • Blaum CS, Qian Ã, Xue L, Michelon E, Semba RD, Fried LP. The association between obesity and the frailty syndrome in older women: the women’s health and aging studies. J Am Geriatr Soc. 2005;53:927–934. doi:10.1111/j.1532-5415.2005.53300.x
  • Batsis JA, Mackenzie TA, Barre LK, Lopez-Jimenez F, Bartels SJ. Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III. Eur J Clin Nutr. 2014;68(9):1001–1007. doi:10.1038/ejcn.2014.117
  • Batsis JA, Mackenzie TA, Lopez-Jimenez F, Bartels SJ. Sarcopenia, sarcopenic obesity, and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999–2004. Nutr Res. 2015;35(12):1031–1039. doi:10.1016/j.nutres.2015.09.003
  • Hebert JR, Allison DB, Archer E, Lavie CJ, Blair SN. Scientific decision making, policy decisions, and the obesity pandemic. Mayo Clin Proc. 2013;88(6):593–604. doi:10.1016/j.mayocp.2013.04.005
  • Walston J, McBurnie MA, Newman A, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162(20):2333–2341.
  • Hubbard RE, O’Mahony MS, Savva GM, Calver BL, Woodhouse KW. Inflammation and frailty measures in older people. J Cell Mol Med. 2009;13(9b):3103–3109. doi:10.1111/j.1582-4934.2009.00733.x
  • Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, et al. Inflammation, oxidative stress, and obesity. IJMS. 2011;12(5):3117–3132. doi:10.3390/ijms12053117
  • Gale C, Baylis D, Cooper C, Sayer A. Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing. Age (Omaha). 2013;35(6):2493–2501. doi:10.1007/s11357-013-9528-9
  • Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017;35:200–221. doi:10.1016/j.arr.2016.09.008
  • Batsis JA, Mackenzie TA, Jones JD, Lopez-Jimenez F, Bartels SJ. Sarcopenia, sarcopenic obesity and inflammation: results from the 1999–2004 National Health and Nutrition Examination Survey. Clin Nutr. 2016;35(6):1472–1483. doi:10.1016/j.clnu.2016.03.028
  • Shivappa N, Stubbs B, Hebert JR, et al. The relationship between the dietary inflammatory index and incident frailty: a longitudinal cohort study. J Am Med Dir Assoc. 2018;19(1):77–82. doi:10.1016/j.jamda.2017.08.006
  • Shivappa N, Wirth MD, Murphy EA, Hurley TG, Hebert JR. Association between the Dietary Inflammatory Index (DII) and urinary enterolignans and C-reactive protein from the National Health and Nutrition Examination Survey-2003–2008. Eur J Nutr. 2018; doi:10.1007/s00394-018-1690-5
  • Wirth MD, Shivappa N, Davis L, et al. Construct validation of the dietary inflammatory index among African Americans. J Nutr Health Aging. 2017;21(5):487–491. doi:10.1007/s12603-016-0775-1
  • Shivappa N, Wirth MD, Hurley TG, Hebert JR. Association between the dietary inflammatory index (DII) and telomere length and C-reactive protein from the National Health and Nutrition Examination Survey-1999–2002. Mol Nutr Food Res 2017;61(4):doi:10.1002/mnfr.201600630
  • Boden S, Wennberg M, Van Guelpen B, et al. Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study. Nutr J. 2017;16(1):21. doi:10.1186/s12937-017-0243-8
  • Ramallal R, Toledo E, Martínez JA, et al. Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: The SUN cohort. Obesity. 2017;25(6):997–1005. doi:10.1002/oby.21833
  • Walston J, Xue Q, Semba RD, et al. Serum antioxidants, inflammation, and total mortality in older women. Am J Epidemiol. 2006;163(1):18–26. doi:10.1093/aje/kwj007
  • Shivappa N, Godos J, Hébert JR, et al. Dietary inflammatory index and cardiovascular risk and mortality – a meta-analysis. Nutrients. 2018;10(2):1–15. doi:10.3390/nu10020200
  • Fowler ME, Akinyemiju TF. Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes. Int J Cancer. 2017;141(11):2215–2227. doi:10.1002/ijc.30922
  • Deng FE, Shivappa N, Tang Y, Mann JR, Hebert JR. Association between diet-related inflammation, all-cause, all-cancer, and cardiovascular disease mortality, with special focus on prediabetics: findings from NHANES III. Eur J Nutr. 2017;56(3):1085–1093. doi:10.1007/s00394-016-1158-4
  • García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease. Inflamm Res. 2009;58(9):537–552. doi:10.1007/s00011-009-0037-3
  • Moreno-Aliaga MJ, Campión J, Milagro FI, Berjón A, Martínez JA. Adiposity and proinflammatory state: the chicken or the egg. Adipocytes. 2005;1:1–13.
