Inside out: Bone marrow adipose tissue as a source of circulating adiponectin

References

• Romacho T, Elsen M, Rohrborn D, Eckel J. Adipose tissue and its role in organ crosstalk. Acta physiologica 2014; 210:733-53; PMID:24495317; http://dx.doi.org/10.1111/apha.12246
   PubMed Web of Science ®Google Scholar
• Scherer PEE. Adiponectin: basic and clinical aspects [Special Issue]. Best Pract Res Clin Endocrinol Metab 2014; 28:1-130; PMID:24417940; http://dx.doi.org/10.1016/j.beem.2013.11.004
   PubMed Web of Science ®Google Scholar
• Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity? Mol Metab 2013; 2:133-41; PMID:24049728; http://dx.doi.org/10.1016/j.molmet.2013.04.001
   PubMed Web of Science ®Google Scholar
• Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, et al. Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab 2014; 20:368-75; PMID:24998914; http://dx.doi.org/10.1016/j.cmet.2014.06.003
   PubMed Web of Science ®Google Scholar
• Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257:79-83; PMID:10092513; http://dx.doi.org/10.1006/bbrc.1999.0255
   PubMed Web of Science ®Google Scholar
• Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J, Hamilton MP, Luby-Phelps K, Scherer PE. Systemic fate of the adipocyte-derived factor adiponectin. Diabetes 2009; 58:1961-70; PMID:19581422; http://dx.doi.org/10.2337/db08-1750
   PubMed Web of Science ®Google Scholar
• Delporte ML, Brichard SM, Hermans MP, Beguin C, Lambert M. Hyperadiponectinaemia in anorexia nervosa. Clin Endocrinol (Oxf) 2003; 58:22-9; PMID:12519408; http://dx.doi.org/10.1046/j.1365-2265.2003.01702.x
   PubMed Web of Science ®Google Scholar
• Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003; 52:268-76; PMID:12540596; http://dx.doi.org/10.2337/diabetes.52.2.268
   PubMed Web of Science ®Google Scholar
• Dolezalova R, Lacinova Z, Dolinkova M, Kleiblova P, Haluzikova D, Housa D, Papezova H, Haluzik M. Changes of endocrine function of adipose tissue in anorexia nervosa: comparison of circulating levels versus subcutaneous mRNA expression. Clin Endocrinol (Oxf) 2007; 67:674-8; PMID:17953628; http://dx.doi.org/10.1111/j.1365-2265.2007.02944.x
   PubMed Web of Science ®Google Scholar
• Qiao L, Lee B, Kinney B, Yoo HS, Shao J. Energy intake and adiponectin gene expression. Am J Physiol Endocrinol Metab 2011; 300:E809-16; PMID:21325106; http://dx.doi.org/10.1152/ajpendo.00004.2011
   PubMedGoogle Scholar
• Zhu M, Lee GD, Ding L, Hu J, Qiu G, de Cabo R, Bernier M, Ingram DK, Zou S. Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol 2007; 42:733-44; PMID:17624709; http://dx.doi.org/10.1016/j.exger.2007.05.011
   PubMed Web of Science ®Google Scholar
• Rohrbach S, Aurich AC, Li L, Niemann B. Age-associated loss in adiponectin-activation by caloric restriction: lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7. Mol Cell Endocrinol 2007; 277:26-34; PMID:17716811; http://dx.doi.org/10.1016/j.mce.2007.07.005
   PubMed Web of Science ®Google Scholar
• Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I. Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. Exp Gerontol 2009; 44:646-52; PMID:19646410; http://dx.doi.org/10.1016/j.exger.2009.07.002
   PubMed Web of Science ®Google Scholar
• Ding Q, Ash C, Mracek T, Merry B, Bing C. Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats. J Nutr Biochem 2012; 23:867-74; PMID:21852089; http://dx.doi.org/10.1016/j.jnutbio.2011.04.011
   PubMed Web of Science ®Google Scholar
• Dai Y, Pang J, Gong H, Fan W, Zhang TM. Roles and tissue source of adiponectin involved in lifestyle modifications. J Gerontol A Biol Sci Med Sci 2013; 68:117-28; PMID:22562959; http://dx.doi.org/10.1093/gerona/gls131
   PubMed Web of Science ®Google Scholar
• Wiesenborn DS, Menon V, Zhi X, Do A, Gesing A, Wang Z, Bartke A, Altomare DA, Masternak MM. The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice. Aging (Albany NY) 2014; 6:900-12; PMID:25411241
   PubMedGoogle Scholar
• Chen JH, Ouyang C, Ding Q, Song J, Cao W, Mao L. A Moderate Low-Carbohydrate Low-Calorie Diet Improves Lipid Profile, Insulin Sensitivity and Adiponectin Expression in Rats. Nutrients 2015; 7:4724-38; PMID:26110252; http://dx.doi.org/10.3390/nu7064724
   PubMed Web of Science ®Google Scholar
• Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R. Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004; 18:415-7; PMID:14688200
   PubMedGoogle Scholar
• Wang Z, Al-Regaiey KA, Masternak MM, Bartke A. Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. The journals of gerontology Series A, Biological sciences and medical sciences 2006; 61:323-31; PMID:16611697; http://dx.doi.org/10.1093/gerona/61.4.323
   PubMed Web of Science ®Google Scholar
• Tahmoorespur M, Ghazanfari S, Nobari K. Evaluation of adiponectin gene expression in the abdominal adipose tissue of broiler chickens: feed restriction, dietary energy, and protein influences adiponectin messenger ribonucleic acid expression. Poult Sci 2010; 89:2092-100; PMID:20852099; http://dx.doi.org/10.3382/ps.2010-00772
   PubMed Web of Science ®Google Scholar
• Zgheib S, Mequinion M, Lucas S, Leterme D, Ghali O, Tolle V, Zizzari P, Bellefontaine N, Legroux-Gerot I, Hardouin P, et al. Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences. PLoS One 2014; 9:e103775; PMID:25090643; http://dx.doi.org/10.1371/journal.pone.0103775
   PubMedGoogle Scholar
• Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of Exercise Increases Plasma Adiponectin and Release from Adipose Tissue. Med Sci Sports Exerc 2015
   Web of Science ®Google Scholar
• Rasouli N, Yao-Borengasser A, Miles LM, Elbein SC, Kern PA. Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am J Physiol Endocrinol Metab 2006; 290:E42-E6; PMID:16118250; http://dx.doi.org/10.1152/ajpendo.00240.2005
   PubMed Web of Science ®Google Scholar
• Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell 2014; 156:20-44; PMID:24439368; http://dx.doi.org/10.1016/j.cell.2013.12.012
   PubMed Web of Science ®Google Scholar
• Fazeli PK, Horowitz MC, Macdougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A. Marrow fat and bone–new perspectives. J Clin Endocrinol Metab 2013; 98:935-45; PMID:23393168; http://dx.doi.org/10.1210/jc.2012-3634
   PubMed Web of Science ®Google Scholar
• Devlin MJ. Why does starvation make bones fat? Am J Hum Biol 2011; 23:577-85; PMID:21793093; http://dx.doi.org/10.1002/ajhb.21202
   PubMed Web of Science ®Google Scholar
• Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004; 35:842-9; PMID:15454091; http://dx.doi.org/10.1016/j.bone.2004.06.008
   PubMed Web of Science ®Google Scholar
• Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, et al. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006; 99:196-208; PMID:16598753; http://dx.doi.org/10.1002/jcb.20890
   PubMed Web of Science ®Google Scholar
• DiMascio L, Voermans C, Uqoezwa M, Duncan A, Lu D, Wu J, Sankar U, Reya T. Identification of adiponectin as a novel hemopoietic stem cell growth factor. J Immunol 2007; 178:3511-20; PMID:17339446; http://dx.doi.org/10.4049/jimmunol.178.6.3511
   PubMed Web of Science ®Google Scholar
• Thorrez L, Van Deun K, Tranchevent LC, Van Lommel L, Engelen K, Marchal K, Moreau Y, Van Mechelen I, Schuit F. Using ribosomal protein genes as reference: a tale of caution. PLoS One 2008; 3:e1854; PMID:18365009; http://dx.doi.org/10.1371/journal.pone.0001854
   PubMedGoogle Scholar
• Lattin JE, Schroder K, Su AI, Walker JR, Zhang J, Wiltshire T, Saijo K, Glass CK, Hume DA, Kellie S, et al. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res 2008; 4:5; PMID:18442421; http://dx.doi.org/10.1186/1745-7580-4-5
   PubMedGoogle Scholar
• Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E, Soejima H, Fukudome K, Sugihara H, Hotokebuchi T, Toda S. Organotypic culture of human bone marrow adipose tissue. Pathol Int 2010; 60:259-67; PMID:20403027; http://dx.doi.org/10.1111/j.1440-1827.2010.02511.x
   PubMed Web of Science ®Google Scholar
• Ugarte F, Ryser M, Thieme S, Fierro FA, Navratiel K, Bornhauser M, Brenner S. Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells. Exp Hematol 2009; 37:867-75 e1; PMID:19540436; http://dx.doi.org/10.1016/j.exphem.2009.03.007
   PubMed Web of Science ®Google Scholar
• Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM. Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone 2010; 47:360-70; PMID:20510392; http://dx.doi.org/10.1016/j.bone.2010.05.021
   PubMed Web of Science ®Google Scholar
• Yokota T, Meka CS, Medina KL, Igarashi H, Comp PC, Takahashi M, Nishida M, Oritani K, Miyagawa J, Funahashi T, et al. Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest 2002; 109:1303-10; PMID:12021245; http://dx.doi.org/10.1172/JCI0214506
