Crosstalk of proteins, miRNAs involved in metastatic and epithelial–mesenchymal transition pathways

References

• Achison M, Elton CM, Hargreaves PG, Knight CG, Barnes MJ, Farndale RW. 2001. Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen. J Biol Chem. 276:3167–3174. doi: 10.1074/jbc.M007186200
   PubMed Web of Science ®Google Scholar
• Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. 2009. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J clin invest. 119(6):1438–1449. doi: 10.1172/JCI38019
   PubMed Web of Science ®Google Scholar
• Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H. 2005. Clustering and conservation patterns of human microRNAs. Nucleic Acids Res. 33:2697–2706. doi: 10.1093/nar/gki567
   PubMed Web of Science ®Google Scholar
• Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, Thomas C, Fauvet F, Puisieux I, Doglioni C, Piccinin S, Maestro R. 2008. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell. 14(1):79–89. doi: 10.1016/j.ccr.2008.06.005
   PubMed Web of Science ®Google Scholar
• Ambros V. 2004. The functions of animal microRNA. Nature. 431:350–355. doi: 10.1038/nature02871
   PubMed Web of Science ®Google Scholar
• Andl CD, McCowan KM, Allison GL, Rustgi AK. 2010. Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia. 12:485–498. doi: 10.1593/neo.10216
   PubMed Web of Science ®Google Scholar
• Arya M, Patel H, McGURK C, Tatoud R, Klocker H, Masters J, Williamson M. 2004. The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. J Exp Therap Oncol. 4:291–303.
   PubMedGoogle Scholar
• Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H. 2008. MicroRNA-21 (miR-21)post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2:72128–72136.
   Google Scholar
• Bae YK, Kim A, Kim MK, Choi JE, Kang SH, Lee SJ. 2013. Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer. Hum Pathol. 44:2028–2037. doi: 10.1016/j.humpath.2013.03.006
   PubMed Web of Science ®Google Scholar
• Barbera MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiro S, Baulida J, Francí C, Dedhar S, Larue L, de Herreros AG. 2004. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 23(44):7345–7354. doi: 10.1038/sj.onc.1207990
   PubMed Web of Science ®Google Scholar
• Barbieri MA, Kohn AD, Roth RA, Stahl PD. 1998. Protein kinase B/akt and Rab5 mediate Ras activation of endocytosis. J Biol Chem. 273:19367–19370. doi: 10.1074/jbc.273.31.19367
   PubMed Web of Science ®Google Scholar
• Bartel DP. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. doi: 10.1016/S0092-8674(04)00045-5
   PubMed Web of Science ®Google Scholar
• Bartel DP. 2009. MicroRNAs: target recognition and regulatory functions. Cell. 136:215–233. doi: 10.1016/j.cell.2009.01.002
   PubMed Web of Science ®Google Scholar
• Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. 2000. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2:84–89. doi: 10.1038/35000034
   PubMed Web of Science ®Google Scholar
• Baum B, Settleman J, Quinlan MP. 2008. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol. 19:294–308. doi: 10.1016/j.semcdb.2008.02.001
   PubMed Web of Science ®Google Scholar
• Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. 1993. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 8(3):745–754.
   PubMed Web of Science ®Google Scholar
• Bellacosa A, Testa JR, Staal SP, Tsichlis PN. 1991. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science. 254(5029):274–277. doi: 10.1126/science.1833819
   PubMed Web of Science ®Google Scholar
• Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, et al. 2005. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 37:766–770. doi: 10.1038/ng1590
   PubMed Web of Science ®Google Scholar
• Berx G, Becker KF, Hofler H, van Roy F. 1998. Mutations of the human E-cadherin (CDH1) gene. Hum Mutat. 12:226–237. doi: 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D
   PubMed Web of Science ®Google Scholar
• Birchmeier W, Behrens J. 1994. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1198:11–26.
   PubMed Web of Science ®Google Scholar
• Boyer B, Valles AM, Edme N. 2000. Induction and regulation of epithelial–mesenchymal transitions. Biochem Pharmacol. 60:1091–1099. doi: 10.1016/S0006-2952(00)00427-5
   PubMed Web of Science ®Google Scholar
• Boyer B, Valles AM, Thiery JP. 1996. Model systems of Epithelium Mesenchyme transitions. Cells Tissues Organs. 156(3):227–239. doi: 10.1159/000147849
   Google Scholar
• Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. 2005. Migrating cancer stem cells–an integrated concept of malignant tumour progression. Nat Rev Cancer. 5(9):744–749. doi: 10.1038/nrc1694
   PubMed Web of Science ®Google Scholar
• Britt DE, Yang DF, Yang DQ, Flanagan D, Callanan H, Lim YP, Lin SH, Hixson DC. 2004. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp cell Res. 300(1):134–148. doi: 10.1016/j.yexcr.2004.06.026
   PubMed Web of Science ®Google Scholar
• Brugnera E, Haney C, Grimsley M, Lu SF, Walk AC, Tosello-Trampont IG, Macara HM, Fink GR, Ravichandra KS. 2002. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol. 4, 574–582.
