References
- Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav. 2008 May 23;94(2):206–218.
- Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445.
- Muir LA, Kiridena S, Griffin C, et al. Frontline Science: rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages. J Leukoc Biol. 2018 Apr;103(4):615–628. .
- Crewe C, An YA, Scherer PE. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. J Clin Invest. 2017 Jan 3;127(1):74–82.
- Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017 Feb 8;542(7640):177–185.
- Ormazabal V, Nair S, Elfeky O, et al. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018 Aug 31;17(1):122.
- Bravo C, Cataldo LR, Galgani J, et al. Leptin/adiponectin ratios using either total or high-molecular-weight adiponectin as biomarkers of systemic insulin sensitivity in normoglycemic women. J Diabetes Res. 2017;2017:9031079.
- Fruhbeck G, Catalan V, Rodriguez A, et al. Adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation. Nutrients. 2019 Feb 22; 11(2). DOI:10.3390/nu11020454.
- Fruhbeck G, Catalan V, Rodriguez A, et al. Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte. 2018 Jan 2;7(1):57–62.
- Mahalle NP, Garg MK, Kulkarni MV, et al. Differences in traditional and non-traditional risk factors with special reference to nutritional factors in patients with coronary artery disease with or without diabetes mellitus. Indian J Endocrinol Metab. 2013 Sep;17(5):844–850.
- Bauer UE, Briss PA, Goodman RA, et al. Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA. Lancet. 2014 Jul 5;384(9937):45–52.
- Eckel RH, Kahn R, Robertson RM, et al. Preventing cardiovascular disease and diabetes: a call to action from the American diabetes association and the American heart association. Diabetes Care. 2006 Jul;29(7):1697–1699.
- Caputo T, Gilardi F, Desvergne B. From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. FEBS Lett. 2017 Oct;591(19):3061–3088.
- Lionetti L, Mollica MP, Lombardi A, et al. From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation. Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):146–152.
- Karelis AD, Rabasa-Lhoret R. Obesity: can inflammatory status define metabolic health? Nat Rev Endocrinol. 2013 Dec;9(12):694–695.
- You S, Yin X, Liu H, et al. Hyperfibrinogenemia is significantly associated with an increased risk of in-hospital mortality in acute ischemic stroke patients. Curr Neurovasc Res. 2017;14(3):242–249. .
- Tangvarasittichai S, Pongthaisong S, Tangvarasittichai O. Tumor necrosis factor-alpha, interleukin-6, c-reactive protein levels and insulin resistance associated with type 2 diabetes in abdominal obesity women. Indian J Clin Biochem. 2016 Mar;31(1):68–74.
- Bastarrachea RA, Laviada-Molina HA, Nava-Gonzalez EJ, et al. Deep multi-OMICs and multi-tissue characterization in a pre- and postprandial state in human volunteers: the GEMM family study research design. Genes (Basel). 2018 Nov 2;9(11). DOI:10.3390/genes9110532.
- Hubal MJ, Nadler EP, Ferrante SC, et al. Circulating adipocyte-derived exosomal MicroRNAs associated with decreased insulin resistance after gastric bypass. Obesity (Silver Spring). 2017 Jan;25(1):102–110. .
- Icli B, Feinberg MW. MicroRNAs in dysfunctional adipose tissue: cardiovascular implications. Cardiovasc Res. 2017 Jul 1;113(9):1024–1034.
- Wang M, Han X. Advanced shotgun lipidomics for characterization of altered lipid patterns in neurodegenerative diseases and brain injury. Methods Mol Biol. 2016;1303:405–422.
- López-Alvarenga JCC-ML, Dávalos-Ibáñez A, González-Barranco J. Reproducibilidad y sensibilidad de un cuestionario de actividad física en población mexicana. Salud Publica de Mexico. 2001;43(4):306–310.
- Perkins BA, Caskey CT, Brar P, et al. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci USA. 2018 Apr 3;115(14):3686–3691.
- Rojas-Martinez A. Confidentiality and data sharing: vulnerabilities of the mexican genomics sovereignty act. J Community Genet. 2015 Jul;6(3):313–319.
- Schwartz-Marin E, Mendez AA. The law of genomic sovereignty and the protection of “Mexican genetic patrimony”. Med Law. 2012 Jun;31(2):283–294.
- Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007 Apr;45(4):846–854. .
- Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959 Aug;37(8):911–917.