  • Bastard J-P, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12.
  • Yarla NS, Polito A, Peluso I. Effects of Olive Oil on TNF-alpha and IL-6 in Humans: Implication in Obesity and Frailty. Endocr Metab Immune Disord Drug Targets 2018;18(1):63–74. doi:10.2174/1871530317666171120150329
  • Crow RS, Lohman MC, Titus AJ, et al. Mortality risk along the frailty spectrum: data from the National Health and Nutrition Examination Survey 1999 to 2004. J Am Geriatr Soc. 2018;66(3):496–502. doi:10.1111/jgs.15220
  • Blodgett J, Theou O, Kirkland S, Andreou P, Rockwood K. Frailty in NHANES: comparing the frailty index and phenotype. Arch Gerontol Geriatr. 2015;60(3):464–470. doi:10.1016/j.archger.2015.01.016
  • Shivappa N, Steck SE, Hurley TG, Hussey JR, Hebert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17(08):1689–1696. doi:10.1017/S1368980013002115
  • Bursac Z, Gauss CH, Williams DK, Hosmer DW. Purposeful selection of variables in logistic regression. Source Code Biol Med. 2008;3(1):17. doi:10.1186/1751-0473-3-17
  • Weinbrenner T, Schroder H, Escurriol V, et al. Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women. Am J Clin Nutr. 2006;83(1):30–32. doi:10.1093/ajcn/83.1.30
  • Tomlinson DJ, Erskine RM, Morse CI, Winwood K, Onambele-Pearson G. The impact of obesity on skeletal muscle strength and structure through adolescence to old age. Biogerontology. 2016;17(3):467–483. doi:10.1007/s10522-015-9626-4
  • Schaap LA, Koster A, Visser M. Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons. Epidemiol Rev. 2013;35(1):51–65. doi:10.1093/epirev/mxs006
  • Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C. Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome. Gerontology. 2007;53(6):329–339. doi:10.1159/000103555
  • Rodriguez-Hernandez H, Simental-Mendia LE, Rodriguez-Ramirez G, Reyes-Romero MA. Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. Int J Endocrinol. 2013;2013:678159. doi:10.1155/2013/678159
  • Mulero J, Zafrilla P, Martinez-Cacha A. Oxidative stress, frailty and cognitive decline. J Nutr Health Aging. 2011;15(9):756–760.
  • Li H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis. 2011;2(6):466–473.
  • Park Y-M, Zhang J, Steck SE, et al. Obesity mediates the association between mediterranean diet consumption and insulin resistance and inflammation in US adults. J Nutr. 2017;147(4):563–571. doi:10.3945/jn.116.243543
  • Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8. doi:10.1016/j.arr.2016.08.006
  • Manal B, Suzana S, Singh DKA. Nutrition and frailty: a review of clinical intervention studies. J Frailty Aging. 2015;4(2):100–106. doi:10.14283/jfa.2015.49
  • Smoliner C, Norman K, Scheufele R, Hartig W, Pirlich M, Lochs H. Effects of food fortification on nutritional and functional status in frail elderly nursing home residents at risk of malnutrition. Nutrition. 2008;24(11–12):1139–1144. doi:10.1016/j.nut.2008.06.024
  • Fiatarone MA, O'Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330(25):1769–1775. doi:10.1056/NEJM199406233302501
  • Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GBJ, Walston JD. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004;52(4):625–634. doi:10.1111/j.1532-5415.2004.52174.x
  • Payette H, Boutier V, Coulombe C, Gray-Donald K. Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomized community trial. J Am Diet Assoc. 2002;102(8):1088–1095.
  • Bandeen-Roche K, Seplaki CL, Huang J, et al. Frailty in older adults: a nationally representative profile in the United States. Gerona. 2015;70(11):1427–1434. doi:10.1093/gerona/glv133
  • Cigolle C, Ofstedal M, Tian Z, Blaum C. Comparing models of frailty: the Health and Retirement Study. J Am Geriatr Soc. 2009;57(5):830–839. doi:10.1111/j.1532-5415.2009.02225.x
  • Hebert JR, Hurley TG, Steck SE, et al. Considering the value of dietary assessment data in informing nutrition-related health policy. Adv Nutr an Int Rev J. 2014;5(4):447–455. doi:10.3945/an.114.006189

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.