Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat

References

• Haslam DW, James WPT. Obesity. Lancet 2005; 366:1197-209; PMID:16198769; http://dx.doi.org/10.1016/S0140-6736(05)67483-1
   PubMed Web of Science ®Google Scholar
• Tseng Y-H, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 2010; 9:465-82; PMID:20514071; http://dx.doi.org/10.1038/nrd3138
   PubMed Web of Science ®Google Scholar
• Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med Nature Publishing Group; 2013; 19:1252-63; PMID:24100998; http://dx.doi.org/10.1038/nm.3361
   PubMedGoogle Scholar
• Shabalina I, Petrovic N, deJong JA, Kalinovich A, Cannon B, Nedergaard J. UCP1 in Brite/Beige adipose tissue mitochondria is functionally thermogenic. Cell Rep The Authors; 2013; 5:1196-203; PMID:24290753; http://dx.doi.org/10.1016/j.celrep.2013.10.044
   PubMed Web of Science ®Google Scholar
• Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev 2013; 27:234-50; PMID:23388824; http://dx.doi.org/10.1101/gad.211649.112
   PubMed Web of Science ®Google Scholar
• Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360:1509-17; PMID:19357406; http://dx.doi.org/10.1097/OGX.0b013e3181ac8aa2
   PubMed Web of Science ®Google Scholar
• Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360:1518-25; PMID:19357407; http://dx.doi.org/10.1056/NEJMoa0808949
   PubMed Web of Science ®Google Scholar
• Van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JMAFL, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360:1500-8; PMID:19357405; http://dx.doi.org/10.1056/NEJMoa0808718
   PubMed Web of Science ®Google Scholar
• Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009; 23:3113-20; PMID:19417078; http://dx.doi.org/10.1096/fj.09-133546
   PubMed Web of Science ®Google Scholar
• Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med Nature Publishing Group; 2013; 19:635-9; PMID:23603815; http://dx.doi.org/10.1038/nm.3112
   PubMedGoogle Scholar
• Lidell ME, Betz MJ, Leinhard OD, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P, et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013; 19:631-4; PMID:23603813; http://dx.doi.org/10.1038/nm.3017
   PubMed Web of Science ®Google Scholar
• Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homøe P, Loft A, de Jong J, Mathur N, Cannon B, Nedergaard J, et al. A classical brown adipose tissue mrna signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013; 17:798-805; PMID:23663743; http://dx.doi.org/10.1016/j.cmet.2013.04.011
   PubMed Web of Science ®Google Scholar
• Spiegelman BM, Seale P, Kajimura S. Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev 2009; 23:788-97; PMID:19339685; http://dx.doi.org/10.1101/gad.1779209
   PubMedGoogle Scholar
• Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab 2010; 11:257-62; PMID:20374957; http://dx.doi.org/10.1016/j.cmet.2010.03.005
   PubMed Web of Science ®Google Scholar
• Trajkovski M, Lodish H. MicroRNA networks regulate development of brown adipocytes. Trends Endocrinol Metab 2013; 24:442-50; PMID:23809233; http://dx.doi.org/10.1016/j.tem.2013.05.002
   PubMed Web of Science ®Google Scholar
• Sun L, Xie H, Mori MA, Alexander R, Yuan B, Hattangadi SM, Liu Q, Kahn CR, Lodish HF. Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol 2011; 13:958-65; PMID:21743466; http://dx.doi.org/10.1038/ncb2286
   PubMed Web of Science ®Google Scholar
• Shinoda K, Luijten IHN, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med 2015; 1-8; PMID:25774848; http://dx.doi.org/10.1038/nm.3819
   PubMedGoogle Scholar
• Zilberfarb V, Piétri-Rouxel F, Jockers R, Krief S, Delouis C, Issad T, Strosberg AD. Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis. J Cell Sci 1997; 110(Pt 7):801-7; PMID:9133667. Available: http://www.ncbi.nlm.nih.gov/pubmed/9133667
   PubMedGoogle Scholar
• Kazantzis M, Takahashi V, Hinkle J, Kota S, Zilberfarb V, Issad T, Abdelkarim M, Chouchane L, Strosberg AD. PAZ6 cells constitute a representative model for human brown pre-adipocytes. Front Endocrinol (Lausanne) 2012; 3:13; PMID:22649407; http://dx.doi.org/10.3389/fendo.2012.00013
   PubMedGoogle Scholar
• Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, Debalsi KL, Ilkayeva OR, Stevens RD, Kheterpal I, Zhang J, et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab 2012; 15:764-77; PMID:22560225; http://dx.doi.org/10.1016/j.cmet.2012.04.005
   PubMed Web of Science ®Google Scholar
• Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7:45-56; PMID:18177724; http://dx.doi.org/10.1016/j.cmet.2007.10.013
   PubMed Web of Science ®Google Scholar
• Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N, Collins S. Acute stimulation of white adipocyte respiration by PKA-induced lipolysis. Diabetes 2010; 59:2474-83; PMID:20682684; http://dx.doi.org/10.2337/db10-0245
   PubMed Web of Science ®Google Scholar
• Walden TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J. Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues. Am J Physiol Endocrinol Metab 2012; 302:E19-31; PMID:21828341; http://dx.doi.org/10.1152/ajpendo.00249.2011
   PubMed Web of Science ®Google Scholar
• Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007; 6:38-54; PMID:17618855; http://dx.doi.org/10.1016/j.cmet.2007.06.001
   PubMed Web of Science ®Google Scholar
• Ahfeldt T, Schinzel RT, Lee Y-K, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol 2012; 14:209-19; PMID:22246346; http://dx.doi.org/10.1038/ncb2411
   PubMed Web of Science ®Google Scholar
• Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, et al. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 2012; 16:394-406; PMID:22958922; http://dx.doi.org/10.1016/j.cmet.2012.08.001
   PubMed Web of Science ®Google Scholar