The role of perivascular adipose tissue in the appearance of ectopic adipocytes in the abdominal aortic aneurysmal wall

References

• Lindsay ME, Dietz HC. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature. 2011;473(7347):308–316.
   PubMed Web of Science ®Google Scholar
• Aggarwal S, Qamar A, Sharma V, et al. Abdominal aortic aneurysm: A comprehensive review. Exp Clin Cardiol. 2011;16(1):11–15.
   PubMedGoogle Scholar
• Tanaka H, Zaima N, Sasaki T, et al. Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. PLoS One. 2013;8(2):e57398.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Zaima N, Sasaki T, et al. Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. PLoS One. 2015;10(8):e0134386.
   PubMed Web of Science ®Google Scholar
• Kugo H, Zaima N, Tanaka H, et al. Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. Sci Rep. 2016;6:31268.
   PubMed Web of Science ®Google Scholar
• Kugo H, Zaima N, Tanaka H, et al. Pathological analysis of the ruptured vascular wall of hypoperfusion-induced abdominal aortic aneurysm animal model. J Oleo Sci. 2017;66(5):499–506.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Zaima N, Sasaki T, et al. Imaging mass spectrometry reveals a unique distribution of triglycerides in the abdominal aortic aneurysmal wall. J Vasc Res. 2015;52(2):127–135.
   PubMed Web of Science ®Google Scholar
• Doderer SA, Gabel G, Kokje VBC, et al. Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm. J Vasc Surg. 2017;67(6):1891–1900.
   PubMed Web of Science ®Google Scholar
• Gabel G, Northoff BH, Weinzierl I, et al. Molecular fingerprint for terminal abdominal aortic aneurysm disease. J Am Heart Assoc. 2017;6(12):e006798.
   PubMed Web of Science ®Google Scholar
• Krueger F, Kappert K, Foryst-Ludwig A, et al. AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice. Clin Sci (Lond). 2017;131(15):1989–2005.
   PubMed Web of Science ®Google Scholar
• Niestrawska JA, Regitnig P, Viertler C, et al. The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysms. Acta Biomater. 2019;88:149–161.
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Kugo H, Tanaka H, et al. The effect of a high-fat diet on the development of abdominal aortic aneurysm in a vascular hypoperfusion-induced animal model. J Vasc Res. 2018;55(2):63–74.
   PubMed Web of Science ®Google Scholar
• Chamberlain G, Fox J, Ashton B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739–2749.
   PubMed Web of Science ®Google Scholar
• Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006;7(12):885–896.
   PubMed Web of Science ®Google Scholar
• Jiang C, Sun J, Dai Y, et al. HIF-1A and C/EBPs transcriptionally regulate adipogenic differentiation of bone marrow-derived MSCs in hypoxia. Stem Cell Res Ther. 2015;6:21.
   PubMed Web of Science ®Google Scholar
• Nobusue H, Onishi N, Shimizu T, et al. Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat Commun. 2014;5:3368.
   PubMed Web of Science ®Google Scholar
• Ciavarella C, Alviano F, Gallitto E, et al. Human vascular wall mesenchymal stromal cells contribute to abdominal aortic aneurysm pathogenesis through an impaired immunomodulatory activity and increased levels of matrix metalloproteinase-9. Circ J. 2015;79(7):1460–1469.
   PubMed Web of Science ®Google Scholar
• Ciavarella C, Gallitto E, Ricci F, et al. The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm. Stem Cell Res Ther. 2017;8(1):99.
   PubMedGoogle Scholar
• Kugo H, Moriyama T, Adipocytes ZN. Abdominal aortic aneurysm: putative potential role of adipocytes in the process of AAA development. Curr Drug Targets. 2018;19(11):1228–1232.
   PubMed Web of Science ®Google Scholar
• Kugo H, Tanaka H, Moriyama T, et al. Pathological implication of adipocytes in AAA development and the rupture. Ann Vasc Dis. 2018;11(2):159–168.
   PubMed Web of Science ®Google Scholar
• Iinuma S, Aikawa E, Tamai K, et al. Transplanted bone marrow-derived circulating PDGFRalpha+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J Immunol. 2015;194(4):1996–2003.
   PubMed Web of Science ®Google Scholar
• Palumbo R, Galvez BG, Pusterla T, et al. Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-kappaB activation. J Cell Biol. 2007;179(1):33–40.
   PubMed Web of Science ®Google Scholar
• Klein D, Weisshardt P, Kleff V, et al. Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation. PLoS One. 2011;6(5):e20540.
   PubMed Web of Science ®Google Scholar
• Klein D. Vascular wall-resident multipotent stem cells of mesenchymal nature within the process of vascular remodeling: cellular basis, clinical relevance, and implications for stem cell therapy. Stem Cells Int. 2016;2016:1905846.
   PubMedGoogle Scholar
• Police SB, Thatcher SE, Charnigo R, et al. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2009;29(10):1458–1464.
   PubMed Web of Science ®Google Scholar
• Kurobe H, Hirata Y, Matsuoka Y, et al. Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model. J Surg Res. 2013;185(1):455–462.
   PubMed Web of Science ®Google Scholar
• Li MW, Mian MO, Barhoumi T, et al. Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 2013;33(10):2306–2315.
   PubMed Web of Science ®Google Scholar
• Blomkalns AL, Gavrila D, Thomas M, et al. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc. 2013;2(2):e000065.
   PubMed Web of Science ®Google Scholar
• Sakaue T, Suzuki J, Hamaguchi M, et al. Perivascular adipose tissue angiotensin II type 1 receptor promotes vascular inflammation and aneurysm formation. Hypertension. 2017;70(4):780–789.
   PubMed Web of Science ®Google Scholar
• Zhang ZB, Ruan CC, Lin JR, et al. Perivascular adipose tissue-derived PDGF-D contributes to aortic aneurysm formation during obesity. Diabetes. 2018;67(8):1549–1560.
   PubMed Web of Science ®Google Scholar
• Folkesson M, Vorkapic E, Gulbins E, et al. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. J Vasc Surg. 2017;65(4):1171–1179 e1171.
   PubMed Web of Science ®Google Scholar
• Thanassoulis G, Massaro JM, Corsini E, et al. Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study. J Am Heart Assoc. 2012;1(6):e000885.
   PubMed Web of Science ®Google Scholar
• Dias-Neto M, Meekel JP, van Schaik TG, et al. High density of periaortic adipose tissue in abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2018;56(5):663–671.
   PubMed Web of Science ®Google Scholar
• Kugo H, Zaima N, Mouri Y, et al. The preventive effect of fish oil on abdominal aortic aneurysm development. Biosci Biotechnol Biochem. 2016;80(6):1186–1191.
   PubMed Web of Science ®Google Scholar
• Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452–458.
   PubMed Web of Science ®Google Scholar