The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis

References

• Cataldo R, Huang J, Calixte R, et al. Effects of overweight and obesity on motor and mental development in infants and toddlers. Pediatr Obes. 2016;11(5):389–396.
   PubMed Web of Science ®Google Scholar
• Pollock NK. Childhood obesity, bone development, and cardiometabolic risk factors. Mol Cell Endocrinol. 2015;410:52–63.
   PubMed Web of Science ®Google Scholar
• Wagner IV, Sabin MA, Pfäffle RW, et al. Effects of obesity on human sexual development. Nat Rev Endocrinol. 2012;8(4):246.
   PubMed Web of Science ®Google Scholar
• Mirza NM, Yanovski JA. Prevalence and consequences of pediatric obesity. In: Bray GA, Bouchard C, editors. Handbook of obesity: epidemiology, etiology, and physiopathology. Boca Raton, FL: CRC Press; 2014. p. 55–74.
   Google Scholar
• Robidoux J, Martin TL, Collins S. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol. 2004;44:297–323.
   PubMed Web of Science ®Google Scholar
• Collins S, Surwit RS. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res. 2001;56:309–328.
   PubMedGoogle Scholar
• Kurylowicz A, Jonas M, Lisik W, et al. Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues. J Transl Med. 2015;13(1):31.
   PubMedGoogle Scholar
• Cao W-Y, Liu Z, Guo F, et al. Adipocyte ADRB3 down-regulated in Chinese overweight individuals adipocyte ADRB3 in overweight. Obes Facts. 2018;11(6):524–533.
   PubMed Web of Science ®Google Scholar
• Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med. 1995;333(6):343–347.
   PubMed Web of Science ®Google Scholar
• Yoshida T, Sakane N, Umekawa T, et al. Mutation of beta 3-adrenergic-receptor gene and response to treatment of obesity. Lancet. 1995;346(8987):1433–1434.
   PubMed Web of Science ®Google Scholar
• Clement K, Vaisse C, Manning BS, et al. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995;333(6):352–354.
   PubMed Web of Science ®Google Scholar
• Piétri‐Rouxel F, St John Manning B, Gros J, et al. The biochemical effect of the naturally occurring Trp644→ Arg mutation on human β3‐adrenoceptor activity. Eur J Biochem. 1997;247(3):1174–1179.
   PubMedGoogle Scholar
• Umekawa T, Yoshida T, Sakane N, et al. Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes. Diabetes. 1999;48(1):117–120.
   PubMed Web of Science ®Google Scholar
• Hinney A, Lentes K, Rosenkranz K, et al. β 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. Int J Obesity. 1997;21(3):224.
   Web of Science ®Google Scholar
• Endo K, Yanagi H, Hirano C, et al. Association of Trp64Arg polymorphism of the β 3-adrenergic receptor gene and no association of Gln223Arg polymorphism of the leptin receptor gene in Japanese schoolchildren with obesity. Int J Obesity. 2000;24(4):443.
   Web of Science ®Google Scholar
• Mo B, Chen R, Guo X, et al. The role of β 3-adrenergic receptor Trp/Arg mutation in childhood obesity. Chin J Med Genet. 2001;18(5):371–374.
   Google Scholar
• Ochoa M, Marti A, Azcona C, et al. Gene–gene interaction between PPARγ2 and ADRβ3 increases obesity risk in children and adolescents. Int J Obesity. 2004;28(S3):S37.
   Google Scholar
• Erhardt É, Czakó M, Csernus K, et al. The frequency of Trp64Arg polymorphism of the β 3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors. Eur J Clin Nutr. 2005;59(8):955.
   PubMed Web of Science ®Google Scholar
• Li Q, Xu J, Zhang Y, et al. Effects of variation of the β3-adrenergic-receptor and uncoupling Protein-2 gene polymorphism on children simple obesity. Chin J Sch Health. 2007;28(3):249–252.