- Wang M, Wang C, Han RH, et al. Novel advances in shotgun lipidomics for biology and medicine. Prog Lipid Res. 2016 Jan;61:83–108.
- Yang K, Cheng H, Gross RW, et al. Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics. Anal Chem. 2009 Jun 1;81(11):4356–4368.
- Han X, Yang K, Gross RW. Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom Rev. 2012 Jan–Feb;31(1):134–178.
- Pietzner M, Kaul A, Henning AK, et al. Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals. BMC Med. 2017 Nov 30;15(1):210.
- Iacomino G, Siani A. Role of microRNAs in obesity and obesity-related diseases. Genes Nutr. 2017;12:23.
- Zhong H, Ma M, Liang T, et al. Role of MicroRNAs in obesity-induced metabolic disorder and immune response. J Immunol Res. 2018;2018:2835761.
- Franzosi MG. Should we continue to use BMI as a cardiovascular risk factor? Lancet. 2006 Aug 19;368(9536):624–625.
- Klein S, Allison DB, Heymsfield SB, et al. Waist circumference and cardiometabolic risk: a consensus statement from shaping America’s health: association for weight management and obesity prevention; NAASO, the obesity society; the American society for nutrition; and the American diabetes association. Am J Clin Nutr. 2007 May;85(5):1197–1202. .
- Eloi JC, Epifanio M, de Goncalves MM, et al. Quantification of abdominal fat in obese and healthy adolescents using 3 tesla magnetic resonance imaging and free software for image analysis. PLoS One. 2017;12(1):e0167625. .
- Jorge-Galarza E, Medina-Urrutia A, Posadas-Sanchez R, et al. Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus. Diabetol Metab Syndr. 2016;8:73.
- Robinson PN. Deep phenotyping for precision medicine. Hum Mutat. 2012 May;33(5):777–780.
- Abdul-Ghani MA, Matsuda M, Balas B, et al. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 2007 Jan;30(1):89–94.
- Mechanick JI, Garber AJ, Grunberger G, et al. Dysglycemia-based chronic disease: an American association of clinical endocrinologists position statement. Endocr Pract. 2018 Nov;24(11):995–1011.
- Konner AC, Bruning JC. Selective insulin and leptin resistance in metabolic disorders. Cell Metab. 2012 Aug 8;16(2):144–152.
- Vega GL, Grundy SM. Metabolic risk susceptibility in men is partially related to adiponectin/leptin ratio. J Obes. 2013;2013:409679.
- Vilahur G, Ben-Aicha S, Badimon L. New insights into the role of adipose tissue in thrombosis. Cardiovasc Res. 2017 Jul 1;113(9):1046–1054.
- Stegenga ME, van der Crabben SN, Dessing MC, et al. Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. Diabet Med. 2008 Feb;25(2):157–164. .
- Stefan N, Haring HU, Hu FB, et al. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013 Oct;1(2):152–162.
- Virtue S, Vidal-Puig A. It’s not how fat you are, it’s what you do with it that counts. PLoS Biol. 2008 Sep 23;6(9):e237.
- Trayhurn P. Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity. Annu Rev Nutr. 2014;34:207–236.
- Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993 Jan 1;259(5091):87–91.
- Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem. 2003 Nov 14;278(46):45777–45784.
- Sutherland JP, McKinley B, Eckel RH. The metabolic syndrome and inflammation. Metab Syndr Relat Disord. 2004 Jun;2(2):82–104.
- Pestka S, Krause CD, Sarkar D, et al. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004;22:929–979.
- Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 2016 May 10;23(5):770–784.
- Aslam M, Aggarwal S, Sharma KK, et al. Postprandial hypertriglyceridemia predicts development of insulin resistance glucose intolerance and type 2 diabetes. PLoS One. 2016;11(1):e0145730.
- Gastaldelli A, Harrison SA, Belfort-Aguilar R, et al. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology. 2009 Oct;50(4):1087–1093. .
- Lomonaco R, Ortiz-Lopez C, Orsak B, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology. 2012 May;55(5):1389–1397. .
- Han X. Lipidomics for studying metabolism. Nat Rev Endocrinol. 2016 Nov;12(11):668–679.
- Wang J, Wang C, Han X. Tutorial on lipidomics. Anal Chim Acta. 2019 Jul;11(1061):28–41.
- Zhong H, Fang C, Fan Y, et al. Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic, and type 2 diabetic individuals. Gigascience. 2017 Jul 1;6(7):1–12.
