Non-obesogenic doses of palmitate disrupt circadian metabolism in adipocytes

References

• Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935.
   PubMed Web of Science ®Google Scholar
• Froy O, Garaulet M. The circadian clock in white and brown adipose tissue: mechanistic, endocrine, and clinical aspects. Endocr Rev. 2018;39:261–273.
   PubMed Web of Science ®Google Scholar
• Panda S, Antoch MP, Miller BH, et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002;109:307–320.
   PubMed Web of Science ®Google Scholar
• Schibler U, Ripperger J, Brown SA. Peripheral circadian oscillators in mammals: time and food. J Biol Rhythms. 2003;18:250–260.
   PubMed Web of Science ®Google Scholar
• Sancar G, Brunner M. Circadian clocks and energy metabolism. Cell Mol Life Sci. 2014;71:2667–2680.
   PubMed Web of Science ®Google Scholar
• Turek FW, Joshu C, Kohsaka A, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005;308:1043–1045.
   PubMed Web of Science ®Google Scholar
• Tsai LL, Tsai YC, Hwang K, et al. Repeated light-dark shifts speed up body weight gain in male F344 rats. Am J Physiol Endocrinol Metab. 2005;289:E212–7.
   PubMed Web of Science ®Google Scholar
• Rudic RD, McNamara P, Curtis AM, et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004;2:e377.
   PubMed Web of Science ®Google Scholar
• Ando H, Yanagihara H, Hayashi Y, et al. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology. 2005;146:5631–5636.
   PubMed Web of Science ®Google Scholar
• Froy O. Metabolism and circadian rhythms—implications for obesity. Endocr Rev. 2009;31:1–24.
   PubMed Web of Science ®Google Scholar
• Aoyagi T, Shimba S, Tezuka M. Characteristics of circadian gene expressions in mice white adipose tissue and 3T3-L1 adipocytes. J Health Sci. 2005;51:21–32.
   Google Scholar
• Shimba S, Ishii N, Ohta Y, et al. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Nat Acad Sci. 2005;102:12071–12076.
   PubMed Web of Science ®Google Scholar
• Sato TK, Panda S, Miraglia LJ, et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004;43:527–537.
   PubMed Web of Science ®Google Scholar
• Delezie J, Dumont S, Dardente H, et al. The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism. Faseb J. 2012;26:3321–3335.
   PubMed Web of Science ®Google Scholar
• Woldt E, Sebti Y, Solt LA, et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 2013;19:1039.
   PubMed Web of Science ®Google Scholar
• Wang N, Yang G, Jia Z, et al. Vascular PPARγ controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 2008;8:482–491.
   PubMed Web of Science ®Google Scholar
• Yang G, Jia Z, Aoyagi T, et al. Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism. PloS One. 2012;7:e38117.
   PubMed Web of Science ®Google Scholar
• Grimaldi B, Bellet MM, Katada S, et al. PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab. 2010;12:509–520.
   PubMed Web of Science ®Google Scholar
• Bellet MM, Sassone-Corsi P. Mammalian circadian clock and metabolism–the epigenetic link. J Cell Sci. 2010;123:3837–3848.
   PubMed Web of Science ®Google Scholar
• Sahar S, Zocchi L, Kinoshita C, et al. Regulation of BMAL1 protein stability and circadian function by GSK3β-mediated phosphorylation. PloS One. 2010;5:e8561.
   PubMed Web of Science ®Google Scholar
• Hsieh M, Yang S, Tseng H, et al. Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice. Int J Obesity. 2010;34:227–239.
   PubMed Web of Science ®Google Scholar
• Kohsaka A, Laposky AD, Ramsey KM, et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 2007;6:414–421.
   PubMed Web of Science ®Google Scholar
• Yanagihara H, Ando H, Hayashi Y, et al. High‐fat feeding exerts minimal effects on rhythmic mRNA expression of clock genes in mouse peripheral tissues. Chronobiol Int. 2006;23:905–914.