   PubMed Web of Science ®Google Scholar
• Bugge TH, Antalis TM, Wu Q. 2009. Type II transmembrane serine proteases. J Biol Chem. 284:23177–23181. doi: 10.1074/jbc.R109.021006
   PubMed Web of Science ®Google Scholar
• Buijs JT, Henriquez NV, van Overveld PGM, van der Horst G, Que I, Schwaninger R, Rentsch C, ten Dijke P, Cleton-Jansen A-M, Driouch K, et al. 2007. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res. 67:8742–8751. doi: 10.1158/0008-5472.CAN-06-2490
   PubMed Web of Science ®Google Scholar
• Buijs JT, van der Horst G, van den Hoogen C, Cheung H, de Rooij B, Kroon J, Petersen M, van Overveld PGM, Pelger RCM, van der Pluijm G. 2012. The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation. Oncogene. 31:2164–2174. doi: 10.1038/onc.2011.400
   PubMed Web of Science ®Google Scholar
• Burden RE, Gormley JA, Kuehn D, Ward C, Kwok HF, Gazdoiu M, McClurg A, Jaquin TJ, Johnston JA, Scott CJ, Olwill SA. 2012. Inhibition of cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas. Biochimie. 94:487–493. doi: 10.1016/j.biochi.2011.08.017
   PubMed Web of Science ®Google Scholar
• Cabeen MT, Jacobs-Wagner C. 2010. The bacterial cytoskeleton. Annu Rev Genet. 44:365–392. doi: 10.1146/annurev-genet-102108-134845
   PubMed Web of Science ®Google Scholar
• Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. 2000. The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2:76–83. doi: 10.1038/35000025
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. 2011. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 10:417–427. doi: 10.1038/nrd3455
   PubMed Web of Science ®Google Scholar
• Castillo SDM. 2012. The SOX family of genes in cancer development: biological relevance and opportunities for therapy. Expert Opin Therap Target. 16:903–919. doi: 10.1517/14728222.2012.709239
   PubMed Web of Science ®Google Scholar
• Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. 2006. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res. 66(23):11271–11278. doi: 10.1158/0008-5472.CAN-06-2044
   PubMed Web of Science ®Google Scholar
• Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, D'Alessio AC, Young RA, Weinberg RA. 2013. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell. 154(1):61–74. doi: 10.1016/j.cell.2013.06.005
   PubMed Web of Science ®Google Scholar
• Chaffer CL, Weinberg RA. 2011. A perspective on cancer cell metastasis. Science. 331:1559–1564. doi: 10.1126/science.1203543
   PubMed Web of Science ®Google Scholar
• Chambers AF, Groom AC, MacDonald IC. 2002. Macdonald dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2:563–572. doi: 10.1038/nrc865
   PubMed Web of Science ®Google Scholar
• Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC. 2009. Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med. 179(2):123–133. doi: 10.1164/rccm.200803-456OC
   PubMed Web of Science ®Google Scholar
• Chen CZ, Li L, Lodish HF, Bartel DP. 2004. MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83–86. doi: 10.1126/science.1091903
   PubMed Web of Science ®Google Scholar
• Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M. 2005. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 102:13944–13949. doi: 10.1073/pnas.0506654102
   PubMed Web of Science ®Google Scholar
• Coussens LM, Fingleton B, Matrisian LM. 2002. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science. 295:2387–2392. doi: 10.1126/science.1067100
   PubMed Web of Science ®Google Scholar
• Croce CM, Calin GA. 2005. miRNAs, cancer, and stem cell division. Cell. 122:6–7. doi: 10.1016/j.cell.2005.06.036
   PubMed Web of Science ®Google Scholar
• Croset M, Goehrig D, Frackowiak A, Bonnelye E, Ansieau S, Puisieux A, Clézardin P. 2014. TWIST1 expression in breast cancer cells facilitates bone metastasis formation. J BoneMiner Res. 29:1886–1899. doi: 10.1002/jbmr.2215
   PubMed Web of Science ®Google Scholar
• Dalmay T, Edwards DR. 2006. MicroRNAs and the hallmarks of cancer. Oncogene. 25:6170–6175. doi: 10.1038/sj.onc.1209911
   PubMed Web of Science ®Google Scholar
• De Craene B, Van Roy F, Berx G. 2005. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal. 17(5):535–547. doi: 10.1016/j.cellsig.2004.10.011
   PubMed Web of Science ®Google Scholar
• Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci. 95(19):11211–11216. doi: 10.1073/pnas.95.19.11211
   PubMed Web of Science ®Google Scholar
• Dolmetsch RE, Xu K, Lewis RS. 1998. Calcium oscillations increase the efficiency and specificity of gene expression. Nature. 392:933–936. doi: 10.1038/31960
   PubMed Web of Science ®Google Scholar
• Dong C, Wilhelm D, Koopman P. 2004. Sox genes and cancer. Cytogenetic Genome Res. 105:442–447. doi: 10.1159/000078217
   PubMed Web of Science ®Google Scholar
• Dourdin N, Bhatt AK, Dutt P, Greer PA, Arthur JS, Elce JS, Huttenlocher A. 2001. Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem. 276:48382–48388.
   PubMed Web of Science ®Google Scholar
• Dufour A, Overall CM. 2013. Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends Pharmacol Sci. 34:233–242. doi: 10.1016/j.tips.2013.02.004
   PubMed Web of Science ®Google Scholar
• Eddy RJ, Pierini LM, Matsumura F, Maxfield FR. 2000. Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration. J Cell Sci. 113:1287–1298.
   PubMed Web of Science ®Google Scholar
• Edme N, Downward J, Thiery JP, Boyer B. 2002. Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. J Cell Sci. 115:2591–2601.
