Leptin stimulates autophagy/lysosome-related degradation of long-lived proteins in adipocytes

References

• Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013 Feb 14;368(7):651–662. doi:10.1056/NEJMra1205406. PubMed PMID: 23406030.
   PubMed Web of Science ®Google Scholar
• Chen Z-H, Kim HP, Sciurba FC, Lee S-J, Feghali-Bostwick C, Stolz DB, Dhir R, Landreneau RJ, Schuchert MJ, Yousem SA, et al. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One 2008;3(10):e3316. doi:10.1371/journal.pone.0003316. PubMed PMID: 18830406; PubMed Central PMCID: PMC2552992.
   PubMed Web of Science ®Google Scholar
• Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell’antonio G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 1;25(7):717–729. doi:10.1101/gad.2016111. PubMed PMID: 21406549; PubMed Central PMCID: PMCPMC3070934.
   PubMed Web of Science ®Google Scholar
• Stienstra R, Haim Y, Riahi Y, Netea M, Rudich A, Leibowitz G. Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes. Diabetologia. 2014 Aug;57(8):1505–1516. doi:10.1007/s00125-014-3255-3. PubMed PMID: 24795087.
   PubMed Web of Science ®Google Scholar
• van Niekerk G, du Toit A, Loos B, Engelbrecht A-M. Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity. Metabolism. 2018 May;82:14–21. doi:10.1016/j.metabol.2017.12.007. PubMed PMID: 29289514.
   PubMed Web of Science ®Google Scholar
• Kovsan J, Blüher M, Tarnovscki T, Klöting N, Kirshtein B, Madar L, Shai I, Golan R, Harman-Boehm I, Schön MR, et al. Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab. 2011 Feb;96(2):E268–E77. doi:10.1210/jc.2010-1681. PubMed PMID: 21047928.
   PubMed Web of Science ®Google Scholar
• Xu Q, Mariman ECM, Roumans NJT, Vink RG, Goossens GH, Blaak EE, Jocken JWE. Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity. Adipocyte. 2018 Jan 2;7(1):12–19. doi:10.1080/21623945.2017.1394537. PubMed PMID: 29400609; PubMed Central PMCID: PMCPMC5915036.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sowers JR, Ren J. Targeting autophagy in obesity: from pathophysiology to management. Nat Rev Endocrinol. 2018 Jun;14(6):356–376. doi:10.1038/s41574-018-0009-1. 10.1038/s41574-018-0009-1. PubMed PMID: 29686432.
   PubMed Web of Science ®Google Scholar
• Maixner N, Bechor S, Vershinin Z, Pecht T, Goldstein N, Haim Y, Rudich A. Transcriptional dysregulation of adipose tissue autophagy in obesity. Physiology. 2016 Jul;31(4):270–282. doi:10.1152/physiol.00048.2015. PubMed PMID: 27252162.
   PubMed Web of Science ®Google Scholar
• Fullgrabe J, Klionsky DJ, Joseph B. The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat Rev Mol Cell Biol. 2014 Jan;15(1):65–74. doi:10.1038/nrm3716. PubMed PMID: 24326622.
   PubMed Web of Science ®Google Scholar
• Soussi H, Reggio S, Alili R, Prado C, Mutel S, Pini M, Rouault C, Clément K, Dugail I. DAPK2 downregulation associates with attenuated adipocyte autophagic clearance in human obesity. Diabetes. 2015 Oct;64(10):3452–3463. doi:10.2337/db14-1933. PubMed PMID: 26038578.
   PubMed Web of Science ®Google Scholar
• Yoshizaki T, Kusunoki C, Kondo M, Yasuda M, Kume S, Morino K, Sekine O, Ugi S, Uzu T, Nishio Y, et al. Autophagy regulates inflammation in adipocytes. Biochem Biophys Res Commun. 2012;417:352–357. doi:10.1016/j.bbrc.2011.11.114.
   PubMed Web of Science ®Google Scholar
• Ost A, Svensson K, Ruishalme I, Brännmark C, Franck N, Krook H, Sandström P, Kjolhede P, Strålfors P. Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med. 2010 Jul-Aug;16(7–8):235–246. doi:10.2119/molmed.2010.00023. PubMed PMID: 20386866; PubMed Central PMCID: PMCPMC2896460.
   PubMed Web of Science ®Google Scholar
• Jansen HJ, van Essen P, Koenen T, Joosten LAB, Netea MG, Tack CJ, Stienstra R. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology. 2012 Dec;153(12):5866–5874. doi:10.1210/en.2012-1625. PubMed PMID: 23117929.
   PubMed Web of Science ®Google Scholar
• Nuñez CE, Rodrigues VS, Gomes FS, de Moura RF, Victorio SC, Bombassaro B, Chaim EA, Pareja JC, Geloneze B, Velloso LA, et al. Defective regulation of adipose tissue autophagy in obesity. Int J Obes. 2013 Nov;37(11):1473–1480. doi:10.1038/ijo.2013.27. PubMed PMID: 23478428.