- Lin Q, Gao Z, Alarcon RM, et al. A role of miR-27 in the regulation of adipogenesis. Febs J. 2009 Apr;276(8):2348–2358.
- Huang N, Wang J, Xie W, et al. MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1. Biochem Biophys Res Commun. 2015 Jan 30;457(1):37–42.
- Landrier JF, Derghal A, Mounien L. MicroRNAs in obesity and related metabolic disorders. Cells. 2019 Aug 9;8(8). DOI:10.3390/cells8080859.
- Krist B, Florczyk U, Pietraszek-Gremplewicz K, et al. The role of miR-378a in metabolism, angiogenesis, and muscle biology. Int J Endocrinol. 2015;2015:281756.
- Price NL, Fernandez-Hernando C. miRNA regulation of white and brown adipose tissue differentiation and function. Biochim Biophys Acta. 2016 Dec;1861(12Pt B):2104–2110.
- Ortega FJ, Mercader JM, Catalan V, et al. Targeting the circulating microRNA signature of obesity. Clin Chem. 2013 May;59(5):781–792. .
- Brennan E, Wang B, McClelland A, et al. Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis. Diabetes. 2017 Aug;66(8):2266–2277. .
- Zhang F, Wang H, Wang X, et al. TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget. 2016 Aug 9;7(32):52294–52306.
- Ohlsson SM, Linge CP, Gullstrand B, et al. Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization. Clin Immunol. 2014 May-Jun;152(1–2):10–19. .
- Wang LX, Zhang SX, Wu HJ, et al. M2b macrophage polarization and its roles in diseases. J Leukoc Biol. 2019 Aug;106(2):345–358.
- Norseen J, Hosooka T, Hammarstedt A, et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May;32(10):2010–2019. .
- Le Dour C, Wu W, Bereziat V, et al. Extracellular matrix remodeling and transforming growth factor-beta signaling abnormalities induced by lamin A/C variants that cause lipodystrophy. J Lipid Res. 2017 Jan;58(1):151–163.
- Fruhbeck G, Catalan V, Rodriguez A, et al. Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome. Sci Rep. 2017 Jul 26;7(1):6619.
- Engin A. Adiponectin-resistance in obesity. Adv Exp Med Biol. 2017;960:415–441.
- Kralova Lesna I, Kralova A, Cejkova S, et al. Characterisation and comparison of adipose tissue macrophages from human subcutaneous, visceral and perivascular adipose tissue. J Transl Med. 2016 Jul 11;14(1):208.
- Bluher M, Fasshauer M, Tonjes A, et al. Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Exp Clin Endocrinol Diabetes. 2005 Oct;113(9):534–537.
- Gotoh K, Inoue M, Masaki T, et al. A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver. Diabetes. 2012 Aug;61(8):1994–2003.
- Xue Y, Cao R, Nilsson D, et al. FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10167–10172.
- Garcia-Martin R, Alexaki VI, Qin N, et al. Adipocyte-specific hypoxia-inducible factor 2alpha deficiency exacerbates obesity-induced brown adipose tissue dysfunction and metabolic dysregulation. Mol Cell Biol. 2016 Feb 1;36(3):376–393.
- Aviles-Santa ML, Perez CM, Schneiderman N, et al. Detecting prediabetes among hispanics/latinos from diverse heritage groups: does the test matter? Findings from the hispanic community health study/study of latinos. Prev Med. 2017 Feb;95:110–118.
- Morales LS, Flores YN, Leng M, et al. Risk factors for cardiovascular disease among Mexican-American adults in the United States and Mexico: a comparative study. Salud Publica Mex. 2014 Apr;56(2):197–205.
- Williams AL, Jacobs SB, Moreno-Macias H, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 2014 Feb 6;506(7486):97–101.
- Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. 1988. Nutrition. 1997 Jan;13(1):65. discussion 4, 6.
- Reaven GM. The metabolic syndrome: requiescat in pace. Clin Chem. 2005 Jun;51(6):931–938.
- Kahn R, Buse J, Ferrannini E, et al. The metabolic syndrome: time for a critical appraisal: joint statement from the American diabetes association and the European association for the study of diabetes. Diabetes Care. 2005 Sep;28(9):2289–2304.
- Yeni-Komshian H, Carantoni M, Abbasi F, et al. Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers. Diabetes Care. 2000 Feb;23(2):171–175.