   PubMed Web of Science ®Google Scholar
• Liu LF, Shen WJ, Ueno M, Patel S, Kraemer FB. Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes. BMC Genomics 2011; 12:212; PMID:21545734; http://dx.doi.org/10.1186/1471-2164-12-212
   PubMed Web of Science ®Google Scholar
• Iwaki M, Matsuda M, Maeda N, Funahashi T, Matsuzawa Y, Makishima M, Shimomura I. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003; 52:1655-63; PMID:12829629; http://dx.doi.org/10.2337/diabetes.52.7.1655
   PubMed Web of Science ®Google Scholar
• Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50:2094-9; PMID:11522676; http://dx.doi.org/10.2337/diabetes.50.9.2094
   PubMed Web of Science ®Google Scholar
• Gustafson B, Jack MM, Cushman SW, Smith U. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. Biochem Biophys Res Commun 2003; 308:933-9; PMID:12927809; http://dx.doi.org/10.1016/S0006-291X(03)01518-3
   PubMed Web of Science ®Google Scholar
• Park B-H, Qiang L, Farmer SR. Phosphorylation of C/EBP{beta} at a consensus extracellular signal-regulated kinase/glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of Mouse fibroblasts into adipocytes. Mol Cell Biol 2004; 24:8671-80; http://dx.doi.org/10.1128/MCB.24.19.8671-8680.2004
   PubMed Web of Science ®Google Scholar
• Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 2005; 54:1744-54; PMID:15919796; http://dx.doi.org/10.2337/diabetes.54.6.1744
   PubMed Web of Science ®Google Scholar
• Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, et al. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nat Cell Biol 2015; 17:1099-111; PMID:26280538; http://dx.doi.org/10.1038/ncb3217
   PubMed Web of Science ®Google Scholar
• Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 2008; 105:5266-70; PMID:18362359; http://dx.doi.org/10.1073/pnas.0711119105
   PubMed Web of Science ®Google Scholar
• Degawa-Yamauchi M, Moss KA, Bovenkerk JE, Shankar SS, Morrison CL, Lelliott CJ, Vidal-Puig A, Jones R, Considine RV. Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha. Obes Res 2005; 13:662-9; PMID:15897474; http://dx.doi.org/10.1038/oby.2005.74
   PubMedGoogle Scholar
• Simons PJ, van den Pangaart PS, van Roomen CP, Aerts JM, Boon L. Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers. Cytokine 2005; 32:94-103; PMID:16213747; http://dx.doi.org/10.1016/j.cyto.2005.08.003
   PubMed Web of Science ®Google Scholar
• Poloni A, Maurizi G, Serrani F, Mancini S, Zingaretti MC, Frontini A, Cinti S, Olivieri A, Leoni P. Molecular and functional characterization of human bone marrow adipocytes. Exp Hematol 2013; 41:558-66 e2; PMID:23435314; http://dx.doi.org/10.1016/j.exphem.2013.02.005
   PubMed Web of Science ®Google Scholar
• Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, Depinho RA, Guo EX, et al. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 2013; PMID:23684624
   PubMed Web of Science ®Google Scholar
• Hayman DM, Blumberg TJ, Scott CC, Athanasiou KA. The effects of isolation on chondrocyte gene expression. Tissue Eng 2006; 12:2573-81; PMID:16995790; http://dx.doi.org/10.1089/ten.2006.12.2573
   PubMedGoogle Scholar
• Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, et al. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun 2015; 6:7808; PMID:26245716; http://dx.doi.org/10.1038/ncomms8808
   PubMed Web of Science ®Google Scholar
• Ryden M, Dicker A, Gotherstrom C, Astrom G, Tammik C, Arner P, Le Blanc K. Functional characterization of human mesenchymal stem cell-derived adipocytes. Biochem Biophys Res Commun 2003; 311:391-7; PMID:14592427; http://dx.doi.org/10.1016/j.bbrc.2003.10.010
   PubMed Web of Science ®Google Scholar
• Hozumi A, Osaki M, Sakamoto K, Goto H, Fukushima T, Baba H, Shindo H. Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes. Biomed Res 2010; 31:281-6; PMID:21079357; http://dx.doi.org/10.2220/biomedres.31.281
   PubMed Web of Science ®Google Scholar
• Liu M, Zhou L, Xu A, Lam KS, Wetzel MD, Xiang R, Zhang J, Xin X, Dong LQ, Liu F. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A 2008; 105:18302-7; PMID:19011089; http://dx.doi.org/10.1073/pnas.0806341105
   PubMed Web of Science ®Google Scholar
• Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 2007; 27:3716-31; PMID:17353260; http://dx.doi.org/10.1128/MCB.00931-06
   PubMed Web of Science ®Google Scholar
• Qiang L, Wang H, Farmer SR. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 2007; 27:4698-707; PMID:17452443; http://dx.doi.org/10.1128/MCB.02279-06
   PubMed Web of Science ®Google Scholar
• Carson BP, Del Bas JM, Moreno-Navarrete JM, Fernandez-Real JM, Mora S. The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. PLoS One 2013; 8:e74687; PMID:24040321; http://dx.doi.org/10.1371/journal.pone.0074687
   PubMedGoogle Scholar
• Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One 2011; 6:e28146; PMID:22140527; http://dx.doi.org/10.1371/journal.pone.0028146
   PubMedGoogle Scholar
• Gesta S, Lolmede K, Daviaud D, Berlan M, Bouloumie A, Lafontan M, Valet P, Saulnier-Blache JS. Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression. Horm Metab Res 2003; 35:158-63; PMID:12734776; http://dx.doi.org/10.1055/s-2003-39070
   PubMed Web of Science ®Google Scholar
• Frayn KN, Coppack SW. Assessment of white adipose tissue metabolism by measurement of arteriovenous differences. Methods Mol Biol 2001; 155:269-79; PMID:11293078
   PubMedGoogle Scholar
• Bennett CN, Ouyang H, Ma YL, Zeng Q, Gerin I, Sousa KM, Lane TF, Krishnan V, Hankenson KD, MacDougald OA. Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res 2007; 22:1924-32; PMID:17708715; http://dx.doi.org/10.1359/jbmr.070810
   PubMed Web of Science ®Google Scholar
• Cawthorn WP, Bree AJ, Yao Y, Du B, Hemati N, Martinez-Santibanez G, MacDougald OA. Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a beta-catenin-dependent mechanism. Bone 2012; 50:477-89; PMID:21872687; http://dx.doi.org/10.1016/j.bone.2011.08.010
   PubMed Web of Science ®Google Scholar
• Cawthorn WP, Scheller EL, Parlee SD, Pham HA, Learman BS, Redshaw CM, Sulston RJ, Burr AA, Das AK, Simon BR, et al. Expansion of bone marrow adipose tissue during caloric restriction is associated with increased circulating glucocorticoids and not with hypoleptinemia. Endocrinology 2015:en20151477
   Google Scholar
• Garg A, Agarwal AK. Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 2009; 1791:507-13; PMID:19162222; http://dx.doi.org/10.1016/j.bbalip.2008.12.014
   PubMed Web of Science ®Google Scholar
• Rajab A, Straub V, McCann LJ, Seelow D, Varon R, Barresi R, Schulze A, Lucke B, Lutzkendorf S, Karbasiyan M, et al. Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS genetics 2010; 6:e1000874; PMID:20300641; http://dx.doi.org/10.1371/journal.pgen.1000874
   PubMed Web of Science ®Google Scholar
• Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes 2002; 51:2727-33; PMID:12196465; http://dx.doi.org/10.2337/diabetes.51.9.2727
   PubMed Web of Science ®Google Scholar
• Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 2013; 19:1338-44; PMID:23995282; http://dx.doi.org/10.1038/nm.3324
   PubMed Web of Science ®Google Scholar
• Semple RK, Soos MA, Luan J, Mitchell CS, Wilson JC, Gurnell M, Cochran EK, Gorden P, Chatterjee VK, Wareham NJ, et al. Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab 2006; 91:3219-23; PMID:16705075; http://dx.doi.org/10.1210/jc.2006-0166
   PubMed Web of Science ®Google Scholar
• Semple RK, Halberg NH, Burling K, Soos MA, Schraw T, Luan J, Cochran EK, Dunger DB, Wareham NJ, Scherer PE, et al. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes 2007; 56:1712-7; PMID:17325257; http://dx.doi.org/10.2337/db06-1665
   PubMed Web of Science ®Google Scholar
• Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 3:25-38; PMID:12110165; http://dx.doi.org/10.1016/S1534-5807(02)00199-5
   PubMed Web of Science ®Google Scholar
• Isobe T, Saitoh S, Takagi S, Takeuchi H, Chiba Y, Katoh N, Shimamoto K. Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study. Eur J Endocrinol 2005; 153:91-8; PMID:15994750; http://dx.doi.org/10.1530/eje.1.01930
   PubMed Web of Science ®Google Scholar
• Imagawa A, Funahashi T, Nakamura T, Moriwaki M, Tanaka S, Nishizawa H, Sayama K, Uno S, Iwahashi H, Yamagata K, et al. Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes. Diabetes Care 2002; 25:1665-6; PMID:12196453; http://dx.doi.org/10.2337/diacare.25.9.1665
   PubMed Web of Science ®Google Scholar
• Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7:947-53; PMID:11479628; http://dx.doi.org/10.1038/90992