   Web of Science ®Google Scholar
• Kosacka J, Nowicki M, Paeschke S, Baum P, Blüher M, Klöting N. Up-regulated autophagy: as a protective factor in adipose tissue of WOKW rats with metabolic syndrome. Diabetol Metab Syndr. 2018;10:13. doi:10.1186/s13098-018-0317-6. PubMed PMID: 29507613; PubMed Central PMCID: PMCPMC5834836.
   PubMed Web of Science ®Google Scholar
• Haim Y, Blüher M, Slutsky N, Goldstein N, Klöting N, Harman-Boehm I, Kirshtein B, Ginsberg D, Gericke M, Guiu Jurado E, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015 Sep 22;11:2074–2088. doi:10.1080/15548627.2015.1094597. PubMed PMID: 26391754.
   PubMed Web of Science ®Google Scholar
• Slutsky N, Vatarescu M, Haim Y, Goldstein N, Kirshtein B, Harman-Boehm I, Gepner Y, Shai I, Bashan N, Blüher M, et al. Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity. Int J Obes. 2016 Jun;40(6):912–920. doi:10.1038/ijo.2016.5. PubMed PMID: 26786352.
   Web of Science ®Google Scholar
• Bechor S, Nachmias D, Elia N, Haim Y, Vatarescu M, Leikin-Frenkel A, Gericke M, Tarnovscki T, Las G, Rudich A. Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux. Biochim Biophys Acta. 2017 Sep;1862(9):1001–1012. doi:10.1016/j.bbalip.2017.06.012. PubMed PMID: 28652194.
   Web of Science ®Google Scholar
• Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995 Nov;1(11):1155–1161. PubMed PMID: 7584987.
   PubMed Web of Science ®Google Scholar
• Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334(5):292–295. doi:10.1056/NEJM199602013340503. PubMed PMID: 8532024.
   PubMed Web of Science ®Google Scholar
• Malik SA, Mariño G, BenYounès A, Shen S, Harper F, Maiuri MC, Kroemer G. Neuroendocrine regulation of autophagy by leptin. Cell Cycle. 2011 Sep 1;10(17):2917–2923. doi:10.4161/cc.10.17.17067. PubMed PMID: 21857156.
   PubMed Web of Science ®Google Scholar
• Cassano S, Pucino V, La Rocca C, Procaccini C, De Rosa V, Marone G, Matarese G. Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metabolism. 2014 Oct;63(10):1272–1279. doi:10.1016/j.metabol.2014.06.010. PubMed PMID: 25060689; PubMed Central PMCID: PMCPMC4180014.
   PubMed Web of Science ®Google Scholar
• Raut PK, Choi DY, Kim SH, Hong JT, Kwon TK, Jeong JH, Park P-H. Estrogen receptor signaling mediates leptin-induced growth of breast cancer cells via autophagy induction. Oncotarget. 2017 Dec 12;8(65):109417–109435. doi:10.18632/oncotarget.22684. PubMed PMID: WOS:000419565400090; English.
   PubMedGoogle Scholar
• Nepal S, Kim MJ, Hong JT, Kim SH, Sohn D-H, Lee SH, Song K, Choi DY, Lee ES, Park P-H. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Oncotarget. 2015 Mar 30;6(9):7166–7181. doi:10.18632/oncotarget.3347. PubMed PMID: 25704884; PubMed Central PMCID: PMCPMC4466676.
   PubMedGoogle Scholar
• Gui X, Chen H, Cai H, Sun L, Gu L. Leptin promotes pulmonary fibrosis development by inhibiting autophagy via PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 2018 Apr 6;498(3):660–666. doi:10.1016/j.bbrc.2018.03.039. PubMed PMID: 29524411.
   PubMed Web of Science ®Google Scholar
• Gan L, Liu Z, Luo D, Ren Q, Wu H, Li C, Sun C. Reduced endoplasmic reticulum stress-mediated autophagy is required for leptin alleviating inflammation in adipose tissue. Front Immunol. 2017;8:1507. doi:10.3389/fimmu.2017.01507. PubMed PMID: 29250056; PubMed Central PMCID: PMCPMC5715390.
   PubMed Web of Science ®Google Scholar
• Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR. beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem. 1999 Dec 3;274(49):34795–34802. PubMed PMID: 10574950.
   PubMed Web of Science ®Google Scholar
• Kovsan J, Osnis A, Maissel A, Mazor L, Tarnovscki T, Hollander L, Ovadia S, Meier B, Klein J, Bashan N, et al. Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes–relevance for partial lipodystrophy. Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E315–E22. doi:10.1152/ajpendo.90486.2008. PubMed PMID: 19033543.
   PubMed Web of Science ®Google Scholar
• Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS. Fatty acids suppress autophagic turnover in beta-cells. J Biol Chem. 2011 Dec 9;286(49):42534–42544. doi:10.1074/jbc.M111.242412. PubMed PMID: 21859708; PubMed Central PMCID: PMCPMC3234912.
   PubMed Web of Science ®Google Scholar
• Bauvy C, Meijer AJ, Codogno P. Assaying of autophagic protein degradation. Methods Enzymol. 2009;452:47–61. doi:10.1016/S0076-6879(08)03604-5. PubMed PMID: 19200875.
