Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice

References

• Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006; 35:93–9; PMID: 16326822; https://doi.org/10.1093/ije/dyi272
   PubMed Web of Science ®Google Scholar
• Roubenoff R, Roubenoff RA, Ward LM, Holland SM, Hellmann DB. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol 1992; 19:1505–10.
   PubMed Web of Science ®Google Scholar
• Giles JT, Ling SM, Ferrucci L, Bartlett SJ, Andersen RE, Towns M, Muller D, Fontaine KR, Bathon JM. Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies. Arthritis Rheum 2008; 59:807–15; PMID: 18512711; https://doi.org/10.1002/art.23719
   PubMed Web of Science ®Google Scholar
• Binymin K, Herrick A, Carlson G, Hopkins S. The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis. J Inflamm Res 2011; 4:61–6; PMID: 22096370; https://doi.org/10.2147/JIR.S16508
   PubMedGoogle Scholar
• Sandberg ME, Bengtsson C, Kallberg H, Wesley A, Klareskog L, Alfredsson L, Saevarsdottir S. Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis. Ann Rheum Dis 2014; 73:2029–33; PMID: 24818635; https://doi.org/10.1136/annrheumdis-2013-205094
   PubMed Web of Science ®Google Scholar
• Heimans L, van den Broek M, le Cessie S, Siegerink B, Riyazi N, Han KH, Kerstens PJ, Huizinga TW, Lems WF, Allaart CF. Association of high body mass index with decreased treatment response to combination therapy in recent-onset rheumatoid arthritis patients. Arthritis Care Res (Hoboken) 2013; 65:1235–42; PMID: 23408767; https://doi.org/10.1002/acr.21978
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95:2409–15; PMID: 7738205; https://doi.org/10.1172/JCI117936
   PubMed Web of Science ®Google Scholar
• Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Douglas KM, Nevill AM, Jamurtas AZ, Kita M, Koutedakis Y, Kitas GD. Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 68:242–5; PMID: 18677010; https://doi.org/10.1136/ard.2008.095596
   PubMed Web of Science ®Google Scholar
• Szasz T, Webb RC. Perivascular adipose tissue: more than just structural support. Clin Sci (Lond) 2012; 122:1–12; PMID: 21910690; https://doi.org/10.1042/CS20110151
   PubMed Web of Science ®Google Scholar
• Cinti S. The adipose organ. Prostaglandins Leukot Essent Fatty Acids 2005; 73:9–15; PMID: 15936182; https://doi.org/10.1016/j.plefa.2005.04.010
   PubMed Web of Science ®Google Scholar
• Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008; 454:961–7; PMID: 18719582; https://doi.org/10.1038/nature07182
   PubMed Web of Science ®Google Scholar
• Chatterjee TK, Aronow BJ, Tong WS, Manka D, Tang Y, Bogdanov VY, Unruh D, Blomkalns AL, Piegore MG, Jr., Weintraub DS, et al. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiol Genomics 2013; 45:697–709; PMID: 23737535; https://doi.org/10.1152/physiolgenomics.00042.2013
   PubMed Web of Science ®Google Scholar
• Ohashi K, Ouchi N, Matsuzawa Y. Adiponectin and hypertension. Am J Hypertens 2011; 24:263–9; PMID: 20930707; https://doi.org/10.1038/ajh.2010.216
   PubMed Web of Science ®Google Scholar
• Rajsheker S, Manka D, Blomkalns AL, Chatterjee TK, Stoll LL, Weintraub NL. Crosstalk between perivascular adipose tissue and blood vessels. Curr Opin Pharmacol 2010; 10:191–6; PMID: 20060362; https://doi.org/10.1016/j.coph.2009.11.005
   PubMed Web of Science ®Google Scholar
• Yamawaki H. Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses. Biol Pharm Bull 2011; 34:307–10; https://doi.org/10.1248/bpb.34.307
