3,318
Views
4
CrossRef citations to date
0
Altmetric
Commentary

Elucidating the role of Lkb1 and mTOR in adipose tissue

, , , & ORCID Icon
Pages 26-30 | Received 01 Jul 2018, Accepted 08 Oct 2018, Published online: 20 Oct 2018

References

  • Lee PL, Jung SM, Guertin DA. The complex roles of mechanistic target of rapamycin in adipocytes and beyond. Trends Endocrin Met. 2017;28(5):319–339.
  • Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150(2):366–376. .
  • Xu Z, Liu J, Shan T. New roles of Lkb1 in regulating adipose tissue development and thermogenesis. J Cell Physiol. 2017;232(9):2296–2298.
  • Lee PL, Jung SM, Guertin DA. The complex roles of mechanistic target of rapamycin in adipocytes and beyond. Trends Endocrinol Metab. 2017;28(5):319–339.
  • Xiong Y, Xu Z, Wang Y, et al. Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance. J Lipid Res. 2018;59(6):974–981.
  • Lamming DW, Sabatini DM. A central role for mTOR in lipid homeostasis. Cell Metab. 2013;18(4):465–469.
  • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274–293.
  • Polak P, Cybulski N, Feige JN, et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 2008;8(5):399–410.
  • Lee PL, Tang Y, Li H, et al. Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease. Mol Metab. 2016;5(6):422–432.
  • Cybulski N, Polak P, Auwerx J, et al. mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A. 2009;106(24):9902–9907.
  • Kumar A, Lawrence JC, Jr., Jung DY, et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 2010;59(6):1397–1406. .
  • Tang Y, Wallace M, Sanchez-Gurmaches J, et al. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016;7:11365.
  • Jeffery E, Berry R, Church CD, et al. Characterization of Cre recombinase models for the study of adipose tissue. Adipocyte. 2014;3(3):206–211.
  • Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med. 2013;34(1):1–11.
  • Liu JQ, Xu ZY, Wu WC, et al. Cre recombinase strains used for the study of adipose tissues and adipocyte progenitors. J Cell Physiol. 2017;232(10):2698–2703.
  • Shan T, Zhang P, Jiang Q, et al. Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice. Diabetologia. 2016;59(9):1995–2004.
  • Chakrabarti P, English T, Shi J, et al. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes. 2010;59(4):775–781.
  • Labbe SM, Mouchiroud M, Caron A, et al. mTORC1 is required for brown adipose tissue recruitment and metabolic adaptation to cold. Sci Rep-Uk. 2016;6:37223.
  • Hung CM, Calejman CM, Sanchez-Gurmaches J, et al. Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease. Cell Rep. 2014;8(1):256–271.
  • Zhang W, Wang Q, Song P, et al. Liver kinase b1 is required for white adipose tissue growth and differentiation. Diabetes. 2013;62(7):2347–2358.
  • Shan T, Xiong Y, Zhang P, et al. Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nat Commun. 2016;7:12205.
  • Shaw RJ, Bardeesy N, Manning BD, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004;6(1):91–99. .
  • Tran CM, Mukherjee S, Ye L, et al. Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes. 2016;65(4):927–941. .
  • Liu DX, Bordicchia M, Zhang CY, et al. Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning. J Clin Invest. 2016;126(5):1704–1716. .
  • Magdalon J, Chimin P, Belchior T, et al. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. Bba-Mol Cell Biol L. 2016;1861(5):430–438.
  • Albert V, Svensson K, Shimobayashi M, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. Embo Mol Med. 2016;8(3):232–246.
  • Xiong Y, Page JC, Narayanan N, et al. Peripheral neuropathy and hindlimb paralysis in a mouse model of adipocyte-specific knockout of Lkb1. EBioMedicine. 2017;24:127–136.
  • Weichhart T, Hengstschlager M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol. 2015;15(10):599–614.