   PubMed Web of Science ®Google Scholar
• Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 2007; 148:774-81; PMID:17068132; http://dx.doi.org/10.1210/en.2006-1168
   PubMed Web of Science ®Google Scholar
• Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A 2012; 109:3143-8; PMID:22315431; http://dx.doi.org/10.1073/pnas.1200797109
   PubMed Web of Science ®Google Scholar
• Langeveld M, Scheij S, Dubbelhuis P, Hollak CE, Sauerwein HP, Simons P, Aerts JM. Very low serum adiponectin levels in patients with type 1 Gaucher disease without overt hyperglycemia. Metabolism 2007; 56:314-9; PMID:17292718; http://dx.doi.org/10.1016/j.metabol.2006.10.014
   PubMed Web of Science ®Google Scholar
• Maas M, Hollak CE, Akkerman EM, Aerts JM, Stoker J, Den Heeten GJ. Quantification of skeletal involvement in adults with type I Gaucher's disease: fat fraction measured by Dixon quantitative chemical shift imaging as a valid parameter. AJR Am J Roentgenol 2002; 179:961-5; PMID:12239046; http://dx.doi.org/10.2214/ajr.179.4.1790961
   PubMed Web of Science ®Google Scholar
• Rosenthal DI, Mayo-Smith W, Goodsitt MM, Doppelt S, Mankin HJ. Bone and bone marrow changes in Gaucher disease: evaluation with quantitative CT. Radiology 1989; 170:143-6; PMID:2909087; http://dx.doi.org/10.1148/radiology.170.1.2909087
   PubMed Web of Science ®Google Scholar
• Geer EB, Shen W, Strohmayer E, Post KD, Freda PU. Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI. J Clin Endocrinol Metab 2012; 97:1702-11; PMID:22419708; http://dx.doi.org/10.1210/jc.2011-3123
   PubMed Web of Science ®Google Scholar
• Schnitzler CM, Mesquita J. Bone marrow composition and bone microarchitecture and turnover in blacks and whites. J Bone Miner Res 1998; 13:1300-7; PMID:9718199; http://dx.doi.org/10.1359/jbmr.1998.13.8.1300
   PubMed Web of Science ®Google Scholar
• Hulver MW, Saleh O, MacDonald KG, Pories WJ, Barakat HA. Ethnic differences in adiponectin levels. Metabolism 2004; 53:1-3; PMID:14681833; http://dx.doi.org/10.1016/j.metabol.2003.07.002
   PubMed Web of Science ®Google Scholar
• Newton AL, Hanks LJ, Davis M, Casazza K. The relationships among total body fat, bone mineral content and bone marrow adipose tissue in early-pubertal girls. BoneKEy Rep 2013; 2
   Google Scholar
• Scheller EL, Rosen CJ. What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Ann N Y Acad Sci 2014; 1311:14-30; PMID:24650218; http://dx.doi.org/10.1111/nyas.12327
   PubMed Web of Science ®Google Scholar
• George J, Patal S, Wexler D, Sharabi Y, Peleg E, Kamari Y, Grossman E, Sheps D, Keren G, Roth A. Circulating adiponectin concentrations in patients with congestive heart failure. Heart 2006; 92:1420-4; PMID:16621874; http://dx.doi.org/10.1136/hrt.2005.083345
   PubMed Web of Science ®Google Scholar
• Mantzoros C, Petridou E, Alexe DM, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Shetty G, Gavrila A, Kedikoglou S, et al. Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns. Eur J Endocrinol 2004; 151:741-6; PMID:15588241; http://dx.doi.org/10.1530/eje.0.1510741
   PubMed Web of Science ®Google Scholar
• Styner M, Thompson WR, Galior K, Uzer G, Wu X, Kadari S, Case N, Xie Z, Sen B, Romaine A, et al. Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise. Bone 2014; 64:39-46; PMID:24709686; http://dx.doi.org/10.1016/j.bone.2014.03.044
   PubMed Web of Science ®Google Scholar
• Doucette CR, Horowitz MC, Berry R, MacDougald OA, Anunciado-Koza R, Koza RA, Rosen CJ. A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice. J Cell Physiol 2015; 230:2032-7; PMID:25663195; http://dx.doi.org/10.1002/jcp.24954
   PubMed Web of Science ®Google Scholar
• Lecka-Czernik B, Stechschulte LA, Czernik PJ, Dowling AR. High bone mass in adult mice with diet-induced obesity results from a combination of initial increase in bone mass followed by attenuation in bone formation; implications for high bone mass and decreased bone quality in obesity. Mol Cell Endocrinol 2015; 410:35-41; PMID:25576855; http://dx.doi.org/10.1016/j.mce.2015.01.001
   PubMed Web of Science ®Google Scholar
• Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magnetic Resonance Imaging: JMRI 2012; 35:117-24; PMID:22190287; http://dx.doi.org/10.1002/jmri.22757
   PubMed Web of Science ®Google Scholar