   PubMed Web of Science ®Google Scholar
• Gao YJ, Lu C, Su LY, Sharma AM, Lee RM. Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 2007; 151:323–31; PMID: 17384669; https://doi.org/10.1038/sj.bjp.0707228
   PubMed Web of Science ®Google Scholar
• Ketonen J, Shi J, Martonen E, Mervaala E. Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice. Circ J 2010 ; 74:1479–87; PMID: 20526041; https://doi.org/10.1253/circj.CJ-09-0661
   PubMed Web of Science ®Google Scholar
• Villacorta L, Chang L. The role of perivascular adipose tissue in vasoconstriction, arterial stiffness, and aneurysm. Horm Mol Biol Clin Investig 2015; 21:137–47; PMID: 25719334; https://doi.org/10.1515/hmbci-2014-0048
   PubMed Web of Science ®Google Scholar
• Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ. The biology of white adipocyte proliferation. Obes Rev 2001; 2:239–54; PMID: 12119995; https://doi.org/10.1046/j.1467-789X.2001.00042.x
   PubMedGoogle Scholar
• Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL, Laharrague P, Casteilla L, Penicaud L. A role for preadipocytes as macrophage-like cells. FASEB J 1999; 13:305–12. PMID: 9973318
   PubMed Web of Science ®Google Scholar
• Owen MK, Witzmann FA, McKenney ML, Lai X, Berwick ZC, Moberly SP, Alloosh M, Sturek M, Tune JD. Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity. Circulation 2013; 128:9–18; PMID: 23685742; https://doi.org/10.1161/CIRCULATIONAHA.112.001238
   PubMed Web of Science ®Google Scholar
• Szasz T, Bomfim GF, Webb RC. The influence of perivascular adipose tissue on vascular homeostasis. Vasc Health Risk Manag 2013; 9:105–16; PMID: 23576873; https://doi.org/10.2147/VHRM.S33760
   PubMedGoogle Scholar
• Reynolds S, Williams AS, Williams H, Smale S, Stephenson HJ, Amos N, George SJ, O'Donnell VB, Lang D. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. Br J Pharmacol 2012; 167:505–14; PMID: 22506619; https://doi.org/10.1111/j.1476-5381.2012.01988.x
   PubMed Web of Science ®Google Scholar
• Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009; 119:1661–70; PMID: 19289637; https://doi.org/10.1161/CIRCULATIONAHA.108.821181
   PubMed Web of Science ®Google Scholar
• Sanchez-Gurmaches J, Hung CM, Guertin DA. Emerging complexities in Adipocyte origins and identity. Trends Cell Biol 2016; 26(5):313-26; https://doi.org/10.1016/j.tcb.2016.01.004
   PubMed Web of Science ®Google Scholar
• Lazar MA. Developmental biology. How now, brown fat?. Science 2008; 321:1048–9; https://doi.org/10.1126/science.1164094
   PubMed Web of Science ®Google Scholar
• Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, et al. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med 2014; 6:247ra103; PMID: 25080478; https://doi.org/10.1126/scitranslmed.3008490
   PubMed Web of Science ®Google Scholar
• Chen Z, Kennedy DJ, Wake KA, Zhuang L, Ganapathy V, Thwaites DT. Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2. Biochem Biophys Res Commun 2003; 304:747–54; PMID: 12727219; https://doi.org/10.1016/S0006-291X(03)00648-X
   PubMed Web of Science ®Google Scholar
• Symonds ME. Brown adipose tissue growth and development. Scientifica 2013; 2013:305763; PMID: 24278771; https://doi.org/10.1155/2013/305763
   PubMedGoogle Scholar
• Gao YJ. Dual modulation of vascular function by perivascular adipose tissue and its potential correlation with adiposity/lipoatrophy-related vascular dysfunction. Curr Pharm Des 2007; 13:2185–92; PMID: 17627551; https://doi.org/10.2174/138161207781039634
   PubMed Web of Science ®Google Scholar
• Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 1992; 103(Pt 4):931–42. PMID: 1362571
   PubMed Web of Science ®Google Scholar
• Bull MJ, Williams AS, Mecklenburgh Z, Calder CJ, Twohig JP, Elford C, Evans BA, Rowley TF, Slebioda TJ, Taraban VY, et al. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J Exp Med 2008; 205:2457–64; PMID: 18824582; https://doi.org/10.1084/jem.20072378
   PubMed Web of Science ®Google Scholar
• Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol 2009; 182:613–22; https://doi.org/10.4049/jimmunol.182.1.613
   PubMed Web of Science ®Google Scholar
• Williams AS, Mizuno M, Richards PJ, Holt DS, Morgan BP. Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Arthritis Rheum 2004; 50:3035–44; PMID: 15457473; https://doi.org/10.1002/art.20478
   PubMed Web of Science ®Google Scholar
• Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, et al. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nat Commun 2014; 5:4982; PMID: 25236782; https://doi.org/10.1038/ncomms5982
   PubMed Web of Science ®Google Scholar
• Kelley EE, Baust J, Bonacci G, Golin-Bisello F, Devlin JE, St Croix CM, Watkins SC, Gor S, Cantu-Medellin N, Weidert ER, et al. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovasc Res 2014; 101:352–63; PMID: 24385344; https://doi.org/10.1093/cvr/cvt341
   PubMed Web of Science ®Google Scholar
• Martinez-Martinez E, Calvier L, Rossignol P, Rousseau E, Fernandez-Celis A, Jurado-Lopez R, Laville M, Cachofeiro V, Lopez-Andres N. Galectin-3 inhibition prevents adipose tissue remodelling in obesity. Int J Obes (Lond) 2005; 2016.
   Google Scholar
• Brand DD, Latham KA, Rosloniec EF. Collagen-induced arthritis. Nat Protoc 2007; 2:1269–75; PMID: 17546023; https://doi.org/10.1038/nprot.2007.173
   PubMed Web of Science ®Google Scholar
• Kim SA, Park SH, Jo SH, Park KH, Kim HS, Han SJ, Park WJ, Ha JW. Alterations of carotid arterial mechanics preceding the wall thickening in patients with hypertension. Atherosclerosis 2016; 248:84–90; PMID: 26990725; https://doi.org/10.1016/j.atherosclerosis.2016.02.017
   PubMed Web of Science ®Google Scholar
• Ryu Y, Yoshida K, Suzuki Y, Nakadate M, Umehara I, Tomita M, Shibuya H. Long-term changes of aortic 18F-FDG uptake and calcification in health-screening subjects. Ann Nucl Med 2013; 27:239–46; PMID: 23264081; https://doi.org/10.1007/s12149-012-0679-z
   PubMed Web of Science ®Google Scholar
• Haskett D, Johnson G, Zhou A, Utzinger U, Vande Geest J. Microstructural and biomechanical alterations of the human aorta as a function of age and location. Biomech Model Mechanobiol 2010; 9:725–36; PMID: 20354753; https://doi.org/10.1007/s10237-010-0209-7
   PubMed Web of Science ®Google Scholar
• Head RJ. Hypernoradrenergic innervation: its relationship to functional and hyperplastic changes in the vasculature of the spontaneously hypertensive rat. Blood Vessels 1989; 26:1–20. PMID: 2540863
   Google Scholar
• Berbee JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 2015; 6:6356; PMID: 25754609; https://doi.org/10.1038/ncomms7356
   PubMed Web of Science ®Google Scholar
• Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol 2014; 10:24–36; PMID: 24146030; https://doi.org/10.1038/nrendo.2013.204
   PubMed Web of Science ®Google Scholar
• Al-Ansari S, Zeebregts CJ, Slart RH, Peppelenbosch M, Tio RA. Galectins in atherosclerotic disease. Trends Cardiovasc Med 2009; 19:164–9; PMID: 20005476; https://doi.org/10.1016/j.tcm.2009.10.001