   PubMed Web of Science ®Google Scholar
• Barnea M, Madar Z, Froy O. High-fat diet followed by fasting disrupts circadian expression of adiponectin signaling pathway in muscle and adipose tissue. Obesity (Silver Spring). 2010;18:230–238.
   PubMed Web of Science ®Google Scholar
• Adamovich Y, Aviram R, Asher G. The emerging roles of lipids in circadian control. Biochim Biophys Acta (BBA)-Mol Cell Biol Lipids. 2015;1851:1017–1025.
   PubMed Web of Science ®Google Scholar
• Eckel-Mahan KL, Patel VR, de Mateo S, et al. Reprogramming of the circadian clock by nutritional challenge. Cell. 2013;155:1464–1478.
   PubMed Web of Science ®Google Scholar
• Listenberger LL, Han X, Lewis SE, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Nat Acad Sci. 2003;100:3077–3082.
   PubMed Web of Science ®Google Scholar
• Fick LJ, Fick GH, Belsham DD. Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons. Biochem Biophys Res Commun. 2011;413:414–419.
   PubMed Web of Science ®Google Scholar
• Greco JA, Oosterman JE, Belsham DD. Differential effects of omega-3 fatty acid docosahexaenoic acid and palmitate on the circadian transcriptional profile of clock genes in immortalized hypothalamic neurons. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1049–R60.
   PubMed Web of Science ®Google Scholar
• Tong X, Zhang D, Arthurs B, et al. Palmitate inhibits SIRT1-dependent BMAL1/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes. PloS One. 2015;10:e0130047.
   PubMed Web of Science ®Google Scholar
• Gil-Lozano M, Wu WK, Martchenko A, et al. High-fat diet and palmitate alter the rhythmic secretion of glucagon-like peptide-1 by the rodent L-cell. Endocrinology. 2015;157:586–599.
   PubMed Web of Science ®Google Scholar
• Kim S-M, Neuendorff N, Chapkin RS, et al. Role of inflammatory signaling in the differential effects of saturated and poly-unsaturated fatty acids on peripheral circadian clocks. EBioMedicine. 2016;7:100–111.
   PubMed Web of Science ®Google Scholar
• Tal Y, Chapnik N, Froy O. Non-obesogenic doses of fatty acids modulate the functionality of the circadian clock in the liver. Cell Mol Life Sci. 2019;76:1795–1806.
   PubMed Web of Science ®Google Scholar
• Sherman H, Frumin I, Gutman R, et al. Long‐term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers. J Cell Mol Med. 2011;15:2745–2759.
   PubMed Web of Science ®Google Scholar
• Sherman H, Froy O. Expression of human β-defensin 1 is regulated via c-myc and the biological clock. Mol Immunol. 2008;45:3163–3167.
   PubMed Web of Science ®Google Scholar
• Gürsel DB, Banu MA, Berry N, et al. Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. J Neurooncol. 2015;121:19–29.
   PubMed Web of Science ®Google Scholar
• Garin-Shkolnik T, Rudich A, Hotamisligil GS, et al. FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes. 2014;63:900–911.
   PubMed Web of Science ®Google Scholar
• Salvadó L, Coll T, Gomez-Foix A, et al. Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. Diabetologia. 2013;56:1372–1382.
   PubMed Web of Science ®Google Scholar
• Kwon B, Querfurth HW. Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: reversal by oleate is similar to metformin. Biochimie. 2015;118:141–150.
   PubMed Web of Science ®Google Scholar
• Hermida MA, Kumar JD, Leslie NR. GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Adv Biol Regul. 2017;65:5–15.
   PubMedGoogle Scholar
• Lu Y, Muller M, Smith D, et al. Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling. Oncogene. 2011;30:4567.
   PubMed Web of Science ®Google Scholar
• Darrington RS, Campa VM, Walker MM, et al. Distinct expression and activity of GSK‐3α and GSK‐3β in prostate cancer. Int J Cancer. 2012;131:E872–E83.
   PubMed Web of Science ®Google Scholar
• Dang F, Sun X, Ma X, et al. Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. Nat Commun. 2016;7:12696.
   PubMed Web of Science ®Google Scholar