   PubMed Web of Science ®Google Scholar
• Eger A, Mikulits W. 2005. Models of epithelial–mesenchymal transition. Drug Discov Today Dis Models. 2:57–63. doi: 10.1016/j.ddmod.2005.04.001
   Google Scholar
• Eriksson JE, Dechat T, Grin B, Helfand B, Mendez M, Pallari HM, Goldman RD. 2009. Introducing intermediate filaments: from discovery to disease. J Clin Invest, 119:1763–1771. doi: 10.1172/JCI38339
   PubMed Web of Science ®Google Scholar
• Fan K, Li D, Zhang Y, Han C, Liang J, Hou C, Xiao H, Ikenaka K, Ma J. 2015. The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation. J Neuroinflammation. 12(1):1. doi: 10.1186/s12974-015-0268-x
   Web of Science ®Google Scholar
• Fanger CM, Hoth M, Crabtree GR, Lewis RS. 1995. Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels. J Cell Biol. 131:655–667. doi: 10.1083/jcb.131.3.655
   PubMed Web of Science ®Google Scholar
• Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS. 2007. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). J Mol Biol. 369:1041–1051. doi: 10.1016/j.jmb.2007.03.078
   PubMed Web of Science ®Google Scholar
• Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. 2006. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 441:179–185. doi: 10.1038/nature04702
   PubMed Web of Science ®Google Scholar
• Feske S, Prakriya M, Rao A, Lewis RS. 2005. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med. 202:651–662. doi: 10.1084/jem.20050687
   PubMed Web of Science ®Google Scholar
• Fidler IJ. 2003. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 3, 453–458. doi: 10.1038/nrc1098
   PubMed Web of Science ®Google Scholar
• Fingleton B. 2008. MMPs as therapeutic targets—still a viable option? Semin Cell Dev Biol. 19:61–68. doi: 10.1016/j.semcdb.2007.06.006
   PubMed Web of Science ®Google Scholar
• Friedman RC, Farh KK, Burge CB, Bartel DP. 2008. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. doi: 10.1101/gr.082701.108
   PubMed Web of Science ®Google Scholar
• Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Huttenlocher A, Palecek SP, et al. 1997. Regulation of cell migration by the calcium-dependent protease calpain. J. Biol. Chem. 272:32719–32722. doi: 10.1074/jbc.272.21.13816
   PubMed Web of Science ®Google Scholar
• Galkin AV, Mullen L, Fox WD, Brown J, Duncan D, Moreno O, Madison EL, Agus DB. 2004. CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumour xenografts. Prostate. 61:228–235. doi: 10.1002/pros.20094
   PubMed Web of Science ®Google Scholar
• Goldman RD, Khuon S, Chou YH, Opal P, Steinert PM. 1996. The function of intermediate filaments in cell shape and cytoskeletal integrity. J Cell Biol. 134:971–983. doi: 10.1083/jcb.134.4.971
   PubMed Web of Science ®Google Scholar
• Gonzalez de Castro D, Clarke PA, Al-Lazikani B, Workman P. 2013. Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. Clin Pharmacol Ther. 93(3):252–259. doi: 10.1038/clpt.2012.237
   PubMed Web of Science ®Google Scholar
• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, et al. 2006. The DNA sequence and biological annotation of human chromosome 1. Nature. 441:315–321. doi: 10.1038/nature04727
   PubMed Web of Science ®Google Scholar
• Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. 2008. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 10:593–601. doi: 10.1038/ncb1722
   PubMed Web of Science ®Google Scholar
• Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L. 2003. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 63:2172–2178.
   PubMed Web of Science ®Google Scholar
• Gupta GP, Massagué J. 2006. Cancer metastasis: building a framework. Cell. 127(4):679–695. doi: 10.1016/j.cell.2006.11.001
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell. 100:57–70. doi: 10.1016/S0092-8674(00)81683-9
   PubMed Web of Science ®Google Scholar
• Humphries B, Wang Z, Oom AL, Fisher T, Tan D, Cui Y, Jiang Y, Yang C. 2014. MicroRNA-200b targets protein kinase C and suppresses triple-negative breast cancer metastasis. Carcinogenesis. 35:2254–2263. doi: 10.1093/carcin/bgu133
   PubMed Web of Science ®Google Scholar
• Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, Eils R, Fehm T, Riethmüller G, Klein CA. 2008. Systemic spread is an early step in breast cancer. Cancer Cell. 13(1):58–68. doi: 10.1016/j.ccr.2007.12.003
   PubMed Web of Science ®Google Scholar
• Huttenlocher A, Horwitz AR. 2011. Integrins in cell migration. CSH Perspect Biol. 3(9):a005074.
   PubMed Web of Science ®Google Scholar
• Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T. 1995. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 377:539–544. doi: 10.1038/377539a0
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. 2010. Loss of miR-200 inhibition of SUZ12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 39:761–772. doi: 10.1016/j.molcel.2010.08.013
   PubMed Web of Science ®Google Scholar
• Jain RK. 2005. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 307:58–62. doi: 10.1126/science.1104819
   PubMed Web of Science ®Google Scholar
• Jakowlew SB. 2006. Transforming growth factor-beta in cancer and metastasis. Caner Metastasis Rev. 25:435–457. doi: 10.1007/s10555-006-9006-2
   PubMed Web of Science ®Google Scholar
• Jevnikar Z, Rojnik M, Jamnik P, Doljak B, Fonovic UP, Kos J. 2013. Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells. J Biol Chem. 288:2201–2209. doi: 10.1074/jbc.M112.436394
   PubMed Web of Science ®Google Scholar
• Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. 2005. RAS is regulated by the let-7 microRNA family. Cell. 120:635–647. doi: 10.1016/j.cell.2005.01.014
   PubMed Web of Science ®Google Scholar
• Kamachi Y, Kondoh H. 2013. Sox proteins: regulators of cell fate specification and differentiation. Development. 140:4129–4144. doi: 10.1242/dev.091793
   PubMed Web of Science ®Google Scholar
• Kang Y, Massagué J. 2004. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell. 118(3):277–279. doi: 10.1016/j.cell.2004.07.011
   PubMed Web of Science ®Google Scholar
• Kassis J, Lauffenburger DA, Turner T, Wells A. 2001. Semin. Cancer Biol. 11:105–117. doi: 10.1006/scbi.2000.0362
   PubMed Web of Science ®Google Scholar
• Katsumoto T, Mitsushima A, Kurimura T. 1990. The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction. Biol Cell. 68:139–146. doi: 10.1016/0248-4900(90)90299-I
   PubMed Web of Science ®Google Scholar
• Keller JM, Schade GR, Ives K, Cheng X, Rosol TJ, Piert M, Siddiqui J, Roberts WW, Keller ET. 2013. A novel canine model for prostate cancer. Prostate. 73:952–959. doi: 10.1002/pros.22642
   PubMed Web of Science ®Google Scholar
• Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S. 2011. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. Brit J Cancer. 104(7):1151–1159. doi: 10.1038/bjc.2011.73
   PubMed Web of Science ®Google Scholar
• Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY, Choung S, Kim YJ, Choi Y-C. 2008. MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). J Biol Chem. 283:18158–18166. doi: 10.1074/jbc.M800186200
   PubMed Web of Science ®Google Scholar
• Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM. 2007. Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. Cancer Res. 67:546–554. doi: 10.1158/0008-5472.CAN-06-2401
   PubMed Web of Science ®Google Scholar
• Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. 2001. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol. 21(3):893–901. doi: 10.1128/MCB.21.3.893-901.2001
   PubMed Web of Science ®Google Scholar
• Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, et al. 2011. P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 208:875–883. doi: 10.1084/jem.20110235
   PubMed Web of Science ®Google Scholar
• Klein R. 2001. Excitatory Eph receptors and adhesive ephrin ligands. Curr Opin Cell Biol. 13(2):196–203. doi: 10.1016/S0955-0674(00)00197-6
   PubMed Web of Science ®Google Scholar
• Kleinerman DI, Troncoso P, Lin SH, Pisters LL, Sherwood ER, Brooks T, von Eschenbach AC, Hsieh JT. 1995. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Cancer Res. 55(6):1215–1220.