   PubMed Web of Science ®Google Scholar
• de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege HL, Bakker SJ, van der Harst P. The fibrosis marker galectin-3 and outcome in the general population. J Intern Med 2012; 272:55–64; PMID: 22026577; https://doi.org/10.1111/j.1365-2796.2011.02476.x
   PubMed Web of Science ®Google Scholar
• Madrigal-Matute J, Lindholt JS, Fernandez-Garcia CE, Benito-Martin A, Burillo E, Zalba G, Beloqui O, Llamas-Granda P, Ortiz A, Egido J, et al. Galectin-3, a biomarker linking oxidative stress and inflammation with the clinical outcomes of patients with atherothrombosis. J Am Heart Assoc 2014; 3:pii: ee000785; https://doi.org/10.1161/JAHA.114.000785
   Web of Science ®Google Scholar
• Chau YY, Bandiera R, Serrels A, Martinez-Estrada OM, Qing W, Lee M, Slight J, Thornburn A, Berry R, McHaffie S, et al. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat Cell Biol 2014; 16:367–75; PMID: 24609269; https://doi.org/10.1038/ncb2922
   PubMed Web of Science ®Google Scholar
• Karastergiou K, Fried SK. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr Atheroscler Rep 2013; 15:361; PMID: 23982264; https://doi.org/10.1007/s11883-013-0361-5
   PubMed Web of Science ®Google Scholar
• Hoffstedt J, Arner E, Wahrenberg H, Andersson DP, Qvisth V, Lofgren P, Ryden M, Thorne A, Wiren M, Palmer M, et al. Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia 2010; 53:2496–503; PMID: 20830466; https://doi.org/10.1007/s00125-010-1889-3
   PubMed Web of Science ®Google Scholar
• Farb MG, Gokce N. Visceral adiposopathy: a vascular perspective. Horm Mol Biol Clin Investig 2015; 21:125–36; PMID: 25781557; https://doi.org/10.1515/hmbci-2014-0047
   PubMed Web of Science ®Google Scholar
• Acosta JR, Douagi I, Andersson DP, Backdahl J, Ryden M, Arner P, Laurencikiene J. Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes. Diabetologia 2016; 59:560–70; PMID: 26607638; https://doi.org/10.1007/s00125-015-3810-6
   PubMed Web of Science ®Google Scholar
• Eriksson-Hogling D, Andersson DP, Backdahl J, Hoffstedt J, Rossner S, Thorell A, Arner E, Arner P, Ryden M. Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight loss. Int J Obes (Lond) 2005 2015; 39:893–8; https://doi.org/10.1038/ijo.2015.18
   Web of Science ®Google Scholar
• Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444:875–80; PMID: 17167476; https://doi.org/10.1038/nature05487
   PubMed Web of Science ®Google Scholar
• Taube A, Schlich R, Sell H, Eckardt K, Eckel J. Inflammation and metabolic dysfunction: links to cardiovascular diseases. Am J Physiol Heart Circ Physiol 2012; 302:H2148–65; PMID: 22447947; https://doi.org/10.1152/ajpheart.00907.2011
   PubMed Web of Science ®Google Scholar
• Williams JO, Wang ECY, Lang D, Williams AS. Characterization of death receptor 3-dependent aortic changes during inflammatory arthritis. Pharmacol Res Perspect 2016; 4:e00240; https://doi.org/10.1002/prp2.240
   Google Scholar
• Moos MP, John N, Grabner R, Nossmann S, Gunther B, Vollandt R, Funk CD, Kaiser B, Habenicht AJ. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2005; 25:2386–91; PMID: 16179593; https://doi.org/10.1161/01.ATV.0000187470.31662.fe
   PubMed Web of Science ®Google Scholar
• Ameer OZ, Salman IM, Avolio AP, Phillips JK, Butlin M. Opposing changes in thoracic and abdominal aortic biomechanical properties in rodent models of vascular calcification and hypertension. Am J Physiol Heart Circ Physiol 2014; 307:H143–51; PMID: 24838503; https://doi.org/10.1152/ajpheart.00139.2014