   PubMed Web of Science ®Google Scholar
• Pérez-Pérez A, Vilariño-García T, Fernández-Riejos P, Martín-González J, Segura-Egea JJ, Sánchez-Margalet V. Role of leptin as a link between metabolism and the immune system. Cytokine Growth Factor Rev. 2017 Jun;35:71–84. doi:10.1016/j.cytogfr.2017.03.001. PubMed PMID: 28285098.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003 Dec;112(12):1796–1808. doi:10.1172/JCI19246. PubMed PMID: 14679176; PubMed Central PMCID: PMCPMC296995.
   PubMed Web of Science ®Google Scholar
• Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang H-G, Dent P, et al. TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy. 2018 Mar 11;1–16. doi:10.1080/15548627.2018.1429875. PubMed PMID: 29368980.
   Web of Science ®Google Scholar
• Chan LL-Y, Shen D, Wilkinson AR, Patton W, Lai N, Chan E, Kuksin D, Lin B, Qiu J. A novel image-based cytometry method for autophagy detection in living cells. Autophagy. 2012 Sep;8(9):1371–1382. doi:10.4161/auto.21028. PubMed PMID: 22895056; PubMed Central PMCID: PMCPMC3442883.
   PubMed Web of Science ®Google Scholar
• Kosacka J, Kern M, Klöting N, Paeschke S, Rudich A, Haim Y, Gericke M, Serke H, Stumvoll M, Bechmann I, et al. Autophagy in adipose tissue of patients with obesity and type 2 diabetes. Mol Cell Endocrinol. 2015;409:21–32. doi:10.1016/j.mce.2015.03.015.
   PubMed Web of Science ®Google Scholar
• Li H, Zhou B, Xu L, Liu J, Zang W, Wu S, Sun H. The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance. Cell Cycle 2014;13(4):565–579. doi:10.4161/cc.27406. PubMed PMID: 24309597.
   PubMed Web of Science ®Google Scholar
• Maixner N, Kovsan J, Harman-Boehm I, Blüher M, Bashan N, Rudich A. Autophagy in adipose tissue. Obes Facts 2012;5(5):710–721. doi:10.1159/000343983. PubMed PMID: 23108431.
   PubMed Web of Science ®Google Scholar
• Mir SU, George NM, Zahoor L, Harms R, Guinn Z, Sarvetnick NE. Inhibition of autophagic turnover in beta-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015 Mar 6;290(10):6071–6085. doi:10.1074/jbc.M114.605345. PubMed PMID: 25548282; PubMed Central PMCID: PMCPMC4358249.
   PubMed Web of Science ®Google Scholar
• Maya-Monteiro CM, Almeida PE, D’Avila H, Martins AS, Rezende AP, Castro-Faria-Neto H, Bozza PT. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J Biol Chem. 2008 Jan 25;283(4):2203–2210. doi: 10.1074/jbc.M706706200. PubMed PMID: 18039669.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12(1):1–222. 3rd edition. doi:10.1080/15548627.2015.1100356. PubMed PMID: 26799652; PubMed Central PMCID: PMCPMC4835977.
   PubMed Web of Science ®Google Scholar
• Cuervo AM, Wong E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 2014 Jan;24(1):92–104. doi:10.1038/cr.2013.153. PubMed PMID: 24281265; PubMed Central PMCID: PMCPMC3879702.
   PubMed Web of Science ®Google Scholar
• Kaushik S, Cuervo AM. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015 Jun;17(6):759–770. doi:10.1038/ncb3166. PubMed PMID: 25961502; PubMed Central PMCID: PMCPMC4449813.
   PubMed Web of Science ®Google Scholar
• Schloesser A, Campbell G, Glüer C-C, Rimbach G, Huebbe P. Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity. Rejuvenation Res. 2015 Feb;18(1):30–39. doi:10.1089/rej.2014.1630. PubMed PMID: 25405871; PubMed Central PMCID: PMCPMC4340804.
   PubMed Web of Science ®Google Scholar
• Minard AY, Wong MKL, Chaudhuri R, Tan S-X, Humphrey SJ, Parker BL, Yang JY, Laybutt DR, Cooney GJ, Coster ACF, et al. Hyperactivation of the insulin signaling pathway improves intracellular proteostasis by coordinately up-regulating the proteostatic machinery in adipocytes. J Biol Chem. 2016 Dec 2;291(49):25629–25640. doi:10.1074/jbc.M116.741140. PubMed PMID: 27738101; PubMed Central PMCID: PMCPMC5207260.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhou YT, Kakuma T, Lee Y, Kalra SP, Kalra PS, Pan W, Unger RH. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Biochem Biophys Res Commun. 2000 Oct 14;277(1):20–26. doi:10.1006/bbrc.2000.3615. PubMed PMID: 11027633.
   PubMed Web of Science ®Google Scholar
• Wang M-Y, Orci L, Ravazzola M, Unger RH. Fat storage in adipocytes requires inactivation of leptin’s paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18011–18016. doi:10.1073/pnas.0509001102. PubMed PMID: 16326804; PubMed Central PMCID: PMCPMC1312408.
   PubMed Web of Science ®Google Scholar