   PubMed Web of Science ®Google Scholar
• Korpal M, Ell BJ, Buffa FM, Ibrahum T, Blanco MA, Celia-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, et al. 2011. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 17:1101–1108. doi: 10.1038/nm.2401
   PubMed Web of Science ®Google Scholar
• Komuro H, Rakic P. 1993. Modulation of neuronal migration by NMDA receptors. Science. 260:95–95. doi: 10.1126/science.8096653
   PubMed Web of Science ®Google Scholar
• Krueger S, Kalinski T, Hundertmark T, Wex T, Küster D, Peitz U, Ebert M, Nägler DK, Kellner U, Malfertheiner P, et al. 2005. Up-regulation of cathepsin X in helicobacter pylori gastritis and gastric cancer. J Pathol. 207:32–42. doi: 10.1002/path.1820
   PubMed Web of Science ®Google Scholar
• Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. 2002. Identification of tissue-specific microRNAs from mouse. Curr Biol. 12:735–739. doi: 10.1016/S0960-9822(02)00809-6
   PubMed Web of Science ®Google Scholar
• Lawson MA, Maxfield FR. 1995. Ca2+ and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 377:75–79. doi: 10.1038/377075a0
   PubMed Web of Science ®Google Scholar
• Leader M, Collins M, Patel J, Henry K. 1987. Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11:63–72. doi: 10.1111/j.1365-2559.1987.tb02609.x
   PubMed Web of Science ®Google Scholar
• Leber MF, Efferth T. 2009. Molecular principles of cancer invasion and metastasis. Int J Oncol. 34:881–895.
   PubMed Web of Science ®Google Scholar
• Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K. 1999. Regulation of cell movement is mediated by stretch-activated calcium channels. Nature. 400:382–386. doi: 10.1038/22578
   PubMed Web of Science ®Google Scholar
• Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. 2007. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 26:3957–3967. doi: 10.1038/sj.emboj.7601818
   PubMed Web of Science ®Google Scholar
• Leland ES, Wright PK. 2006. Resonance tuning of piezoelectric vibration energy scavenging generators using compressive axial preload. Smart Mater Struct. 15(5):1413–1420. doi: 10.1088/0964-1726/15/5/030
   Web of Science ®Google Scholar
• Leelawat K, Leelawat S, Tepaksorn P, Rattanasinganchan P, Leungchaweng A, Tohtong R, Sobhon P. 2006. Involvement of c-Met/hepatocyte growth factor pathway in cholangiocarcinoma cell invasion and its therapeutic inhibition with small interfering RNA specific for c-Met. J Surg Res. 136:78–84. doi: 10.1016/j.jss.2006.05.031
   PubMed Web of Science ®Google Scholar
• Lesnikoff N, Attema JL, Roslan S, Bert AG, Schwarz QP, Gregory PA, Goodall GJ. 2014. Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial–mesenchymal transition. J Biol Chem. 289:11194–11205. doi: 10.1074/jbc.M113.529172
   PubMed Web of Science ®Google Scholar
• Lewis RS. 2007. The molecular choreography of a store-operated calcium channel. Nature. 446:284–287. doi: 10.1038/nature05637
   PubMed Web of Science ®Google Scholar
• Lewis RS. 2001. Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol. 19:497–521. doi: 10.1146/annurev.immunol.19.1.497
   PubMed Web of Science ®Google Scholar
• Lewis BP, Burge CB, Bartel DP. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. doi: 10.1016/j.cell.2004.12.035
   PubMed Web of Science ®Google Scholar
• Li P, Jiang S, Lee SL, Lin CY, Johnson MD, Dickson RB, Michejda CJ, Roller PP. 2007. Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1. J Med Chem. 50:5976–5983. doi: 10.1021/jm0704898
   PubMed Web of Science ®Google Scholar
• Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B. 2010. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell. 7(1):51–63. doi: 10.1016/j.stem.2010.04.014
   PubMed Web of Science ®Google Scholar
• Li X, Pei D, Zheng H. 2014. Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell. 5(8):580–591. doi: 10.1007/s13238-014-0064-x
   PubMed Web of Science ®Google Scholar
• Li X, Roslan S, Johnstone CN, Wright JA, Bracken CP, Anderson M, Bert AG, Selth LA, Anderson RL, Goodall GJ, et al. 2014. MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene. 33:4077–4088. doi: 10.1038/onc.2013.370
   PubMed Web of Science ®Google Scholar
• Li G, Shrotriya V, Huang J, Yao Y, Moriarty T, Emery K, Yang Y. 2005. High-efficiency solution processable polymer photovoltaic cells by self-organization of polymer blends. Nat Mater. 4(11):864–868. doi: 10.1038/nmat1500
   Web of Science ®Google Scholar
• Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM. 2005. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. doi: 10.1038/nature03315
   PubMed Web of Science ®Google Scholar
• Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP. 2003. The microRNAs of Caenorhabditis elegans. Genes Dev. 17:991–1008. doi: 10.1101/gad.1074403
   PubMed Web of Science ®Google Scholar
• Lin SL, Chiang A, Chang D, Ying SY. 2008. Loss of mir-146a function in hormone-refractory prostate cancer. RNA. 14:417–424. doi: 10.1261/rna.874808
   PubMed Web of Science ®Google Scholar
• Lin CY, Tseng IC, Chou FP, Su SF, Chen YW, Johnson MD, Dickson RB. 2008. Zymogen activation, inhibition, and ectodomain shedding of matriptase. Front Biosci. 13:621–635. doi: 10.2741/2707
   PubMed Web of Science ®Google Scholar
• Linder S. 2009. Invadosomes at a glance. J Cell Sci. 122(17):3009–3013. doi: 10.1242/jcs.032631