   PubMed Web of Science ®Google Scholar
• Hong HC, Hwang SY, Park S, Ryu JY, Choi HY, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, et al. Implications of Pericardial, Visceral and Subcutaneous Adipose Tissue on Vascular Inflammation Measured Using 18FDG-PET/CT. PLoS One 2015; 10:e0135294; PMID: 26270050; https://doi.org/10.1371/journal.pone.0135294
   PubMed Web of Science ®Google Scholar
• Samaras K, Botelho NK, Chisholm DJ, Lord RV. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity 2010; 18:884–9; PMID: 20019678; https://doi.org/10.1038/oby.2009.443
   PubMed Web of Science ®Google Scholar
• Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF, Jr., Meigs JB, Lipinska I, Kathiresan S, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 2007; 116:1234–41; PMID: 17709633; https://doi.org/10.1161/CIRCULATIONAHA.107.710509
   PubMed Web of Science ®Google Scholar
• Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116:39–48; PMID: 17576866; https://doi.org/10.1161/CIRCULATIONAHA.106.675355
   PubMed Web of Science ®Google Scholar
• Lehman SJ, Massaro JM, Schlett CL, O'Donnell CJ, Hoffmann U, Fox CS. Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study. Atherosclerosis 2010; 210:656–61; PMID: 20152980; https://doi.org/10.1016/j.atherosclerosis.2010.01.007
   PubMed Web of Science ®Google Scholar
• Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, et al. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun 2015; 6:6676; PMID: 25813085; https://doi.org/10.1038/ncomms7676
   PubMed Web of Science ®Google Scholar
• Sakamoto T, Takahashi N, Sawaragi Y, Naknukool S, Yu R, Goto T, Kawada T. Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes. Am J Physiol Cell Physiol 2013; 304:C729–38; PMID: 23302779; https://doi.org/10.1152/ajpcell.00312.2012
   Google Scholar
• Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 2007; 148:868–77; PMID: 17082259; https://doi.org/10.1210/en.2006-0687
   PubMed Web of Science ®Google Scholar
• Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol 2011; 301:H1425–37; PMID: 21765057; https://doi.org/10.1152/ajpheart.00376.2011
   PubMed Web of Science ®Google Scholar
• Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiol Regul Integr Comp Physiol 2013; 304:R543–52; PMID: 23389108; https://doi.org/10.1152/ajpregu.00567.2012
   PubMed Web of Science ®Google Scholar
• Verhagen SN, Visseren FL. Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 2011; 214:3–10; PMID: 20646709; https://doi.org/10.1016/j.atherosclerosis.2010.05.034
   PubMed Web of Science ®Google Scholar
• Nayor M, Wang N, Larson MG, Vasan RS, Levy D, Ho JE. Circulating Galectin-3 is associated with cardiometabolic disease in the community. J Am Heart Assoc 2016; 5:e002347; https://doi.org/10.1161/JAHA.115.002347
   Web of Science ®Google Scholar
• Maiolino G, Rossitto G, Pedon L, Cesari M, Frigo AC, Azzolini M, Plebani M, Rossi GP. Galectin-3 predicts long-term cardiovascular death in high-risk patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2015; 35:725–32; PMID: 25614283; https://doi.org/10.1161/ATVBAHA.114.304964
   PubMed Web of Science ®Google Scholar
• Ohshima S, Kuchen S, Seemayer CA, Kyburz D, Hirt A, Klinzing S, Michel BA, Gay RE, Liu FT, Gay S, et al. Galectin 3 and its binding protein in rheumatoid arthritis. Arthritis Rheum 2003; 48:2788–95; PMID: 14558084; https://doi.org/10.1002/art.11287
   PubMed Web of Science ®Google Scholar