• Bredella MA, Gill CM, Gerweck AV, Landa MG, Kumar V, Daley SM, Torriani M, Miller KK. Ectopic and serum lipid levels are positively associated with Bone Marrow fat in obesity. Radiology 2013; PMID:23861502
   PubMed Web of Science ®Google Scholar
• Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, et al. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone 2015; 74:140-5; PMID:25603463; http://dx.doi.org/10.1016/j.bone.2015.01.010
   PubMed Web of Science ®Google Scholar
• Halade GV, El Jamali A, Williams PJ, Fajardo RJ, Fernandes G. Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Exp Gerontol 2011; 46:43-52; PMID:20923699; http://dx.doi.org/10.1016/j.exger.2010.09.014
   PubMed Web of Science ®Google Scholar
• Mangialardi G, Spinetti G, Reni C, Madeddu P. Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes. Antioxidants Redox Signaling 2014; 21:1620-33; PMID:25089632; http://dx.doi.org/10.1089/ars.2014.5944
   PubMed Web of Science ®Google Scholar
• Gallagher KA, Joshi A, Carson WF, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman EL, Henke PK, Hogaboam C, et al. Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes 2015; 64:1420-30; PMID:25368099; http://dx.doi.org/10.2337/db14-0872
   PubMed Web of Science ®Google Scholar
• Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009; 5:e1000768; PMID:20011104; http://dx.doi.org/10.1371/journal.pgen.1000768
   PubMedGoogle Scholar
• Jee SH, Sull JW, Lee JE, Shin C, Park J, Kimm H, Cho EY, Shin ES, Yun JE, Park JW, et al. Adiponectin concentrations: a genome-wide association study. Am J Hum Genet 2010; 87:545-52; PMID:20887962; http://dx.doi.org/10.1016/j.ajhg.2010.09.004
   PubMed Web of Science ®Google Scholar
• Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikainen LP, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012; 8:e1002607; PMID:22479202; http://dx.doi.org/10.1371/journal.pgen.1002607
   PubMed Web of Science ®Google Scholar
• Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360:1509-17; PMID:19357406; http://dx.doi.org/10.1056/NEJMoa0810780
   PubMed Web of Science ®Google Scholar
• Pannacciulli N, Vettor R, Milan G, Granzotto M, Catucci A, Federspil G, De Giacomo P, Giorgino R, De Pergola G. Anorexia nervosa is characterized by increased adiponectin plasma levels and reduced nonoxidative glucose metabolism. J Clin Endocrinol Metab 2003; 88:1748-52; PMID:12679468; http://dx.doi.org/10.1210/jc.2002-021215
   PubMed Web of Science ®Google Scholar
• Housova J, Anderlova K, Krizova J, Haluzikova D, Kremen J, Kumstyrova T, Papezova H, Haluzik M. Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2005; 90:1366-70; PMID:15598689; http://dx.doi.org/10.1210/jc.2004-1364
   PubMed Web of Science ®Google Scholar
• Bosy-Westphal A, Brabant G, Haas V, Onur S, Paul T, Nutzinger D, Klein H, Hauer M, Muller MJ. Determinants of plasma adiponectin levels in patients with anorexia nervosa examined before and after weight gain. Eur J Nutr 2005; 44:355-9; PMID:15793670; http://dx.doi.org/10.1007/s00394-005-0533-3
   PubMed Web of Science ®Google Scholar
• Modan-Moses D, Stein D, Pariente C, Yaroslavsky A, Ram A, Faigin M, Loewenthal R, Yissachar E, Hemi R, Kanety H. Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab 2007; 92:1843-7; PMID:17327386; http://dx.doi.org/10.1210/jc.2006-1683
   PubMed Web of Science ®Google Scholar
• Dostalova I, Kavalkova P, Haluzikova D, Lacinova Z, Mraz M, Papezova H, Haluzik M. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab 2008; 93:3627-32; PMID:18559909; http://dx.doi.org/10.1210/jc.2008-0746
   PubMed Web of Science ®Google Scholar
• Karczewska-Kupczewska M, Straczkowski M, Adamska A, Nikolajuk A, Otziomek E, Gorska M, Kowalska I. Insulin sensitivity, metabolic flexibility, and serum adiponectin concentration in women with anorexia nervosa. Metabolism 2010; 59:473-7; PMID:19846178; http://dx.doi.org/10.1016/j.metabol.2009.07.036
   PubMed Web of Science ®Google Scholar
• Terra X, Auguet T, Aguera Z, Quesada IM, Orellana-Gavalda JM, Aguilar C, Jimenez-Murcia S, Berlanga A, Guiu-Jurado E, Menchon JM, et al. Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration. Int J Eat Disord 2013; 46:855-61; PMID:23881663; http://dx.doi.org/10.1002/eat.22166
   PubMed Web of Science ®Google Scholar
• Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 2004; 89:3486-95; PMID:15240636; http://dx.doi.org/10.1210/jc.2003-032251
   PubMed Web of Science ®Google Scholar
• Nogueira JP, Maraninchi M, Lorec AM, Corroller AB, Nicolay A, Gaudart J, Portugal H, Barone R, Vialettes B, Valero R. Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa. Eur J Clin Nutr 2010; 64:840-4; http://dx.doi.org/10.1038/ejcn.2010.66
   PubMed Web of Science ®Google Scholar
• Amitani H, Asakawa A, Ogiso K, Nakahara T, Ushikai M, Haruta I, Koyama K, Amitani M, Cheng KC, Inui A. The role of adiponectin multimers in anorexia nervosa. Nutrition 2013; 29:203-6; PMID:23237649; http://dx.doi.org/10.1016/j.nut.2012.07.011
   PubMed Web of Science ®Google Scholar
• Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, Kuzuya H. Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2004; 89:1833-7; PMID:15070952; http://dx.doi.org/10.1210/jc.2003-031260
   PubMed Web of Science ®Google Scholar
• Iwahashi H, Funahashi T, Kurokawa N, Sayama K, Fukuda E, Okita K, Imagawa A, Yamagata K, Shimomura I, Miyagawa JI, et al. Plasma adiponectin levels in women with anorexia nervosa. Horm Metab Res 2003; 35:537-40; PMID:14517770; http://dx.doi.org/10.1055/s-2003-42655
   PubMed Web of Science ®Google Scholar
• Bredella MA, Fazeli PK, Daley SM, Miller KK, Rosen CJ, Klibanski A, Torriani M. Marrow fat composition in anorexia nervosa. Bone 2014
   Web of Science ®Google Scholar
• Fazeli PK, Bredella MA, Freedman L, Thomas BJ, Breggia A, Meenaghan E, Rosen CJ, Klibanski A. Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa. J Bone Miner Res 2012; PMID:22508185
   PubMed Web of Science ®Google Scholar
• Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Clemmons DR, Breggia A, Miller KK, Klibanski A. Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa. J Clin Endocrinol Metab 2010; 95:407-13; PMID:19850693; http://dx.doi.org/10.1210/jc.2009-1152
   PubMed Web of Science ®Google Scholar
• Ecklund K, Vajapeyam S, Feldman HA, Buzney CD, Mulkern RV, Kleinman PK, Rosen CJ, Gordon CM. Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res 2010; 25:298-304; PMID:19653811; http://dx.doi.org/10.1359/jbmr.090805
   PubMed Web of Science ®Google Scholar
• Bredella MA, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 2009; 94:2129-36; PMID:19318450; http://dx.doi.org/10.1210/jc.2008-2532
   PubMed Web of Science ®Google Scholar
• Shinmura K, Tamaki K, Saito K, Nakano Y, Tobe T, Bolli R. Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 2007; 116:2809-17; PMID:18040027; http://dx.doi.org/10.1161/CIRCULATIONAHA.107.725697
   PubMed Web of Science ®Google Scholar
• Wang Z, Masternak MM, Al-Regaiey KA, Bartke A. Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology 2007; 148:2845-53; PMID:17347312; http://dx.doi.org/10.1210/en.2006-1313
   PubMed Web of Science ®Google Scholar
• Fenton JI, Nunez NP, Yakar S, Perkins SN, Hord NG, Hursting SD. Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array. Diabetes, obesity & metabolism 2009; 11:343-54; http://dx.doi.org/10.1111/j.1463-1326.2008.00974.x
   PubMed Web of Science ®Google Scholar
• Varady KA, Allister CA, Roohk DJ, Hellerstein MK. Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction. J Nutr Biochem 2010; 21:188-95; PMID:19195863; http://dx.doi.org/10.1016/j.jnutbio.2008.11.001
   PubMed Web of Science ®Google Scholar
• Harvey AE, Lashinger LM, Otto G, Nunez NP, Hursting SD. Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression. Mol Carcinog 2013; 52:997-1006; PMID:22778026; http://dx.doi.org/10.1002/mc.21940
   PubMed Web of Science ®Google Scholar
• Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol 2004; 39:1049-59; PMID:15236764; http://dx.doi.org/10.1016/j.exger.2004.03.024
   PubMed Web of Science ®Google Scholar
• Sharma N, Castorena CM, Cartee GD. Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines. Nutr Metab (Lond) 2012; 9:90; PMID:23067400; http://dx.doi.org/10.1186/1743-7075-9-90
   PubMed Web of Science ®Google Scholar
• Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, Hellerstein MK. Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. J Lipid Res 2007; 48:2212-9; PMID:17607017; http://dx.doi.org/10.1194/jlr.M700223-JLR200
   PubMed Web of Science ®Google Scholar