   PubMed Web of Science ®Google Scholar
• Liou J, Kim ML, Do Heo W, Jones JT, Myers JW, Ferrell JE, Meyer T. 2005. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 15(13):1235–1241. doi: 10.1016/j.cub.2005.05.055
   PubMed Web of Science ®Google Scholar
• List K. 2009. Matriptase: a culprit in cancer? Future Oncol. 5:97–104. doi: 10.2217/14796694.5.1.97
   PubMed Web of Science ®Google Scholar
• List K, Bugge TH, Szabo R. 2006. Matriptase: potent proteolysis on the cell surface. Mol Med. 12:1–7. doi: 10.2119/2006-00022.List
   PubMed Web of Science ®Google Scholar
• Liu H, Wang S, Sun H, Pan Z, Zhou W, Wu M. 2010. Inhibition of tumorigenesis and invasion of hepatocellular carcinoma by siRNA mediated silencing of the livin gene. Mol Med Report. 3:903–907.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zhang B, Liu K, Ding Z, Hu X. 2012. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS ONE. 7(7):e40480. doi: 10.1371/journal.pone.0040480
   Google Scholar
• Ma L, Teruya-Feldstein J, Weinberg RA. 2007. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449(7163):682–688. doi: 10.1038/nature06174
   PubMed Web of Science ®Google Scholar
• Ma PC, Tretiakova MS, Nallasura V, Jagadeeswaran R, Husain AN, Salgia R. 2007. Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion. Br J Cancer. 97:368–377. doi: 10.1038/sj.bjc.6603884
   PubMed Web of Science ®Google Scholar
• Mallini P, Lennard T, Kirby J, Meeson A. 2014. Epithelial-to-mesenchymal transition: what is the impact on breast cancer stem cells and drug resistance. Cancer Treat Rev. 40(3):341–348. doi: 10.1016/j.ctrv.2013.09.008
   PubMed Web of Science ®Google Scholar
• Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL. 2008. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133(4):704–715. doi: 10.1016/j.cell.2008.03.027
   PubMed Web of Science ®Google Scholar
• Marks PW, Maxfield FR. 1990. Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils. J. Cell Biol. 110:43–52. doi: 10.1083/jcb.110.1.43
   PubMed Web of Science ®Google Scholar
• McKenzie JA, Liu T, Jung JY, Jones BB, Ekiz HA, Welm AL, Grossman D. 2013. Survivin promotion of melanoma metastasis requires upregulation of α5 integrin. Carcinogenesis. 34(9):2137–2144. doi: 10.1093/carcin/bgt155
   PubMed Web of Science ®Google Scholar
• Mehlen P, Puisieux A. 2006. Metastasis: a question of life or death. Nat Rev Cancer. 6:449–458. doi: 10.1038/nrc1886
   PubMed Web of Science ®Google Scholar
• Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, Putney Jr, JW. 2006. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem, 281:24979–24990. doi: 10.1074/jbc.M604589200
   PubMed Web of Science ®Google Scholar
• Michael MZ, O’Connor SM, van Holst Pellekaan NG, Young GP, James RJ. 2003. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res. 1:882–891.
   PubMed Web of Science ®Google Scholar
• Mogami H, Nakano K, Tepikin AV, Petersen OH. 1997. Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch. Cell. 88:49–55. doi: 10.1016/S0092-8674(00)81857-7
   PubMed Web of Science ®Google Scholar
• Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. 2008. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS one. 3(8):e2888. doi: 10.1371/journal.pone.0002888
   PubMed Web of Science ®Google Scholar
• Musiyenko A, Bitko V, Barik S. 2008. Ectopic expression regulates protein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med. 86:313–322. doi: 10.1007/s00109-007-0296-9
   PubMed Web of Science ®Google Scholar
• Nakajima Y, Yamagishi T, Hokari S, Nakamura H. 2000. Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec, 258:119–145. doi: 10.1002/(SICI)1097-0185(20000201)258:2<119::AID-AR1>3.0.CO;2-U
   PubMedGoogle Scholar
• Nakaya Y, Kuroda S, Katagiri YT, Kaibuchi K, Takahashi Y. 2004. Mesenchymal–epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell. 7:425–438. doi: 10.1016/j.devcel.2004.08.003
   PubMed Web of Science ®Google Scholar
• Napp J, Dullin C, Muller F, Uhland K, Petri JB, van de Locht A, Steinmetzer T, Alves F. 2010. Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumour therapies. Int J Cancer. 127:1958–1974. doi: 10.1002/ijc.25405
   PubMed Web of Science ®Google Scholar
• Nishiyama M, Hoshino A, Tsai L, Henley JR, Goshima Y, Tessier-Lavigne M, Poo MM, Hong K. 2003. Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature. 423, 990–995. doi: 10.1038/nature01751
   PubMed Web of Science ®Google Scholar
• Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, Dedhar S. 1998. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways. Proc Natl Acad Sci USA. 95:4374–4379. doi: 10.1073/pnas.95.8.4374
   PubMed Web of Science ®Google Scholar
• Ocaña OH, Córcoles R, Fabra Á, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A, Nieto MA. 2012. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell. 22(6):709–724. doi: 10.1016/j.ccr.2012.10.012
   PubMed Web of Science ®Google Scholar
• Palmer HG, Larriba MJ, Garcia JM, Ordonez-Moran P, Pena C, Peiro S, Puig I, Rodriguez R, de la Fuente R, Bernad A, et al. 2004. Nat Med. 10:917–919. doi: 10.1038/nm1095
   PubMed Web of Science ®Google Scholar
• Parekh AB, Penner R. 1997. Store depletion and calcium influx. Physiol Rev. 7:901–930.