   Google Scholar
• Wang Z, Gao W-H. Gene polymorphism study of β3 adrenergic receptor in school aged children in Shenzhen. Chin J Misdiagnostics. 2008;8(25):6052–6053.
   Google Scholar
• Peng A, Yang S, Zhang B, et al. Detection and significance of Trp64Arg Mutat ion of β3-AR in preschool children with simple obesity. Acta Medicinae Universitatis Scientiae Et Technologiae Huazhong. 2010;39(6):868–871.
   Google Scholar
• Chou YC, Tsai CN, Lee YS, et al. Association of adrenergic receptor gene polymorphisms with adolescent obesity in Taiwan. Pediatr Int. 2012;54(1):111–116.
   PubMed Web of Science ®Google Scholar
• Csernus K, Pauler G, Erhardt E, et al. Uncoupling protein‐2 gene polymorphisms are associated with obesity in Hungarian children. Acta Paediatrica. 2013;102(5):e200–e04.
   PubMed Web of Science ®Google Scholar
• Oguri K, Tachi T, Matsuoka T. Visceral fat accumulation and metabolic syndrome in children: the impact of T rp64 A rg polymorphism of the beta3‐adrenergic receptor gene. Acta Paediatrica. 2013;102(6):613–619.
   PubMed Web of Science ®Google Scholar
• Zhu C, Zhang J, Xu P, et al. Association of polymorphism of β3-adrenergic receptor gene and the leptin gene with Kazak obese children in Xinjiang. Chin J Appl Clin Pediatr. 2013;28(11):816–819.
   Google Scholar
• Kuo N-W, Tung K-Y, Tsai C-H, et al. β3-Adrenergic receptor gene modifies the association between childhood obesity and asthma. J Allergy Clin Immunol. 2014;134(3):731–33. e3.
   PubMed Web of Science ®Google Scholar
• Verdi H, Kınık ST, Yalçın YY, et al. β-3AR W64R polymorphism and 30-Minute post-challenge plasma glucose levels in obese children. J Clin Res Pediatr Endocrinol. 2015;7(1):7.
   PubMed Web of Science ®Google Scholar
• Ursu R-I, Cucu N, Ursu G-F, et al. Frequency study of the FTO and ADRB3 genotypes in a Romanian cohort of obese children. Rom Biotechnol Lett. 2016;21(3):11611.
   Web of Science ®Google Scholar
• Aradillas-Garcia C, Cruz M, Pérez-Luque E, et al. Obesity is associated with the Arg389Gly ADRB1 but not with the Trp64Arg ADRB3 polymorphism in children from San Luis Potosí and León, México. J Biomed Res. 2017;31(1):40.
   Web of Science ®Google Scholar
• Zhang J, Li M, Xu P, et al. Distribution of beta3-adrenergic receptor Trp64Arg mutation of Karzak school-aged children in Xinjiang. J Xinjiang Med Univ. 2008;31(1):74–76.
   Google Scholar
• Mo B, Chen R, Guo X, et al. The detection and significance of Trp64Arg Mutation of β3-adrenergic receptor in school-age children. Acta Universitatis Medicinalis Nanjing. 2000;20(9):359–361.
   Google Scholar
• Peng A, Yang S, Zhang B, et al. Detection and significance of Trp64Arg mutation of β3-AR and temperament in preschool children with simple obesity. Chin J Sch Health. 2011;32(2):186–187.
   Google Scholar
• Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719–748.
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–188.
   PubMedGoogle Scholar
• Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634.
   PubMed Web of Science ®Google Scholar
• Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;1088–1101. DOI:10.2307/2533446
   PubMed Web of Science ®Google Scholar
• Duval S, Tweedie R. Trim and fill: a simple funnel‐plot–based method of testing and adjusting for publication bias in meta‐analysis. Biometrics. 2000;56(2):455–463.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339. DOI:10.1136/bmj.b2535.
   Web of Science ®Google Scholar
• Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–1558.
   PubMed Web of Science ®Google Scholar