• Piccio L, Stark JL, Cross AH. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J Leukoc Biol 2008; 84:940-8; PMID:18678605; http://dx.doi.org/10.1189/jlb.0208133
   PubMed Web of Science ®Google Scholar
• Jiang HY, Koike T, Li P, Wang ZH, Kawata Y, Oshida Y. Combined effects of short-term calorie restriction and exercise on insulin action in normal rats. Horm Metab Res 2010; 42:950-4; PMID:20938891; http://dx.doi.org/10.1055/s-0030-1267174
   PubMed Web of Science ®Google Scholar
• Fontana L, Klein S, Holloszy JO. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age 2010; 32:97-108; PMID:19904628; http://dx.doi.org/10.1007/s11357-009-9118-z
   PubMed Web of Science ®Google Scholar
• Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, et al. Effect of two-year caloric restriction on Bone metabolism and Bone mineral density in non-obese younger adults: a randomized clinical trial. J Bone Miner Res 2015; [Epub ahead of print]; PMID:26332798; http://dx.doi.org/10.1002/jbmr.2701
   PubMed Web of Science ®Google Scholar
• Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 2006; 84:1033-42; PMID:17093155
   PubMed Web of Science ®Google Scholar
• Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol (Oxf) 2004; 61:332-8; PMID:15355449; http://dx.doi.org/10.1111/j.1365-2265.2004.02101.x
   PubMed Web of Science ®Google Scholar
• Karschin J, Lagerpusch M, Enderle J, Eggeling B, Muller MJ, Bosy-Westphal A. Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men. PLoS One 2015; 10:e0117865; PMID:25723719; http://dx.doi.org/10.1371/journal.pone.0117865
   PubMedGoogle Scholar
• Haque WA, Shimomura I, Matsuzawa Y, Garg A. Serum adiponectin and leptin levels in patients with lipodystrophies. J Clin Endocrinol Metab 2002; 87:2395; PMID:11994394; http://dx.doi.org/10.1210/jcem.87.5.8624
   PubMed Web of Science ®Google Scholar
• Antuna-Puente B, Boutet E, Vigouroux C, Lascols O, Slama L, Caron-Debarle M, Khallouf E, Levy-Marchal C, Capeau J, Bastard JP, et al. Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency. J Clin Endocrinol Metab 2010; 95:1463-8; PMID:20097706; http://dx.doi.org/10.1210/jc.2009-1824
   PubMed Web of Science ®Google Scholar
• Shastry S, Delgado MR, Dirik E, Turkmen M, Agarwal AK, Garg A. Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations. Am J Med Genet Part A 2010; 152A:2245-53; PMID:20684003; http://dx.doi.org/10.1002/ajmg.a.33578
   PubMed Web of Science ®Google Scholar
• Dwianingsih EK, Takeshima Y, Itoh K, Yamauchi Y, Awano H, Malueka RG, Nishida A, Ota M, Yagi M, Matsuo M. A Japanese child with asymptomatic elevation of serum creatine kinase shows PTRF-CAVIN mutation matching with congenital generalized lipodystrophy type 4. Mol Genet Metab 2010; 101:233-7; PMID:20638880; http://dx.doi.org/10.1016/j.ymgme.2010.06.016
   PubMed Web of Science ®Google Scholar
• Kim CA, Delepine M, Boutet E, El Mourabit H, Le Lay S, Meier M, Nemani M, Bridel E, Leite CC, Bertola DR, et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J Clin Endocrinol Metab 2008; 93:1129-34; PMID:18211975; http://dx.doi.org/10.1210/jc.2007-1328
   PubMed Web of Science ®Google Scholar
• Garg A, Peshock RM, Fleckenstein JL. Adipose tissue distribution pattern in patients with familial partial lipodystrophy (Dunnigan variety). J Clin Endocrinol Metab 1999; 84:170-4; PMID:9920078
   PubMed Web of Science ®Google Scholar
• Huang JS, Mulkern RV, Grinspoon S. Reduced intravertebral bone marrow fat in HIV-infected men. AIDS 2002; 16:1265-9; PMID:12045492; http://dx.doi.org/10.1097/00002030-200206140-00009
   PubMed Web of Science ®Google Scholar
• Misra A, Garg A. Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore) 2003; 82:129-46; PMID:12640189; http://dx.doi.org/10.1097/00005792-200303000-00007
   PubMed Web of Science ®Google Scholar
• Koutkia P, Grinspoon S. HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies. Annu Rev Med 2004; 55:303-17; PMID:14746523; http://dx.doi.org/10.1146/annurev.med.55.091902.104412
   PubMed Web of Science ®Google Scholar
• Mory PB, Crispim F, Freire MB, Salles JE, Valerio CM, Godoy-Matos AF, Dib SA, Moises RS. Phenotypic diversity in patients with lipodystrophy associated with LMNA mutations. Eur J Endocrinol 2012; 167:423-31; PMID:22700598; http://dx.doi.org/10.1530/EJE-12-0268
   PubMed Web of Science ®Google Scholar