   Google Scholar
• Park SM, Gaur AB, Lengyel E, Peter ME. 2008. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22:894–907. doi: 10.1101/gad.1640608
   PubMed Web of Science ®Google Scholar
• Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ. 2002. Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J Biol Chem. 277(4):2573–2578. doi: 10.1074/jbc.M110299200
   PubMed Web of Science ®Google Scholar
• Park CY, Kim DK, Sheen YY. 2011. EW-7203, a novel small molecule inhibitor of transforming growth factor-ß (TGF-ß) type I receptor/activin receptor/like kinase-5, blocks TGF-ß1- mediated epithelial-to-mesenchymal transition in mammary epithelial cells. Cancer Sci. 102:1889–1896. doi: 10.1111/j.1349-7006.2011.02014.x
   PubMed Web of Science ®Google Scholar
• Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistics. CA Cancer J Clin. 55:74–108. doi: 10.3322/canjclin.55.2.74
   PubMed Web of Science ®Google Scholar
• Patrussi L, Baldari CT. 2011. The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection. Curr Med Chem. 18(4):497–512. doi: 10.2174/092986711794480159
   PubMed Web of Science ®Google Scholar
• Pavlaki M, Zucker S. 2003. Matrix metalloproteinase inhibitors (MMPIs): the beginning of phase I or the termination of phase III clinical trials. Cancer Metastasis Rev. 22:177–203. doi: 10.1023/A:1023047431869
   PubMed Web of Science ®Google Scholar
• Pavlaki M, Zucker S, Dufour A, Calabrese N, Bahou W, Cao J. 2010. Furin functions as a nonproteolytic chaperone for matrix metalloproteinase-28: MMP-28 propeptide sequence requirement. Biochem res int. 2011. doi:10.1155/2011/630319.
   PubMedGoogle Scholar
• Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP. 2006. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 8:771–773. doi: 10.1038/ncb1435
   PubMed Web of Science ®Google Scholar
• Pettit EJ, Fay FS. 1998. Cytosolic free calcium and the cytoskeleton in the control of leukocyte chemotaxis. Physiol Rev. 78:949–967.
   PubMed Web of Science ®Google Scholar
• Pillai RS. 2005. MicroRNA function: multiple mechanisms for a tiny RNA? RNA. 11:1753–1761. doi: 10.1261/rna.2248605
   PubMed Web of Science ®Google Scholar
• Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. 2006. Orai1 is an essential pore subunit of the CRAC channel. Nature. 443:230–233. doi: 10.1038/nature05122
   PubMed Web of Science ®Google Scholar
• Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward SW. 2013. Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium. Am J Pathol. 73:476–488.
   Google Scholar
• Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J, Rünger TM. 2008. Cathepsin K in melanoma invasion. J Invest Dermatol. 128:2281–2288. doi: 10.1038/jid.2008.63
   PubMed Web of Science ®Google Scholar
• Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, et al. 2005. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123–127. doi: 10.1038/nature03688
   PubMed Web of Science ®Google Scholar
• Ren XD, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, Schwartz MA. 2000. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci. 113:3673–3678.
   PubMed Web of Science ®Google Scholar
• Ren G, Tian Q, An Y, Feng B, Lu Y, Liang J, Li K, Shang Y, Nie Y, Wang X, Fan D. 2012. Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. Mol Cancer. 11:67. doi: 10.1186/1476-4598-11-67.
   PubMed Web of Science ®Google Scholar
• Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G. 2005. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 169(3):435–445. doi: 10.1083/jcb.200502019
   PubMed Web of Science ®Google Scholar
• Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL. 2010. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 7(1):64–77. doi: 10.1016/j.stem.2010.04.015
   PubMed Web of Science ®Google Scholar
• Sarkar A, Hochedlinger K. 2013. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell. 12:15–30. doi: 10.1016/j.stem.2012.12.007
   PubMed Web of Science ®Google Scholar
• Saunders LR, McClay DR. 2014. Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. Development. 141:1503–1513. doi: 10.1242/dev.101436
   PubMed Web of Science ®Google Scholar
• Sela-Passwell N, Trahtenherts A, Kruger A, Sagi I. 2011. New opportunities in drug design of metalloproteinase inhibitors: combination between structure–function experimental approaches and systems biology. Expert Opin Drug Discov. 6:527–542. doi: 10.1517/17460441.2011.560936
   PubMed Web of Science ®Google Scholar
• Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen C-J, Hildesheim A, Sugden B, Ahlquist P. 2008. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci USA. 105:5874–5878. doi: 10.1073/pnas.0801130105
   PubMed Web of Science ®Google Scholar
• Senol O, Schaaij-Visser TBM, Erkan EP, Dorfer C, Lewandrowski G, Pham TV, Piersma SR, Peerdeman SM, Ströbel T, Tannous B, et al. 2014. miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo. Oncogene. 120(14):1790–1798.
   Google Scholar
• Shen X, Wang S, Wang H, Liang M, Xiao L, Wang Z. 2009. The role of SDF-1/ CXCR4 axis in ovarian cancer metastasis. J Huazhong Univ Sci Technol Med Sci. 29:363–367. doi: 10.1007/s11596-009-0320-0
   PubMed Web of Science ®Google Scholar
• Shi YE, Torri J, Yieh L, Wellstein A, Lippman ME, Dickson RB. 1993. Identification and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer cells. Cancer Res. 53:1409–1415.
   PubMed Web of Science ®Google Scholar
• Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, Diehn M, Liu H, Panula SP, Chiao E, Dirbas FM. 2009. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 138(3):592–603. doi: 10.1016/j.cell.2009.07.011
   PubMed Web of Science ®Google Scholar
• Siciliano JC, Toutant M, Derkinderen P, Sasaki T, Girault JA. 1996. Differential regulation of proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and depolarization in rat hippocampus. J Biol Chem. 271:28942–28946. doi: 10.1074/jbc.271.46.28942
   PubMed Web of Science ®Google Scholar
• Siegel R, Ma J, Zou Z, Jemal A. 2014. Cancer statistics. CA Cancer J Clin. 64: 9–29 doi: 10.3322/caac.21208
   PubMed Web of Science ®Google Scholar
• Sipeki S, Bander E, Buday L, Farkas G, Bácsy E, Ways DK, Faragó A. 1999. Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering. Cell Signal. 11:885–890. doi: 10.1016/S0898-6568(99)00060-1
   PubMed Web of Science ®Google Scholar
• Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL. 2006. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem. 281:20661–20665. doi: 10.1074/jbc.C600126200
   PubMed Web of Science ®Google Scholar
• Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hasida H, Takabayashi A, Sasaki M, Robine S, et al. 2011. Suppression of colon cancer metastasis by Aes through inhibition of notch signaling. Cancer Cell. 19:125–137. doi: 10.1016/j.ccr.2010.11.008
   PubMed Web of Science ®Google Scholar
• Staal SP. 1987. Proc Natl Acad Sci USA. 84:5034–5037. doi: 10.1073/pnas.84.14.5034
   PubMed Web of Science ®Google Scholar
• Steeg PS. 2006. Tumour metastasis: mechanistic insights and clinical challenges. Nat Med. 12:895–904. doi: 10.1038/nm1469
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S. 1997. Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library. Gene. 200:149–156. doi: 10.1016/S0378-1119(97)00411-3
   PubMed Web of Science ®Google Scholar
• Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, Dedhar S. 2001. Inhibition of integrin linked kinase (ILK) suppresses b-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells. Oncogene. 20:133–140. doi: 10.1038/sj.onc.1204052
   PubMed Web of Science ®Google Scholar
• Tarver T. 2012. Cancer Facts & Figures 2012. American Cancer Society (ACS) Atlanta, GA: American Cancer Society, 2012. J Consum Health Internet. 16(3):366–367. doi: 10.1080/15398285.2012.701177
   Google Scholar
• Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. 2008. Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 451:147–152. doi: 10.1038/nature06487
   PubMed Web of Science ®Google Scholar
• Testa JR, Bellacosa A. 2001. Proc Natl Acad Sci USA. 98:10983–10985. doi: 10.1073/pnas.211430998
   PubMed Web of Science ®Google Scholar
• Thiery JP. 2002. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. doi: 10.1038/nrc822. PMID 12189386.
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RYJ, Nieto MA. 2009. Epithelial–mesenchymal transitions in development and disease. Cell. 139(5):871–890. doi: 10.1016/j.cell.2009.11.007
   PubMed Web of Science ®Google Scholar
• Thiery JP, Morgan M. 2004. Breast cancer progression with a Twist. Nat med. 10(8):777–778. doi: 10.1038/nm0804-777
   PubMed Web of Science ®Google Scholar
• Thompson NL, Lin SH, Panzica MA, Hixson DC. 1994. Cell CAM 105 isoform RNA expression is differentially regulated during rat liver regeneration and carcinogenesis. Pathobiology. 62(4):209–220. doi: 10.1159/000163912
   PubMed Web of Science ®Google Scholar
• Thompson EW, Newgreen DF. 2005. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res. 65(14):5991–5995. doi: 10.1158/0008-5472.CAN-05-0616
   PubMed Web of Science ®Google Scholar
• Thorgeirsson SS, Grisham JW. 2002. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 31:339–346. doi: 10.1038/ng0802-339
   PubMed Web of Science ®Google Scholar
• Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. 2004. Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci USA. 101:15370–15375. doi: 10.1073/pnas.0406499101
   PubMed Web of Science ®Google Scholar
• Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC, de la Pompa JL. 2004. Notch promotes epithelial–mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18:99–115. doi: 10.1101/gad.276304
   PubMed Web of Science ®Google Scholar
• Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. 2012. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell. 22(6):725–736. doi: 10.1016/j.ccr.2012.09.022
   PubMed Web of Science ®Google Scholar
• Van Dusen NJ, Firulli AB. 2012. Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart. Differentiation. 84:79–88. doi: 10.1016/j.diff.2012.03.002
   PubMed Web of Science ®Google Scholar
• Veeraraghavalu K, Subbaiah VK, Srivastava S, Chakrabarti O, Syal R, Krishna S. 2005. Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation. J Virol. 79:7889–7898. doi: 10.1128/JVI.79.12.7889-7898.2005
   PubMed Web of Science ®Google Scholar
• Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP. 2006. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 312(5777):1220–1223. doi: 10.1126/science.1127883
   PubMed Web of Science ®Google Scholar
• Vleminckx K, Vakaet Jr, L, Mareel M, Fiers W, van Roy F. 1991. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 66:107–119. doi: 10.1016/0092-8674(91)90143-M
   PubMed Web of Science ®Google Scholar
• Wang Z, Humphries B, Xiao H, Jiang Y, Yang C. 2014. MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b protein kinase Cα-positive feedback loop and inhibiting Rac1 activation. J Biol Chem. 289:18373–18386. doi: 10.1074/jbc.M114.554246
   PubMed Web of Science ®Google Scholar
• Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. 2004. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol. 6:154–161. doi: 10.1038/ncb1094
   PubMed Web of Science ®Google Scholar
• Wegner SV, Arslan H, Sunbul M, Yin J, He C. 2010. Dynamic copper (I) imaging in mammalian cells with a genetically encoded fluorescent copper (I) sensor. J Am Chem Soc. 132(8):2567–2569. doi: 10.1021/ja9097324
   PubMed Web of Science ®Google Scholar
• Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC. 2008. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 13(5):385–393. doi: 10.1016/j.ccr.2008.03.015
   PubMed Web of Science ®Google Scholar
• Wells A, Yates C, Shepard CR. 2008. E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metast. 25:621–628. doi: 10.1007/s10585-008-9167-1
   PubMed Web of Science ®Google Scholar
• Weston CR, Davis RJ. 2001. Signal transduction – signaling specificity – a complex affair. Science. 292:2439–2440. doi: 10.1126/science.1063279
   PubMed Web of Science ®Google Scholar
• Williams LV, Veliceasa D, Vinokour E, Volpert OV. 2013. miR-200b inhibits prostate cancer, EMT, growth and metastasis. PLoS ONE. 34(6):1735–1744.
   Google Scholar
• Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M. 2006. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 34:1735–1744. doi: 10.1093/nar/gkl105
   PubMed Web of Science ®Google Scholar
• Wu C. 1999. Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction. J Cell Sci. 112:4485–4489.
   PubMed Web of Science ®Google Scholar
• Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. 1998. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem. 273(1):528–536. doi: 10.1074/jbc.273.1.528
   PubMed Web of Science ®Google Scholar
• Wu F, Yang LY, Li YF, Ou DP, Chen DP, Fan C. 2009. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. Hepatology. 50:1839–1850. doi: 10.1002/hep.23197
   PubMed Web of Science ®Google Scholar
• Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER, Segall JE, Pollard JW, Condeelis J. 2007. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67:2649–2656. doi: 10.1158/0008-5472.CAN-06-1823
   PubMed Web of Science ®Google Scholar
• Xue G, Hemmings BA. 2012. Phosphorylation of basic helix-loop-helix transcription factor twist in development and disease. Biochem Soc Trans. 40:90–93. doi: 10.1042/BST20110678
   PubMed Web of Science ®Google Scholar
• Yang YL, Ju HZ, Liu SF, Lee TC, Shih YW, Chuang LY, Guh J-Y, Yang Y-Y, Liao T-N, Hung T-J, Hung M-Y. 2011. BMP-2 suppresses renal interstitial fibrosis by regulating epithelial–mesenchymal transition. J Cell Biochem. 112:2558–2565. doi: 10.1002/jcb.23180
   PubMed Web of Science ®Google Scholar
• Yang Y, Lim SK, Choong LY, Lee H, Chen Y, Chong PK, Ashktorab H, Wang TT, Salto-Tellez M, Yeoh KG, et al. 2010. Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins. J Proteome Res. 9:4767–4778. doi: 10.1021/pr100492x
   PubMed Web of Science ®Google Scholar
• Yang Z, Rayala S, Nguyen D, Vadlamudi RK, Chen S, Kumar R. 2005. Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail’s subcellular localization and functions. Cancer Res. 65:3179–3184.
   PubMed Web of Science ®Google Scholar
• Yang J, Weinberg RA. 2008. Epithelial-mesenchymal transition: at the crossroads of development and tumour metastasis. Dev Cell. 14:818–829. doi: 10.1016/j.devcel.2008.05.009
   PubMed Web of Science ®Google Scholar
• Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng S-C, Wu K-J. 2008. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol. 10:295–305. doi: 10.1038/ncb1691
   PubMed Web of Science ®Google Scholar
• Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD. 2006. Cahalan molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature. 443:226–229. doi: 10.1038/nature05108
   PubMed Web of Science ®Google Scholar
• Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, et al. 2000. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27:561–572. doi: 10.1016/S0896-6273(00)00066-0
   PubMed Web of Science ®Google Scholar
• Zamore PD, Haley B. 2005. Ribo-gnome: the big world of small RNAs. Science. 309:1519–1524. doi: 10.1126/science.1111444
   PubMed Web of Science ®Google Scholar
• Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X, et al. 2013. Hypoxia induces epithelial–mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1a in hepatocellular carcinoma. BMC Cancer. 13:444. doi: 10.1186/1471-2407-13-108. doi: 10.1186/1471-2407-13-444
   PubMed Web of Science ®Google Scholar
• Zhang K, Zhang S, Jiao X, Wang H, Zhang D, Niu Z, Shen Y, Lv L, Zhou Y. 2010. Slug regulates proliferation and invasiveness of esophageal adenocarcinoma cells in vitro and in vivo. Med Oncol. 28:1089–1100. doi: 10.1007/s12032-010-9652-7
   PubMed Web of Science ®Google Scholar
• Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. 2008. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 18:350–359. doi: 10.1038/cr.2008.24
   PubMed Web of Science ®Google Scholar
• Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. 2006. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci USA. 103(24):9357–9362. ( Export to RIS). doi: 10.1073/pnas.0603161103
   PubMed Web of Science ®Google Scholar